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Maternal depression during pregnancy and offspring depression in adulthood: Role of child maltreatment
Open accessAbstract
BACKGROUND: Studies have shown that maternal depression during pregnancy predicts offspring depression in adolescence. Child maltreatment is also a risk factor for depression. AIMS: To investigate (a) whether there is an association between offspring exposure to maternal depression in pregnancy and depression in early adulthood, and (b) whether offspring child maltreatment mediates this association. METHOD: Prospectively collected data on maternal clinical depression in pregnancy, offspring child maltreatment and offspring adulthood (18-25 years) DSM-IV depression were analysed in 103 mother-offspring dyads of the South London Child Development Study. RESULTS: Adult offspring exposed to maternal depression in pregnancy were 3.4 times more likely to have a DSM-IV depressive disorder, and 2.4 times more likely to have experienced child maltreatment, compared with non-exposed offspring. Path analysis revealed that offspring experience of child maltreatment mediated the association between exposure to maternal depression in pregnancy and depression in adulthood. CONCLUSIONS: Maternal depression in pregnancy is a key vulnerability factor for offspring depression in early adulthood.
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“association that is mediated, at least in part, by an increased risk of the offspring being exposed to maltreatment and other stressful events in childhood (Plant et al., 2013(Plant et al., , 2015)).”
From Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation (2017) · cites this paper as Plant et al., 2015
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Metadata
- Authors
- Plant, D. T., Pariante, C. M., Sharp, D., & Pawlby, S.
- Affiliations
- King's College London (GB)
- Corresponding author
- Plant, Dominic T.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2015-09
- Volume
- 207
- Issue
- 3
- Pages
- 213-220
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC4555443
- OpenAlex
- W1857560301
- Cited by
- 184
- References
- 59
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 15 · 2023: 15 · 2022: 18 · 2021: 21 · 2020: 27 · 2019: 21 · 2018: 17 · 2017: 18 · 2016: 9 · 2015: 2
- FWCI
- 16.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Funders
- Wellcome Trust
- Psychiatry Research Trust
- National Institute for Health and Care Research
- King's College London
- Cardiff University
- Medical Research Council (MR/J002739/1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- maternal depression, pregnancy, offspring depression, early adulthood, child abuse, mediation, intergenerational transmission, vulnerability factors
- MeSH terms
- Adolescent, Adult, Child, Child Abuse, Child, Preschool, Depressive Disorder, Female, Humans, Longitudinal Studies, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Prospective Studies, Depression, Postpartum, Adult Survivors of Child Abuse, Young Adult
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