Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.

Rifkin-Graboi, Anne; Bai, Jordan; Chen, Helen; Hameed, Waseem Bak’r; Sim, Lit Wee; Tint, Mya Thway; Leutscher-Broekman, Birit; Chong, Yap-Seng; Gluckman, Peter D.; Fortier, Marielle V.; Meaney, Michael J.; Qiu, Anqi

doi:10.1016/j.biopsych.2013.06.019

Cited by 258Maternal Mental Health During Pregnancy and PostpartumStress Responses and CortisolChild and Adolescent Psychosocial and Emotional Development

Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.

Rifkin-Graboi, Anne, Bai, Jordan, Chen, Helen, Hameed, Waseem Bak’r, Sim, Lit Wee, Tint, Mya Thway, Leutscher-Broekman, Birit, Chong, Yap-Seng +4 more·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.06.019

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Abstract

Background Antenatal maternal cortisol levels associate with alterations in the amygdala, a structure associated with emotion regulation, in the offspring. However, because offspring brain and behavior are commonly assessed years after birth, the timing of such maternal influences is unclear. This study aimed to examine the association between antenatal maternal depressive symptomatology and neonatal amygdala volume and microstructure and thus establish evidence for the transgenerational transmission of vulnerability for affective disorders during prenatal development.Methods Our study recruited Asian mothers at 10 to 13 weeks pregnancy and assessed maternal depression at 26 weeks gestation using the Edinburgh Postnatal Depression Scale. Structural magnetic resonance imaging and diffusion tensor imaging were performed with 157 nonsedated, 6- to 14-day-old newborns and then analyzed to extract the volume, fractional anisotropy, and axial diffusivity values of the amygdala.Results Adjusting for household income, maternal age, and smoking exposure, postconceptual age at magnetic resonance imaging, and birth weight, we found significantly lower fractional anisotropy (p = .009) and axial diffusivity (p = .028), but not volume (p = .993), in the right amygdala in the infants of mothers with high compared with those with low-normal Edinburgh Postnatal Depression Scale scores.Conclusions The results reveal a significant relation between antenatal maternal depression and the neonatal microstructure of the right amygdala, a brain region closely associated with stress reactivity and vulnerability for mood anxiety disorders. These findings suggest the prenatal transmission of vulnerability for depression from mother to child and that interventions targeting maternal depression should begin early in pregnancy.

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Exposure to prenatal maternal stress has enduring and wide-ranging consequences on brain development in the offspring, including altered regional brain volumetric growth, cortical folding, metabolism, microstructure, and functional connectivity.
“Importantly, exposure to prenatal maternal stress is shown to have enduring and wide-ranging consequences on brain development in the offspring, including altered regional brain volumetric growth, cortical folding, metabolism, microstructure, and functional connectivity [4, 15, 19, 23–27, 35–39].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [15]
Maternal depression is connected with lower FA and axial diffusivity in the right amygdala of newborns.
“Maternal depression is also connected with lower FA and axial diffusivity in the right amygdala of newborns [15].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [15]
Maternal depression during pregnancy is associated with altered microstructure and functional connectivity of the amygdala in 6-month-olds.
“altered microstructure and functional connectivity of the amygdala in 6-month-olds175, 176.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [175]
Prenatal maternal stress exposure has enduring consequences on offspring brain development and long-term neurodevelopment.
“Prenatal maternal stress exposure has been shown to have enduring consequences on brain development in the offspring”
From Association of Elevated Maternal Psychological Distress, Altered Fetal Brain, and Offspring Cognitive and Social-Emotional Outcomes at 18 Months (2022) · cites this paper as [10]

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Maternal depression during pregnancy and offspring depression in adulthood: role of child maltreatment
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ALL OUR SONS: THE DEVELOPMENTAL NEUROBIOLOGY AND NEUROENDOCRINOLOGY OF BOYS AT RISK
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Does prenatal stress alter the developing connectome?
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Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure
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“…exposure to prenatal maternal stress is shown to have enduring and wide-ranging consequences on brain development in the offspring, including altered regional brain volumetric growth, cortical folding, metabolism, microstructure, and functional connectivity [4, 15, 19, 23 – 27 , 35 – 39 ].”
Background
Family Environment, Neurodevelopmental Risk, and the Environmental Influences on Child Health Outcomes (ECHO) Initiative: Looking Back and Moving Forward
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Risk of Depression in the Adolescent and Adult Offspring of Mothers With Perinatal Depression
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Maternal depressive symptoms during and after pregnancy and child developmental milestones
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Association of Elevated Maternal Psychological Distress, Altered Fetal Brain, and Offspring Cognitive and Social-Emotional Outcomes at 18 Months
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Prenatal maternal anxiety and children's brain structure and function: A systematic review of neuroimaging studies
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Prenatal maternal depression is associated with offspring inflammation at 25 years: a prospective longitudinal cohort study
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Prenatal Stress and the Developing Brain: Postnatal Environments Promoting Resilience
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An experimental test of the fetal programming hypothesis: Can we reduce child ontogenetic vulnerability to psychopathology by decreasing maternal depression?
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Prenatal Maternal Stress, Child Cortical Thickness, and Adolescent Depressive Symptoms
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Perinatal maternal depressive symptoms alter amygdala functional connectivity in girls
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Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months
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Prenatal Major Depressive Disorder, Placenta Glucocorticoid and Serotonergic Signaling, and Infant Cortisol Response
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Association of Prenatal Maternal Anxiety With Fetal Regional Brain Connectivity
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Associations between different dimensions of prenatal distress, neonatal hippocampal connectivity, and infant memory
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Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance
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Beyond the neuron: Role of non-neuronal cells in stress disorders
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Prenatal stress exposure and multimodal assessment of amygdala–medial prefrontal cortex connectivity in infants
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Prenatal Maternal Distress During the COVID-19 Pandemic and Associations With Infant Brain Connectivity
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Variations in Neurodevelopmental Outcomes in Children with Prenatal SSRI Antidepressant Exposure
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Preconception origins of perinatal maternal mental health
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Thalamocortical functional connectivity and behavioral disruptions in neonates with prenatal cocaine exposure
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Prenatal exposure to maternal and paternal depressive symptoms and white matter microstructure in children
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Authors: Rifkin-Graboi, A., Bai, J., Chen, H., Hameed, W. B., Sim, L. W., Tint, M. T., Leutscher-Broekman, B., Chong, Y.-S., Gluckman, P. D., Fortier, M. V., Meaney, M. J., & Qiu, A.
Affiliations: Singapore Institute for Clinical Sciences (SG)
KK Women's and Children's Hospital (SG)
National University of Singapore (SG)
Douglas Mental Health University Institute (CA)
Corresponding author: Qiu, Anqi
ORCID: Rifkin-Graboi, Anne
Chen, Helen
Tint, Mya Thway
Chong, Yap-Seng
Gluckman, Peter D.
Fortier, Marielle V.
Meaney, Michael J.
Qiu, Anqi
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-12
Volume: 74
Issue: 11
Pages: 837-844
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.06.019
OpenAlex: W2005527520
Cited by: 258
References: 66
Citations by year: 2026: 16 · 2025: 16 · 2024: 17 · 2023: 14 · 2022: 17 · 2021: 29 · 2020: 33 · 2019: 25 · 2018: 18 · 2017: 23 · 2016: 21 · 2015: 16 · 2014: 10 · 2013: 3
FWCI: 17.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
National University of Singapore (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Agency for Science, Technology and Research (SICS-09/1/1/001)
National Medical Research Council (NMRC/CBRG12nov057, NMRC/TCR/004-NUS/2008)
National University of Singapore (NUSYIA FY10 P07)
Ministry of Education - Singapore (MOE2012-T2-2-130)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: maternal depression, antenatal depression, fractional anisotropy, axial diffusivity, transgenerational transmission, prenatal stress, maternal cortisol, mood disorders, stress reactivity
MeSH terms: Adult, Amygdala, Depression, Female, Humans, Infant, Newborn, Male, Pregnancy, Prenatal Exposure Delayed Effects, Singapore, Magnetic Resonance Angiography, Asian People, Diffusion Tensor Imaging

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Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.

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