Maternal Depression During Pregnancy and the Postnatal Period: Risks and Possible Mechanisms for Offspring Depression at Age 18 Years
Open accessAbstract
IMPORTANCE: Some small studies suggest that maternal postnatal depression is a risk factor for offspring adolescent depression. However, to our knowledge, no large cohort studies have addressed this issue. Furthermore, only 1 small study has examined the association between antenatal depression and later offspring depression. Understanding these associations is important to inform prevention. OBJECTIVE: To investigate the hypothesis that there are independent associations between antenatal and postnatal depression with offspring depression and that the risk pathways are different, such that the risk is moderated by disadvantage (low maternal education) with postnatal depression but not with antenatal depression. DESIGN, SETTING, AND PARTICIPANTS: Prospective investigation of associations between symptoms of antenatal and postnatal parental depression with offspring depression at age 18 years in a UK community-based birth cohort (Avon Longitudinal Study of Parents and Children) with data from more than 4500 parents and their adolescent offspring. MAIN OUTCOMES AND MEASURES: Diagnosis of offspring aged 18 years with major depression using the International Classification of Diseases, 10th Revision. RESULTS: Antenatal depression was an independent risk factor. Offspring were 1.28 times (95% CI, 1.08-1.51; P = .003) more likely to have depression at age 18 years for each standard deviation increase in maternal depression score antenatally, independent of later maternal depression. Postnatal depression was also a risk factor for mothers with low education, with offspring 1.26 times (95% CI, 1.06-1.50; P = .01) more likely to have depression for each standard deviation increase in postnatal depression score. However, for more educated mothers, there was little association (odds ratio, 1.09; 95% CI, 0.88-1.36; P = .42). Analyses found that maternal education moderated the effects of postnatal but not antenatal depression. Paternal depression antenatally was not associated with offspring depression, while postnatally, paternal depression showed a similar pattern to maternal depression. CONCLUSIONS AND RELEVANCE: The findings suggest that treating maternal depression antenatally could prevent offspring depression during adulthood and that prioritizing less advantaged mothers postnatally may be most effective.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This may leave women at increased risk of both PTB and postpartum depression, which has long-term effects for mother and child.
“This may leave women at increased risk of both PTB and postpartum depression, which has long-term effects for mother and child [17].”
From The mastery lifestyle intervention to reduce biopsychosocial risks for pregnant Latinas and African Americans and their infants: protocol for a randomized controlled trial (2022) · cites this paper as [17]
The Abstract Results and Conclusions link maternal postnatal depression to offspring depression at age 18, supporting a long-term effect on children, particularly where mothers have low education. The paper does not establish the claimed increased risk of preterm birth or long-term effects on mothers; preterm birth appears only in the title of a cited reference. Page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredChildren of mothers with antepartum depression have a higher risk of suffering from depression later in life.
“and they have a higher risk of suffering from depression later in life.13”
From Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial (2020) · cites this paper as [13]
Prenatal depression appears to affect infant and child development and may increase the risk of developing depression in adulthood.
“Furthermore, prenatal depression appears to affect infant and child development and may increase the risk of developing depression in adulthood (17, 22).”
From Acceptance, experiences, and needs of hospitalized pregnant women toward an electronic mindfulness-based intervention: A pilot mixed-methods study (2022) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Detection of Postnatal Depression: Development of the 10-item Edinburgh Postnatal Depression Scale
Cox, J. L., Holden, J. M., & Sagovsky, R. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.6.782 · Cited by 14,183 · see citing works
Multiple imputation using chained equations: Issues and guidance for practice
White, I. R., Royston, P., & Wood, A. M. (2011) · Statistics in Medicine · doi:10.1002/sim.4067 · Cited by 9,792 · see citing works
Maternal depression and parenting behavior
Lovejoy, M. C., Graczyk, P. A., O'Hare, E., & Neuman, G. (2000) · Clinical Psychology Review · doi:10.1016/s0272-7358(98)00100-7 · Cited by 2,667 · see citing works
Maternal Depression and Child Psychopathology: A Meta-Analytic Review
Goodman, S. H., Rouse, M. H., Connell, A. M., Broth, M. R., Hall, C. M., & Heyward, D. (2011) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-010-0080-1 · Cited by 2,621 · see citing works
Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., Henderson, J., Macleod, J., Molloy, L., Ness, A., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys066 · Cited by 2,494 · see citing works
Goodman, S. H., & Gotlib, I. H. (1999) · Psychological Review · doi:10.1037/0033-295x.106.3.458 · Cited by 2,493 · see citing works
Thapar, A., Collishaw, S., Pine, D. S., & Thapar, A. K. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60871-4 · Cited by 2,365 · see citing works
Handbook of infant development
Osofsky, J. D. (1979) · Cited by 2,270 · see citing works
Grote, N. K., Bridge, J. A., Gavin, A. R., Melville, J. L., Iyengar, S., & Katon, W. J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.111 · Cited by 1,882 · see citing works
Postpartum depression effects on early interactions, parenting, and safety practices: a review
Field, T. (2010) · Infant Behavior and Development · doi:10.1016/j.infbeh.2009.10.005 · Cited by 1,493 · see citing works
Lewis, G., Pelosi, A. J., Araya, R., & Dunn, G. (1992) · Psychological Medicine · doi:10.1017/s0033291700030415 · Cited by 1,487 · see citing works
Self-citationAntenatal maternal stress and long‐term effects on child neurodevelopment: how and why?
Talge, N. M., Neal, C., Glover, V., & the Early Stress, T. R. A. P. S. N. F. A. N. E. O. C. A. A. M. H. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01714.x · Cited by 1,349 · see citing works
Gaynes, B. N., Gavin, N., Meltzer-Brody, S., Lohr, K. N., Swinson, T., Gartlehner, G., Brody, S., & Miller, W. C. (2005) · PsycEXTRA Dataset · doi:10.1037/e439372005-001 · Cited by 1,211 · see citing works
The course of anxiety and depression through pregnancy and the postpartum in a community sample
Heron, J., O'Connor, T. G., Evans, J., Golding, J., & Glover, V. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2003.08.004 · Cited by 1,151 · see citing works
Self-citationPetersen, A. C., Compas, B. E., Brooks-Gunn, J., Stemmler, M., Ey, S., & Grant, K. E. (1993) · American Psychologist · doi:10.1037/0003-066x.48.2.155 · Cited by 788 · see citing works
Rutter's Child and Adolescent Psychiatry
(2015) · doi:10.1002/9781118381953 · Cited by 639 · see citing works
O'Connor, T., Heron, J., & Glover, V. (2002) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-200212000-00019 · Cited by 611 · see citing works
Self-citationStatistic Notes: Regression towards the mean
Bland, J. M., & Altman, D. G. (1994) · BMJ · doi:10.1136/bmj.308.6942.1499 · Cited by 547 · see citing works
Maternal postnatal depression and the development of depression in offspring up to 16 years of age.
Murray, L., Arteche, A., Fearon, P., Halligan, S., Goodyer, I., & Cooper, P. (2011) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1016/j.jaac.2011.02.001 · Cited by 466 · see citing works
Implications of Timing of Maternal Depressive Symptoms for Early Cognitive and Language Development
Sohr-Preston, S. L., & Scaramella, L. V. (2006) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-006-0004-2 · Cited by 450 · see citing works
Bowes, L., Maughan, B., Caspi, A., Moffitt, T. E., & Arseneault, L. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02216.x · Cited by 412 · see citing works
Toward a Clearer Definition of Confounding
Weinberg, C. R. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116591 · Cited by 401 · see citing works
Separate and Joint Modeling of Longitudinal and Event Time Data Using Standard Computer Packages
Guo, X., & Carlin, B. P. (2004) · The American Statistician · doi:10.1198/0003130042854 · Cited by 356 · see citing works
Pawlby, S. J., Hay, D. F., Sharp, D., Waters, C. S., & O’Keane, V. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.05.018 · Cited by 333 · see citing works
Hewitt, C., Gilbody, S., Brealey, S., Paulden, M., Palmer, S., Mann, R., Green, J., Morrell, J., Barkham, M., Light, K., et al. (2009) · Health Technology Assessment · doi:10.3310/hta13360 · Cited by 330 · see citing works
Raviv, T., Kessenich, M., & Morrison, F. J. (2004) · Early Childhood Research Quarterly · doi:10.1016/j.ecresq.2004.10.007 · Cited by 302 · see citing works
Edmondson, O., Psychogiou, L., Vlachos, H., Netsi, E., & Ramchandani, P. G. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.01.069 · Cited by 262 · see citing works
Self-citationBebbington, P., Dunn, G., Jenkins, R., Lewis, G., Brugha, T. S., Farrell, M., & Meltzer, H. (2003) · International Review of Psychiatry · doi:10.1080/0954026021000045976 · Cited by 216 · see citing works
Self-citationStein, A., Malmberg, L. ‐., Sylva, K., Barnes, J., Leach, P., & the FCCC team (2008) · Child: Care, Health and Development · doi:10.1111/j.1365-2214.2008.00837.x · Cited by 195 · see citing works
Self-citationThe timing of maternal depressive symptoms and child cognitive development: a longitudinal study
Evans, J., Melotti, R., Heron, J., Ramchandani, P., Wiles, N., Murray, L., & Stein, A. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02513.x · Cited by 184 · see citing works
Self-citationEffects of Postnatal Depression on Mother–Infant Interactions and Child Development
Murray, L., Halligan, S. L., & Cooper, P. (2010) · Wiley eBooks · doi:10.1002/9781444327588.ch8 · Cited by 156 · see citing works
Do prenatal risk factors cause psychiatric disorder? Be wary of causal claims
Thapar, A., & Rutter, M. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.062828 · Cited by 155 · see citing works
Depressive disorders in childhood and adolescence
Brent, D. A., & Maalouf, F. (2015) · Wiley eBooks · doi:10.1002/9781118381953.ch63 · Cited by 94 · see citing works
Patton, G. C., Coffey, C., Posterino, M., Carlin, J. B., Wolfe, R. S., & Bowes, G. (1999) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s001270050129 · Cited by 72 · see citing works
Pearson, R. M., Heron, J., Melotti, R., Joinson, C., Stein, A., Ramchandani, P. G., & Evans, J. (2011) · Infant Behavior and Development · doi:10.1016/j.infbeh.2011.07.003 · Cited by 60 · see citing works
Self-citationSocial support networks and type of neurotic symptom among adults in British households
Brugha, T., Morgan, Z., Bebbington, P., Jenkins, R., Lewis, G., Farrell, M., & Meltzer, H. (2003) · Psychological Medicine · doi:10.1017/s0033291702006505 · Cited by 57 · see citing works
Self-citationFactors associated with being a false positive on the General Health Questionnaire
Bell, T., Watson, M. C., Sharp, D., Lyons, I., & Lewis, G. (2005) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-005-0881-6 · Cited by 44 · see citing works
Self-citationDepressive Disorders in Childhood and Adolescence
Brent, D. A., & Weersing, V. R. (2008) · doi:10.1002/9781444300895.ch37 · Cited by 30 · see citing works
Parenting knowledge among adolescent mothers
Parks, P. L., & Smeriglio, V. L. (1983) · Journal of Adolescent Health Care · doi:10.1016/s0197-0070(83)80369-6 · Cited by 27 · see citing works
Brugha, T. S., Meltzer, H., Jenkins, R., Bebbington, P., & Taub, N. A. (2005) · Psychological Medicine · doi:10.1017/s0033291705005180 · Cited by 15 · see citing works
Pawlby, S. J., Sharp, D., Hay, D. F., & O’Keane, V. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.12.013 · Cited by 12 · see citing works
Maternal Postnatal Depression and the Development of Depression in Offspring Up to 16Years of Age
Stockman, J. A. (2012) · Yearbook of Pediatrics · doi:10.1016/j.yped.2011.09.002 · Cited by 9 · see citing works
Flagged first, then by citations
2 of the 44 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [30]Brugha TS Meltzer H Jenkins R Bebbington PE Taub NA Comparison of the CIS-R and CIDI lay diagnostic interviews for anxiety and depressive disorders Psychol Med 2005 35 1089 1091 16045074
Cited by
Sorted by citations
Effects of perinatal mental disorders on the fetus and child
Stein, A., Pearson, R. M., Goodman, S. H., Rapa, E., Rahman, A., McCallum, M., Howard, L. M., & Pariante, C. M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61277-0 · Cited by 2,166 · see citing works
Self-citationVan den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181 · see citing works
Meltzer-Brody, S., Colquhoun, H., Riesenberg, R., Epperson, C. N., Deligiannidis, K. M., Rubinow, D. R., Li, H., Sankoh, A. J., Clemson, C., Schacterle, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31551-4 · Cited by 795 · see citing works
Association of persistent and severe postnatal depression with child outcomes
Netsi, E., Pearson, R. M., Murray, L., Cooper, P., Craske, M. G., & Stein, A. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.4363 · Cited by 632 · see citing works
Self-citationFetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis
O’Donnell, K. J., & Meaney, M. J. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16020138 · Cited by 608 · see citing works
Gentile, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.001 · Cited by 431 · see citing works
Biringen, Z. C., Derscheid, D. J., Vliegen, N., Closson, L., & Easterbrooks, M. A. (2014) · Developmental Review · doi:10.1016/j.dr.2014.01.002 · Cited by 403 · see citing works
Adolescence and the next generation
Patton, G. C., Olsson, C. A., Skirbekk, V., Saffery, R., Wlodek, M. E., Azzopardi, P. S., Stonawski, M., Rasmussen, B., Spry, E., Francis, K., et al. (2018) · Nature · doi:10.1038/nature25759 · Cited by 385 · see citing works
Lifetime costs of perinatal anxiety and depression
Bauer, A., Knapp, M., & Parsonage, M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.005 · Cited by 382 · see citing works
Postpartum psychiatric disorders
Meltzer-Brody, S., Howard, L. M., Bergink, V., Vigod, S., Jones, I., Munk-Olsen, T., Honikman, S., & Milgrom, J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.22 · Cited by 357 · see citing works
Mansur, R. B., Brietzke, E. M., & McIntyre, R. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.017 · Cited by 325 · see citing works
Maternal prenatal depressive symptoms predict infant<i>NR3C1</i>1F and<i>BDNF</i>IV DNA methylation
Braithwaite, E., Kundakovic, M., Ramchandani, P., Murphy, S., & Champagne, F. (2015) · Epigenetics · doi:10.1080/15592294.2015.1039221 · Cited by 299 · see citing works
Self-citationPregnancy as a period of risk, adaptation, and resilience for mothers and infants
Davis, E. P., & Narayan, A. J. (2020) · Development and Psychopathology · doi:10.1017/s0954579420001121 · Cited by 297 · see citing works
“The link between prenatal maternal mental health problems and offspring internalizing psychopathology is also apparent in young adulthood, as documented in several large cohort studies (Capron et al., 2015; Pearson et al., 2013; Plant, Pariante, Sharp, & Pawlby, 2015).”
BackgroundPrenatal maternal depression alters amygdala functional connectivity in 6-month-old infants
Qiu, A., Anh, T. T., Li, Y., Chen, H., Rifkin-Graboi, A., Broekman, B. F. P., Kwek, K., Saw, S.-M., Chong, Y.-S., Gluckman, P. D., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.3 · Cited by 282 · see citing works
Graham, A. M., Rasmussen, J. M., Rudolph, M. D., Heim, C. M., Gilmore, J. H., Styner, M., Potkin, S. G., Entringer, S., Wadhwa, P. D., Fair, D. A., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.027 · Cited by 282 · see citing works
Effect of Zuranolone vs Placebo in Postpartum Depression
Deligiannidis, K. M., Meltzer-Brody, S., Gunduz-Bruce, H., Doherty, J., Jonas, J., Li, S., Sankoh, A. J., Silber, C., Campbell, A. D., Werneburg, B., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.1559 · Cited by 277 · see citing works
Glover, V., O'Donnell, K. J., O'Connor, T. G., & Fisher, J. (2018) · Development and Psychopathology · doi:10.1017/s095457941800038x · Cited by 271 · see citing works
Intergenerational Transmission of Depression
Goodman, S. H. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-071519-113915 · Cited by 275 · see citing works
McLeish, J., & Redshaw, M. (2017) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-017-1220-0 · Cited by 259 · see citing works
Lebel, C., Walton, M., Letourneau, N., Giesbrecht, G. F., Kaplan, B. J., & Dewey, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.004 · Cited by 237 · see citing works
Dimidjian, S., Goodman, S. H., Felder, J. N., Gallop, R., Brown, A. P., & Beck, A. (2016) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000068 · Cited by 223 · see citing works
Fellmeth, G. L., Fazel, M. S., & Plugge, E. (2016) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14184 · Cited by 219 · see citing works
Osborne, S., Biaggi, A., Chua, T.-E., Preez, A. D., Hazelgrove, K. M., Nikkheslat, N., Previti, G., Zunszain, P. A., Conroy, S., & Pariante, C. M. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.06.017 · Cited by 207 · see citing works
Malm, H., Brown, A. S., Gissler, M., Gyllenberg, D., Hinkka-Yli-Salomäki, S., McKeague, I. W., Weissman, M., Wickramaratne, P., Artama, M., Gingrich, J. A., et al. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.02.013 · Cited by 206 · see citing works
Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms
Kim, D. R., Bale, T. L., & Epperson, C. N. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-014-0546-9 · Cited by 203 · see citing works
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203 · see citing works
Perinatal Maternal Depressive Symptoms as an Issue for Population Health
Meaney, M. J. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17091031 · Cited by 194 · see citing works
Wen, D. J., Poh, J. S., Ni, S. N., Chong, Y.-S., Chen, H., Kwek, K., Shek, L. P., Gluckman, P. D., Fortier, M. V., Meaney, M. J., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.74 · Cited by 186 · see citing works
Cooper, M., Kilvert, H., Hodgkins, P., Roskell, N., & Eldar‐Lissai, A. (2019) · CNS Drugs · doi:10.1007/s40263-019-00672-w · Cited by 192 · see citing works
Betancourt, T. S., McBain, R. K., Newnham, E. A., & Brennan, R. T. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12389 · Cited by 187 · see citing works
Plant, D. T., Pariante, C. M., Sharp, D., & Pawlby, S. (2015) · British Journal of Psychiatry · doi:10.1192/bjp.bp.114.156620 · Cited by 184 · see citing works
Kwong, A. S. F., López-López, J. A., Hammerton, G., Manley, D., Timpson, N. J., Leckie, G., & Pearson, R. M. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.6587 · Cited by 198 · see citing works
Self-citationNo health without perinatal mental health
Howard, L. M., Piot, P. K., & Stein, A. L. (2014) · The Lancet · doi:10.1016/s0140-6736(14)62040-7 · Cited by 180 · see citing works
Self-citationAssociations of maternal and paternal antenatal mood with offspring anxiety disorder at age 18 years
Capron, L., Glover, V. A. S., Pearson, R. M., Evans, J., O’Connor, T. G., Stein, A. L., Murphy, S. E., & Ramchandani, P. G. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.012 · Cited by 165 · see citing works
Self-citationPaternal depression in the postnatal period and child development: mediators and moderators
Gutierrez-Galve, L., Stein, A., Hanington, L., Heron, J., & Ramchandani, P. (2015) · Pediatrics · doi:10.1542/peds.2014-2411 · Cited by 158 · see citing works
Self-citationMorrell, C. J., Sutcliffe, P., Booth, A., Stevens, J., Scope, A., Stevenson, M., Harvey, R., Bessey, A., Cantrell, A., Dennis, C.-L., et al. (2016) · Health Technology Assessment · doi:10.3310/hta20370 · Cited by 155 · see citing works
Perinatal depression and infant mental health
Goodman, J. H. (2019) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2019.01.010 · Cited by 154 · see citing works
Associations of parental depression with child school performance at age 16 years in Sweden
Shen, H., Magnusson, C., Rai, D., Lundberg, M., Lê-Scherban, F., Dalman, C., & Lee, B. K. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.2917 · Cited by 144 · see citing works
Sanger, C., Iles, J. E., Andrew, C. S., & Ramchandani, P. G. (2014) · Archives of Women s Mental Health · doi:10.1007/s00737-014-0463-2 · Cited by 146 · see citing works
Self-citationDoes prenatal stress alter the developing connectome?
Scheinost, D., Sinha, R., Cross, S., Kwon, S. H., Sze, G. K., Constable, R. T., & Ment, L. R. (2016) · Pediatric Research · doi:10.1038/pr.2016.197 · Cited by 143 · see citing works
Maternal Depressive Symptoms During and After Pregnancy and Psychiatric Problems in Children
Lahti‐Pulkkinen, M., Savolainen, K., Tuovinen, S., Pesonen, A., Lahti, J. M. T., Heinonen, K., Hämäläinen, E. K., Laivuori, H. M., Villa, P., Reynolds, R. M., et al. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.10.007 · Cited by 139 · see citing works
Frøkjær, V. G., Pinborg, A. B., Holst, K. K., Overgaard, A., Henningsson, S., Heede, M., Larsen, E. C., Jensen, P. S., Agn, M., Nielsen, A. P., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.015 · Cited by 141 · see citing works
Aktar, E., Qu, J., Lawrence, P. J., Tollenaar, M. S., Elzinga, B. M., & Bögels, S. M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00391 · Cited by 140 · see citing works
The Impact of Perinatal Depression on Children’s Social-Emotional Development: A Longitudinal Study
Junge, C., Garthus‐Niegel, S., Slinning, K., Polte, C., Simonsen, T. B., & Eberhard‐Gran, M. (2016) · Maternal and Child Health Journal · doi:10.1007/s10995-016-2146-2 · Cited by 143 · see citing works
Pearlstein, T. B. (2015) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2015.04.004 · Cited by 142 · see citing works
Prenatal stress alters amygdala functional connectivity in preterm neonates
Scheinost, D., Kwon, S. H., Lacadie, C., Sze, G., Sinha, R., Constable, R. T., & Ment, L. R. (2016) · NeuroImage: Clinical · doi:10.1016/j.nicl.2016.08.010 · Cited by 130 · see citing works
Maternal prenatal stress and infant emotional reactivity six months postpartum
Nolvi, S., Karlsson, L., Bridgett, D. J., Korja, R., Huizink, A. C., Kataja, E., & Karlsson, H. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.020 · Cited by 135 · see citing works
Pearson, R. M., Bornstein, M. H., Cordero, M., Scerif, G., Mahedy, L., Evans, J., Abioye, A., & Stein, A. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12483 · Cited by 133 · see citing works
Self-citationAllopregnanolone in postpartum depression: Role in pathophysiology and treatment
Meltzer-Brody, S. E., & Kanes, S. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100212 · Cited by 133 · see citing works
Kumar, M., Huang, K., Othieno, C. J., Wamalwa, D. C., Madeghe, B. A., Osok, J., Njuguna, S., Nato, J., & McKay, M. M. (2017) · Global Social Welfare · doi:10.1007/s40609-017-0102-8 · Cited by 131 · see citing works
Patel, V., Chisholm, D., Dua, T., Laxminarayan, R., & Medina-Mora, M. E. (2016) · doi:10.1596/978-1-4648-0426-7 · Cited by 130 · see citing works
Prenatal maternal mood patterns predict child temperament and adolescent mental health
Glynn, L. M., Howland, M. A., Sandman, C. A., Davis, E. P., Phelan, M. J., Baram, T. Z., & Stern, H. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.065 · Cited by 131 · see citing works
Betts, K. S., Williams, G. M., Najman, J. M., & Alati, R. (2014) · Depression and Anxiety · doi:10.1002/da.22272 · Cited by 128 · see citing works
Zemestani, M., & Fazeli Nikoo, Z. (2020) · Archives of Women's Mental Health · doi:10.1007/s00737-019-00962-8 · Cited by 127 · see citing works
Use of psychotropic drugs during pregnancy and breast‐feeding
Larsen, E. R., Damkier, P., Pedersen, L. H., Fenger‐Grøn, J., Mikkelsen, R. L., Nielsen, R. E., Linde, V., Knudsen, H. E. D., Skaarup, L. M., & Videbech, P. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12479 · Cited by 125 · see citing works
Positive maternal mental health, parenting, and child development
Phua, D. Y., Kee, M. Z. L., & Meaney, M. J. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.028 · Cited by 124 · see citing works
Galley, J. D., Mashburn‐Warren, L., Blalock, L. C., Lauber, C. L., Carroll, J., Ross, K. M., Hobel, C. J., Coussons‐Read, M. E., Schetter, C. D., & Gur, T. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.10.005 · Cited by 120 · see citing works
Risk of Depression in the Adolescent and Adult Offspring of Mothers With Perinatal Depression
Tirumalaraju, V., Suchting, R., Evans, J., Goetzl, L. M., Refuerzo, J., Neumann, A., Anand, D., Ravikumar, R., Green, C. E., Cowen, P. J., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.8783 · Cited by 120 · see citing works
Self-citationCorwin, E. J., PAJER, K. A., Paul, S., Lowe, N. K., Weber, M., & McCarthy, D. O. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.012 · Cited by 112 · see citing works
Zelkowitz, P., Gold, I., Feeley, N., Hayton, B. C., Carter, C. S., Tulandi, T., Abenhaim, H. A., & Levin, P. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.06.014 · Cited by 114 · see citing works
Babore, A., Trumello, C., Lombardi, L., Candelori, C., Chirumbolo, A., Cattelino, E., Baiocco, R., Bramanti, S. M., Viceconti, M. L., Pignataro, S., et al. (2021) · Child Psychiatry & Human Development · doi:10.1007/s10578-021-01230-6 · Cited by 115 · see citing works
Abbott, P. W., Gumusoglu, S. B., Bittle, J., Beversdorf, D. Q., & Stevens, H. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.01.019 · Cited by 109 · see citing works
de Mola, C. L., de França, G. V. A., Quevedo, L. D. Á., & Horta, B. L. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.139014 · Cited by 113 · see citing works
Maternal and paternal sleep during pregnancy in the Child-sleep birth cohort
Paavonen, E. J., Saarenpää‐Heikkilä, O., Pölkki, P., Kylliäinen, A., Porkka‐Heiskanen, T., & Paunio, T. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.09.011 · Cited by 110 · see citing works
Family process and youth internalizing problems: A triadic model of etiology and intervention
Schleider, J. L., & Weisz, J. R. (2016) · Development and Psychopathology · doi:10.1017/s095457941600016x · Cited by 112 · see citing works
Mindfulness for pregnancy: a randomised controlled study of online mindfulness during pregnancy
Krusche, A., Dymond, M., Murphy, S. E., & Crane, C. (2018) · Midwifery · doi:10.1016/j.midw.2018.07.005 · Cited by 97 · see citing works
Plant, D. T., Pawlby, S., Sharp, D., Zunszain, P. A., & Pariante, C. M. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.155 · Cited by 108 · see citing works
Intergenerational transmission of depression: clinical observations and molecular mechanisms
Sawyer, K. M., Zunszain, P. A., Dazzan, P., & Pariante, C. M. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0265-4 · Cited by 107 · see citing works
Determinants of cortisol during pregnancy – The ABCD cohort
Bleker, L. S., Roseboom, T. J., Vrijkotte, T. G. M., Reynolds, R. M., & de Rooij, S. R. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.026 · Cited by 107 · see citing works
Fredriksen, E., von Soest, T., Smith, L., & Moe, V. (2018) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-018-0428-4 · Cited by 106 · see citing works
Gobinath, A. R., Mahmoud, R., & Galea, L. A. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00420 · Cited by 105 · see citing works
Houtepen, L. C., Heron, J., Suderman, M. J., Tilling, K. M., & Howe, L. D. (2018) · Wellcome Open Research · doi:10.12688/wellcomeopenres.14716.1 · Cited by 100 · see citing works
Self-citationSheridan, M. A., McLaughlin, K. A., Winter, W., Fox, N., Zeanah, C., & Nelson, C. A. (2018) · Nature Communications · doi:10.1038/s41467-018-04381-8 · Cited by 101 · see citing works
Ringoot, A. P., Tiemeier, H. W., Jaddoe, V. W. V., So, P., Albert Hofman, D., Verhulst, F. C., & Jansen, P. W. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.03.009 · Cited by 95 · see citing works
van Dijk, M. T., Murphy, E. J., Posner, J. E., Talati, A., & Weissman, M. M. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.0350 · Cited by 94 · see citing works
Pesonen, A., Lahti‐Pulkkinen, M., Kuusinen, T., Tuovinen, S., Villa, P., Hämäläinen, E. K., Laivuori, H. M., Kajantie, E., & Räikkönen, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150058 · Cited by 89 · see citing works
Davis, E. P., Hankin, B. L., Swales, D. A., & Hoffman, M. C. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000470 · Cited by 90 · see citing works
Maternal Sleep in Pregnancy and Postpartum Part I: Mental, Physical, and Interpersonal Consequences
Christian, L. M., Carroll, J., Teti, D. M., & Hall, M. H. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-0999-y · Cited by 88 · see citing works
Investigation on the mental health status of pregnant women in China during the Pandemic of COVID-19
Dong, H., Hu, R., Lu, C., Huang, D., Cui, D., Huang, G.-Y., & Zhang, M. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05805-x · Cited by 88 · see citing works
Gutierrez-Galve, L., Stein, A., Hanington, L., Heron, J., Lewis, G., O’Farrelly, C., & Ramchandani, P. G. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.3667 · Cited by 85 · see citing works
Self-citationPerinatal maternal depressive symptoms alter amygdala functional connectivity in girls
Soe, N. N., Wen, D. J., Poh, J. S., Chong, Y., Broekman, B. F., Chen, H., Shek, L. P., Tan, K. H., Gluckman, P. D., Fortier, M. V., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.23873 · Cited by 86 · see citing works
Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner
Braithwaite, E., Pickles, A. R., Sharp, H. M., Glover, V. A. S., O’Donnell, K. J., Tibu, F., & Hill, J. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.017 · Cited by 85 · see citing works
Lim, G., Farrell, L. M., Facco, F. L., Gold, M. S., & Wasan, A. D. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002720 · Cited by 84 · see citing works
Quarini, C., Pearson, R. M., Stein, A. L., Ramchandani, P. G., Lewis, G., & Evans, J. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.039 · Cited by 84 · see citing works
Self-citationStroud, L. R., Papandonatos, G. D., Parade, S. H., Salisbury, A. L., PHIPPS, M. G., Lester, B. M., Padbury, J. F., & Marsit, C. J. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000410 · Cited by 82 · see citing works
Kim, D. R., Wang, E., McGeehan, B., Snell, J. L., Ewing, G., Iannelli, C., O’Reardon, J. P., Sammel, M. D., & Epperson, C. N. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.09.005 · Cited by 83 · see citing works
Advance in Stress for Depressive Disorder
Ding, Y., & Dai, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_8 · Cited by 82 · see citing works
Lewis, G., Neary, M., Polek, E., Flouri, E., & Lewis, G. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30408-x · Cited by 81 · see citing works
Self-citationDoes maternal postpartum depression affect children's developmental outcomes?
Aoyagi, S., & Tsuchiya, K. J. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14064 · Cited by 86 · see citing works
Patterns of pregnancy and postpartum depressive symptoms: Latent class trajectories and predictors.
Fredriksen, E., von Soest, T., Smith, L., & Moe, V. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000246 · Cited by 79 · see citing works
Fumeaux, C. J. F., Harari, M. M., Weisskopf, E., Eap, C. B., Epiney, M., Vial, Y., Csajka, C., Graz, M. B., & Panchaud, A. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1658740 · Cited by 80 · see citing works
Verkuijl, N. E., Richter, L., Norris, S. A., Stein, A. L., Avan, B. I., & Ramchandani, P. G. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70361-x · Cited by 78 · see citing works
Self-citationDoherty, K., Barry, M., Marcano-Belisario, J., Arnaud, B., Morrison, C., Car, J., & Doherty, G. (2018) · JMIR Mental Health · doi:10.2196/10007 · Cited by 67 · see citing works
Rubertsson, C., Pallant, J., Sydsjö, G., Haines, H. M., & Hildingsson, I. (2014) · Journal of Reproductive and Infant Psychology · doi:10.1080/02646838.2014.992009 · Cited by 75 · see citing works
Scheinost, D., Spann, M. N., McDonough, L., Peterson, B. S., & Monk, C. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0677-0 · Cited by 73 · see citing works
Solmi, F., Bentivegna, F., Bould, H., Mandy, W., Kothari, R., Rai, D., Skuse, D., & Lewis, G. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13255 · Cited by 73 · see citing works
Self-citationSoe, N. N., Wen, D. J. R., Poh, J. S., Li, Y., Broekman, B. F. P., Chen, H., Chong, Y. S., Kwek, K. Y. C., Saw, S., Gluckman, P. D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152991 · Cited by 73 · see citing works
Faherty, L. J., Hantsoo, L., Appleby, D., Sammel, M. D., Bennett, I. M., & Wiebe, D. J. (2017) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocx005 · Cited by 62 · see citing works
Korja, R., Nolvi, S., Kataja, E., Scheinin, N. M., Junttila, N., Lahtinen, H., Saarni, S. E., Karlsson, L., & Karlsson, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207856 · Cited by 71 · see citing works
Galbally, M., van IJzendoorn, M. H., Permezel, M., Saffery, R., Lappas, M., Ryan, J. L., van Rossum, E. F. C., Johnson, A. R., Teti, D. M., & Lewis, A. J. (2017) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1558 · Cited by 71 · see citing works
- Authors
- Pearson, R. M., Evans, J., Kounali, D., Lewis, G., Heron, J., Ramchandani, P. G., O’Connor, T. G., & Stein, A.
- Affiliations
- University of Bristol (GB)
- Imperial College London (GB)
- University of Rochester Medicine (US)
- University of Oxford (GB)
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2013-12-01
- Volume
- 70
- Issue
- 12
- Pages
- 1312
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC3930009
- OpenAlex
- W2112790937
- Cited by
- 589
- References
- 44
- Citations by year
- 2026: 25 · 2025: 34 · 2024: 42 · 2023: 34 · 2022: 48 · 2021: 56 · 2020: 62 · 2019: 61 · 2018: 54 · 2017: 44 · 2016: 40 · 2015: 49 · 2014: 38 · 2013: 2
- FWCI
- 43.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- e-space (Manchester Metropolitan University) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Wellcome Trust (076467/Z/05/Z, 090139, 084268, 084268/Z/07/Z)
- National Institute of Mental Health (R01MH073842)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Keywords
- maternal depression, antenatal depression, postpartum depression, offspring depression, adolescent depression, major depressive disorder, maternal education, socioeconomic deprivation, paternal depression, depression prevention, Avon Longitudinal Study of Parents and Children
- MeSH terms
- Adolescent, Adult, Major Depressive Disorder, Educational Status, England, Female, Humans, Male, Middle Aged, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors, Cohort Studies, Odds Ratio, Depression, Postpartum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
