The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Extracellular vesicles: lipids as key components of their biogenesis and functions
Open accessAbstract
Intercellular communication has been known for decades to involve either direct contact between cells or to operate via circulating molecules, such as cytokines, growth factors, or lipid mediators. During the last decade, we have begun to appreciate the increasing importance of intercellular communication mediated by extracellular vesicles released by viable cells either from plasma membrane shedding (microvesicles, also named microparticles) or from an intracellular compartment (exosomes). Exosomes and microvesicles circulate in all biological fluids and can trigger biological responses at a distance. Their effects include a large variety of biological processes, such as immune surveillance, modification of tumor microenvironment, or regulation of inflammation. Extracellular vesicles can carry a large array of active molecules, including lipid mediators, such as eicosanoids, proteins, and nucleic acids, able to modify the phenotype of receiving cells. This review will highlight the role of the various lipidic pathways involved in the biogenesis and functions of microvesicles and exosomes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This specific lipid enrichment, their membrane high protein/lipid ratio and asymmetric distribution are associated with a higher membrane rigidity in ELVs in comparison with parent cells (Record et al., 2018).”
From Skeletal Muscle-Released Extracellular Vesicles: State of the Art (2019) · cites this paper as Record et al., 2018
Citations
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426
Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
Flagged first, then by citations
Research works printed but not linked: 1
- Trajkovic, 2008, Ceramide triggers budding of exosome vesicles into multivesicular endosomes, Science., 319, 1244, 10.1126/science.1153124 · DOI
Cited by
Sorted by citations
Items 301–328 of 328
Isolation of small extracellular vesicles by interacting with inorganic surface
Obuchi, S., Morita, M., Kuno, G., Mogami, T., Shuno, T., Ito, Y., Miyagishi, M., Ohba, Y., Kuramochi, A., & Teramura, Y. (2026) · Regenerative Therapy · doi:10.1016/j.reth.2026.101063
Gómez-Larrauri, A., Gangoiti, P., Camacho, L., Presa, N., Martin, C., & Gómez‐Muñoz, A. (2026) · Genetics. · doi:10.5772/intechopen.1014164
Cooper, J., Airey, S. T., Patino, E., Andriot, T., Ghosh, M., & Pearse, D. D. (2026) · Methods and Protocols · doi:10.3390/mps9020040
Advancements in stem cell therapy facilitated by exosomes
Ojha, A., Banerjee, A., Singh, A. K., & Singh, R. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36390-0.00003-8
Dong, Z., Dai, F., Xing, N., Wu, Q., Gao, H., Kan, P., Han, Y., Cheng, X., Wang, Y., Feng, X., et al. (2026) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2026.109425
Exploring the potential of extracellular vesicles as therapeutic protein delivery vectors
Saux, S. L. (2019) · theses.fr (ABES) · doi:10.70675/4c1c1220ze70dz4948z9cddz682d3502dce2
Lipids in bovine ovarian follicle : mass spectrometry analysis and regulation
Bertevello, P. S. (2019) · theses.fr (ABES) · doi:10.70675/5c4b6a21z1fc9z4cb1z87dez48d053104db6
Aitamer, M. (2020) · theses.fr (ABES) · doi:10.70675/8062e8e0zaf45z4934z8c6cz25b9ef818da3
Novel electrokinetic and analytical approaches for isolation and detection of extracellular vesicles
Morani, M. (2022) · theses.fr (ABES) · doi:10.70675/80b177bbzbe04z48adza9ccz4c8c5edcceac
The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
Bachynskyj‐Bilas, G., Otto, D. J., Stratton, D., Rietdorf, K., Johnson, D. M., & McMullen, C. J. (2026) · The Journal of Physiology · doi:10.1113/jp289298
The relevance of membrane lipid composition in exosome‐based precision dermatology
Paolino, G., Nicola, M. R. D., Lugini, L., & Federici, C. (2026) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.70468
Brown spider venom phospholipase D as a tool to modulate melanoma cell biology
Mello, E. D. S., Schemczssen-Graeff, Z., Donatti, L., Vargas, J. E., Ribeiro, A. S., Arni, R. K., Gremski, L. H., & Veiga, S. S. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152230
Exploring the Isoprenoid Biosynthesis Pathway’s Role in Oncogenic Viruses
Blaha, L. N., Neighbors, J. D., Sandeep, R., Kondaka, A., & Hohl, R. J. (2026) · Viruses · doi:10.3390/v18060637
D’Agostino, A., Marco, G. D., Pontecorvi, C., Suanno, C., Ruggirello, F., Zuccheri, G., Ulian, G., Valdré, G., Canini, A., Duca, S. D., et al. (2026) · Journal of Experimental Botany · doi:10.1093/jxb/erag303
Extracellular vesicles (EVs) in neurodevelopment: The emerging role of lipids
Germelli, L., Daniele, S., Martini, C., & Pozzo, E. D. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118175
Exosomes—nano-messengers in tumors: capturing techniques, birth codes, and functional deciphering
Li, Y., Gao, Y., Wang, Y.-H., Zhou, K.-F., Zhao, Y., & Zhao, L. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1825151 · Cited by 1
Andrilli, L. H. D. S., Hayann, L., Tokuhara, C. K., Puelles, A., Ramos, A. P., Farquharson, C., Millán, J. L., de Oliveira, F. A., & Ciancaglini, P. (2026) · Bone · doi:10.1016/j.bone.2026.118096
Wang, C. (2026) · Medical Hypotheses · doi:10.1016/j.mehy.2026.112167
Hegde, N. N., Shetty, J., Lakshmi, C., & Hegde, M. N. (2026) · Nutrients · doi:10.3390/nu18193198
Yasutake, T., Tano, K., Oya, S., Oka, A., Tsukahara‐Kawamura, T., & Hirayama, M. (2026) · Biologics · doi:10.3390/biologics6040028
Rani, S., Guanzon, D., Lai, A., Scholz‐Romero, K., Reed, S., Ritmejerytė, E., Lourie, R., Chetty, N., Ferguson, K., & Salomón, C. (2026) · Molecular Oncology · doi:10.1002/1878-0261.70327
Goodarzi, F. A., Sattariabro, F., Majlesi, Z. A., Aghaei, Z. H., Esfidani, T., Danjeh, M., Ghiasi, F., & Zamanifard, S. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.104055
Metadata
- Authors
- Record, M., Silvente-Poirot, S., Poirot, M., & Wakelam, M. O.
- Affiliations
- Université Toulouse III - Paul Sabatier (FR)
- Corresponding author
- Record, Michel
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 59
- Issue
- 8
- Pages
- 1316-1324
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC6071772
- OpenAlex
- W2804173945
- Cited by
- 328
- References
- 97
- Citations by year
- 2026: 31 · 2025: 33 · 2024: 35 · 2023: 36 · 2022: 56 · 2021: 50 · 2020: 55 · 2019: 27 · 2018: 5
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Cancer Research UK (18720)
- Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0411, BBS/E/B/000C0433, BBS/E/B/000C0431, BBS/E/B/0000S227)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- extracellular vesicles, exosomes, microvesicles, lipid mediators, eicosanoids, vesicle biogenesis, intercellular communication, tumor microenvironment, inflammation, immune surveillance
- MeSH terms
- Extracellular Vesicles, Humans, Signal Transduction, Lipid Metabolism, Cell-Derived Microparticles, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
