Cited by 328Extracellular vesicles in diseaseCellular transport and secretionCaveolin-1 and cellular processes

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Extracellular vesicles: lipids as key components of their biogenesis and functions

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Record, Michel, Silvente-Poirot, Sandrine, Poirot, Marc, Wakelam, MichaelJ.O.·2018·Journal of Lipid Research

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Abstract

Intercellular communication has been known for decades to involve either direct contact between cells or to operate via circulating molecules, such as cytokines, growth factors, or lipid mediators. During the last decade, we have begun to appreciate the increasing importance of intercellular communication mediated by extracellular vesicles released by viable cells either from plasma membrane shedding (microvesicles, also named microparticles) or from an intracellular compartment (exosomes). Exosomes and microvesicles circulate in all biological fluids and can trigger biological responses at a distance. Their effects include a large variety of biological processes, such as immune surveillance, modification of tumor microenvironment, or regulation of inflammation. Extracellular vesicles can carry a large array of active molecules, including lipid mediators, such as eicosanoids, proteins, and nucleic acids, able to modify the phenotype of receiving cells. This review will highlight the role of the various lipidic pathways involved in the biogenesis and functions of microvesicles and exosomes.

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Additional file 9 of Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice
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Additional file 1 of Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice
Pergande, M. R., Kang, C., George, D., Sutter, P. A., Crocker, S. J., Cologna, S. M., & Givogri, M. I. (2022) · Figshare · doi:10.6084/m9.figshare.19451556
Additional file 4 of Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice
Pergande, M. R., Kang, C., George, D., Sutter, P. A., Crocker, S. J., Cologna, S. M., & Givogri, M. I. (2022) · Figshare · doi:10.6084/m9.figshare.19451565
Additional file 2 of Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice
Pergande, M. R., Kang, C., George, D., Sutter, P. A., Crocker, S. J., Cologna, S. M., & Givogri, M. I. (2022) · Figshare · doi:10.6084/m9.figshare.19451559
Additional file 10 of Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice
Pergande, M. R., Kang, C., George, D., Sutter, P. A., Crocker, S. J., Cologna, S. M., & Givogri, M. I. (2022) · Figshare · doi:10.6084/m9.figshare.19451550
Additional file 1 of Lipidomic landscape of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication: a sex difference study
Perpiñá-Clérigues, C., Mellado, S., Català-Senent, J. F., Ibáñez, F., Costa, P., Marcos, M., Guerri, C., García-García, F., & Pascual, M. (2023) · Figshare · doi:10.6084/m9.figshare.22678340
Additional file 6 of Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice
Pergande, M. R., Kang, C., George, D., Sutter, P. A., Crocker, S. J., Cologna, S. M., & Givogri, M. I. (2022) · Figshare · doi:10.6084/m9.figshare.19451574
Additional file 11 of Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice
Pergande, M. R., Kang, C., George, D., Sutter, P. A., Crocker, S. J., Cologna, S. M., & Givogri, M. I. (2022) · Figshare · doi:10.6084/m9.figshare.19451553
Additional file 5 of Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice
Pergande, M. R., Kang, C., George, D., Sutter, P. A., Crocker, S. J., Cologna, S. M., & Givogri, M. I. (2022) · Figshare · doi:10.6084/m9.figshare.19451568
Additional file 1 of An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency
Zhang, R., Bu, T., Cao, R., Li, Z., Wang, C., Huang, B., Wei, M., Yuan, L., & Yang, G. (2022) · Figshare · doi:10.6084/m9.figshare.21432942

Authors: Record, M., Silvente-Poirot, S., Poirot, M., & Wakelam, M. O.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Corresponding author: Record, Michel
ORCID: Record, Michel
Poirot, Marc
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2018-08
Volume: 59
Issue: 8
Pages: 1316-1324
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.e086173
PMC: PMC6071772
OpenAlex: W2804173945
Cited by: 328
References: 97
Citations by year: 2026: 31 · 2025: 33 · 2024: 35 · 2023: 36 · 2022: 56 · 2021: 50 · 2020: 55 · 2019: 27 · 2018: 5
FWCI: 3.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 764 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Cancer Research UK (18720)
Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0411, BBS/E/B/000C0433, BBS/E/B/000C0431, BBS/E/B/0000S227)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords: extracellular vesicles, exosomes, microvesicles, lipid mediators, eicosanoids, vesicle biogenesis, intercellular communication, tumor microenvironment, inflammation, immune surveillance
MeSH terms: Extracellular Vesicles, Humans, Signal Transduction, Lipid Metabolism, Cell-Derived Microparticles, Exosomes

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Extracellular vesicles: lipids as key components of their biogenesis and functions

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