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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

Tang, Jing-Jie, Li, Jia-Gui, Qi, Wei, Qiu, Wen-Wei, Li, Pei-Shan, Li, Bo-Liang, Song, Bao-Liang·2011·Cell Metabolism
DOI 10.1016/j.cmet.2010.12.004
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Abstract

Sterol regulatory element-binding proteins (SREBPs) are major transcription factors activating the expression of genes involved in biosynthesis of cholesterol, fatty acid and triglyceride. In this study, we identified a small molecule, betulin, that specifically inhibited the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig. Inhibition of SREBP by betulin decreased the biosynthesis of cholesterol and fatty acid. In vivo, betulin ameliorated diet-induced obesity, decreased the lipid contents in serum and tissues, and increased insulin sensitivity. Furthermore, betulin reduced the size and improved the stability of atherosclerotic plaques. Our study demonstrates that inhibition SREBP pathway can be employed as a therapeutic strategy to treat metabolic diseases including type II diabetes and atherosclerosis. Betulin, which is abundant in birch bark, could be a leading compound for development of drugs for hyperlipidemia.

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Crossref · 10.1016/j.cmet.2010.12.004

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  • Pharmacological or antisense-mediated inhibition of hepatic SCAP function in rodents and non-human primates is emerging as a potential lipid-lowering and hepato/cardio-protective strategy.

    “pharmacological or antisense-mediated inhibition of hepatic SCAP function in rodents and non-human primates is emerging as a potential lipid-lowering and hepato/cardio-protective strategy32,42,43”

    From Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans (2023) · cites this paper as [43]

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Research works printed but not linked: 36

  1. Alakurtti, 2006, Pharmacological properties of the ubiquitous natural product betulin, Eur. J. Pharm. Sci., 29, 1, 10.1016/j.ejps.2006.04.006 · DOI
  2. Brown, 2009, Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL, J. Lipid Res., 50, S15, 10.1194/jlr.R800054-JLR200 · DOI · Paper page
  3. Brown, 2007, Lipases as modulators of atherosclerosis in murine models, Curr. Drug Targets, 8, 1307, 10.2174/138945007783220614 · DOI
  4. Brunzell, 1999, Dyslipidemia of central obesity and insulin resistance, Diabetes Care, 22, C10
  5. DeBose-Boyd, 2008, Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase, Cell Res., 18, 609, 10.1038/cr.2008.61 · DOI · Paper page
  6. Duval, 2007, PPARalpha and dyslipidemia, Biochim. Biophys. Acta, 1771, 961, 10.1016/j.bbalip.2007.05.003 · DOI · Paper page
  7. Goldstein, 2009, The LDL receptor, Arterioscler. Thromb. Vasc. Biol., 29, 431, 10.1161/ATVBAHA.108.179564 · DOI · Paper page
  8. Goldstein, 2006, Protein sensors for membrane sterols, Cell, 124, 35, 10.1016/j.cell.2005.12.022 · DOI · Paper page
  9. Havel, 2002, Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin, Curr. Opin. Lipidol., 13, 51, 10.1097/00041433-200202000-00008 · DOI · Paper page
  10. Ishibashi, 1993, Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery, J. Clin. Invest., 92, 883, 10.1172/JCI116663 · DOI · Paper page
  11. Ishida, 1990, Effect of simvastatin (MK-733) on sterol and bile acid excretion in rabbits, Jpn. J. Pharmacol., 53, 35, 10.1254/jjp.53.35 · DOI
  12. Jeon, 2004, Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits, Clin. Nutr., 23, 1025, 10.1016/j.clnu.2004.01.006 · DOI
  13. Joseph, 2002, Synthetic LXR ligand inhibits the development of atherosclerosis in mice, Proc. Natl. Acad. Sci. USA, 99, 7604, 10.1073/pnas.112059299 · DOI
  14. Kita, 1980, Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase, J. Clin. Invest., 66, 1094, 10.1172/JCI109938 · DOI
  15. Le, 2006, Hyperlipidemia and cardiovascular disease, Curr. Opin. Lipidol., 17, 702, 10.1097/MOL.0b013e328010a05b · DOI
  16. Madan, 2008, Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings, PLoS ONE, 3, e3204, 10.1371/journal.pone.0003204 · DOI
  17. Matsuda, 2001, SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation, Genes Dev., 15, 1206, 10.1101/gad.891301 · DOI · Paper page
  18. Nielsen, 1993, Effect of lovastatin on cholesterol absorption in cholesterol-fed rabbits, Pharmacol. Toxicol., 72, 148, 10.1111/j.1600-0773.1993.tb00307.x · DOI
  19. Otto, 1995, Lovastatin inhibits diet induced atherosclerosis in F1B golden Syrian hamsters, Atherosclerosis, 114, 19, 10.1016/0021-9150(94)05457-T · DOI
  20. Peet, 1998, Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha, Cell, 93, 693, 10.1016/S0092-8674(00)81432-4 · DOI
  21. Qiu, 2006, Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin, Bioorg. Med. Chem. Lett., 16, 3306, 10.1016/j.bmcl.2006.03.021 · DOI
  22. Radhakrishnan, 2008, Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance, Cell Metab., 8, 512, 10.1016/j.cmet.2008.10.008 · DOI · Paper page
  23. Repa, 2000, The role of orphan nuclear receptors in the regulation of cholesterol homeostasis, Annu. Rev. Cell Dev. Biol., 16, 459, 10.1146/annurev.cellbio.16.1.459 · DOI
  24. Repa, 2000, Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta, Genes Dev., 14, 2819, 10.1101/gad.844900 · DOI
  25. Repa, 2002, Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta, J. Biol. Chem., 277, 18793, 10.1074/jbc.M109927200 · DOI
  26. Sato, 1996, Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2, J. Biol. Chem., 271, 26461, 10.1074/jbc.271.43.26461 · DOI
  27. Schultz, 2000, Role of LXRs in control of lipogenesis, Genes Dev., 14, 2831, 10.1101/gad.850400 · DOI · Paper page
  28. Shimomura, 1998, Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy, Genes Dev., 12, 3182, 10.1101/gad.12.20.3182 · DOI · Paper page
  29. Singer, 1984, Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers, Proc. Natl. Acad. Sci. USA, 81, 5556, 10.1073/pnas.81.17.5556 · DOI
  30. Steinberg, 2002, Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime, Nat. Med., 8, 1211, 10.1038/nm1102-1211 · DOI
  31. Sundqvist, 2005, Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7), Cell Metab., 1, 379, 10.1016/j.cmet.2005.04.010 · DOI
  32. Terasaka, 2003, T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice, FEBS Lett., 536, 6, 10.1016/S0014-5793(02)03578-0 · DOI
  33. van Dijk, 1999, Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models, Curr. Atheroscler. Rep., 1, 101, 10.1007/s11883-999-0005-y · DOI
  34. Venkateswaran, 2000, Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha, Proc. Natl. Acad. Sci. USA, 97, 12097, 10.1073/pnas.200367697 · DOI · Paper page
  35. Wang, 1993, Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization, J. Biol. Chem., 268, 14497, 10.1016/S0021-9258(19)85266-3 · DOI · Paper page
  36. Yang, 2001, Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene, Proc. Natl. Acad. Sci. USA, 98, 13607, 10.1073/pnas.201524598 · DOI · Paper page

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Metadata

Authors
Tang, J.-J., Li, J.-G., Qi, W., Qiu, W.-W., Li, P.-S., Li, B.-L., & Song, B.-L.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2011-01
Volume
13
Issue
1
Pages
44-56
ISSN
1550-4131
DOI
10.1016/j.cmet.2010.12.004
Cited by
365
References
2
Language
en
Update notices
erratum (2021-01-05)
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