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Scap is required for sterol synthesis and crypt growth in intestinal mucosa
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The effect of hepatic Spring silencing on SREBP2 is similar to the phenotype observed in liver- or intestine-specific Scap knockout mice.
“The effect on SREBP2 is similar to the phenotype observed in liver- or intestine-specific Scap knockout mice46,55”
From Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism (2020) · cites this paper as [55]
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Cited by
Sorted by citations
Lu, F., Liang, Q., Abi-Mosleh, L., Das, A., De Brabander, J. K., Goldstein, J. L., & Brown, M. S. (2015) · eLife · doi:10.7554/elife.12177 · Cited by 333
Loregger, A., Raaben, M., Nieuwenhuis, J., Tan, J. M. E., Jae, L. T., van den Hengel, L. G., Hendrix, S., van den Berg, M., Scheij, S., Song, J.-Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14811-1 · Cited by 51
Metadata
- Authors
- McFarlane, M. R., Cantoria, M. J., Linden, A. G., January, B. A., Liang, G., & Engelking, L. J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 56
- Issue
- 8
- Pages
- 1560-1571
- ISSN
- 0022-2275
- Cited by
- 33
- References
- 0
- Language
- en
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