Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

Regulation of the mevalonate pathway

Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431

Statins and the risk of dementia

Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,764

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

Wolozin, B. L. (2000) · Archives of Neurology · doi:10.1001/archneur.57.10.1439 · Cited by 1,408

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

Simons, M., Keller, P., Strooper, B. D., Beyreuther, K. T., Dotti, C. G., & Simons, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6460 · Cited by 1,177

Brain Cholesterol: Long Secret Life Behind a Barrier

Björkhem, I., & Meaney, S. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000120374.59826.1b · Cited by 1,044

SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

Li, X., Zhang, S., Blander, G., Tse, J. G., Krieger, M., & Guarente, L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.032 · Cited by 649

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

Zimmer, S., Grebe, A., Bakke, S. S., Bode, N., Halvorsen, B. L., Ulas, T., Skjelland, M., Nardo, D. D., Labzin, L. I., Kerksiek, A., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad6100 · Cited by 367

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Heverin, M., Bogdanović, N., Lütjohann, D., Bayer, T. A., Pikuleva, I. A., Brétillon, L., Diczfalusy, U., Winblad, B. G., & Björkhem, I. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300320-jlr200 · Cited by 325

High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial

PAIVA, H., THELEN, K., COSTER, R., SMET, J., PAEPE, B., MATTILA, K., LAAKSO, J., LEHTIMAKI, T., VONBERGMANN, K., & LUTJOHANN, D. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.03.006 · Cited by 308

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

Nieweg, K., Schaller, H., & Pfrieger, F. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05917.x · Cited by 307

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

Hudry, E., Dam, D. V., Kulik, W., Deyn, P. P. D., Stet, F. S., Ahouansou, O., Benraiss, A., Delacourte, A., Bougneres, P. F., Aubourg, P. R., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.175 · Cited by 214

DHCR7: A vital enzyme switch between cholesterol and vitamin D production

Prabhu, A. V., Luu, W., Li, D., Sharpe, L. J., & Brown, A. J. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.09.003 · Cited by 198

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

Schierwagen, R., Maybüchen, L., Zimmer, S., Hittatiya, K., Bäck, C., Klein, S., Uschner, F., Reul, W., Boor, P., Nickenig, G., et al. (2015) · Scientific Reports · doi:10.1038/srep12931 · Cited by 176

Reduction in Levels of 24S-Hydroxycholesterol by Statin Treatment in Patients With Alzheimer Disease

Vega, G. L., Weiner, M., Lipton, A. M., von Bergmann, K., Lütjohann, D., Moore, C. B., & Svetlik, D. A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.4.510 · Cited by 172

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

Hooijmans, C. R., van der Zee, C. E. E. M., Dederen, P. J. W. C., Brouwer, K. M., Reijmer, Y. D., Groen, T. V., Broersen, L. M., Lütjohann, D., Heerschap, A., & Kiliaan, A. J. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.002 · Cited by 177

The role of seladin‐1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo

Crameri, A., Biondi, E., Kuehnle, K., Lütjohann, D., Thelen, K., Perga, S., Dotti, C. G., Nitsch, R. M., Ledesma, M. D., & Mohajeri, M. H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600938 · Cited by 170

Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease

Wood, W. G., Eckert, G. P., Igbavboa, U., & Müller, W. E. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00025-7 · Cited by 168

Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)

Hooijmans, C. R., Rutters, F., Dederen, P. J. W. C., Gambarota, G., Veltien, A. A., Groen, T. V., Broersen, L. M., Lütjohann, D., Heerschap, A., Tanila, H., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.06.007 · Cited by 154

Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function

Karasinska, J. M., Rinninger, F., Lütjohann, D., Ruddle, P., Franciosi, S., Kruit, J. K., Singaraja, R. R., Hirsch-Reinshagen, V., Fan, J., Brunham, L. R., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4741-08.2009 · Cited by 133

Selective sterol accumulation in ABCG5/ABCG8-deficient mice

Yu, L., von Bergmann, K., Lütjohann, D., Hobbs, H. H., & Cohen, J. C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300377-jlr200 · Cited by 141

Significance of Sterol Structural Specificity

Vainio, S., Jansen, M., Koivusalo, M., Róg, T., Karttunen, M., Vattulainen, I., & Ikonen, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509530200 · Cited by 137

Liver X receptor β (LXRβ): A link between β-sitosterol and amyotrophic lateral sclerosis–Parkinson's dementia

Kim, H.-J., Fan, X., Gabbi, C., Yakimchuk, K., Parini, P., Warner, M., & Gustafsson, J.-Å. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711599105 · Cited by 136

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

Popp, J., Meichsner, S., Kölsch, H., Lewczuk, P., Maier, W., Kornhuber, J., Jessen, F., & Lütjohann, D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.12.007 · Cited by 142

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation

Valenza, M., Carroll, J. B., Leoni, V., Bertram, L. N., Bjorkhem, I., Singaraja, R. R., Di Donato, S., Lutjohann, D., Hayden, M. R., & Cattaneo, E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm170 · Cited by 115

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

Vanmierlo, T., Rutten, K., Dederen, J., Bloks, V. W., van Vark-van der Zee, L. C., Kuipers, F., Kiliaan, A., Blokland, A., Sijbrands, E. J. G., Steinbusch, H., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.07.005 · Cited by 154

Emerging roles for cholesterol in Huntington's disease

Valenza, M., & Cattaneo, E. F. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.005 · Cited by 125

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

Vanmierlo, T., Weingärtner, O., van der Pol, S. M. A., Husche, C., Kerksiek, A., Friedrichs, S., Sijbrands, E. J. G., Steinbusch, H. W. M., Grimm, M. O. W., Hartmann, T., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m017244 · Cited by 119

Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols

Karu, K., Hornshaw, M. P., Woffendin, G., Bodin, K., Hámberg, M., Alvélius, G., Sjövall, J., Turton, J. A., Wang, Y., & Griffiths, W. J. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600497-jlr200 · Cited by 116

Analysis of oxysterols by electrospray tandem mass spectrometry

Griffiths, W. J., Wang, Y., Alvélius, G., Liu, S., Bodin, K., & Sjövall, J. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.10.012 · Cited by 115

Reductions in cholesterol and synaptic markers in association cortex in mood disorders

Beasley, C. L., Honer, W. G., von Bergmann, K., Falkai, P., Lütjohann, D., & Bayer, T. A. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00239.x · Cited by 111

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice

Wouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lütjohann, D., Kerksiek, A., Staels, B., Hofker, M. H., & Shiri-Sverdlov, R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.046 · Cited by 109

Cholesterol synthesis rate in human hippocampus declines with aging

Thelen, K. M., Falkai, P., Bayer, T. A., & Lütjohann, D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.034 · Cited by 107

Dietary plant sterols accumulate in the brain

Jansen, P. J., Lütjohann, D., Abildayeva, K., Vanmierlo, T., Plösch, T., Plat, J., von Bergmann, K., Groen, A. K., Ramaekers, F. C. S., Kuipers, F., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.03.015 · Cited by 103

Incorporation of β-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor-mediated PI3K/GSK3β signaling

Shi, C., Wu, F., Zhu, X., & Xu, J. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.12.012 · Cited by 101

Polymorphisms in glutathione S -transferase omega-1 and AD, vascular dementia, and stroke

Kölsch, H., Linnebank, M., Lütjohann, D., Jessen, F., Wüllner, U., Harbrecht, U., Thelen, K., Kreis, M., Hentschel, F., Schulz, A., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000147294.29309.47 · Cited by 100

ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile

Langheim, S., Yu, L., von Bergmann, K., Lütjohann, D., Xu, F., Hobbs, H. H., & Cohen, J. C. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500115-jlr200 · Cited by 96

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer’s disease mouse model

Bogie, J. F. J., Hoeks, C., Schepers, M., Tiane, A., Cuypers, A., Leijten, F. P. J., Chintapakorn, Y., Suttiyut, T., Pornpakakul, S., Struik, D., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41399-4 · Cited by 94

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects

Millar, J. S., Reyes‐Soffer, G., Jumes, P. A., Dunbar, R. L., deGoma, E. M., Baer, A. L., Karmally, W., Donovan, D. S., Rafeek, H., Pollan, L. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80025 · Cited by 89

Customary Use of Plant Sterol and Plant Stanol Enriched Margarine Is Associated with Changes in Serum Plant Sterol and Stanol Concentrations in Humans1

Fransen, H. P., de Jong, N., Wolfs, M. C. J., Verhagen, H., Verschuren, W. M. M., Lütjohann, D., von Bergmann, K., Plat, J., & Mensink, R. P. (2007) · Journal of Nutrition · doi:10.1093/jn/137.5.1301 · Cited by 86

Analysis of neurosterols by GC–MS and LC–MS/MS

Griffiths, W. J., & Wang, Y. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.05.017 · Cited by 77

Methodological considerations for the harmonization of non-cholesterol sterol bio-analysis

MacKay, D., Jones, P. J. H., Myrie, S. B., Plat, J., & Lütjohann, D. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.02.052 · Cited by 77

The origin of fetal sterols in second-trimester amniotic fluid: endogenous synthesis or maternal-fetal transport?

Baardman, M. E., Erwich, J. J., Berger, R. M. F., Hofstra, R. M. W., Kerstjens‐Frederikse, W. S., Lütjohann, D., & Plösch, T. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.06.003 · Cited by 75

Brain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase‐1

Hascalovici, J., Vaya, J., Khatib, S., Holcroft, C., Zukor, H., Song, W., Arvanitakis, Z., Bennett, D. A., & Schipper, H. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06213.x · Cited by 73

The Isoform-Specific Pathological Effects of ApoE4 in vivo are Prevented by a Fish Oil (DHA) Diet and are Modified by Cholesterol

Kariv-Inbal, Z., Yacobson, S., Berkecz, R., Péter, M., Janáky, T., Lütjohann, D., Broersen, L. M., Hartmann, T., & Michaelson, D. M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111265 · Cited by 70

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease

Barrier, L., Ingrand, S. S., Damjanac, M., Bilan, A. R., Hugon, J., & Page, G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.002 · Cited by 68

Long-term efficacy and safety of ezetimibe 10 mg in patients with homozygous sitosterolemia: a 2-year, open-label extension study

Lütjohann, D., von Bergmann, K., Sirah, W., Macdonell, G., Johnson‐Levonas, A. O., Shah, A. K., Lin, J., Sapre, A., & Musliner, T. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01841.x · Cited by 67

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

Burgess, B. L., Parkinson, P. F., Racke, M. M., Hirsch‐Reinshagen, V., Fan, J., Wong, C. A., Stukas, S. K., Théroux, L., Chan, J. Y., Donkin, J. J., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m700481-jlr200 · Cited by 66

Effects of type 2 diabetes mellitus on plasma fatty acid composition and cholesterol content of erythrocyte and leukocyte membranes

Bakan, E., Yıldırım, A., Kurtul, N., Polat, M., Dursun, H., & Cayir, K. (2006) · Acta Diabetologica · doi:10.1007/s00592-007-0224-4 · Cited by 63

APP23 Mice as a Model of Alzheimer's Disease: An Example of a Transgenic Approach to Modeling a CNS Disorder

Dam, D. V., Vloeberghs, E., Abramowski, D., Staufenbiel, M., & Deyn, P. P. D. (2005) · CNS Spectrums · doi:10.1017/s1092852900010051 · Cited by 62

Cholesterol metabolism in the brain: importance of 24S-hydroxylation

Lütjohann, D. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00683.x · Cited by 63

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

Wiesmann, M., Zerbi, V., Jansen, D., Haast, R., Lütjohann, D., Broersen, L. M., Heerschap, A., & Kiliaan, A. J. (2016) · Neural Plasticity · doi:10.1155/2016/6846721 · Cited by 60

Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain

Li, T., Yin, Y., Zhou, Z., Qiu, J., Liu, W., Zhang, X., He, K., Cai, Y. A., & Zhu, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-24672-x · Cited by 60

Changes in Brain Cholesterol Metabolome After Excitotoxicity

Ong, W., Kim, J., He, X., Chen, P., Farooqui, A. A., & Jenner, A. M. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8099-3 · Cited by 60

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1

Goyal, S., Xiao, Y., Porter, N. A., Xu, L., & Guengerich, F. P. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m051508 · Cited by 57

Analysis of bioactive oxysterols in newborn mouse brain by LC/MS

Meljon, A., Theofilopoulos, S., Shackleton, C. H. L., Watson, G. L., Javitt, N. B., Knölker, H., Saini, R., Arenas, E., Wang, Y., & Griffiths, W. J. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d028233 · Cited by 57

Secretion of Sterols and the NPC2 Protein from Primary Astrocytes

Mutka, A.-L., Lusa, S., Linder, M. D., Jokitalo, E., Kopra, O., Jauhiainen, M., & Ikonen, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405345200 · Cited by 56

Plasma lipoprotein β-amyloid in subjects with Alzheimer's disease or mild cognitive impairment

Mamo, J. C. L., Jian, L., James, A. P., Flicker, L. A., Esselmann, H., & Wiltfang, J. (2008) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.007214 · Cited by 53

Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice

Wiesmann, M., Zerbi, V., Jansen, D., Lütjohann, D., Veltien, A. A., Heerschap, A., & Kiliaan, A. J. (2017) · Theranostics · doi:10.7150/thno.18509 · Cited by 54

Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function

Clement, A. B., Gamerdinger, M., Tamboli, I. Y., Lütjohann, D., Walter, J., Greeve, I., Gimpl, G., & Behl, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06360.x · Cited by 55

Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients

Zarrouk, A., Hammouda, S., Ghzaiel, I., Hammami, S. O., Khamlaoui, W., Ahmed, S. H., Lizard, G., & Hammami, M. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666201203123046 · Cited by 52

Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor

Sun, S., Yang, S., Mao, Y., Jia, X., & Zhang, Z. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0020-7 · Cited by 52

Efficacy, safety and effect on biomarkers related to cholesterol and lipoprotein metabolism of rosuvastatin 10 or 20 mg plus ezetimibe 10 mg vs. simvastatin 40 or 80 mg plus ezetimibe 10 mg in high-risk patients: Results of the GRAVITY randomized study

Ballantyne, C. M., Hoogeveen, R. C., Raya, J. L., Cain, V. A., Palmer, M. K., & Karlson, B. W. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.022 · Cited by 49

Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AβPPswe-PS1dE9 Mice

Jansen, D., Zerbi, V., Arnoldussen, I. A. C., Wiesmann, M., Rijpma, A., Fang, X. T., Dederen, P. J. W. C., Mutsaers, M. P. C., Broersen, L. M., Lütjohann, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075393 · Cited by 47

Metabolomics and Metabolite Profiling: Past Heroes and Future Developments

Griffiths, W. J., Karu, K., Hornshaw, M. P., Woffendin, G., & Wang, Y. (2007) · European Journal of Mass Spectrometry · doi:10.1255/ejms.850 · Cited by 46

Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8

Yu, L., von Bergmann, K., Lütjohann, D., Hobbs, H. H., & Cohen, J. C. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500124-jlr200 · Cited by 46

Differential Mobilization of Newly Synthesized Cholesterol and Biosynthetic Sterol Precursors from Cells

Lusa, S., Heino, S., & Ikonen, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212503200 · Cited by 45

Metabolomics and metabolite profiling

Schuhmacher, R., Krska, R., Weckwerth, W., & Goodacre, R. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-6939-5 · Cited by 45

Active liver X receptor signaling in phagocytes in multiple sclerosis lesions

Mailleux, J., Vanmierlo, T., Bogie, J. F. J., Wouters, E., Lütjohann, D., Hendriks, J. J. A., & van Horssen, J. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517696595 · Cited by 49

Targeted lipidomic analysis of oxysterols in the embryonic central nervous system

Wang, Y., Sousa, K. M., Bodin, K., Theofilopoulos, S., Sacchetti, P., Hornshaw, M. P., Woffendin, G., Karu, K., Sjövall, J., Arenas, E., et al. (2009) · Molecular BioSystems · doi:10.1039/b819502a · Cited by 44

Vitamin D3 Effects on Lipids Differ in Statin and Non-Statin-Treated Humans: Superiority of Free 25-OH D Levels in Detecting Relationships

Kane, L., Moore, K. L., Lütjohann, D., Bikle, D. D., & Schwartz, J. B. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1922 · Cited by 42

What dictates the accumulation of desmosterol in the developing brain?

Jansen, M., Wang, W., Greco, D., Bellenchi, G. C., di Porzio, U., Brown, A. J., & Ikonen, E. (2013) · The FASEB Journal · doi:10.1096/fj.12-211235 · Cited by 42

Analysis of neurosterols and neurosteroids by mass spectrometry

Wang, Y., Karu, K., & Griffiths, W. J. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.008 · Cited by 42

Alterations in Brain Cholesterol Metabolism in the APPSLxPS1mut mouse, a Model for Alzheimer's Disease

Vanmierlo, T., Bloks, V. W., der Zee, L. C. V. V., Rutten, K., Kerksiek, A., Friedrichs, S., Sijbrands, E. J. G., Steinbusch, H. W. M., Kuipers, F., Lütjohann, D., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1209 · Cited by 41

Cerebral Accumulation of Dietary Derivable Plant Sterols does not Interfere with Memory and Anxiety Related Behavior in Abcg5−/− Mice

Vanmierlo, T., Rutten, K., van der Zee, L. C. V. V. –., Friedrichs, S., Bloks, V. W., Blokland, A., Ramaekers, F. C. S., Sijbrands, E. J. G., Steinbusch, H. W. M., Prickaerts, J., et al. (2011) · Plant Foods for Human Nutrition · doi:10.1007/s11130-011-0219-3 · Cited by 40

Aging Induces Tissue‐Specific Changes in Cholesterol Metabolism in Rat Brain and Liver

Smiljanić, K., Vanmierlo, T., Mladenović, A., Perović, M., Lončarević‐Vasiljković, N., Tešić, V., Rakić, L., Ruždijić, S., Lütjohann, D., & Kanazir, S. (2013) · Lipids · doi:10.1007/s11745-013-3836-9 · Cited by 39

Alzheimer's disease: Cholesterol a menace?

Mathew, A., Yoshida, Y., Maekawa, T., & Kumar, D. S. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.006 · Cited by 38

Variations in dietary intake and plasma concentrations of plant sterols across plant‐based diets among North American adults

Jaceldo‐Siegl, K., Lütjohann, D., Sirirat, R., Mashchak, A., Fraser, G. E., & Haddad, E. H. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600828 · Cited by 38

Gender-dependent accumulation of ceramides in the cerebral cortex of the APPSL/PS1Ki mouse model of Alzheimer’s disease

Barrier, L., Ingrand, S. S., Fauconneau, B., & Page, G. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.011 · Cited by 36

24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer’s Disease

Martens, N., Schepers, M., Zhan, N., Leijten, F. P. J., Voortman, G. J., Tiane, A., Rombaut, B., Poisquet, J., van de Sande, N., Kerksiek, A., et al. (2021) · Marine Drugs · doi:10.3390/md19040190 · Cited by 37

Dietary Cholesterol and Its Effect on Tau Protein: A Study in Apolipoprotein E-Deficient and P301L Human Tau Mice

Glöckner, F., Meske, V., Lütjohann, D., & Ohm, T. G. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318212f185 · Cited by 35

The role of extracerebral cholesterol homeostasis and ApoE e4 in cognitive decline

van den Kommer, T. N., Dik, M. G., Comijs, H. C., Lütjohann, D., Lips, P. T. A. M., Jonker, C., & Deeg, D. J. H. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.019 · Cited by 35

The lipid-lowering effect of ezetimibe in pure vegetarians

Clarenbach, J. J., Reber, M., Lütjohann, D., von Bergmann, K., & Sudhop, T. (2006) · Journal of Lipid Research · doi:10.1194/jlr.p600009-jlr200 · Cited by 34

Increased plant sterol deposition in vascular tissue characterizes patients with severe aortic stenosis and concomitant coronary artery disease

Luister, A., Schött, H.-F., Husche, C., Schäfers, H., Böhm, M., Plat, J., Gräber, S., Lütjohann, D., Laufs, U., & Weingärtner, O. (2015) · Steroids · doi:10.1016/j.steroids.2015.03.011 · Cited by 33

Changes in cholesterol biosynthetic and transport pathways after excitotoxicity

Kim, J., Jittiwat, J., Ong, W., Farooqui, A. A., & Jenner, A. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06449.x · Cited by 33

High Fibre Diets and Alzheimer’s Disease

Martins, I. J., & Fernando, W. M. A. D. B. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.54049 · Cited by 33

Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation

Levi, O., Lütjohann, D., Devir, A., Von Bergmann, K., Hartmann, T., & Michaelson, D. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03441.x · Cited by 29

Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice

Jansen, D., Zerbi, V., Janssen, C. I. F., van Rooij, D., Zinnhardt, B., Dederen, P. J. W. C., Wright, A. J., Broersen, L. M., Lütjohann, D., Heerschap, A., et al. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0606-7 · Cited by 35

Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels

Weingärtner, O., Bogeski, I., Kummerow, C., Schirmer, S. H., Husche, C., Vanmierlo, T., Wagenpfeil, G., Hoth, M., Böhm, M., Lütjohann, D., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.07.016 · Cited by 31

Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man

Laaksonen, R., Thelen, K., Päivä, H., Matinheikki, J., Vesalainen, R. K., Janatuinen, T., Knuuti, J. M., Rontu, R., von Bergmann, K., Lütjohann, D., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.06.007 · Cited by 31

New insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm

Peri, A., Danza, G., Benvenuti, S., Luciani, P., Deledda, C., Rosati, F., Cellai, I., & Serio, M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.006 · Cited by 30

The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2, ε3 and ε4 knock-in mice

Jenner, A. M., Lim, W. L. F., Ng, M. P.-E., Wenk, M. R., Shui, G., Sharman, M. J., Gandy, S., & Martins, R. N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.026 · Cited by 29

Fate of dietary phytosteryl/-stanyl esters: analysis of individual intact esters in human feces

Lubinus, T., Barnsteiner, A., Skurk, T., Hauner, H., & Engel, K. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0407-4 · Cited by 27

Adaptation of cholesterol synthesis to fasting and TNF-α: Profiling cholesterol intermediates in the liver, brain, and testis

Tacer, K. F., Pompon, D., & Rozman, D. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.026 · Cited by 25

Increased plant sterol and stanol levels in brain of Watanabe rabbits fed rapeseed oil derived plant sterol or stanol esters

Fricke, C., Schrøder, M., Poulsen, M., von Bergmann, K., Wester, I., Knudsen, I., Mortensen, A., & Lütjohann, D. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507756532 · Cited by 26

Oxidation of sitosterol and transport of its 7-oxygenated products from different tissues in humans and ApoE knockout mice

Schött, H.-F., Baumgartner, S., Husche, C., Luister, A., Friedrichs, S., Miller, C. M., McCarthy, F. O., Plat, J., Laufs, U., Weingärtner, O., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.04.011 · Cited by 25

Apolipoprotein CI Knock-Out Mice Display Impaired Memory Functions

Berbée, J. F. P., Vanmierlo, T., Abildayeva, K., Blokland, A., Jansen, P. J., Lütjohann, D., Gautier, T., Sijbrands, E., Prickaerts, J., Hadfoune, M., et al. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100576 · Cited by 25

Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis

Lopez, A. M., Chuang, J.-C., Posey, K. S., & Turley, S. D. (2017) · Brain Research · doi:10.1016/j.brainres.2016.10.021 · Cited by 24

Sterol lipidomics in health and disease: Methodologies and applications

Griffiths, W. J., & Wang, Y. (2009) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.200800116 · Cited by 24

Hydroxypropyl-Beta-Cyclodextrin Reduces Inflammatory Signaling from Monocytes: Possible Implications for Suppression of HIV Chronic Immune Activation

Matassoli, F. L., Leão, I. C., Bezerra, B. B., Pollard, R. B., Lütjohann, D., Hildreth, J. E. K., & de Arruda, L. B. (2018) · mSphere · doi:10.1128/msphere.00497-18 · Cited by 26

An Evidence-Based Systematic Review of Beta-Sitosterol, Sitosterol (22,23- dihydrostigmasterol, 24-ethylcholesterol) by the Natural Standard Research Collaboration

Ulbricht, C. E. (2015) · Journal of Dietary Supplements · doi:10.3109/19390211.2015.1008812 · Cited by 24

The relationships of phytosterols and oxyphytosterols in plasma and aortic valve cusps in patients with severe aortic stenosis

Schött, H.-F., Luister, A., Husche, C., Schäfers, H., Böhm, M., Plat, J., Lütjohann, D., Laufs, U., & Weingärtner, O. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.007 · Cited by 23

Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases

Zhan, N., Wang, B., Martens, N., Liu, Y., Zhao, S., Voortman, G. J., van Rooij, J., Leijten, F. P. J., Vanmierlo, T., Kuipers, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021290 · Cited by 24

Consuming Functional Foods Enriched with Plant Sterol or Stanol Esters for 85 Weeks Does Not Affect Neurocognitive Functioning or Mood in Statin-Treated Hypercholesterolemic Individuals

Schiepers, O. J. G., de Groot, R. H. M., van Boxtel, M. P. J., Jolles, J., de Jong, A., Lütjohann, D., Plat, J., & Mensink, R. P. (2009) · Journal of Nutrition · doi:10.3945/jn.108.103721 · Cited by 22

CYP46A1-dependent and independent effects of efavirenz treatment

Mast, N., El‐Darzi, N., Petrov, A. M., Li, Y., & Pikuleva, I. A. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa180 · Cited by 21

Alterations in Brain Cholesterol Metabolism in the APPSLxPS1mut mouse, a Model for Alzheimer's Disease

Vanmierlo, T., Bloks, V. W., der Zee, L. C. V. V., Rutten, K., Kerksiek, A., Friedrichs, S., Sijbrands, E. J. G., Steinbusch, H. W. M., Kuipers, F., Lütjohann, D., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1209 · Cited by 41

Aging Induces Tissue‐Specific Changes in Cholesterol Metabolism in Rat Brain and Liver

Smiljanić, K., Vanmierlo, T., Mladenović, A., Perović, M., Lončarević‐Vasiljković, N., Tešić, V., Rakić, L., Ruždijić, S., Lütjohann, D., & Kanazir, S. (2013) · Lipids · doi:10.1007/s11745-013-3836-9 · Cited by 39

Brain sterol metabolism : modulating Alzheimer’s disease

Vanmierlo, T. (2010) · Research Publications (Maastricht University) · doi:10.26481/dis.20100930tv

Cholesterol Accumulates in Senile plaques of Alzheimer Disease patients and in Transgenic APPswMice

Mori, T., Paris, D., Town, T., Rojiani, A. M., Sparks, D. L., Delledonne, A., Crawford, F., Abdullah, L. I., Humphrey, J. A., Dickson, D. W., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.778 · Cited by 159

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

Halford, R. W., & Russell, D. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813349106 · Cited by 75