Acute hyperglycemia induces an oxidative stress in healthy subjects
Open accessAbstract
Recent prospective studies indicate that long-term glycemic control of diabetes is an important predictor not only of microvascular disease but also of macrovascular complications, including coronary heart disease (1). Possible links between glucose and cardiovascular events in the diabetic patient include modifications of important vascular functions of the endothelium with a switch from a quiescent, relaxant, antithrombotic, antioxidant, and antiadhesive state to an activated state displaying a more atherogenetic risk profile (2). Generation of reactive oxygen species could be a common downstream mechanism by means of which multiple byproducts of glucose are exerting their adverse effects on blood vessels (3). Indeed, in April 2001, Pennathur et al. (4) reported in the JCI that hyperglycemia favors oxidative reactions in the microenvironment of the artery wall in vivo. We studied the effect of acute elevations of plasma glucose levels on plasma nitrotyrosine, a marker of oxidative stress, in 20 healthy subjects (11 men, 9 women). Their age was 34 ± 4 years (mean ± SD), and the body mass index was 24 ± 1 kg/m2. None used any medication. After giving informed written consent to participate in the study, each subject underwent a hyperglycemic glucose clamp test in which plasma glucose concentrations were acutely raised at about 15 mmol/l for 120 minutes (Figure (Figure1).1). Mean blood pressure and nitrotyrosine (5) rose significantly during the clamp; there was a positive correlation (r = 0.49) between nitrotyrosine and mean blood pressure increases during hyperglycemia. In control studies (n = 6), in which plasma glucose was maintained at normal concentrations (5 mmol/l for 120 minutes), we could detect no variation in nitrotyrosine plasma levels from baseline (baseline: 0.15 ± 0.05 μmol/l; 120-minute values: 0.13 ± 0.05 μmol/l, P = not significant). Figure 1 Twenty healthy subjects were submitted to a hyperglycemic glucose clamp study in which plasma glucose levels were acutely raised to 15 mmol/l (0.33 g/kg as intravenous bolus injection followed by a variable 30% glucose infusion). Mean blood pressure ... We show here that acute hyperglycemia in normal subjects causes an oxidative stress as evidenced by the raised circulating nitrotyrosine levels during the hyperglycemic clamp. However, we cannot exclude the possibility that some nitrotyrosine can be generated via a peroxynitrite-independent mechanism, or that a reduced nitrotyrosine clearance during hyperglycemia could also contribute to its raised plasma concentrations. Since nitrotyrosine is considered a good marker of peroxynitrite formation (6), and since peroxynitrite may account for a considerable portion of the toxic effects previously attributed to nitric oxide or the superoxide anion (7), it is possible that some of the toxic effects of hyperglycemia on the vascular tree may be modulated by peroxynitrite. Acute hyperglycemia in normal subjects may in fact induce vasoconstriction, activate thrombosis, increase the circulating levels of soluble adhesion molecules, and prolong the QT interval (8, 9). The recent demonstration (10) that apoptosis of myocytes, endothelial cells, and fibroblasts in heart biopsies taken from diabetic patients is selectively associated with intracellular levels of nitrotyrosine supports a role for high-energy oxidants (such as peroxynitrite) as mediators of the vascular damage brought about by hyperglycemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Postprandial hyperglycemia and hypertriglyceridemia cause endothelial dysfunction and inflammation via oxidative stress.
“Evidence suggests that postprandial hypertriglyceridemia and hyperglycemia induce endothelial dysfunction and inflammation through oxidative stress.”
In healthy people, a sudden rise in blood glucose raises nitrotyrosine and impairs endothelial function at the same time.
“Evidence that an acute increase in glycemia simultaneously induces an increase in nitrotyrosine (NT) and endothelial dysfunction in healthy subjects 14”
Rising nitrotyrosine levels during hyperglycemia or fat loading support the idea that glucose and free fatty acids trigger oxidative stress through shared pathways.
“The increase in NT, a useful marker of both peroxynitrite and NO activity, during hyperglycemia or fat load supports this hypothesis.[13][14][15]”
Weight loss is accompanied by decreased circulating CRP, TNF-a, IL-6, and sICAM-1.
“Weight loss is accompanied by decreased concentrations of circulating mediators of inflammation, such as CRP, TNF-a, IL-6 and sICAM-1 (155,268 -270) , although it is difficult to dissect whether this effect is due to the weight loss per se or to the nature of the diet used to induce weight loss.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [268]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
Capes, S. E., Hunt, D., Malmberg, K., & Gerstein, H. C. (2000) · The Lancet · doi:10.1016/s0140-6736(99)08415-9 · Cited by 2,187 · see citing works
Cuzzocrea, S., Riley, D. P., Caputi, A. P., & Salvemini, D. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01484-4 · Cited by 1,087 · see citing works
Myocardial Cell Death in Human Diabetes
Frustaci, A., Kajstura, J., Chimenti, C., Jakoniuk, I., Leri, A., Maseri, A., Nadal-Ginard, B., & Anversa, P. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1123 · Cited by 796 · see citing works
Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite
van der Vliet, A., Eiserich, J. P., Halliwell, B., & Cross, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7617 · Cited by 780 · see citing works
Giugliano, D., Marfella, R., Coppola, L., Verrazzo, G., Acampora, R., Giunta, R., Nappo, F., Lucarelli, C., & D’Onofrio, F. (1997) · Circulation · doi:10.1161/01.cir.95.7.1783 · Cited by 360 · see citing works
Self-citationCirculating Adhesion Molecules in Humans
Marfella, R., Esposito, K., Giunta, R. E., Coppola, G., Angelis, L. D., Farzati, B., Paolisso, G., & Giugliano, D. (2000) · Circulation · doi:10.1161/01.cir.101.19.2247 · Cited by 221 · see citing works
Self-citationThe effect of acute hyperglycaemia on QTc duration in healthy man
Marfella, R., Angelis, L. D., Siniscalchi, M., Rossi, F., Giugliano, D., & Nappo, F. (2000) · Diabetologia · doi:10.1007/s001250051345 · Cited by 186 · see citing works
Self-citationPennathur, S., Wagner, J. D., Leeuwenburgh, C., Litwak, K. N., & Heinecke, J. W. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11194 · Cited by 151 · see citing works
FROST, M. T., Halliwell, B. B., & Moore, K. P. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3450453 · Cited by 151 · see citing works
Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA
ter Steege, J. C. A., Koster‐Kamphuis, L., van Straaten, E. A., Forget, P. P., & Buurman, W. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00184-1 · Cited by 138 · see citing works
Yi, D., Ingelse, B. A., Duncan, M. W., & Smythe, G. A. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00113-6 · Cited by 101 · see citing works
Artefacts in HPLC Detection of 3‐Nitrotyrosine in Human Brain Tissue
Kaur, H., Lyras, L., Jenner, P. G., & Halliwell, B. B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052220.x · Cited by 70 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., & for The STOP-NIDDM Trial Research Group (2003) · JAMA · doi:10.1001/jama.290.4.486 · Cited by 1,624 · see citing works
Ceriello, A., Esposito, K., Piconi, L., Ihnat, M. A., Thorpe, J. E., Testa, R., Boemi, M., & Giugliano, D. (2008) · Diabetes · doi:10.2337/db08-0063 · Cited by 1,310 · see citing works
Self-citationManagement of diabetes and hyperglycemia in hospitals.
Clement, S., Braithwaite, S. S., Magee, M. F., Ahmann, A., Smith, E. P., Schafer, R. G., Hirsch, I. B., & on behalf of the Diabetes in Hospitals Writing Committee (2004) · Diabetes Care · doi:10.2337/diacare.27.2.553 · Cited by 1,266 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Postprandial Hyperglycemia and Diabetes Complications
Ceriello, A. (2005) · Diabetes · doi:10.2337/diabetes.54.1.1 · Cited by 945 · see citing works
Self-citationAdipokines: molecular links between obesity and atheroslcerosis
Lau, D., Dhillon, B., Yan, H., Szmitko, P. E., & Verma, S. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01058.2004 · Cited by 930 · see citing works
Ceriello, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1589 · Cited by 734 · see citing works
Self-citationRodbard, H. W., Blonde, L., Ss, B., Brett, E. M., Cobin, R. H., Handelsman, Y., Hellman, R., Jellinger, P. S., Jovanovic, L. G., Levy, P., et al. (2007) · Endocrine Practice · doi:10.4158/ep.13.s1.1 · Cited by 693 · see citing works
Ceriello, A., Taboga, C., Tonutti, L., Quagliaro, L., Piconi, L., Bais, B., Da Ros, R., & Motz, E. (2002) · Circulation · doi:10.1161/01.cir.0000027569.76671.a8 · Cited by 655 · see citing works
Self-citationImpact of postprandial glycaemia on health and prevention of disease
Blaak, E. E., Antoine, J. M., Benton, D., Björck, I., Bozzetto, L., Brouns, F. J. P. H., Diamant, M., Dye, L., Hulshof, T. G., Holst, J. J., et al. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01011.x · Cited by 486 · see citing works
Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 467 · see citing works
Hyperglycemia and Glycation in Diabetic Complications
Nègre‐Salvayre, A., Salvayre, R., Augè, N., Pamplona, R., & Portero‐Otín, M. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2484 · Cited by 424 · see citing works
STEATOSIS IN CHRONIC HEPATITIS C: WHY DOES IT REALLY MATTER?
Asselah, T., Rubbia-Brandt, L., Marcellin, P., & Negro, F. (2005) · Gut · doi:10.1136/gut.2005.069757 · Cited by 394 · see citing works
Protein Nitration in Cardiovascular Diseases
Turko, I. V., & Murad, F. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.4.619 · Cited by 372 · see citing works
Clinical Significance, Pathogenesis, and Management of Postprandial Hyperglycemia
Gerich, J. E. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.11.1306 · Cited by 321 · see citing works
Joshi, S., Standl, E., Tong, N., Shah, P., Kalra, S., & Rathod, R. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1070827 · Cited by 310 · see citing works
Ceriello, A., Assaloni, R., Da Ros, R., Maier, A., Piconi, L., Quagliaro, L., Esposito, K., & Giugliano, D. (2005) · Circulation · doi:10.1161/01.cir.0000165070.46111.9f · Cited by 298 · see citing works
Self-citationGlucose metabolism and hyperglycemia
Giugliano, D., Ceriello, A., & Esposito, K. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.217s · Cited by 278 · see citing works
Self-citationRole of Hyperglycemia in Nitrotyrosine Postprandial Generation
Ceriello, A., Quagliaro, L., Catone, B., Pascon, R., Piazzola, M., Bais, B., Marra, G., Tonutti, L., Taboga, C., & Motz, E. (2002) · Diabetes Care · doi:10.2337/diacare.25.8.1439 · Cited by 257 · see citing works
Self-citationOxidative Stress and Diabetes-Associated Complications
Ceriello, A. (2006) · Endocrine Practice · doi:10.4158/ep.12.s1.60 · Cited by 254 · see citing works
Self-citationPostprandial recruitment of neutrophils may contribute to endothelial dysfunction
van Oostrom, A. J. H. H. M., Sijmonsma, T. P., Verseyden, C., Jansen, E. H. J. M., de Koning, E. J. P., Rabelink, T. J., & Castro Cabezas, M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200419-jlr200 · Cited by 249 · see citing works
DiNicolantonio, J. J., Bhutani, J., & O’Keefe, J. H. (2015) · Open Heart · doi:10.1136/openhrt-2015-000327 · Cited by 228 · see citing works
Guideline for management of postmeal glucose
Ceriello, A., Colagiuri, S., Gerich, J. E., & Tuomilehto, J. O. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.01.012 · Cited by 208 · see citing works
Self-citationBurke, A., & Lucey, M. R. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00432.x · Cited by 192 · see citing works
Leiter, L. A., FITCHETT, D. H., Gilbert, R. E., Gupta, M., Mancini, G. B. J., McFarlane, P. A., Ross, R., Teoh, H., Verma, S., Anand, S. S., et al. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.12.054 · Cited by 184 · see citing works
Dickinson, S., Hancock, D. P., Petocz, P., Ceriello, A., & Brand-Miller, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1188 · Cited by 184 · see citing works
Self-citationPostprandial hyperglycemia as an etiological factor in vascular failure
Node, K., & Inoue, T. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-23 · Cited by 182 · see citing works
Talior‐Volodarsky, I., Yarkoni, M., Bashan, N., & Eldar-Finkelman, H. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00044.2003 · Cited by 176 · see citing works
Bandeira, S. D. M., Guedes, G. D. S., da Fonseca, L. J. S., Pires, A. S., Gelain, D. P., Moreira, J. C. F., Rabelo, L. A., Vasconcelos, S. M. L., & Goulart, M. O. F. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/819310 · Cited by 170 · see citing works
Endothelial Microparticles Correlate with Endothelial Dysfunction in Obese Women
Esposito, K., Ciotola, M., Schisano, B., Gualdiero, R., Sardelli, L., Misso, L., Giannetti, G., & Giugliano, D. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0851 · Cited by 162 · see citing works
Self-citationPost-Meal Glucose Peaks at Home Associate with Carotid Intima-Media Thickness in Type 2 Diabetes
Esposito, K., Ciotola, M., Carleo, D., Schisano, B., Sardelli, L., Tommaso, D. D., Misso, L., Saccomanno, F., Ceriello, A., & Giugliano, D. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2000 · Cited by 162 · see citing works
Self-citationNassar, H. A., Kantarcı, A., & Dyke, T. E. V. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00168.x · Cited by 149 · see citing works
Acute hyperglycemia and oxidative stress: Direct cause and effect?
Choi, S.-W., Benzie, I. F. F., Ma, S.-W., Strain, J. J., & Hannigan, B. M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.005 · Cited by 149 · see citing works
Acute hyperglycaemia: a ‘new’ risk factor during myocardial infarction
Ceriello, A. (2004) · European Heart Journal · doi:10.1093/eurheartj/ehi049 · Cited by 146 · see citing works
Self-citationBruttomesso, D., Crazzolara, D., Maran, A., Costa, S., Pos, M. D., Girelli, A., Lepore, G., Aragona, M., Iori, E., Valentini, U., et al. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02365.x · Cited by 136 · see citing works
Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome
Fortuño, A., San José, G., Moreno, M. U., Beloqui, O., Díez, J., & Zalba, G. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0751 · Cited by 128 · see citing works
Badawi, A. F. (2011) · Biologics · doi:10.2147/btt.s14417 · Cited by 124 · see citing works
Ceriello, A. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.11.020 · Cited by 123 · see citing works
Self-citationInflammation and Insulin Resistance
Bloomgarden, Z. T. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1922 · Cited by 124 · see citing works
Zhang, Y., Han, P., Wu, N., He, B., Lü, Y., Li, S., Liu, Y., Zhao, S., Liu, L., & Li, Y. (2011) · Obesity · doi:10.1038/oby.2011.121 · Cited by 122 · see citing works
Glucose “peak” and glucose “spike”: Impact on endothelial function and oxidative stress
Ceriello, A., Esposito, K., Piconi, L., Ihnat, M. A., Thorpe, J. E., Testa, R., Bonfigli, A. R., & Giugliano, D. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.07.015 · Cited by 122 · see citing works
Self-citationTalior, I., Tennenbaum, T., Kuroki, T., & Eldar-Finkelman, H. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00378.2004 · Cited by 120 · see citing works
Zhang, Y., Han, H. J., Wang, J., Wang, H., Yang, B., & Wang, Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211044200 · Cited by 118 · see citing works
Stolker, J. M., McCullough, P. A., Rao, S. C., Inzucchi, S. E., Spertus, J. A., Maddox, T. M., Masoudi, F. A., Xiao, L., & Kosiborod, M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.072 · Cited by 112 · see citing works
Role of oxidative stress in diabetic nephropathy
Vasavada, N., & Agarwal, R. (2005) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2005.01.001 · Cited by 111 · see citing works
Giaccari, A., Sorice, G. P., & Muscogiuri, G. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.03.018 · Cited by 107 · see citing works
Imasawa, T., Obre, É., Bellancé, N., Lavie, J., Imasawa, T., Rigothier, C., Delmas, Y., Combe, C., Lacombe, D., Bénard, G., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600293r · Cited by 104 · see citing works
Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance
Blouet, C., Mariotti, F., Azzout‐Marniche, D., Mathé, V., Mikogami, T., Tomé, D., & Huneau, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.006 · Cited by 101 · see citing works
Oxidative stress in the metabolic syndrome
Esposito, K., Ciotola, M., Schisano, B., Misso, L., Giannetti, G., Ceriello, A., & Giugliano, D. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03347372 · Cited by 99 · see citing works
Self-citationValue of Self-Monitoring Blood Glucose Pattern Analysis in Improving Diabetes Outcomes
Parkin, C. G., & Davidson, J. A. (2009) · Journal of Diabetes Science and Technology · doi:10.1177/193229680900300314 · Cited by 96 · see citing works
Protein and energy provision in critical illness
Hoffer, L. J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.5.906 · Cited by 93 · see citing works
Road Maps to Achieve Glycemic Control in Type 2 Diabetes Mellitus
Jellinger, P. S., Davidson, J. A., Blonde, L., EINHORN, D. F., Grunberger, G., Handelsman, Y., Hellman, R., Lebovitz, H. E., Levy, P., & Roberts, V. L. (2007) · Endocrine Practice · doi:10.4158/ep.13.3.260 · Cited by 92 · see citing works
Tang, W. H., Cheng, W. T., Kravtsov, G. M., Tong, X., Hou, X. Y., Chung, S. K., & Chung, S. S. M. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00137.2010 · Cited by 84 · see citing works
Ceriello, A., Esposito, K., Sala, L. L., Pujadas, G., Nigris, V. D., Testa, R., Bucciarelli, L. G., Rondinelli, M., & Genovese, S. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0140-9 · Cited by 82 · see citing works
Self-citationDiet-Microbe-Host Interactions That Affect Gut Mucosal Integrity and Infection Resistance
Forgie, A. J., Fouhse, J. M., & Willing, B. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01802 · Cited by 85 · see citing works
Meugnier, E., Faraj, M., Rome, S., Beauregard, G., Michaut, A., Pelloux, V., Chiasson, J.-L., Laville, M., Clement, K., Vidal, H., et al. (2007) · Diabetes · doi:10.2337/db06-1242 · Cited by 76 · see citing works
Ellis, E. A., Guberski, D. L., Hutson, B., & Grant, M. B. (2002) · Nitric Oxide · doi:10.1006/niox.2001.0419 · Cited by 75 · see citing works
Coumarins from Angelica decursiva inhibit α-glucosidase activity and protein tyrosine phosphatase 1B
Ali, M. Y., Jannat, S., Jung, H. A., Jeong, H. O., Chung, H. Y., & Choi, J. S. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.04.020 · Cited by 72 · see citing works
Chiasson, J., Josse, R. G., Markolf Hanefeld, E., & Laakso, M. (2017) · Cited by 71 · see citing works
ROS, R. D., Assaloni, R., & Ceriello, A. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01312.x · Cited by 70 · see citing works
Self-citationMarfella, R., Amico, M. D., di Filippo, C., Siniscalchi, M., Sasso, F., Ferraraccio, F., Rossi, F., & Paolisso, G. (2007) · Cardiovascular Diabetology · doi:10.1186/1475-2840-6-35 · Cited by 70 · see citing works
Self-citationPostprandial lipid oxidation and cardiovascular disease risk
Bowen, P. E., & Borthakur, G. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0089-3 · Cited by 65 · see citing works
Mechanisms of Vascular Complications in Prediabetes
Milman, S., & Crandall, J. P. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2010.11.004 · Cited by 66 · see citing works
Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability
Swärd, P., & Rippe, B. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02343.x · Cited by 64 · see citing works
Hyperglycaemia and cardiovascular disease
Bartnik, M., Norhammar, A., & Rydén, L. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01831.x · Cited by 63 · see citing works
Effects on cognitive performance of modulating the postprandial blood glucose profile at breakfast
Nilsson, A. C., Radeborg, K., & Björck, I. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.80 · Cited by 61 · see citing works
Delorme, S., & Chiasson, J. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.11.005 · Cited by 61 · see citing works
Jung, H. A., Ali, M. Y., Bhakta, H. K., Min, B.-S., & Choi, J. S. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0852-3 · Cited by 58 · see citing works
Endocrine Changes in Critical Illness
Nylen, E. S., & Müller-Stich, B. P. (2004) · Journal of Intensive Care Medicine · doi:10.1177/0885066603259551 · Cited by 58 · see citing works
Adolphe, J. L., Drew, M. D., Huang, Q., Silver, T. I., & Weber, L. P. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.03.002 · Cited by 55 · see citing works
Endothelial progenitor cells in vascular health: Focus on lifestyle
Craenenbroeck, E. M. V., & Conraads, V. M. (2010) · Microvascular Research · doi:10.1016/j.mvr.2009.12.009 · Cited by 56 · see citing works
Siervo, M., Corander, M., Stranges, S., & Bluck, L. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.003 · Cited by 55 · see citing works
The importance of tight glycemic control
Gerich, J. E. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.07.051 · Cited by 55 · see citing works
Nomiyama, T., Tanaka, Y., Hattori, N., Nishimaki, K., Nagasaka, K., Kawamori, R., & Ohta, S. (2002) · Diabetologia · doi:10.1007/s00125-002-0893-7 · Cited by 55 · see citing works
Yasuda, S., Miyazaki, S., Kanda, M., Goto, Y., Suzuki, M., Harano, Y., & Nonogi, H. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi876 · Cited by 53 · see citing works
Avogaro, A., Bonora, E., Consoli, A., Prato, S. D., Genovese, S., & Giorgino, F. (2019) · Diabetes and Vascular Disease Research · doi:10.1177/1479164119845612 · Cited by 53 · see citing works
Tamita, K., Katayama, M., Takagi, T., Akasaka, T., Yamamuro, A., Kaji, S., Morioka, S., & Kihara, Y. (2007) · Circulation Journal · doi:10.1253/circj.71.834 · Cited by 52 · see citing works
Acute hyperglycaemia induces an inflammatory response in young patients with type 1 diabetes
Gordin, D., Forsblom, C. M., Rönnback, M., Parkkonen, M., Wadén, J., Hietala, K., & Groop, P. (2008) · Annals of Medicine · doi:10.1080/07853890802126547 · Cited by 52 · see citing works
Rebolledo, O. R., & Dato, S. M. A. (2005) · PubMed · Cited by 51 · see citing works
Andreadou, I., Daiber, A., Baxter, G. F., Brizzi, M. F., Lisa, F. D., Kaludercic, N., Lazou, A., Varga, Z. V., Zuurbier, C. J., Schulz, R., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.012 · Cited by 52 · see citing works
Zeymer, U., Schwarzmaier-D'Assie, A., Petzinna, D., & Chiasson, J. L. (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000140712.71649.5a · Cited by 51 · see citing works
Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice
Ghaisas, M. M., Navghare, V. V., Takawale, A. R., Zope, V., Tanwar, M., & Deshpande, A. D. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.01.008 · Cited by 50 · see citing works
Is Hyperglycemia a Causal Factor in Cardiovascular Disease?
Davidson, J. A., & Parkin, C. G. (2009) · Diabetes Care · doi:10.2337/dc09-s333 · Cited by 49 · see citing works
Hypoglycemic pharmacological treatment of type 2 diabetes: Targeting the endothelium
Nathanson, D., & Nyström, T. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.016 · Cited by 48 · see citing works
Bala, C. G., Rusu, A., Ciobanu, D. M., Bucșa, C., & Román, G. (2021) · Antioxidants · doi:10.3390/antiox10040610 · Cited by 47 · see citing works
Fat, diabetes, and liver injury in chronic hepatitis C
Ratziu, V., Trabut, J., & Poynard, T. (2004) · Current Gastroenterology Reports · doi:10.1007/s11894-004-0022-5 · Cited by 47 · see citing works
Choi, S. W., Benzie, I. F. F., Lam, C. S. Y., Chat, S. W., Lam, J. K. Y., Yiu, C. H., Kwan, J. J., Tang, Y. H., Yeung, G. S. P., Yeung, M. W., et al. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01647.x · Cited by 45 · see citing works
Liao, Y., Takashima, S., ZHAO, H., ASANO, Y., Shintani, Y., Minamino, T., KIM, J., Fujita, M., HORI, M., & Kitakaze, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.021 · Cited by 45 · see citing works
Sriharan, M., Reichelt, A. J., Oppermann, M. L. R., Duncan, B. B., Mengue, S. S., Crook, M. A., & Schmidt, M. I. (2002) · Diabetes Care · doi:10.2337/diacare.25.8.1331 · Cited by 43 · see citing works
Sun, Y., Chang, P.-Y., Tsao, K., Wu, T., Sun, C., Wu, L., & Wu, J. T. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.11.014 · Cited by 43 · see citing works
Preeclampsia and Obesity—The Preventive Role of Exercise
Poniedziałek‐Czajkowska, E., Mierzyński, R., & Leszczyńska‐Gorzelak, B. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20021267 · Cited by 69 · see citing works
Takei, Y., Tomiyama, H., Tanaka, N., & Yamashina, A. (2007) · Circulation Journal · doi:10.1253/circj.71.202 · Cited by 42 · see citing works
Baack, M. L., Wang, C., Hu, S., Segar, J. L., & Norris, A. W. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.03.013 · Cited by 41 · see citing works
Postprandial endothelial dysfunction: role of glucose, lipids and insulin
Nitenberg, A., Cosson, E., & Pham, I. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(06)70482-7 · Cited by 40 · see citing works
Postprandial hyperglycaemia and vascular damage - the benefits of acarbose
Båvenholm, P., & Efendić, S. (2006) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2006.017 · Cited by 38 · see citing works
Neuroendocrine System Regulatory Mechanisms: Acute Coronary Syndrome and Stress Hyperglycaemia
de la Hoz, R. A. P., Swieszkowski, S. P., Cintora, F. M., Aladio, M., Papini, C., Matsudo, M., & Scazziota, A. (2018) · European Cardiology Review · doi:10.15420/ecr.2017:19:3 · Cited by 37 · see citing works
Sugiura, M., Nakamura, M., Ikoma, Y., Yano, M., Ogawa, K., Matsumoto, H., Kato, M., Ohshima, M., & Nagao, A. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.05.004 · Cited by 37 · see citing works
Coate, K. C., & Huggins, K. W. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.01.003 · Cited by 36 · see citing works
Chen-Scarabelli, C. A., & Scarabelli, T. M. (2006) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2006.00298.x · Cited by 36 · see citing works
Antidiabetic therapies and male reproductive function: where do we stand?
Tavares, R. S., Escada‐Rebelo, S., Silva, A. F., Sousa, M., Ramalho‐Santos, J., & Amaral, S. (2017) · Reproduction · doi:10.1530/rep-17-0390 · Cited by 35 · see citing works
- Authors
- Marfella, R., Quagliaro, L., Nappo, F., Ceriello, A., & Giugliano, D.
- Corresponding author
- Giugliano, Dario
- Venue
- Journal of Clinical Investigation
- Published
- 2001-08-15
- Volume
- 108
- Issue
- 4
- Pages
- 635-636
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC209408
- OpenAlex
- W2052924362
- Cited by
- 242
- References
- 14
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 8 · 2012: 12
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Clinical Investigation (publishedVersion, cc-by)
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- acute hyperglycemia, oxidative stress, nitrotyrosine, glucose clamp, reactive oxygen species, endothelial dysfunction, blood pressure, healthy volunteers, cardiovascular risk, diabetes complications, vascular function, nitrosative stress, nitric oxide, nitric oxide synthase, nitric oxide radical
- MeSH terms
- Adult, Diabetic Angiopathies, Female, Hemodynamics, Humans, Hydrogen-Ion Concentration, Hyperglycemia, Male, Nitrates, Tyrosine, Vasoconstriction, Glucose Clamp Technique, Biomarkers, Confounding Factors, Epidemiologic, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
