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Molecular interactions between apoE and ABCA1

Krimbou, Larbi, Denis, Maxime, Haidar, Bassam, Carrier, Marilyn, Marcil, Michel, Genest, Jacques·2004·Journal of Lipid Research

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Crossref · 10.1194/jlr.m300418-jlr200

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  • Extracellular ApoE, like ApoA1, can induce assembly of cholesterol-laden HDL-like particles via an ABCA1-dependent pathway, and this process is largely unaffected by ApoE polymorphism.

    “Overall, these data support the idea that extracellular ApoE, like ApoA1, can induce the assembly of cholesterol-laden HDL-like particles via an ABCA1-dependent pathway (Krimbou et al., 2004;Wahrle et al., 2004; Figure 2D) and that this process seems largely unaffected by ApoE polymorphism.”

    From Isoform- and cell-state-specific lipidation of ApoE in astrocytes (2022) · cites this paper as Krimbou et al., 2004

  • There were no significant differences in cholesterol efflux between the two isoforms of ApoE (ApoE2 and ApoE4) in BLECs.

    “Interestingly, and as previously reported for brain pericytes [42], neurons [59], fibroblasts [60], and plexus choroid cells [61], there were no significant differences in efflux between the two isoforms of ApoE.”

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Metadata

Authors
Krimbou, L., Denis, M., Haidar, B., Carrier, M., Marcil, M., & Genest, J.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2004-05
Volume
45
Issue
5
Pages
839-848
ISSN
0022-2275
Cited by
116
References
3
Language
en

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