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Molecular interactions between apoE and ABCA1
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Extracellular ApoE, like ApoA1, can induce assembly of cholesterol-laden HDL-like particles via an ABCA1-dependent pathway, and this process is largely unaffected by ApoE polymorphism.
“Overall, these data support the idea that extracellular ApoE, like ApoA1, can induce the assembly of cholesterol-laden HDL-like particles via an ABCA1-dependent pathway (Krimbou et al., 2004;Wahrle et al., 2004; Figure 2D) and that this process seems largely unaffected by ApoE polymorphism.”
From Isoform- and cell-state-specific lipidation of ApoE in astrocytes (2022) · cites this paper as Krimbou et al., 2004
There were no significant differences in cholesterol efflux between the two isoforms of ApoE (ApoE2 and ApoE4) in BLECs.
“Interestingly, and as previously reported for brain pericytes [42], neurons [59], fibroblasts [60], and plexus choroid cells [61], there were no significant differences in efflux between the two isoforms of ApoE.”
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Apolipoprotein E polymorphism and atherosclerosis.
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“ability of apoE to promote cholesterol efflux from cultured cells (14, 15, 36).”
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Metadata
- Authors
- Krimbou, L., Denis, M., Haidar, B., Carrier, M., Marcil, M., & Genest, J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 45
- Issue
- 5
- Pages
- 839-848
- ISSN
- 0022-2275
- Cited by
- 116
- References
- 3
- Language
- en
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