Bile salt biotransformations by human intestinal bacteria

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913

Prokaryotes: The unseen majority

Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 1×

MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT

Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436

The interaction between bacteria and bile

Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776

Comparative Genomics of Listeria Species

Glaser, P., Frangeul, L., Buchrieser, C., Rusniok, C., Amend, A., Baquero, F., Berche, P., Blöcker, H., Brandt, P., Chakraborty, T., et al. (2001) · Science · doi:10.1126/science.1063447 · Cited by 1,505

Vitamin D Receptor As an Intestinal Bile Acid Sensor

Makishima, M., Lu, T. T., Xie, W., Whitfield, G. K., Domoto, H., Evans, R. M., Haussler, M. R., & Mangelsdorf, D. J. (2002) · Science · doi:10.1126/science.1070477 · Cited by 1,176

The Continuing Importance of Bile Acids in Liver and Intestinal Disease

Hofmann, A. F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.22.2647 · Cited by 972

QUANTIFICATION OF CEREBRAL OXYGENATION AND HAEMODYNAMICS IN SICK NEWBORN INFANTS BY NEAR INFRARED SPECTROPHOTOMETRY

Wyatt, J. S., Delpy, D. T., Cope, M., Wray, S., & Reynolds, E. O. R. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90467-8 · Cited by 875

Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2

Narisawa, T., Magadia, N. E., Weisburger, J. H., & Wynder, E. L. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.4.1093 · Cited by 704

Hepatology. A Textbook of Liver Disease

(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-259_2 · Cited by 624

Anatomy and Physiology of the Small Intestine

Campbell, J., Berry, J., & Liang, Y. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-40232-3.00071-6 · Cited by 64

Gut Microbiota Dysbiosis Is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis

Wang, Y., Gao, X., Zhang, X., Xiao, Y., Huang, J., Yu, D., Li, X., Hu, H., Ge, T., Li, D., et al. (2019) · mSystems · doi:10.1128/msystems.00463-19 · Cited by 64

Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites

Martínez-Gili, L., McDonald, J. A. K., Liu, Z., Kao, D. H., Allegretti, J. R., Monaghan, T. M., Barker, G. F., Blanco, J. M., Williams, H. R. T., Holmes, E. C., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1810531 · Cited by 65

Gut Dysbiosis and Its Associations with Gut Microbiota-Derived Metabolites in Dogs with Myxomatous Mitral Valve Disease

Li, Q., Larouche‐Lebel, É., Loughran, K. A., Huh, T. P., Suchodolski, J. S., & Oyama, M. A. (2021) · mSystems · doi:10.1128/msystems.00111-21 · Cited by 64

Characterisation and response of intestinal microflora and mucins to manno-oligosaccharide and antibiotic supplementation in broiler chickens

Chee, S. H., Iji, P. A., Choct, M., Mikkelsen, L. L., & Kocher, A. (2010) · British Poultry Science · doi:10.1080/00071668.2010.503477 · Cited by 64

Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect

Haring, E., Uhl, F. M., Andrieux, G., Proietti, M., Bulashevska, A., Sauer, B., Braun, L. M., Gomez, E. D. V., Esser, P. R., Martin, S. F., et al. (2020) · Haematologica · doi:10.3324/haematol.2019.242990 · Cited by 63

The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders

Marzal, L. N. P., Prince, N., Bajić, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810052 · Cited by 67

Capturing the environment of the Clostridioides difficile infection cycle

Schnizlein, M. K., & Young, V. B. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00610-0 · Cited by 63

The Effect of Lithocholic Acid on the Gut-Liver Axis

Sheng, W., Ji, G., & Zhang, L. R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.910493 · Cited by 65

Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis

Qian, W., Li, M., Yu, L., Tian, F., Zhao, J., & Zhai, Q. (2023) · Biomedicines · doi:10.3390/biomedicines11041048 · Cited by 63

Taxonomic identification of bile salt hydrolase‐encoding lactobacilli: Modulation of the enterohepatic bile acid profile

Song, Z., Feng, S., Zhou, X., Song, Z.-X., Li, J., & Li, P. (2023) · iMeta · doi:10.1002/imt2.128 · Cited by 63

Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review

Meade, S., Kiow, J. L. C., Massaro, C. A., Kaur, G., Squirell, E., Bressler, B. L., & Lunken, G. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2287073 · Cited by 63

Bile salt deconjugation and cholesterol removal from media by Lactobacillus strains used as probiotics in chickens

Ramasamy, K., Abdullah, N., Wong, M. C., Chinna, K., & Ho, Y. W. (2009) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3780 · Cited by 63

Comparative genomics reveals evidence of marine adaptation in Salinispora species

Penn, K., & Jensen, P. R. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-86 · Cited by 63

Glucocorticoids and gut bacteria: “The GALF Hypothesis” in the metagenomic era

Morris, D. J., & Ridlon, J. M. (2017) · Steroids · doi:10.1016/j.steroids.2017.06.002 · Cited by 63

Clostridium scindens ATCC 35704: Integration of Nutritional Requirements, the Complete Genome Sequence, and Global Transcriptional Responses to Bile Acids

Devendran, S., Shrestha, R., Alves, J. M. P., Wolf, P. G., Ly, L. K., Hernández, Á. G., Méndez–García, C., Inboden, A. M., Wiley, J., Paul, O., et al. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.00052-19 · Cited by 63

Host-microbial interactions in the metabolism of different dietary fats

Chadaideh, K. S., & Carmody, R. N. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.011 · Cited by 63

The Role of Microbiota in Primary Sclerosing Cholangitis and Related Biliary Malignancies

Özdirik, B., Müller, T., Wree, A., Tacke, F., & Sigal, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136975 · Cited by 62

The water extract of Radix scutellariae, its total flavonoids and baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid metabolism in T2DM mice

Yan, X., Zhang, Y., Peng, Y., & Li, X. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115238 · Cited by 62

Gut Microbial Metabolites on Host Immune Responses in Health and Disease

Yoon, J.-H., Do, J.-S., Velankanni, P., Lee, C., & Kwon, H. (2023) · Immune Network · doi:10.4110/in.2023.23.e6 · Cited by 64

High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection

Nagai, M., Moriyama, M., Ishii, C., Mori, H., Watanabe, H., Nakahara, T., Yamada, T., Ishikawa, D., Ishikawa, T., Hirayama, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39569-0 · Cited by 63

Host-microbiota interaction in intestinal stem cell homeostasis

Wu, H., Mu, C., Xu, L., Yu, K., Shen, L., & Zhu, W. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2353399 · Cited by 62

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

Risstad, H., Kristinsson, J. A., Fagerland, M. W., le Roux, C. W., Birkeland, K. I., Gulseth, H. L., Thorsby, P. M., Vincent, R. P., Engström, M., Olbers, T., et al. (2017) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2017.05.024 · Cited by 62

Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice

Wang, G., Liu, Q., Guo, L., Zeng, H., Ding, C., Zhang, W., Xu, D., Wang, X., Qiu, J., Dong, Q., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01874 · Cited by 62

Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism

Zhang, Y., Bobe, G., Revel, J. S., Rodrigues, R. R., Sharpton, T. J., Fantacone, M. L., Raslan, K., Miranda, C. L., Lowry, M. B., Blakemore, P. R., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900789 · Cited by 62

Dysbiosis modulates capacity for bile acid modification in the gut microbiomes of patients with inflammatory bowel disease: a mechanism and marker of disease?: Figure 1

Ogilvie, L. A., & Jones, B. V. (2012) · Gut · doi:10.1136/gutjnl-2012-302137 · Cited by 61

Role of bile acids in liver diseases mediated by the gut microbiome

Shao, J., Ge, T., Chen, S., Wang, G., Yang, Q., Huang, C., Xu, L., & Chen, Z. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i22.3010 · Cited by 61

Substituting meat for mycoprotein reduces genotoxicity and increases the abundance of beneficial microbes in the gut: Mycomeat, a randomised crossover control trial

Farsi, D. N., Lara, J., Koutsidis, G., Nelson, A., Finnigan, T. J. A., Cheung, W., Muñoz-Muñoz, J., & Commane, D. M. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03088-x · Cited by 62

Host-Gut Microbiota Metabolic Interactions and Their Role in Precision Diagnosis and Treatment of Gastrointestinal Cancers

Cao, C., Yue, S., Lü, A., & Liang, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107321 · Cited by 64

Effects of Konjac Glucomannan on Putative Risk Factors for Colon Carcinogenesis in Rats Fed a High-Fat Diet

Wu, W., & Chen, H. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103532x · Cited by 61

Effect of probiotic yoghurt on animal-based diet-induced change in gut microbiota: an open, randomised, parallel-group study

Odamaki, T., Kato, K., Sugahara, H., Xiao, J., Abe, F., & Benno, Y. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0173 · Cited by 61

Bacterial bile salt hydrolase: an intestinal microbiome target for enhanced animal health

Geng, W., & Lin, J. (2016) · Animal Health Research Reviews · doi:10.1017/s1466252316000153 · Cited by 61

Bile acids and their effects on diabetes

Rajani, C., & Jia, W. P. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0644-x · Cited by 61

Alterations in Bile Acid Metabolism Associated With Inflammatory Bowel Disease

Li, N., Zhan, S., Tian, Z., Liu, C., Xie, Z., Zhang, S., Chen, M., Zeng, Z., & Zhuang, X. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa342 · Cited by 60

Probiotics, Pre-biotics and Synbiotics in the Treatment of Pre-diabetes: A Systematic Review of Randomized Controlled Trials

Wang, X., Yang, J., Qiu, X., Wen, Q., Liu, M., Zhou, D., & Chen, Q. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.645035 · Cited by 60

Factors Affecting Gut Microbiome in Daily Diet

Su, Q., & Liu, Q. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.644138 · Cited by 60

The contribution of bile acid metabolism to the pathogenesis of Clostridioides difficile infection

Mullish, B. H., & Allegretti, J. R. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211017725 · Cited by 61

Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms

Chi, L., Tu, P., Ru, H., & Lü, K. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1921912 · Cited by 60

The intestinal and biliary microbiome in autoimmune liver disease—current evidence and concepts

Liwinski, T., Heinemann, M., & Schramm, C. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00936-6 · Cited by 60

Fermented Rosa Roxburghii Tratt Juice Alleviates High-Fat Diet-Induced Hyperlipidemia in Rats by Modulating Gut Microbiota and Metabolites

Ji, J., Zhang, S., Yuan, M., Zhang, M., Tang, L., Wang, P., Liu, Y., Xu, C., Luo, P., & Gao, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.883629 · Cited by 60

Microbial Metabolite Dysbiosis and Colorectal Cancer

Niekamp, P., & Kim, C. H. (2023) · Gut and Liver · doi:10.5009/gnl220260 · Cited by 60

A Gut Odyssey: The Impact of the Microbiota on Clostridium difficile Spore Formation and Germination

Shen, A. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005157 · Cited by 60

Determinants of postprandial plasma bile acid kinetics in human volunteers

Fiamoncini, J., Yiorkas, A. M., Gedrich, K., Rundle, M., Alsters, S., Roeselers, G., van den Broek, T. J., Clavel, T., Lagkouvardos, I., Wopereis, S., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00157.2017 · Cited by 60

Targeting the gut microbiota by dietary nutrients: A new avenue for human health

Li, D., Wang, P., Wang, P., Hu, X., & Chen, F. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1363708 · Cited by 60

Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor β-Deficient Colon Cancer

Daniel, S. G., Ball, C. L., Besselsen, D. G., Doetschman, T. C., & Hurwitz, B. L. (2017) · mSystems · doi:10.1128/msystems.00065-17 · Cited by 60

Hierarchical recognition of amino acid co-germinants during Clostridioides difficile spore germination

Shrestha, R., & Sorg, J. A. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.12.001 · Cited by 60

Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass

Laferrère, B., & Pattou, F. N. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00530 · Cited by 60

Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of FGF21 and bile acids

Zhang, H., Zhang, W., Yun, D., Li, L., Zhao, W., Li, Y., Liu, X., & Liu, Z. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108403 · Cited by 60

A single‐component multidrug transporter of the major facilitator superfamily is part of a network that protects E scherichia coli from bile salt stress

Paul, S., Alegre, K. O., Holdsworth, S. R., Rice, M., Brown, J. A., McVeigh, P., Kelly, S. M., & Law, C. J. (2014) · Molecular Microbiology · doi:10.1111/mmi.12597 · Cited by 59

Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice

Fu, Z. D., & Klaassen, C. D. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.020 · Cited by 59

Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration

Zeng, H., Li, D., Qin, X., Chen, P., Tan, H., Zeng, X., Li, X., Fan, X., Jiang, Y., Zhou, Y., et al. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.066969 · Cited by 59

The gut microbiota: a key regulator of metabolic diseases

Yang, J., & Kweon, M. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.10.144 · Cited by 59

Colonic Transit and Bile Acid Synthesis or Excretion in Patients With Irritable Bowel Syndrome–Diarrhea Without Bile Acid Malabsorption

Peleman, C., Camilleri, M., Busciglio, I. A., Burton, D. D., Donato, L. J., & Zinsmeister, A. R. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.11.012 · Cited by 59

Mechanisms of cross-talk between the diet, the intestinal microbiome, and the undernourished host

Velly, H., Britton, R. A., & Preidis, G. A. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1267888 · Cited by 59

Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway

Monaghan, T. M., Mullish, B. H., Patterson, J., Wong, G. K., Marchesi, J. R., Xu, H., Jilani, T. A., & Kao, D. H. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1506667 · Cited by 59

Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2–Mediated Water Homeostasis

Li, S., Qiu, M., Kong, Y., Zhao, X., Choi, H.-J., Reich, M., Bunkelman, B. H., Liu, Q., Hu, S., Han, M., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018030271 · Cited by 59

Gut microbiome and its meta-omics perspectives: profound implications for cardiovascular diseases

Xu, J., & Yang, Y. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1936379 · Cited by 61

Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats

Behr, C., Slopianka, M., Haake, V., Strauss, V., Sperber, S., Kamp, H., Walk, T., Beekmann, K., Rietjens, I. M. C. M., & van Ravenzwaay, B. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.11.012 · Cited by 58

Metabolic fate of tea polyphenols and their crosstalk with gut microbiota

Wang, M., Li, J., Hu, T., & Zhao, H. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.12.003 · Cited by 55

State of the art in research on the gut-liver and gut-brain axis in poultry

Bełdowska, A., Barszcz, M., & Dunisławska, A. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00853-0 · Cited by 58

Emerging Roles of Gut Microbial Modulation of Bile Acid Composition in the Etiology of Cardiovascular Diseases

Yntema, T., Koonen, D. P. Y., & Kuipers, F. (2023) · Nutrients · doi:10.3390/nu15081850 · Cited by 58

Role of Microbiota and Innate Immunity in RecurrentClostridium difficileInfection

Bibbò, S., Lopetuso, L. R., Ianiro, G., Rienzo, T. D., Gasbarrini, A., & Cammarota, G. (2014) · Journal of Immunology Research · doi:10.1155/2014/462740 · Cited by 59

Reexamining the Germination Phenotypes of Several Clostridium difficile Strains Suggests Another Role for the CspC Germinant Receptor

Bhattacharjee, D., Francis, M. B., Ding, X., McAllister, K. N., Shrestha, R., & Sorg, J. A. (2015) · Journal of Bacteriology · doi:10.1128/jb.00908-15 · Cited by 58

Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells

Centuori, S. M., Gomes, C. J., Trujillo, J., Borg, J. L., Brownlee, J., Putnam, C. W., & Martinez, J. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.006 · Cited by 58

β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

Somm, E., Henry, H., Bruce, S. J., Aeby, S., Rosikiewicz, M., Sykiotis, G. P., Asrih, M., Jornayvaz, F. R., Denechaud, P., Albrecht, U., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.91809 · Cited by 58

Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis

Cheng, S. L., Li, X., Lehmler, H., Phillips, B., Shen, D. D., & Cui, J. Y. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy208 · Cited by 58

Establishment of Listeria monocytogenes in the Gastrointestinal Tract

Davis, M. L., Ricke, S. C., & Donaldson, J. R. (2019) · Microorganisms · doi:10.3390/microorganisms7030075 · Cited by 58

A Reasonable Diet Promotes Balance of Intestinal Microbiota: Prevention of Precolorectal Cancer

Huang, P., & Liu, Y. (2019) · BioMed Research International · doi:10.1155/2019/3405278 · Cited by 58

Fucose Ameliorate Intestinal Inflammation Through Modulating the Crosstalk Between Bile Acids and Gut Microbiota in a Chronic Colitis Murine Model

Ke, J., Li, Y., Han, C., He, R., Lin, R., Qian, W., & Hou, X. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa007 · Cited by 58

The Interface of Vibrio cholerae and the Gut Microbiome

Cho, J. Y., Liu, R., Macbeth, J. C., & Hsiao, A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1937015 · Cited by 58

Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: mechanistic insights and therapeutic strategies

Tong, Y., & Lou, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1638352 · Cited by 64

Ecology and Physiology of the Intestinal Tract

Blaut, M. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_192 · Cited by 57

Biochemical and Genetic Investigation of Initial Reactions in Aerobic Degradation of the Bile Acid Cholate in Pseudomonas sp. Strain Chol1

Birkenmaier, A., Holert, J., Erdbrink, H., Moeller, H. M., Friemel, A., Schönenberger, R., Suter, M. J. ‐., Klebensberger, J., & Philipp, B. (2007) · Journal of Bacteriology · doi:10.1128/jb.00665-07 · Cited by 57

Effect of prebiotics on bacteriocin production and cholesterol lowering activity of Pediococcus acidilactici LAB 5

Mandal, V., Sen, S. K., & Mandal, N. C. (2009) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-009-0085-4 · Cited by 57

Characterization of AQPs in Mouse, Rat, and Human Colon and Their Selective Regulation by Bile Acids

Yde, J., Keely, S. J., Wu, Q., Borg, J. F., Lajczak, N., O’Dwyer, A. M., Dalsgaard, P., Fenton, R. A., & Moeller, H. B. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00046 · Cited by 57

Disruption of the Prostaglandin Metabolome and Characterization of the Pharmaceutical Exposome in Fish Exposed to Wastewater Treatment Works Effluent As Revealed by Nanoflow-Nanospray Mass Spectrometry-Based Metabolomics

David, A., Lange, A., Abdul‐Sada, A. K., Tyler, C. R., & Hill, E. M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b04365 · Cited by 57

Irritable bowel syndrome and diet

Portincasa, P., Bonfrate, L., de Bari, O., Lembo, A. J., & Ballou, S. (2017) · Gastroenterology report · doi:10.1093/gastro/gow047 · Cited by 57

Regulation of Gastrointestinal Immunity by Metabolites

Gu, B., Kim, M., & Yun, C. (2021) · Nutrients · doi:10.3390/nu13010167 · Cited by 57

Cross-talk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implications

Kundu, S., Kumar, S., & Bajaj, A. (2015) · IUBMB Life · doi:10.1002/iub.1399 · Cited by 56

A Gut-Restricted Lithocholic Acid Analog as an Inhibitor of Gut Bacterial Bile Salt Hydrolases

Adhikari, A. A., Ramachandran, D., Chaudhari, S. N., Powell, C. E., Li, W., McCurry, M. D., Banks, A. S., & Devlin, A. S. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00192 · Cited by 56

Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota

García, C. J., Kosek, V., Beltrán, D., Tomás-Barberán, F. A., & Hajšlová, J. (2022) · Biomolecules · doi:10.3390/biom12050687 · Cited by 56

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Heo, J.-Y., Seo, M., Park, H., Lee, W. K., Guan, L. L., Yoon, J. H., Caetano-Anollés, K., Ahn, H., Kim, S., Kang, Y.-M., et al. (2016) · Scientific Reports · doi:10.1038/srep33566 · Cited by 56

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Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

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Modulation of Bile Acid Metabolism by 1α-Hydroxyvitamin D3 Administration in Mice

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Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1

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