The DOI matches its Crossref record; 178 of the 181 references it cites were found in a registry or an index.
Bile salt biotransformations by human intestinal bacteria
Open accessAbstract
Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels in the enterohepatic circulation of some individuals and may contribute to the pathogenesis of colon cancer, gallstones, and other gastrointestinal (GI) diseases. Bile salt hydrolysis and hydroxy group dehydrogenation reactions are carried out by a broad spectrum of intestinal anaerobic bacteria, whereas bile acid 7-dehydroxylation appears restricted to a limited number of intestinal anaerobes representing a small fraction of the total colonic flora. Microbial enzymes modifying bile salts differ between species with respect to pH optima, enzyme kinetics, substrate specificity, cellular location, and possibly physiological function. Crystallization, site-directed mutagenesis, and comparisons of protein secondary structure have provided insight into the mechanisms of several bile acid-biotransforming enzymatic reactions. Molecular cloning of genes encoding bile salt-modifying enzymes has facilitated the understanding of the genetic organization of these pathways and is a means of developing probes for the detection of bile salt-modifying bacteria. The potential exists for altering the bile acid pool by targeting key enzymes in the 7alpha/beta-dehydroxylation pathway through the development of pharmaceuticals or sequestering bile acids biologically in probiotic bacteria, which may result in their effective removal from the host after excretion.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Primary conjugated BAs synthesized in the liver, such as the tauro- and glycoconjugates of cholic acid (TCA, GCA), are deconjugated by BSHs to generate cholic acid (CA)”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [11]
In the citing paper
“This vanguard reaction acts as a ‘gatekeeper’ for subsequent BA transformations that turn primary BAs into secondary BAs”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [11]
In the citing paper
“There is an intensive bidirectional interaction between BAs and intestinal microbiota.51”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [51]
In the citing paper
“Primary bile acids are converted to secondary bile acids by the local microbiota, partly in the small intestine and predominantly in the colon. This involves multiple steps and typically begins with the initial deconjugation of glycine or taurine, followed by dehydroxylation (Ridlon et al., 2006).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Ridlon et al., 2006
In the citing paper
“Bile acid activity of commensal bacteria is involved in a complex interplay with host hepatic enzymes, and together they promote digestion and absorption of dietary lipids.42”
From The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids (2015) · cites this paper as [42]
Citations
Cites
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 1×
“Bacterial density in the human colon is among the highest found in nature, approaching 10(12) bacteria/ gram wet weight feces (2, 3).”
BackgroundMICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776
Comparative Genomics of Listeria Species
Glaser, P., Frangeul, L., Buchrieser, C., Rusniok, C., Amend, A., Baquero, F., Berche, P., Blöcker, H., Brandt, P., Chakraborty, T., et al. (2001) · Science · doi:10.1126/science.1063447 · Cited by 1,505
Vitamin D Receptor As an Intestinal Bile Acid Sensor
Makishima, M., Lu, T. T., Xie, W., Whitfield, G. K., Domoto, H., Evans, R. M., Haussler, M. R., & Mangelsdorf, D. J. (2002) · Science · doi:10.1126/science.1070477 · Cited by 1,176
The Continuing Importance of Bile Acids in Liver and Intestinal Disease
Hofmann, A. F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.22.2647 · Cited by 972
Wyatt, J. S., Delpy, D. T., Cope, M., Wray, S., & Reynolds, E. O. R. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90467-8 · Cited by 875
Narisawa, T., Magadia, N. E., Weisburger, J. H., & Wynder, E. L. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.4.1093 · Cited by 704
Hepatology. A Textbook of Liver Disease
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-259_2 · Cited by 624
Cited by
Sorted by citations
Items 301–400 of 1,014
Association between the gut microbiota and diet: Fetal life, early childhood, and further life
Kashtanova, D. A., Popenko, A., Ткачева, О. Н., Tyakht, A., Alexeev, D. G., & Boytsov, S. A. (2016) · Nutrition · doi:10.1016/j.nut.2015.12.037 · Cited by 176
Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis
Bajaj, J. S., & Khoruts, A. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.01.017 · Cited by 172
Ma, J., Hong, Y., Zheng, N., Xie, G., Lyu, Y., Gu, Y., Xi, C., Chen, L., Wu, G., Li, Y., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1763770 · Cited by 171
Probiotic Bile Salt Hydrolase: Current Developments and Perspectives
Patel, A. K., Singhania, R. R., Pandey, A., & Chincholkar, S. B. (2009) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-009-8738-1 · Cited by 171
Lee, J., Arai, H., Nakamura, Y., Fukiya, S., Wada, M., & Yokota, A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m039834 · Cited by 171
Antibiotic effects on gut microbiota and metabolism are host dependent
Fujisaka, S., Ussar, S., Clish, C. B., Devkota, S., Dreyfuss, J. M., Sakaguchi, M., Soto, M., Konishi, M., Softic, S., Altındiş, E., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86674 · Cited by 171
Zhang, J., Ni, Y., Qian, L., Fang, Q., Zheng, T., Zhang, M., Gao, Q., Zhang, Y., Ni, J., Hou, X., et al. (2021) · Advanced Science · doi:10.1002/advs.202100536 · Cited by 171
Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity
Su, L., Gao, Y., & Yang, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127743 · Cited by 174
Visekruna, A., & Luu, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.703218 · Cited by 170
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis
Freedman, S. N., Shahi, S. K., & Mangalam, A. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0588-x · Cited by 168
Lucas, L. N., Barrett, K., Kerby, R. L., Zhang, Q., Cattaneo, L. E., Stevenson, D., Rey, F. E., & Amador-Noguez, D. (2021) · mSystems · doi:10.1128/msystems.00805-21 · Cited by 168
Zhu, D., Sorg, J. A., & Sun, X. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00029 · Cited by 168
Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles
Erawijantari, P. P., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Saito, Y., Fukuda, S., Yachida, S., & Yamada, T. (2020) · Gut · doi:10.1136/gutjnl-2019-319188 · Cited by 168
Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease
Sultan, S., El‐Mowafy, M., Elgaml, A., Ahmed, T. A., Hassan, H., & Mottawea, W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715506 · Cited by 170
Dual role of microbiota-derived short-chain fatty acids on host and pathogen
Mirzaei, R., Dehkhodaie, E., Bouzari, B., Rahimi, M., Gholestani, A., Hosseini‐Fard, S. R., Keyvani, H., Teimoori, A., & Karampoor, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112352 · Cited by 167
The Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease
Thomas, J. P., Módos, D., Rushbrook, S., Powell, N., & Korcsmáros, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.829525 · Cited by 169
Intestinal bile acid physiology and pathophysiology
Martínez‐Augustin, O., & de Medina, F. S. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5630 · Cited by 167
Payne, C. M., Weber, C., Crowley-Skillicorn, C., Dvorak, K., Bernstein, H., Bernstein, C., Holubec, H., Dvorakova, B., & Garewal, H. (2007) · Carcinogenesis · doi:10.1093/carcin/bgl139 · Cited by 166
Chen, W., Wei, Y., Xiong, A., Li, Y., Guan, H., Wang, Q., Miao, Q., Bian, Z., Xiao, X., Lian, M., et al. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08731-2 · Cited by 166
Shen, W., Gaskins, H. R., & McIntosh, M. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.009 · Cited by 166
Ciaula, A. D., Baj, J., Garruti, G., Celano, G., Angelis, M. D., Wang, H. H., Palo, D. M. D., Bonfrate, L., Wang, D. Q. ‐., & Portincasa, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082648 · Cited by 166
Chen, X., Zhuang, J., Chen, Q., Xu, L., Yue, X., & Qiao, D. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113809 · Cited by 166
Beneficial Bile Acid Metabolism from Lactobacillus plantarum of Food Origin
Prete, R., Long, S. L., Gallardo, A. L., Gahan, C. G., Corsetti, A., & Joyce, S. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-58069-5 · Cited by 165
Altered Microbiome in Patients With Cirrhosis and Complications
Acharya, C., & Bajaj, J. S. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.008 · Cited by 164
Pursuing Human-Relevant Gut Microbiota-Immune Interactions
Spencer, S. P., Fragiadakis, G. K., & Sonnenburg, J. L. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.002 · Cited by 167
The Role of Gut Barrier Dysfunction and Microbiome Dysbiosis in Colorectal Cancer Development
Genua, F., Raghunathan, V., Jenab, M., Gallagher, W. M., & Hughes, D. J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626349 · Cited by 164
Palau‐Rodriguez, M., Tulipani, S., Queipo‐Ortuño, M. I., Urpí-Sardà, M., Tinahones, F. J., & Andrés‐Lacueva, C. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01151 · Cited by 163
Linking dietary patterns with gut microbial composition and function
Sheflin, A. M., Melby, C. L., Carbonero, F., & Weir, T. L. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1270809 · Cited by 162
Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice
Zhang, Y., Limaye, P. B., Renaud, H. J., & Klaassen, C. D. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.03.009 · Cited by 162
Gastrointestinal cancers: Influence of gut microbiota, probiotics and prebiotics
Serban, D. E. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.013 · Cited by 162
Mathur, R., & Barlow, G. M. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1051029 · Cited by 162
Leu, R. K. L., Winter, J. M., Christophersen, C. T., Young, G. P., Humphreys, K. J., Hu, Y. C., Gratz, S. W., Miller, R. B., Topping, D. L., Bird, A. R., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515001750 · Cited by 161
Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling
Yang, Y., Hao, C., Jiao, T., Yang, Z., Li, H., Zhang, Y., Zhang, W., Doherty, M., Sun, C., Yang, T., et al. (2025) · Science · doi:10.1126/science.adt0548 · Cited by 160
Wei, X., Yan, X., Zou, D., Yang, Z., Wang, X., Liu, W., Wang, S., Li, X., Han, J., Huang, L., et al. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-175 · Cited by 160
Metabolite Profiles During Oral Glucose Challenge
Ho, J. E., Larson, M. G., Vasan, R. S., Ghorbani, A., Cheng, S. C., Rhee, E. P., Florez, J. C., Clish, C. B., Gerszten, R. E., & Wang, T. J. (2013) · Diabetes · doi:10.2337/db12-0754 · Cited by 160
Weingarden, A. R., Dosa, P. I., DeWinter, E., Steer, C. J., Shaughnessy, M. K., Johnson, J. R., Khoruts, A., & Sadowsky, M. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147210 · Cited by 160
Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?
Fukui, H. (2019) · Diseases · doi:10.3390/diseases7040058 · Cited by 159
Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia
Haeusler, R. A., Pratt–Hyatt, M., Welch, C. L., Klaassen, C. D., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.010 · Cited by 157
Kanbay, M., Onal, E. M., Afşar, B., Dağel, T., Yerlikaya, A., Covic, A. C., & Vaziri, N. D. (2018) · International Urology and Nephrology · doi:10.1007/s11255-018-1873-2 · Cited by 157
Liu, H., Shiver, A. L., Price, M. N., Carlson, H. K., Trotter, V. V., Chen, Y., Escalante, V., Ray, J., Hern, K. E., Petzold, C. J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108789 · Cited by 157
Xiao, L., Sonne, S. B., Feng, Q., Chen, N., Xia, Z., Li, X., Fang, Z., Zhang, D., Fjære, E., Midtbø, L. K., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0258-6 · Cited by 156
Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo
Cremers, C. M., Knoefler, D., Vitvitsky, V., Banerjee, R. V., & Jakob, U. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401941111 · Cited by 155
Winston, J. A., & Theriot, C. M. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.05.003 · Cited by 155
Li, X., Su, C., Jiang, Z., Yang, Y., Zhang, Y., Yang, M., Zhang, X., Du, Y., Zhang, J., Wang, L., et al. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00205-8 · Cited by 155
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
Gut microbiome and bile acids in obesity-related diseases
Li, R., Andreu‐Sánchez, S., Kuipers, F., & Fu, J. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101493 · Cited by 154
Sipos, A., Ujlaki, G., Mikó, E., Maka, E., Szabó, J., Uray, K., Krasznai, Z. T., & Bai, P. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00295-2 · Cited by 153
Potential Benefits of Probiotics and Prebiotics for Coronary Heart Disease and Stroke
Wu, H., & Chiou, J. A. (2021) · Nutrients · doi:10.3390/nu13082878 · Cited by 153
Gut microbiota and host metabolism in liver cirrhosis
Usami, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11597 · Cited by 152
Govindarajan, K., MacSharry, J. A., Casey, P. G., Shanahan, F., Joyce, S. A., & Gahan, C. G. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167319 · Cited by 152
Romano, N., Kumar, V., Yang, G., Kajbaf, K., Rubio, M. B., Overturf, K., Brezas, A., & Hardy, R. W. (2020) · Reviews in Aquaculture · doi:10.1111/raq.12410 · Cited by 152
Ridlon, J. M., & Hylemon, P. B. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m020313 · Cited by 151
Self-citationEffects of Low-Dose Non-Caloric Sweetener Consumption on Gut Microbiota in Mice
Uebanso, T., Ohnishi, A., Kitayama, R., Yoshimoto, A., Nakahashi, M., Shimohata, T., Mawatari, K., & Takahashi, A. (2017) · Nutrients · doi:10.3390/nu9060560 · Cited by 151
Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
Bourgin, M., Kriaa, A., Mkaouar, H., Mariaule, V., Jablaoui, A., Maguin, E., & Rhimi, M. (2021) · Microorganisms · doi:10.3390/microorganisms9061122 · Cited by 152
The human microbiome and bile acid metabolism: Dysbiosis, dysmetabolism, disease and intervention
Jones, M. L., Martoni, C. J., Ganopolsky, J. G., Labbé, A., & Prakash, S. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.880420 · Cited by 150
The features of mucosa‐associated microbiota in primary sclerosing cholangitis
Torres, J., Bao, X., Goel, A., Colombel, J. ‐., Pekow, J., Jabri, B., Williams, K. M., Castillo, A., Odin, J. A., Meckel, K., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13552 · Cited by 149
Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut
Vital, M., Rud, T., Rath, S., Pieper, D. H., & Schlüter, D. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.07.012 · Cited by 152
Bile acids and bariatric surgery
Albaugh, V. L., Banan, B., Ajouz, H., Abumrad, N. N., & Flynn, C. R. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.04.001 · Cited by 148
Labbé, A., Ganopolsky, J. G., Martoni, C., Prakash, S., & Jones, M. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115175 · Cited by 149
Ou, J., DeLany, J. P., Zhang, M., Sharma, S. K., & O’Keefe, S. J. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2012.630164 · Cited by 148
Bajaj, J. S., Kakiyama, G., Savidge, T., Takei, H., Kassam, Z., Fagan, A., Gavis, E. A., Pandak, W. M., Nittono, H., Hylemon, P. B., et al. (2018) · Hepatology · doi:10.1002/hep.30037 · Cited by 148
Self-citationMicrobial markers in colorectal cancer detection and/or prognosis
Villéger, R., Lopès, A., Véziant, J., Gagnière, J., Barnich, N., Billard, E., Boucher, D., & Bonnet, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i22.2327 · Cited by 146
Mitochondrial function and gastrointestinal diseases
Haque, P. S., Kapur, N., Barrett, T. A., & Theiss, A. L. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00931-2 · Cited by 146
Bile acids: a communication channel in the gut-brain axis
Monteiro-Cardoso, V. F., Corlianò, M., & Singaraja, R. R. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08625-z · Cited by 145
Implications of microbiota and bile acid in liver injury and regeneration
Liu, H., Keane, R., Sheng, L., & Wan, Y. Y. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.001 · Cited by 145
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2009) · Anaerobe · doi:10.1016/j.anaerobe.2009.05.004 · Cited by 145
Self-citationKoppel, N., Bisanz, J. E., Pandelia, M., Turnbaugh, P. J., & Balskus, E. P. (2018) · eLife · doi:10.7554/elife.33953 · Cited by 145
Chen, B., Bai, Y., Tong, F., Yan, J., Zhang, R., Zhong, Y., Tan, H., & Ma, X. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2192155 · Cited by 145
Human metabolome variation along the upper intestinal tract
Folz, J., Culver, R. N., Morales, J. M., Grembi, J., Triadafilopoulos, G., Relman, D. A., Huang, K. C., Shalon, D., & Fiehn, O. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00777-z · Cited by 143
How bile acids and the microbiota interact to shape host immunity
Lee, M. H., Nuccio, S.-P., Mohanty, I., Hagey, L. R., Dorrestein, P. C., Chu, H., & Raffatellu, M. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-024-01057-x · Cited by 143
In vitro and in vivo characterization of Clostridium scindens bile acid transformations
Marion, S., Studer, N., Desharnais, L., Menin, L., Escrig, S., Meibom, A., Hapfelmeier, S., & Bernier‐Latmani, R. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1549420 · Cited by 143
Delzenne, N. M., Knudsen, C., Beaumont, M., Rodriguez, J., Neyrinck, A. M., & Bindels, L. B. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118002756 · Cited by 146
Altered microbiota, fecal lactate, and fecal bile acids in dogs with gastrointestinal disease
Blake, A. B., Guard, B. C., Honneffer, J. B., Lidbury, J. A., Steiner, J. M., & Suchodolski, J. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224454 · Cited by 143
A microbial metabolite remodels the gut-liver axis following bariatric surgery
Chaudhari, S. N., Luo, J. N., Harris, D. A., Aliakbarian, H., Yao, L., Paik, D., Subramaniam, R., Adhikari, A. A., Vernon, A. H., Kılıç, A., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2020.12.004 · Cited by 143
Diakidou, A., Vertzoni, M., Goumas, K., Söderlind, E., Abrahamsson, B., Dressman, J., & Reppas, C. I. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9927-x · Cited by 143
Zhao, L., Ni, Y., Su, M., Li, H., Dong, F., Chen, W., Wei, R., Zhang, L., Guiraud, S. P., Martin, F., et al. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00660 · Cited by 142
Bile acids: short and long term effects in the intestine
Bajor, A., Gillberg, P., & Abrahamsson, H. (2010) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521003702734 · Cited by 142
Watanabe, M., Fukiya, S., & Yokota, A. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m075143 · Cited by 142
Ridlon, J. M., Devendran, S., Alves, J. M. P., Doden, H. L., Wolf, P. G., Pereira, G. V., Ly, L. K., Volland, A., Takei, H., Nittono, H., et al. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1618173 · Cited by 141
Self-citationExploring and Understanding the Biochemical Diversity of the Human Microbiota
Koppel, N., & Balskus, E. P. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.12.008 · Cited by 140
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
Basson, A. R., Trotter, A., Rodriguez‐Palacios, A., & Cominelli, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00290 · Cited by 140
Metabolism of hydrogen gases and bile acids in the gut microbiome
Hylemon, P. B., Harris, S. C., & Ridlon, J. M. (2018) · FEBS Letters · doi:10.1002/1873-3468.13064 · Cited by 140
Self-citationVogt, S. L., Peña-Díaz, J., & Finlay, B. B. (2015) · Anaerobe · doi:10.1016/j.anaerobe.2015.05.002 · Cited by 140
Hanafi, N. I., Mohamed, A. S., Kadir, S. H. S. A., & Othman, M. H. D. (2018) · Biomolecules · doi:10.3390/biom8040159 · Cited by 140
Dale, J. L., Cagnazzo, J., Phan, C. Q., Barnes, A. M. T., & Dunny, G. M. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00344-15 · Cited by 141
Microbial regulation of GLP-1 and L-cell biology
Greiner, T. U., & Bäckhed, F. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.012 · Cited by 139
Gut microbiota: novel therapeutic target for nonalcoholic fatty liver disease
Suk, K. T., & Kim, D. J. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1569513 · Cited by 139
Tsiaoussis, J., Antoniou, M. N., Koliarakis, I., Mesnage, R., Vardavas, C. I., Izotov, B. N., Psaroulaki, A., & Tsatsakis, A. M. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.04.014 · Cited by 139
Wang, T., Han, J., Dai, H., Sun, J., Ren, J., Wang, W., Qiao, S., Liu, C., Sun, L., Liu, S., et al. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119862 · Cited by 139
Arresting microbiome development limits immune system maturation and resistance to infection in mice
Lubin, J., Green, J., Maddux, S., Denu, L., Duranova, T., Lanza, M. R., Wynosky-Dolfi, M. A., Flores, J. N., Grimes, L. P., Brodsky, I. E., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.006 · Cited by 139
Metagenomics and novel gene discovery
Culligan, E. P., Sleator, R. D., Marchesi, J. R., & Hill, C. (2013) · Virulence · doi:10.4161/viru.27208 · Cited by 138
Pols, T. W. H., Puchner, T., Korkmaz, H. I., Vos, M., Soeters, M. R., & de Vries, C. J. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176715 · Cited by 138
Sex differences in lipid metabolism are affected by presence of the gut microbiota
Baars, A., Oosting, A., Lohuis, M. A. M., Koehorst, M., Aidy, S. E., Hugenholtz, F., Smidt, H., Mischke, M., Boekschoten, M. V., Verkade, H. J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31695-w · Cited by 138
Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites
Xie, G., Zhong, W. H., Zheng, X., Li, Q., Qiu, Y., Li, H., Chen, H., Zhou, Z., & Jia, W. P. (2013) · Journal of Proteome Research · doi:10.1021/pr400362z · Cited by 137
Genetic determinants of gut microbiota composition and bile acid profiles in mice
Kemis, J. H., Linke, V., Barrett, K. L., Boehm, F. J., Traeger, L. L., Keller, M. P., Rabaglia, M. E., Schueler, K. L., Stapleton, D. S., Gatti, D. M., et al. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008073 · Cited by 136
Cross-talk between bile acids and intestinal microbiota in host metabolism and health
Nie, Y., Hu, J. P., & Yan, X. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400327 · Cited by 136
Baars, A., Oosting, A., Knol, J., Garssen, J., & Van Bergenhenegouwen, J. (2015) · Microorganisms · doi:10.3390/microorganisms3040641 · Cited by 135
Pavlidis, P., Powell, N., Vincent, R. P., Ehrlich, S. D., Bjarnason, I., & Hayee, B. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13333 · Cited by 135
Interplay between bile acids and the gut microbiota promotes intestinal carcinogenesis
Wang, S., Dong, W., Liu, L., Xu, M., Wang, Y., Liu, T., Zhang, Y., Wang, B., & Cao, H. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.22999 · Cited by 135
An in vitro model maintaining taxon-specific functional activities of the gut microbiome
Li, L., Abou-Samra, E., Ning, Z., Zhang, X., Mayne, J., Wang, J., Cheng, K., Walker, K., Stintzi, A., & Figeys, D. (2019) · Nature Communications · doi:10.1038/s41467-019-12087-8 · Cited by 135
Metadata
- Authors
- Ridlon, J. M., Kang, D.-J., & Hylemon, P. B.
- Affiliations
- Virginia Commonwealth University (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 47
- Issue
- 2
- Pages
- 241-259
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2071273298
- Cited by
- 2,829
- References
- 181
- Citations by year
- 2026: 202 · 2025: 220 · 2024: 211 · 2023: 245 · 2022: 263 · 2021: 252 · 2020: 238 · 2019: 200 · 2018: 191 · 2017: 161 · 2016: 130 · 2015: 119 · 2014: 87 · 2013: 91 · 2012: 51
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK038030, P01 DK 38030)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- secondary bile acids, enterohepatic circulation, enzyme kinetics, enzyme structure, gene cloning, probiotics, bile acid sequestration, colon cancer, gallstones
- MeSH terms
- Amidohydrolases, Amino Acid Sequence, Bacteria, Bile Acids and Salts, Biotransformation, Cholic Acids, Colonic Neoplasms, Humans, Hydrogen Sulfide, Hydroxysteroid Dehydrogenases, Intestinal Mucosa, Intestines, Models, Molecular, Molecular Sequence Data, Taurine, Molecular Structure, Sequence Homology, Amino Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review