Cited by 2,829Gut microbiota and healthSteroid Chemistry and BiochemistryDrug Transport and Resistance Mechanisms

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Bile salt biotransformations by human intestinal bacteria

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Ridlon, Jason M., Kang, Dae-Joong, Hylemon, Phillip B.·2006·Journal of Lipid Research

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Abstract

Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels in the enterohepatic circulation of some individuals and may contribute to the pathogenesis of colon cancer, gallstones, and other gastrointestinal (GI) diseases. Bile salt hydrolysis and hydroxy group dehydrogenation reactions are carried out by a broad spectrum of intestinal anaerobic bacteria, whereas bile acid 7-dehydroxylation appears restricted to a limited number of intestinal anaerobes representing a small fraction of the total colonic flora. Microbial enzymes modifying bile salts differ between species with respect to pH optima, enzyme kinetics, substrate specificity, cellular location, and possibly physiological function. Crystallization, site-directed mutagenesis, and comparisons of protein secondary structure have provided insight into the mechanisms of several bile acid-biotransforming enzymatic reactions. Molecular cloning of genes encoding bile salt-modifying enzymes has facilitated the understanding of the genetic organization of these pathways and is a means of developing probes for the detection of bile salt-modifying bacteria. The potential exists for altering the bile acid pool by targeting key enzymes in the 7alpha/beta-dehydroxylation pathway through the development of pharmaceuticals or sequestering bile acids biologically in probiotic bacteria, which may result in their effective removal from the host after excretion.

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Authors: Ridlon, J. M., Kang, D.-J., & Hylemon, P. B.
Affiliations: Virginia Commonwealth University (US)
ORCID: Ridlon, Jason M.
Hylemon, Phillip B.
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2006-02
Volume: 47
Issue: 2
Pages: 241-259
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.r500013-jlr200
OpenAlex: W2071273298
Cited by: 2,829
References: 181
Citations by year: 2026: 202 · 2025: 220 · 2024: 211 · 2023: 245 · 2022: 263 · 2021: 252 · 2020: 238 · 2019: 200 · 2018: 191 · 2017: 161 · 2016: 130 · 2015: 119 · 2014: 87 · 2013: 91 · 2012: 51
FWCI: 1.11
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5326 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P01DK038030, P01 DK 38030)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: secondary bile acids, enterohepatic circulation, enzyme kinetics, enzyme structure, gene cloning, probiotics, bile acid sequestration, colon cancer, gallstones
MeSH terms: Amidohydrolases, Amino Acid Sequence, Bacteria, Bile Acids and Salts, Biotransformation, Cholic Acids, Colonic Neoplasms, Humans, Hydrogen Sulfide, Hydroxysteroid Dehydrogenases, Intestinal Mucosa, Intestines, Models, Molecular, Molecular Sequence Data, Taurine, Molecular Structure, Sequence Homology, Amino Acid

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Bile salt biotransformations by human intestinal bacteria

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