The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Bile acids as regulatory molecules
Open accessAbstract
In the past, bile acids were considered to be just detergent molecules derived from cholesterol in the liver. They were known to be important for the solubilization of cholesterol in the gallbladder and for stimulating the absorption of cholesterol, fat-soluble vitamins, and lipids from the intestines. However, during the last two decades, it has been discovered that bile acids are regulatory molecules. Bile acids have been discovered to activate specific nuclear receptors (farnesoid X receptor, preganane X receptor, and vitamin D receptor), G protein coupled receptor TGR5 (TGR5), and cell signaling pathways (c-jun N-terminal kinase 1/2, AKT, and ERK 1/2) in cells in the liver and gastrointestinal tract. Activation of nuclear receptors and cell signaling pathways alter the expression of numerous genes encoding enzyme/proteins involved in the regulation of bile acid, glucose, fatty acid, lipoprotein synthesis, metabolism, transport, and energy metabolism. They also play a role in the regulation of serum triglyceride levels in humans and rodents. Bile acids appear to function as nutrient signaling molecules primarily during the feed/fast cycle as there is a flux of these molecules returning from the intestines to the liver following a meal. In this review, we will summarize the current knowledge of how bile acids regulate hepatic lipid and glucose metabolism through the activation of specific nuclear receptors and cell signaling pathways.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This process is controlled by a negative-feedback loop through the activation of the nuclear farnesoid X receptor (FXR) in the ileum and liver (7, 8).”
In the citing paper
“BAs are synthesized from cholesterol by CYP7A1 in the liver and play a central role in cholesterol homoeostasis (8).”
In the citing paper
“Bile acids are cholesterol metabolites that facilitate the absorption of dietary fat and fat-soluble molecules and are now also recognized as regulators of energy metabolism through activation of the receptors TGR5 and FXR (Hylemon et al., 2009; Lefebvre et al., 2009).”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Hylemon et al., 2009
In the citing paper
“Following systemic adsorption, some secondary BAs in turn impact host physiology though interaction with a variety of host nuclear receptors including FXR, liver X receptor (LXR), pregnane X receptor (PXR), and specific G-protein coupled receptors like TGR5 (Figure 1)40–44.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Orphan Receptor Small Heterodimer Partner Is an Important Mediator of Glucose Homeostasis
Wang, L., Huang, J., Saha, P., Kulkarni, R., Hu, M., Kim, Y., Park, K., Chan, L., Rajan, A. S., Lee, I. K., et al. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0224 · Cited by 41
RetractedInternational Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829
Self-citationIdentification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940
Cited by
Sorted by citations
Items 201–300 of 697
Diet‐derived microbial metabolites in health and disease
Roager, H. M., & Dragsted, L. O. (2019) · Nutrition Bulletin · doi:10.1111/nbu.12396 · Cited by 65
Aldo-Keto Reductases 1B in Endocrinology and Metabolism
Pastel, E., Pointud, J., Volat, F., Martinez, A., & Lefrançois‐Martinez, A. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00148 · Cited by 61
Fedorova, O. V., Zernetkina, V. I., Shilova, V. Y., Grigorova, Y. N., Juhász, O., Wei, W., Marshall, C. A., Lakatta, E. G., & Bagrov, A. Y. (2015) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.115.001217 · Cited by 61
Effect of asymmetric dimethylarginine (ADMA) on heart failure development
Liu, X., Hou, L., Xu, D., Chen, A., Yang, L., Zhuang, Y., Xu, Y., Fassett, J. T., & Chen, Y. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.02.006 · Cited by 61
Cortez, L. M., Campeau, J. L., Norman, G., Kalayil, M., van der Merwe, J., McKenzie, D. I., & Sim, V. L. (2015) · Journal of Virology · doi:10.1128/jvi.01165-15 · Cited by 59
Ren, S., & Ning, Y. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00552.2013 · Cited by 60
Self-citationZhang, H., Zhang, W., Yun, D., Li, L., Zhao, W., Li, Y., Liu, X., & Liu, Z. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108403 · Cited by 60
Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats
Behr, C., Slopianka, M., Haake, V., Strauss, V., Sperber, S., Kamp, H., Walk, T., Beekmann, K., Rietjens, I. M. C. M., & van Ravenzwaay, B. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.11.012 · Cited by 58
Centuori, S. M., Gomes, C. J., Trujillo, J., Borg, J. L., Brownlee, J., Putnam, C. W., & Martinez, J. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.006 · Cited by 58
Jergens, A. E., Guard, B. C., Redfern, A., Rossi, G., Mochel, J. P., Pilla, R., Chandra, L. C., Seo, Y., Steiner, J. M., Lidbury, J. A., et al. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00199 · Cited by 65
The role of bile acid receptor TGR5 in regulating inflammatory signalling
Ye, D., He, J., & He, X. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13361 · Cited by 61
Starring role of toll-like receptor-4 activation in the gut-liver axis
Carotti, S. (2015) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v6.i4.99 · Cited by 59
Yu, H., Ni, Y., Bao, Y., Zhang, P., Zhao, A., Chen, T., Xie, G., Tu, Y., Zhang, L., Su, M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2884 · Cited by 57
Li, Q., Larouche‐Lebel, É., Loughran, K. A., Huh, T. P., Suchodolski, J. S., & Oyama, M. A. (2021) · mSystems · doi:10.1128/msystems.00111-21 · Cited by 64
5β-Reduced steroids and human Δ4-3-ketosteroid 5β-reductase (AKR1D1)
Chen, M., & Penning, T. M. (2014) · Steroids · doi:10.1016/j.steroids.2014.01.013 · Cited by 55
Gut microbiome and its meta-omics perspectives: profound implications for cardiovascular diseases
Xu, J., & Yang, Y. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1936379 · Cited by 61
Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases
Stanimirov, B., Stankov, K., & Mikov, M. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60307-6 · Cited by 56
Inflammatory bowel diseases, celiac disease, and bone
Bianchi, M. L. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.06.026 · Cited by 57
Bifidobacteria-Host Interactions—An Update on Colonisation Factors
Grimm, V., Westermann, C., & Riedel, C. U. (2014) · BioMed Research International · doi:10.1155/2014/960826 · Cited by 56
Nizamutdinov, D., DeMorrow, S., McMillin, M., Kain, J., Mukherjee, S., Zeitouni, S., Frampton, G. A., Bricker, P. C. S., Hurst, J., & Shapiro, L. A. (2017) · Scientific Reports · doi:10.1038/srep40112 · Cited by 57
Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes
McLean, K. J., Hans, M., & Munro, A. W. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120077 · Cited by 55
Gut microbiota and metabolites in the pathogenesis of endocrine disease
Fenneman, A. C., Rampanelli, E., Yin, Y. S., Ames, J., Blaser, M. J., Fliers, E., & Nieuwdorp, M. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190686 · Cited by 51
Cheng, Z., Qiao, D., Zhao, S., Zhang, B., Lin, Q., & Xie, F. (2022) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12985 · Cited by 56
FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho
Fu, T., Kim, Y., Byun, S., Kim, D.-H., Seok, S., Suino-Powell, K. M., Xu, H. E., KEMPER, B. W., & Kemper, J. K. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1226 · Cited by 53
Desmarchelier, C., Dahlhoff, C., Keller, S., Sailer, M., Jahreis, G., & Daniel, H. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-84 · Cited by 51
Corbin, K. D., Abdelmalek, M. F., Spencer, M., da Costa, K.-A., Galanko, J. A., Sha, W., Suzuki, A., Guy, C. D., Cardona, D. M., Torquati, A., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-219097 · Cited by 51
Bhowmik, S., Jones, D. H., Chiu, H., Park, I., Chiu, H., Axelrod, H. L., Farr, C. L., Tien, H. J., Agarwalla, S., & Lesley, S. A. (2013) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24353 · Cited by 52
Tanaka, M., Sanefuji, M., Morokuma, S., Yoden, M., Momoda, R., Sonomoto, K., Ogawa, M., Kato, K., & Nakayama, J. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1650997 · Cited by 51
Enterohepatic circulation of bile acids and their emerging roles on glucolipid metabolism
Chen, M., Liu, C., Wan, Y., Yang, L., Jiang, S., Qian, D., & Duan, J. (2020) · Steroids · doi:10.1016/j.steroids.2020.108757 · Cited by 55
The chemistry of gut microbiome in health and diseases
Lau, A., Tan, L. T., Mutalib, N. A., Wong, S. H., Letchumanan, V., & Lee, L. (2021) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000175 · Cited by 55
Zheng, N., Wang, H., Zhu, W., Li, Y., & Li, H. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117401 · Cited by 50
Perreault, M., Bialek, A. P., Trottier, J., Verreault, M., Caron, P., Milkiewicz, P., & Barbier, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080994 · Cited by 50
Bhowmik, S., Chiu, H., Jones, D. H., Chiu, H., Miller, M. D., Xu, Q., Farr, C. L., Ridlon, J. M., Wells, J. E., Elsliger, M., et al. (2015) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24971 · Cited by 53
Self-citationTiessen, R. G., Kennedy, C., Keller, B. T., Levin, N., Acevedo, L. M., Gedulin, B. R., van Vliet, A. A., Dorenbaum, A., & Palmer, M. (2018) · BMC Gastroenterology · doi:10.1186/s12876-017-0736-0 · Cited by 49
Association between 12α-hydroxylated bile acids and hepatic steatosis in rats fed a high-fat diet
Hori, S., Abe, T., Lee, D. G., Fukiya, S., Yokota, A., Aso, N., Shirouchi, B., Satô, M., & Ishizuka, S. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108412 · Cited by 53
Faecal bile acids are natural ligands of the mouse accessory olfactory system
Doyle, W. I., Dinser, J. A., Cansler, H. L., Zhang, X., Dinh, D. D., Browder, N. S., Riddington, I. M., & Meeks, J. P. (2016) · Nature Communications · doi:10.1038/ncomms11936 · Cited by 52
The gut microbiota-artery axis: A bridge between dietary lipids and atherosclerosis?
Zhang, Q., Zhang, L., Chen, C., Li, P., & Lu, B. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101209 · Cited by 50
Zhang, W., Zhou, L., Yin, P., Wang, J., Lu, X., Wang, X., Chen, J., Lin, X., & Xu, G. (2015) · Scientific Reports · doi:10.1038/srep08984 · Cited by 51
Jia, Y., Yuan, Z., Zhang, X.-S., Dong, J., Liu, X.-N., Peng, X., Yao, W., Ji, P., Wei, Y., & Hua, Y. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112775 · Cited by 49
Yao, T., Gu, X., Liang, X., Fall, F. N., Cao, A., Zhang, S., Guan, Y., Sun, B., & Xue, M. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737012 · Cited by 48
Ji, G., Si, X., Dong, S., Xu, Y., Li, M., Yang, B., Tang, Z., Fang, X., Huang, L., Song, W., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01360 · Cited by 47
Bile acid metabolism in health and ageing-related diseases
Li, X., Fang, C., Zhao, R., Zou, L., Miao, H., & Zhao, Y. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116313 · Cited by 50
Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine
Frank, D. N., Bales, E. S., Monks, J., Jackman, M. J., MacLean, P. S., Ir, D., Robertson, C. E., Orlicky, D. J., & McManaman, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131944 · Cited by 49
Gut microbiota: a promising target against cardiometabolic diseases
Warmbrunn, M. V., Herrema, H., Aron‐Wisnewsky, J., Soeters, M. R., van Raalte, D. H., & Nieuwdorp, M. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1720511 · Cited by 49
Bile acids: emerging role in management of liver diseases
Asgharpour, A., Kumar, D. P., & Sanyal, A. J. (2015) · Hepatology International · doi:10.1007/s12072-015-9656-7 · Cited by 47
Ørntoft, N. W., Munk, O. L., Frisch, K., Ott, P., Keiding, S., & Sørensen, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.02.023 · Cited by 46
Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases
Schiattarella, G. G., Sannino, A., Esposito, G., & Perrino, C. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.08.003 · Cited by 47
The clinical and mechanistic roles of bile acids in depression, Alzheimer's disease, and stroke
Wu, L., Zhao, M., Li, M., Guo, Q., Zhenxing, R., Xiaojiao, Z., & Chen, T. (2022) · PROTEOMICS · doi:10.1002/pmic.202100324 · Cited by 47
Wang, Y., Nan, X., Zhao, Y., Jiang, L., Wang, H., Zhang, F., Hua, D., Liu, J., Yang, L., Yao, J., et al. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-21654 · Cited by 44
Li, W., Chen, H., & Tang, J. (2024) · Pathogens · doi:10.3390/pathogens13080702 · Cited by 49
Roles of Ileal ASBT and OSTα-OSTβ in Regulating Bile Acid Signaling
Dawson, P. A. (2017) · Digestive Diseases · doi:10.1159/000450987 · Cited by 44
Zhu, X., Zhang, C., Feng, S., He, R., & Zhang, S. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01304-4 · Cited by 52
Seok, S., Kanamaluru, D., Xiao, Z., Ryerson, D., Choi, S., Suino-Powell, K. M., Xu, H. E., Veenstra, T. D., & Kemper, J. K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.452037 · Cited by 42
Estrogen receptor beta mediates hepatotoxicity induced by perfluorooctane sulfonate in mouse
Xu, C. Y., Jiang, Z., Liu, Q., Liu, H., & Gu, A. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-8943-3 · Cited by 43
Ding, L., Zhang, L., Shi, H.-H., Wang, C., Jiang, X., Xue, C., Yanagita, T., Zhang, T., & Wang, Y.-M. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08296 · Cited by 42
Dey, P., & Chaudhuri, S. R. (2022) · Biology · doi:10.3390/biology11050757 · Cited by 45
Jung, J. H., Kim, S. E., Suk, K. T., & Kim, D. J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.913842 · Cited by 42
Pathogenesis of Alcoholic Fatty Liver a Narrative Review
Seitz, H. K., Moreira, B., & Neuman, M. G. (2023) · Life · doi:10.3390/life13081662 · Cited by 41
Młynarska, E., Wasiak, J., Gajewska, A., Steć, G., Jasińska, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16121938 · Cited by 46
Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD
Termite, F., Archilei, S., D’Ambrosio, F., Petrucci, L., Viceconti, N., Iaccarino, R., Liguori, A., Gasbarrini, A., & Miele, L. (2025) · Antioxidants · doi:10.3390/antiox14010056 · Cited by 50
Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators
Pellicciari, R., Gioiello, A., Sabbatini, P., Venturoni, F., Nuti, R., Colliva, C., Rizzo, G., Adorini, L., Pruzanski, M., Roda, A., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml200256d · Cited by 40
Human Gut Microbiome and Liver Diseases: From Correlation to Causation
Li, R., Mao, Z., Ye, X., & Zuo, T. (2021) · Microorganisms · doi:10.3390/microorganisms9051017 · Cited by 40
Clerbaux, L., Manco, R., Hul, N. V., Bouzin, C., Sciarra, A., Sempoux, C. L., Theise, N. D., & Leclercq, I. A. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.04.011 · Cited by 39
Li, R., Zeng, L., Xie, S., Chen, J., Yu, Y., & Zhong, L. (2019) · PeerJ · doi:10.7717/peerj.7145 · Cited by 40
EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism
Ding, L., Zhang, L., Shi, H., Xue, C., Yanagita, T., Zhang, T., & Wang, Y. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103824 · Cited by 39
Sun, Z., Huang, C., Shi, Y., Wang, R., Fan, J., Yu, Y., Zhang, Z., Zhu, K., Li, M., Ni, Q., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.708495 · Cited by 40
Bile Formation and the Enterohepatic Circulation
Dawson, P. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00053-1 · Cited by 39
Xu, N., Bai, Y., Han, X., Yuan, J., Wang, L., He, Y., Liu, Y., Wu, H., Shi, H., & Wu, X. (2023) · Immunobiology · doi:10.1016/j.imbio.2023.152388 · Cited by 38
Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
Arlia‐Ciommo, A., Piano, A., Svistkova, V., Mohtashami, S., & Titorenko, V. I. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916522 · Cited by 39
He, Y., Mao, C., Wen, H., Chen, Z., Lai, T., Li, L., Lü, W., & Wu, H. (2017) · Scientific Reports · doi:10.1038/srep44553 · Cited by 38
Zhou, M., Zhang, Q., Zhao, J., Liao, M., Wen, S., & Yang, M. (2017) · Oncology Reports · doi:10.3892/or.2017.5830 · Cited by 37
Han, R., Ma, J., & Li, H. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0645-9 · Cited by 39
Zhang, W., Song, Y., Chai, T., Liao, G., Zhang, L., Jia, Q., Qian, Y., & Qiu, J. Y. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.136565 · Cited by 38
The altered lipidome of hepatocellular carcinoma
Tan, S. L. W., Israeli, E., Ericksen, R. E., Chow, P. K. H., & Han, W. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.02.004 · Cited by 37
Ma, Z., Huang, Z., Zhang, C., Liu, X., Zhang, J., Shu, H., Ma, Y., Liu, Z., Feng, Y. Y., Chen, X., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05829-9 · Cited by 36
Insights by which TUDCA is a potential therapy against adiposity
Freitas, I. N., junior, J. A. D. S., de Oliveira, K. M., Alves, B. L., Araújo, T. R., Camporez, J. P., Carneiro, E. M., & Davel, A. P. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1090039 · Cited by 41
Tang, Y., Fan, Y., Wang, Y., Wang, D., Huang, Q., Chen, T., Cao, X., Wen, C., Shen, X., Li, J., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116658 · Cited by 38
Protein kinase C induces endocytosis of the sodium taurocholate cotransporting polypeptide
Stroß, C., Helmer, A., Weissenberger, K., Görg, B., Keitel, V., Häussinger, D., & Kubitz, R. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00180.2010 · Cited by 37
Habitual animal fat consumption in shaping gut microbiota and microbial metabolites
Wan, Y., Tong, W., Zhou, R., Li, J., Yuan, J., Wang, F., & Li, D. (2019) · Food & Function · doi:10.1039/c9fo01490j · Cited by 37
Vitamin D modulates biliary fibrosis in ABCB4-deficient mice
Hochrath, K., Stokes, C. S., Geisel, J., Pollheimer, M. J., Fickert, P., Dooley, S., & Lammert, F. (2014) · Hepatology International · doi:10.1007/s12072-014-9548-2 · Cited by 36
FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model
Kunne, C., Acco, A., Duijst, S., de Waart, D. R., Paulusma, C. C., Gaemers, I. C., & Elferink, R. P. J. O. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.004 · Cited by 41
Xu, L., Wei, Y., Dong, D., Yin, L., Qi, Y., Han, X., Xu, Y., Zhao, Y., Liu, K., & Peng, J. (2014) · RSC Advances · doi:10.1039/c4ra03948c · Cited by 36
Akwabi-Ameyaw, A., Caravella, J. A., Chen, L., Creech, K. L., Deaton, D. N., Madauss, K. P., Marr, H. B., Miller, A. B., Navas, F., Parks, D. J., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.08.034 · Cited by 37
Epigenomic regulation of bile acid metabolism: Emerging role of transcriptional cofactors
Smith, Z., Ryerson, D., & Kemper, J. K. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.04.008 · Cited by 36
Liu, Z., Zhang, Y. X., Zhang, R., Gu, L., & Chen, X. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.12.021 · Cited by 35
Yang, C., Wan, M., Xu, D., Pan, D., Xia, H., Yang, L., & Sun, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910858 · Cited by 35
Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease
Ganesan, R., Jeong, J., Kim, D. J., & Suk, K. T. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.841281 · Cited by 38
Ho, R. H., Leake, B. F., Urquhart, B. L., Gregor, J. C., Dawson, P. A., & Kim, R. B. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06805.x · Cited by 35
Patterns and processes of human life history evolution
Muehlenbein, M. P., & Flinn, M. V. (2011) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199568765.003.0012 · Cited by 37
Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block
Yanovsky, Y., Schubring, S. R., Yao, Q., Zhao, Y., Li, S., May, A., Haas, H. L., Lin, J.-S., & Sergeeva, O. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042512 · Cited by 34
Warden, C., & Brantley, M. A. (2021) · Biomolecules · doi:10.3390/biom11050626 · Cited by 34
Berberine alters gut microbial function through modulation of bile acids
Wolf, P. G., Devendran, S., Doden, H. L., Ly, L. K., Moore, T., Takei, H., Nittono, H., Murai, T., Kurosawa, T., Chlipala, G. E., et al. (2021) · BMC Microbiology · doi:10.1186/s12866-020-02020-1 · Cited by 36
Degradation of Bile Acids by Soil and Water Bacteria
Feller, F. M., Holert, J., Yücel, O., & Philipp, B. (2021) · Microorganisms · doi:10.3390/microorganisms9081759 · Cited by 36
Kasai, Y., Kessoku, T., Tanaka, K., Yamamoto, A., Takahashi, K., Kobayashi, T., Iwaki, M., Ozaki, A., Nogami, A., Honda, Y., et al. (2022) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000503 · Cited by 33
The role of intestinal microbiota in the pathogenesis of NAFLD: starting points for intervention
Gentilucci, U. V., Gallo, P., & Picardi, A. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.58831 · Cited by 34
The enteric microbiome in hepatobiliary health and disease
Tabibian, J. H., Varghese, C., LaRusso, N. F., & O’Hara, S. P. (2015) · Liver International · doi:10.1111/liv.13009 · Cited by 33
Pavagadhi, S., Natera, S., Roessner, U., & Balasubramanian, R. (2013) · Environmental Science & Technology · doi:10.1021/es4004125 · Cited by 33
He, B., Liu, Y., Hoang, T. K., Tian, X., Taylor, C. M., Luo, M., Tran, D. Q., Tatevian, N., & Rhoads, J. M. (2019) · Microbiome · doi:10.1186/s40168-019-0751-1 · Cited by 33
Targeting gut-liver axis by dietary lignans ameliorate obesity: evidences and mechanisms
Chu, Z., Hu, Z., Luo, Y., Zhou, Y., Yang, F., & Luo, F. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2272269 · Cited by 35
Silvennoinen, R., Quesada, H., Kareinen, I., Julve, J., Kaipiainen, L., Gylling, H., Blanco‐Vaca, F., Escolá‐Gil, J. C., Kovanen, P. T., & Lee‐Rueckert, M. (2015) · Physiological Reports · doi:10.14814/phy2.12402 · Cited by 33
Metadata
- Authors
- Hylemon, P. B., Zhou, H., Pandak, W. M., Ren, S., Gil, G., & Dent, P.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Hylemon, Phillip B.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 50
- Issue
- 8
- Pages
- 1509-1520
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC2724047
- OpenAlex
- W2165877587
- Cited by
- 694
- References
- 99
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 37 · 2023: 40 · 2022: 43 · 2021: 51 · 2020: 37 · 2019: 52 · 2018: 36 · 2017: 43 · 2016: 43 · 2015: 50 · 2014: 50 · 2013: 46 · 2012: 39
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK52825, R01DK052825, DK-057543, R01DK057543)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- bile acids, bile acid signaling, farnesoid X receptor, pregnane X receptor, vitamin D receptor, TGR5, c-Jun N-terminal kinase, Akt signaling, ERK signaling, hepatic lipid metabolism, hepatic glucose metabolism, nutrient sensing, serum triglycerides, bile acid transport, energy metabolism
- MeSH terms
- Animals, Bile, Bile Acids and Salts, Digestion, Enterohepatic Circulation, Fibroblast Growth Factors, Humans, Liver, Signal Transduction, Receptors, Cytoplasmic and Nuclear, Gastrointestinal Tract, Receptors, G-Protein-Coupled
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
