The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Bile acids as regulatory molecules
Open accessAbstract
In the past, bile acids were considered to be just detergent molecules derived from cholesterol in the liver. They were known to be important for the solubilization of cholesterol in the gallbladder and for stimulating the absorption of cholesterol, fat-soluble vitamins, and lipids from the intestines. However, during the last two decades, it has been discovered that bile acids are regulatory molecules. Bile acids have been discovered to activate specific nuclear receptors (farnesoid X receptor, preganane X receptor, and vitamin D receptor), G protein coupled receptor TGR5 (TGR5), and cell signaling pathways (c-jun N-terminal kinase 1/2, AKT, and ERK 1/2) in cells in the liver and gastrointestinal tract. Activation of nuclear receptors and cell signaling pathways alter the expression of numerous genes encoding enzyme/proteins involved in the regulation of bile acid, glucose, fatty acid, lipoprotein synthesis, metabolism, transport, and energy metabolism. They also play a role in the regulation of serum triglyceride levels in humans and rodents. Bile acids appear to function as nutrient signaling molecules primarily during the feed/fast cycle as there is a flux of these molecules returning from the intestines to the liver following a meal. In this review, we will summarize the current knowledge of how bile acids regulate hepatic lipid and glucose metabolism through the activation of specific nuclear receptors and cell signaling pathways.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This process is controlled by a negative-feedback loop through the activation of the nuclear farnesoid X receptor (FXR) in the ileum and liver (7, 8).”
In the citing paper
“BAs are synthesized from cholesterol by CYP7A1 in the liver and play a central role in cholesterol homoeostasis (8).”
In the citing paper
“Bile acids are cholesterol metabolites that facilitate the absorption of dietary fat and fat-soluble molecules and are now also recognized as regulators of energy metabolism through activation of the receptors TGR5 and FXR (Hylemon et al., 2009; Lefebvre et al., 2009).”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Hylemon et al., 2009
In the citing paper
“Following systemic adsorption, some secondary BAs in turn impact host physiology though interaction with a variety of host nuclear receptors including FXR, liver X receptor (LXR), pregnane X receptor (PXR), and specific G-protein coupled receptors like TGR5 (Figure 1)40–44.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Orphan Receptor Small Heterodimer Partner Is an Important Mediator of Glucose Homeostasis
Wang, L., Huang, J., Saha, P., Kulkarni, R., Hu, M., Kim, Y., Park, K., Chan, L., Rajan, A. S., Lee, I. K., et al. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0224 · Cited by 41
RetractedInternational Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829
Self-citationIdentification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940
Cited by
Sorted by citations
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331
Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924
Gut microbiota in cardiovascular health and disease
Tang, W. H. W., Kitai, T., & Hazen, S. L. (2017) · Circulation Research · doi:10.1161/circresaha.117.309715 · Cited by 1,670
Bile Acid Metabolism and Signaling
Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120023 · Cited by 1,662
Bile acids and the gut microbiome
Ridlon, J. M., Kang, D. J., Hylemon, P. B., & Bajaj, J. S. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000057 · Cited by 1,329
Self-citationThe Human Gut Microbiome – A Potential Controller of Wellness and Disease
Kho, Z. Y., & Lal, S. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01835 · Cited by 1,180
Gut microbiota and cardiovascular disease.
Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051
Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
Duboc, H., Rajca, S., Rainteau, D., Benarous, D., Maubert, M.-A., Quervain, E., Thomas, G., Barbu, V., Humbert, L., Despras, G., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302578 · Cited by 930
Nogal, A., Valdes, A. M., & Menni, C. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1897212 · Cited by 917
Tremaroli, V., Karlsson, F., Werling, M., Ståhlman, M., Kovatcheva-Datchary, P., Olbers, T., Fändriks, L., le Roux, C. W., Nielsen, J., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.009 · Cited by 757
Chen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio · doi:10.1128/mbio.02210-15 · Cited by 754
“BAs are synthesized from cholesterol by CYP7A1 in the liver and play a central role in cholesterol homoeostasis (8).”
BackgroundDawson, P. A., Lan, T., & Rao, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900012-jlr200 · Cited by 683
Effects of environmental pollutants on gut microbiota
Jin, Y., Wu, S., Zeng, Z., & Fu, Z. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2016.11.045 · Cited by 683
Intestinal transport and metabolism of bile acids
Dawson, P. A., & Karpen, S. J. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r054114 · Cited by 598
Metabolism of Cholesterol and Bile Acids by the Gut Microbiota
Gérard, P. (2013) · Pathogens · doi:10.3390/pathogens3010014 · Cited by 580
“Therefore, they may modulate lipid, glucose, energy and drug metabolisms as well as their own biosynthesis [29].”
BackgroundInteraction of gut microbiota with bile acid metabolism and its influence on disease states
Staley, C. M., Weingarden, A. R., Khoruts, A., & Sadowsky, M. J. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-8006-6 · Cited by 595
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression
Corbin, K. D., & Zeisel, S. H. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834e7b4b · Cited by 518
Zeng, H., Umar, S., Rust, B., Lazarova, D., & Bordonaro, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051214 · Cited by 480
Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review
Zhao, M., Chu, J., Feng, S., Guo, C., Xue, B., He, K., & Li, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114985 · Cited by 510
Microbial modulation of cardiovascular disease
Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440
Human Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids
Haeusler, R. A., Astiarraga, B., Camastra, S., Accili, D., & Ferrannini, E. (2013) · Diabetes · doi:10.2337/db13-0639 · Cited by 444
An Integrated View of Immunometabolism
Lee, Y. S., Wollam, J., & Olefsky, J. M. (2018) · Cell · doi:10.1016/j.cell.2017.12.025 · Cited by 452
Bile salts of vertebrates: structural variation and possible evolutionary significance
Hofmann, A. F., Hagey, L. R., & Krasowski, M. D. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r000042 · Cited by 427
Targeted Metabolomics for Biomarker Discovery
Griffiths, W. J., Koal, T., Wang, Y., Kohl, M., Enot, D. P., & Deigner, H. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200905579 · Cited by 418
Kars, M., Yang, L., Gregor, M. F., Mohammed, B. S., Pietka, T., Finck, B. N., Patterson, B. W., Horton, J. D., Mittendorfer, B., Hotamışlıgil, G. S., et al. (2010) · Diabetes · doi:10.2337/db10-0308 · Cited by 409
Precision Nutrition and the Microbiome, Part I: Current State of the Science
Mills, S., Stanton, C., Lane, J. A., Smith, G., & Ross, R. P. (2019) · Nutrients · doi:10.3390/nu11040923 · Cited by 426
Bile acid transporters and regulatory nuclear receptors in the liver and beyond
Halilbasic, E., Claudel, T., & Trauner, M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.002 · Cited by 415
Gut microbial molecules in behavioural and neurodegenerative conditions
Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00381-0 · Cited by 379
Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease
Mouzaki, M., Wang, A. Y., Bandsma, R., Comelli, E. M., Arendt, B. M., Zhang, L., Fung, S., Fischer, S. E., McGilvray, I. G., & Allard, J. P. (2016) · PLOS ONE · doi:10.1371/journal.pone.0151829 · Cited by 385
Taurine: a critical nutrient for future fish feeds
Salze, G. P., & Davis, D. A. (2014) · Aquaculture · doi:10.1016/j.aquaculture.2014.12.006 · Cited by 394
Secondary bile acids: an underrecognized cause of colon cancer
Ajouz, H., Mukherji, D., & Shamseddine, A. I. (2014) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-12-164 · Cited by 373
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
Sun, L., Suo, C., Li, S., Zhang, H., & Gao, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.005 · Cited by 374
Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?
Rajilić-Stojanović, M., Jonkers, D. M., Salonen, A., Hanevik, K., Raes, J., Jalanka, J., de Vos, W. M., Manichanh, C., Golic, N., Enck, P., et al. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.427 · Cited by 359
The Crosstalk between the Gut Microbiota and Mitochondria during Exercise
Clark, A. P., & Mach, N. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00319 · Cited by 345
Kemper, J. K., Xiao, Z., Ponugoti, B., Miao, J., Fang, S., Kanamaluru, D., Tsang, S., Wu, S.-Y., Chiang, C.-M., & Veenstra, T. D. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.009 · Cited by 332
Conjugated Bile Acids Activate the Sphingosine–1–Phosphate Receptor 2 in Primary Rodent Hepatocytes
Studer, E. J., Zhou, X., Zhao, R., Wang, Y., Takabe, K., Nagahashi, M., Pandak, W. M., Dent, P., Spiegel, S., Shi, R., et al. (2011) · Hepatology · doi:10.1002/hep.24681 · Cited by 327
Self-citationRidlon, J. M., Ikegawa, S., Alves, J. M. P., Zhou, B., Kobayashi, A., Iida, T., Mitamura, K., Tanabe, G., Serrano, M., De Guzman, A., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m038869 · Cited by 319
Self-citationBile Acids as Regulators of Hepatic Lipid and Glucose Metabolism
Trauner, M. A., Claudel, T., Fickert, P., Moustafa, T., & Wagner, M. (2010) · Digestive Diseases · doi:10.1159/000282091 · Cited by 310
Gut microbial metabolites in depression: understanding the biochemical mechanisms
Caspani, G., Kennedy, S. H., Foster, J. A., & Swann, J. R. (2019) · Microbial Cell · doi:10.15698/mic2019.10.693 · Cited by 289
Anticancer steroids: linking natural and semi-synthetic compounds
Salvador, J. A. R., Carvalho, J. F. S., Neves, M. A. C., Silvestre, S., Leitão, A. J., Silva, M. M., & Melo, M. L. S. E. (2012) · Natural Product Reports · doi:10.1039/c2np20082a · Cited by 283
García‐Cañaveras, J. C., Donato, M. T., Castell, J. V., & Lahoz, A. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d028803 · Cited by 276
Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice
Udayappan, S. D., Mannerås-Holm, L., Chaplin, A. M. L., Belzer, C., Herrema, H., Dallinga‐Thie, G. M., Duncan, S. H., Stroes, E. S. G., Groen, A. K., Flint, H. J., et al. (2016) · npj Biofilms and Microbiomes · doi:10.1038/npjbiofilms.2016.9 · Cited by 269
Pellicciari, R., Gioiello, A., Macchiarulo, A., Thomas, C., Rosatelli, E., Natalini, B., Sardella, R., Pruzanski, M., Roda, A., Pastorini, E., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm901390p · Cited by 269
Quinn, M., McMillin, M., Galindo, C., Frampton, G., Pae, H. Y., & DeMorrow, S. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.01.159 · Cited by 259
Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
Bjork, J. A., Butenhoff, J. L., & Wallace, K. B. (2011) · Toxicology · doi:10.1016/j.tox.2011.06.012 · Cited by 266
Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis
Xie, G., Wang, X., Huang, F., Zhao, A., Chen, W., Yan, J., Zhang, Y., Lei, S., Ge, K., Zheng, X., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30219 · Cited by 252
The therapeutic potential of chemical chaperones in protein folding diseases
Cortez, L. M., & Sim, V. L. (2014) · Prion · doi:10.4161/pri.28938 · Cited by 254
Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
Ding, L., Chang, M., Guo, Y., Zhang, L., Xue, C., Yanagita, T., Zhang, T., & Wang, Y. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0939-6 · Cited by 250
Hersoug, L., Möller, P., & Loft, S. H. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422417000269 · Cited by 253
Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242
Wang, Y., Aoki, H., Yang, J., Peng, K., Liu, R., Li, X., Qiang, X., Sun, L., Gurley, E. C., Lai, G., et al. (2017) · Hepatology · doi:10.1002/hep.29076 · Cited by 241
Self-citationKusaczuk, M. (2019) · Cells · doi:10.3390/cells8121471 · Cited by 250
Bile acid metabolism and signalling in liver disease
Fuchs, C. D., Simbrunner, B., Baumgartner, M., Campbell, C., Reiberger, T., & Trauner, M. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.09.032 · Cited by 265
Copple, B. L., & Li, T. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.007 · Cited by 238
Developmental origins of NAFLD: a womb with a clue
Wesolowski, S. R., Kasmi, K. C. E., Jonscher, K. R., & Friedman, J. E. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.160 · Cited by 239
Nutritional Keys for Intestinal Barrier Modulation
De Santis, S., Cavalcanti, E., Mastronardi, M., Jirillo, E., & Chieppa, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00612 · Cited by 232
Molecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion
Parker, H. E., Wallis, K., le Roux, C. W., Wong, K. Y., Reimann, F. M., & Gribble, F. M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01561.x · Cited by 234
Li, T., Matozel, M., Boehme, S., Kong, B., Nilsson, L.-M., Guo, G. L., Ellis, E. C. S., & Chiang, J. Y. L. (2010) · Hepatology · doi:10.1002/hep.24107 · Cited by 225
Nagahashi, M., Takabe, K., Liu, R., Peng, K., Wang, X., Wang, Y., Hait, N. C., Wang, X., Allegood, J. C., Yamada, A., et al. (2014) · Hepatology · doi:10.1002/hep.27592 · Cited by 211
Self-citationMolecular Pathogenesis of NASH
Caligiuri, A., Gentilini, A., & Marra, F. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091575 · Cited by 219
Impact of Gut Microbiota on Host Glycemic Control
Gérard, C., & Vidal, H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00029 · Cited by 220
The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics
Ridlon, J. M., & Bajaj, J. S. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.006 · Cited by 210
Bile acids in the colon, from healthy to cytotoxic molecules
Barrasa, J. I., Olmo, N., Lizarbe, M. A., & Turnay, J. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.12.020 · Cited by 210
Whole cereal grains and potential health effects: Involvement of the gut microbiota
Gong, L., Cao, W., Chi, H., Wang, J., Zhang, H., Liu, J., & Sun, B. (2017) · Food Research International · doi:10.1016/j.foodres.2017.10.025 · Cited by 207
Qi, Y., Jiang, C., Cheng, J., Krausz, K. W., Li, T., Ferrell, J. M., Gonzalez, F. J., & Chiang, J. Y. L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.04.008 · Cited by 209
Novel insight into mechanisms of cholestatic liver injury
Woolbright, B. L. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i36.4985 · Cited by 202
Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy
Ma, J., Zhou, Q., & Li, H. (2017) · Nutrients · doi:10.3390/nu9101124 · Cited by 197
Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption
Xie, G., Zhong, W. H., Li, H., Li, Q., Qiu, Y., Zheng, X., Chen, H., Zhao, X., Zhang, S., Zhou, Z., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-231860 · Cited by 194
Liver X Receptors in Atherosclerosis and Inflammation
Im, S., & Osborne, T. F. (2011) · Circulation Research · doi:10.1161/circresaha.110.226878 · Cited by 199
Wada, M., Tamura, A., Takahashi, N., & Tsukita, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.035 · Cited by 185
Ohtani, N., & Kawada, N. (2019) · Hepatology Communications · doi:10.1002/hep4.1331 · Cited by 187
Uriarte, I., Fernandez-Barrena, M. G., Monte, M., Latasa, M., Chang, H. C. Y., Carotti, S., Vespasiani-Gentilucci, U., Morini, S., Vicente, E., Concepcion, A., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302945 · Cited by 196
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
Harach, T., Pols, T. W. H., Nomura, M., Maida, A., 渡辺, 光., Auwerx, J. H., & Schoonjans, K. (2012) · Scientific Reports · doi:10.1038/srep00430 · Cited by 183
Intestinal microbiota and type 2 diabetes: From mechanism insights to therapeutic perspective
Han, J.-L., & Lin, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17737 · Cited by 188
Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism
Frazier, K., & Chang, E. B. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.013 · Cited by 171
The role of the gut microbiome in chronic liver disease: the clinical evidence revised
Schwenger, K. J. P., Clermont‐Dejean, N. M., & Allard, J. P. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.04.004 · Cited by 179
Role of taurine in the pathogenesis of obesity
Murakami, S. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500067 · Cited by 181
Sterol Regulation of Metabolism, Homeostasis, and Development
Wollam, J., & Antebi, A. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-081308-165917 · Cited by 172
Xiao, S., Liu, C., Chen, M., Zou, J., Zhang, Z., Cui, X., Jiang, S., Shang, E., Qian, D., & Duan, J. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10174-w · Cited by 167
Kida, T., Tsubosaka, Y., Hori, M., Ozaki, H., & Murata, T. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301565 · Cited by 174
Ahmad, N. N., Pfalzer, A., & Kaplan, L. M. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.38 · Cited by 163
Wenniger, L. J. M. D. B., & Beuers, U. H. (2010) · Digestive and Liver Disease · doi:10.1016/j.dld.2010.03.015 · Cited by 161
Cyphert, H. A., Ge, X., Kohan, A. B., Salati, L. M., Zhang, Y., & Hillgartner, F. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.375907 · Cited by 162
Ke, X., Walker, A., Haange, S., Lagkouvardos, I., Liu, Y., Schmitt‐Kopplin, P., von Bergen�, M., Jehmlich, N., He, X., Clavel, T., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.01.012 · Cited by 168
Mafra, D., Lobo, J. C., Barros, A. F. H., Koppe, L., Vaziri, N. D., & Fouque, D. P. (2014) · Future Microbiology · doi:10.2217/fmb.13.165 · Cited by 159
Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease
Sultan, S., El‐Mowafy, M., Elgaml, A., Ahmed, T. A., Hassan, H., & Mottawea, W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715506 · Cited by 170
Understanding the role of the gut ecosystem in diabetes mellitus
Aw, W., & Fukuda, S. (2017) · Journal of Diabetes Investigation · doi:10.1111/jdi.12673 · Cited by 158
Bile Acids Regulate Cardiovascular Function
Khurana, S., Raufman, J., & Pallone, T. L. (2011) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2011.00272.x · Cited by 153
Takagi, S., Nakajima, M., Kida, K., Yamaura, Y., Fukami, T., & Yokoi, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085431 · Cited by 158
The role of bile acids in metabolic regulation
Vítek, L., & Haluzík, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0469 · Cited by 157
Relationship of Non-alcoholic Fatty Liver Disease With Cholecystectomy in the US Population
Ruhl, C. E., & Everhart, J. E. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.70 · Cited by 149
Wolfe, A. R., Thomas, A., Edwards, G., Jaseja, R., Guo, G. L., & Apte, U. M. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.179390 · Cited by 145
Feng, P., Ye, Z., Kakade, A., Virk, A. K., Li, X., & Liu, P. (2018) · Nutrients · doi:10.3390/nu11010022 · Cited by 151
Masyuk, A. I., Huang, B. Q., Radtke, B. N., Gajdos, G. B., Splinter, P. L., Masyuk, T. V., Gradilone, S. A., & LaRusso, N. F. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2012 · Cited by 143
Kumar, D. P., Asgharpour, A., Mirshahi, F., Park, S. H., Liu, S., Imai, Y., Nadler, J. L., Grider, J. R., Murthy, K. S., & Sanyal, A. J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.699504 · Cited by 150
Acarbose improves health and lifespan in aging HET3 mice
Harrison, D. E., Strong, R., Alavez, S., Astle, C. M., DiGiovanni, J., Fernández, E., Flurkey, K., Garratt, M., Gelfond, J., Javors, M. A., et al. (2019) · Aging Cell · doi:10.1111/acel.12898 · Cited by 140
Kortner, T. M., Gu, J., Krogdahl, Å., & Bakke, A. M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002024 · Cited by 142
Wang, D. Q. ‐. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9952 · Cited by 138
Microbial Metabolites Determine Host Health and the Status of Some Diseases
Sittipo, P., Shim, J., & Lee, Y. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215296 · Cited by 146
Metadata
- Authors
- Hylemon, P. B., Zhou, H., Pandak, W. M., Ren, S., Gil, G., & Dent, P.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Hylemon, Phillip B.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 50
- Issue
- 8
- Pages
- 1509-1520
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC2724047
- OpenAlex
- W2165877587
- Cited by
- 694
- References
- 99
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 37 · 2023: 40 · 2022: 43 · 2021: 51 · 2020: 37 · 2019: 52 · 2018: 36 · 2017: 43 · 2016: 43 · 2015: 50 · 2014: 50 · 2013: 46 · 2012: 39
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK52825, R01DK052825, DK-057543, R01DK057543)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- bile acids, bile acid signaling, farnesoid X receptor, pregnane X receptor, vitamin D receptor, TGR5, c-Jun N-terminal kinase, Akt signaling, ERK signaling, hepatic lipid metabolism, hepatic glucose metabolism, nutrient sensing, serum triglycerides, bile acid transport, energy metabolism
- MeSH terms
- Animals, Bile, Bile Acids and Salts, Digestion, Enterohepatic Circulation, Fibroblast Growth Factors, Humans, Liver, Signal Transduction, Receptors, Cytoplasmic and Nuclear, Gastrointestinal Tract, Receptors, G-Protein-Coupled
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
