The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Inflammatory Bowel Disease and the Apical Junctional Complex
Abstract
Abstract: A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the underlying interstitium. This intestinal barrier is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised in a number of intestinal diseases, including inflammatory bowel disease (IBD).In vitro studies have demonstrated that proinflammatory cytokines, such as interferon‐gamma (IFN‐γ) and tumor necrosis factor‐alpha (TNF‐α), that are increased in the intestinal mucosa of patients with IBD can induce a leaky mucosal barrier. There is a growing evidence that the increased permeability and altered AJC structure observed in IBD are mediated by internalization of junctional proteins. This review summarizes barrier defects observed in IBD and addresses mechanisms by which proinflammatory cytokines, such as IFN‐γ and TNF‐α, modulate AJC structure and epithelial barrier function.
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Citations
Cites
Inflammatory bowel disease: Etiology and pathogenesis
Fiocchi, C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70381-6 · Cited by 2,059
Intestinal permeability and the prediction of relapse in Crohn's disease
Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H. (1993) · The Lancet · doi:10.1016/0140-6736(93)90882-h · Cited by 626
Control of nonmuscle myosins by phosphorylation
Tan, J. L., Ravid, S., & Spudich, J. A. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.003445 · Cited by 353
Irvine, E. J., & Marshall, J. K. (2000) · Gastroenterology · doi:10.1053/gast.2000.20231 · Cited by 286
Ivanov, A. I., Nusrat, A., & Parkos, C. A. (2004) · Novartis Foundation Symposia · doi:10.1002/0470090480.ch9 · Cited by 103
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Cited by
Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00327.2009 · Cited by 676
Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function
Ewaschuk, J. B., Diaz, H., Meddings, L., Diederichs, B., Dmytrash, A., Backer, J., Looijer-van Langen, M., & Madsen, K. L. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90227.2008 · Cited by 590
Anderson, R. C., Cookson, A. L., McNabb, W. C., Park, Z., McCann, M. J., Kelly, W. J., & Roy, N. C. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-316 · Cited by 510
Landy, J., Ronde, E., English, N., Clark, S. K., Hart, A. L., Knight, S. C., Ciclitira, P. J., & Al-Hassi, H. O. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i11.3117 · Cited by 507
Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia
Vanheel, H., Vicario, M., Vanuytsel, T., Van Oudenhove, L., Martinez, C., Keita, Å. V., Pardon, N., Santos, J., Söderholm, J. D., Tack, J., et al. (2014) · Gut · doi:10.1136/gutjnl-2012-303857 · Cited by 424
Metadata
- Authors
- BRUEWER, M., SAMARIN, S., & NUSRAT, A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2006-08
- Volume
- 1072
- Issue
- 1
- Pages
- 242-252
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2091457240
- Cited by
- 223
- References
- 5
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- BRUEWER, M., SAMARIN, S., & NUSRAT, A. (2006). Inflammatory Bowel Disease and the Apical Junctional Complex. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1326.017
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
