Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

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Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

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Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

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Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

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Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein claudin-1 transcription

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Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

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Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells

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Occludin: Structure, function and regulation

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Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis

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Claudin-2, a component of the tight junction, forms a paracellular water channel

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Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism

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Epithelial Tight Junctions in Intestinal Inflammation

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Barriers built on claudins

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A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

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Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

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The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

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Biology of claudins

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Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function

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The tight junction in inflammatory disease: communication breakdown

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Tight junction, selective permeability, and related diseases

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Quercetin Enhances Epithelial Barrier Function and Increases Claudin-4 Expression in Caco-2 Cells3

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Junctions gone bad: Claudins and loss of the barrier in cancer

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