Medication-related clinical decision support in computerized provider order entry systems: a review
Open accessAbstract
While medications can improve patients' health, the process of prescribing them is complex and error prone, and medication errors cause many preventable injuries. Computer provider order entry (CPOE) with clinical decision support (CDS), can improve patient safety and lower medication-related costs. To realize the medication-related benefits of CDS within CPOE, one must overcome significant challenges. Healthcare organizations implementing CPOE must understand what classes of CDS their CPOE systems can support, assure that clinical knowledge underlying their CDS systems is reasonable, and appropriately represent electronic patient data. These issues often influence to what extent an institution will succeed with its CPOE implementation and achieve its desired goals. Medication-related decision support is probably best introduced into healthcare organizations in two stages, basic and advanced. Basic decision support includes drug-allergy checking, basic dosing guidance, formulary decision support, duplicate therapy checking, and drug-drug interaction checking. Advanced decision support includes dosing support for renal insufficiency and geriatric patients, guidance for medication-related laboratory testing, drug-pregnancy checking, and drug-disease contraindication checking. In this paper, the authors outline some of the challenges associated with both basic and advanced decision support and discuss how those challenges might be addressed. The authors conclude with summary recommendations for delivering effective medication-related clinical decision support addressed to healthcare organizations, application and knowledge base vendors, policy makers, and researchers.
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Medication-related CDS is especially useful.
“and medication-related CDS is especially useful. 2”
From Overrides of medication-related clinical decision support alerts in outpatients (2014) · cites this paper as [2]
The complexities of prescribing CDSSs and current technology mean most organizations will probably gain only moderate benefits from implementing such systems.
“The complexities relating to CDSSs for prescribing and the state of current technology means that most organizations will probably only realize moderate benefits from the implementation of such systems.4”
From Computerized clinical decision support for prescribing: provision does not guarantee uptake (2010) · cites this paper as [4]
The challenge of implementing effective decision support for prescribing, and specifically alert fatigue, is international.
“Our study was UK-based, although the challenge of implementing effective decision support for prescribing, and specifically the problem of alert fatigue, is international.12 24 50”
From ‘Too much, too late’: mixed methods multi-channel video recording study of computerized decision support systems and GP prescribing (2013) · cites this paper as [12]
Excessive alerts, especially when procedural and cost information are added to safety alerts, may be counterproductive because they cause user fatigue.
“excessive alerts, exacerbated in contemporary practice when procedural information and cost advice are provided in addition to safety alerts, may be counterproductive as they lead to user fatigue.12 20”
From ‘Too much, too late’: mixed methods multi-channel video recording study of computerized decision support systems and GP prescribing (2013) · cites this paper as [12]
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Clinician collaboration to improve clinical decision support: the Clickbusters initiative
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- Authors
- Kuperman, G. J., Bobb, A., Payne, T. H., Avery, A. J., Gandhi, T. K., Burns, G., Classen, D. C., & Bates, D. W.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Kuperman, G. J.
- Venue
- Journal of the American Medical Informatics Association
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-01-01
- Volume
- 14
- Issue
- 1
- Pages
- 29-40
- ISSN
- 1067-5027 (ISSN-L)
- 1527-974X
- PMC
- PMC2215064
- OpenAlex
- W2128124510
- Cited by
- 763
- References
- 68
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 18 · 2023: 24 · 2022: 34 · 2021: 41 · 2020: 39 · 2019: 34 · 2018: 31 · 2017: 35 · 2016: 42 · 2015: 51 · 2014: 44 · 2013: 69 · 2012: 47
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Medical Informatics Association (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
- Keywords
- computerized physician order entry, medication errors, patient safety, clinical knowledge base, CPOE implementation
- MeSH terms
- Contraindications, Drug Therapy, Computer-Assisted, Pharmaceutical Preparations, Formularies as Topic, Humans, Medication Errors, Medication Systems, Hospital, Decision Support Systems, Clinical, Medical Order Entry Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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