Cited by 763Electronic Health Records SystemsPharmaceutical Practices and Patient OutcomesPatient Safety and Medication Errors

Medication-related clinical decision support in computerized provider order entry systems: a review

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Kuperman, G. J., Bobb, A., Payne, T. H., Avery, A. J., Gandhi, T. K., Burns, G., Classen, D. C., Bates, D. W.·2007·Journal of the American Medical Informatics Association

Abstract

While medications can improve patients' health, the process of prescribing them is complex and error prone, and medication errors cause many preventable injuries. Computer provider order entry (CPOE) with clinical decision support (CDS), can improve patient safety and lower medication-related costs. To realize the medication-related benefits of CDS within CPOE, one must overcome significant challenges. Healthcare organizations implementing CPOE must understand what classes of CDS their CPOE systems can support, assure that clinical knowledge underlying their CDS systems is reasonable, and appropriately represent electronic patient data. These issues often influence to what extent an institution will succeed with its CPOE implementation and achieve its desired goals. Medication-related decision support is probably best introduced into healthcare organizations in two stages, basic and advanced. Basic decision support includes drug-allergy checking, basic dosing guidance, formulary decision support, duplicate therapy checking, and drug-drug interaction checking. Advanced decision support includes dosing support for renal insufficiency and geriatric patients, guidance for medication-related laboratory testing, drug-pregnancy checking, and drug-disease contraindication checking. In this paper, the authors outline some of the challenges associated with both basic and advanced decision support and discuss how those challenges might be addressed. The authors conclude with summary recommendations for delivering effective medication-related clinical decision support addressed to healthcare organizations, application and knowledge base vendors, policy makers, and researchers.

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  1. Joint Formulary Committee. British National Formulary 49th Edition. London, British Medical Association and Royal Phar- maceutical Society of Great Britain: 2005.
  2. Sipila J, Klaukka T, Martikainen J, Himberg JJ. Occurrence of potentially harmful drug combinations among Finish primary care patients. International Pharmacy Journal. 1995;9:104 -10.

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Authors
Kuperman, G. J., Bobb, A., Payne, T. H., Avery, A. J., Gandhi, T. K., Burns, G., Classen, D. C., & Bates, D. W.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Kuperman, G. J.
Venue
Journal of the American Medical Informatics Association
Published
2007-01-01
Volume
14
Issue
1
Pages
29-40
ISSN
  • 1067-5027 (ISSN-L)
  • 1527-974X
OpenAlex
W2128124510
Cited by
763
References
68
Citations by year
2026: 10 · 2025: 25 · 2024: 18 · 2023: 24 · 2022: 34 · 2021: 41 · 2020: 39 · 2019: 34 · 2018: 31 · 2017: 35 · 2016: 42 · 2015: 51 · 2014: 44 · 2013: 69 · 2012: 47
FWCI
6.64
Type
journal article
Language
en
Open access
Locations
  • Journal of the American Medical Informatics Association (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
  • Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
Keywords
computerized physician order entry, medication errors, patient safety, clinical knowledge base, CPOE implementation
MeSH terms
Contraindications, Drug Therapy, Computer-Assisted, Pharmaceutical Preparations, Formularies as Topic, Humans, Medication Errors, Medication Systems, Hospital, Decision Support Systems, Clinical, Medical Order Entry Systems

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