The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Long-Term Outcomes in Patients With Muscle-Invasive Bladder Cancer After Selective Bladder-Preserving Combined-Modality Therapy: A Pooled Analysis of Radiation Therapy Oncology Group Protocols 8802, 8903, 9506, 9706, 9906, and 0233
Open accessAbstract
Purpose: Multiple prospective Radiation Therapy Oncology Group (RTOG) protocols have evaluated bladder-preserving combined-modality therapy (CMT) for muscle-invasive bladder cancer (MIBC), reserving cystectomy for salvage treatment. We performed a pooled analysis of long-term outcomes in patients with MIBC enrolled across multiple studies. Patients and Methods: Four hundred sixty-eight patients with MIBC were enrolled onto six RTOG bladder-preservation studies, including five phase II studies (RTOG 8802, 9506, 9706, 9906, and 0233) and one phase III study (RTOG 8903). Overall survival (OS) was estimated using the Kaplan-Meier method, and disease-specific survival (DSS), muscle-invasive and non–muscle-invasive local failure (LF), and distant metastasis (DM) were estimated by the cumulative incidence method. Results: The median age of patients was 66 years (range, 34 to 93 years), and clinical T stage was T2 in 61%, T3 in 35%, and T4a in 4% of patients. Complete response to CMT was documented in 69% of patients. With a median follow-up of 4.3 years among all patients and 7.8 years among survivors (n = 205), the 5- and 10-year OS rates were 57% and 36%, respectively, and the 5- and 10-year DSS rates were 71% and 65%, respectively. The 5- and 10-year estimates of muscle-invasive LF, non–muscle-invasive LF, and DM were 13% and 14%, 31% and 36%, and 31% and 35%, respectively. Conclusion: This pooled analysis of multicenter, prospective RTOG bladder-preserving CMT protocols demonstrates long-term DSS comparable to modern immediate cystectomy studies, for patients with similarly staged MIBC. Given the low incidence of late recurrences with long-term follow-up, CMT can be considered as an alternative to radical cystectomy, especially in elderly patients not well suited for surgery.
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Cites
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Self-citationCYSTECTOMY FOR BLADDER CANCER: A CONTEMPORARY SERIES
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Self-citationDyrskjøt, L., Hansel, D. E., Efstathiou, J. A., Knowles, M. A., Galsky, M. D., Teoh, J., & Theodorescu, D. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00468-9 · Cited by 544
Self-citationCurrent best practice for bladder cancer: a narrative review of diagnostics and treatments
Compérat, E., Amin, M. B., Cathomas, R., Choudhury, A., De Santis, M., Kamat, A., Stenzl, A., Thoeny, H. C., & Witjes, J. A. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01188-6 · Cited by 435
Kulkarni, G. S., Hermanns, T., Wei, Y., Bhindi, B., Satkunasivam, R., Athanasopoulos, P., Bostrom, P. J., Kuk, C., Li, K., Templeton, A. J., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.69.2327 · Cited by 313
Metadata
- Authors
- Mak, R. H., Hunt, D., Shipley, W. U., Efstathiou, J. A., Tester, W. J., Hagan, M. P., Kaufman, D. S., Heney, N. M., & Zietman, A. L.
- Venue
- Journal of Clinical Oncology
- Published
- 2014-12-01
- Volume
- 32
- Issue
- 34
- Pages
- 3801-3809
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2118328604
- Cited by
- 465
- References
- 19
- FWCI
- 34.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mak, R. H., Hunt, D., Shipley, W. U., Efstathiou, J. A., Tester, W. J., Hagan, M. P., Kaufman, D. S., Heney, N. M., & Zietman, A. L. (2014). Long-Term Outcomes in Patients With Muscle-Invasive Bladder Cancer After Selective Bladder-Preserving Combined-Modality Therapy: A Pooled Analysis of Radiation Therapy Oncology Group Protocols 8802, 8903, 9506, 9706, 9906, and 0233. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2014.57.5548
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