The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Delivery of Small Interfering RNA to Inhibit Vascular Endothelial Growth Factor in Zebrafish Using Natural Brain Endothelia Cell-Secreted Exosome Nanovesicles for the Treatment of Brain Cancer
Abstract
Although small interfering RNA (siRNA) holds great therapeutic promise, its delivery to the disease site remains a paramount obstacle. In this study, we tested whether brain endothelial cell-derived exosomes could deliver siRNA across the blood-brain barrier (BBB) in zebrafish. Natural exosomes were isolated from brain endothelial bEND.3 cell culture media and vascular endothelial growth factor (VEGF) siRNA was loaded in exosomes with the assistance of a transfection reagent. While fluorescence-activated cell flow cytometry and immunocytochemistry staining studies indicated that wild-type exosomes significantly increased the uptake of fluorescence-labeled siRNA in the autologous brain endothelial cells, decreased fluorescence intensity was observed in the cells treated with the tetraspanin CD63 antibody-blocked exosome-delivered formulation (p < 0.05). In the transport study, exosomes also enhanced the permeability of rhodamine 123 in a co-cultured monolayer of brain endothelial bEND.3 cell and astrocyte. Inhibition at the expression of VEGF RNA and protein levels was observed in glioblastoma-astrocytoma U-87 MG cells treated with exosome-delivered siRNAs. Imaging results showed that exosome delivered more siRNAs across the BBB in Tg(fli1:GFP) zebrafish. In a xenotransplanted brain tumor model, exosome-delivered VEGF siRNAs decreased the fluorescence intensity of labeled cancer cells in the brain of zebrafish. Brain endothelial cell-derived exosomes could be potentially used as a natural carrier for the brain delivery of exogenous siRNA.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Some natural cell membranes such as exosomes without any functionalization have ability to cross the BBB.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [361]
Citations
Cites
The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)
Westerfield, M. (1995) · Medical Entomology and Zoology · Cited by 6,813
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
Exosomes – vesicular carriers for intercellular communication
Simons, M., & Raposo, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.03.007 · Cited by 2,410
Vlassov, A. V., Magdaleno, S. M., Setterquist, R. A., & Conrad, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.017 · Cited by 1,984
Delivery materials for siRNA therapeutics
Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800
Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579
Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356
Interfering with disease: a progress report on siRNA-based therapeutics
de Fougerolles, A., Vornlocher, H., Maraganore, J. M., & Lieberman, J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2310 · Cited by 1,223
Pardridge, W. M. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2006.10.013 · Cited by 1,191
Cited by
Sorted by citations
Items 101–200 of 204
Extracellular Vesicles as Drug Delivery System for Cancer Therapy
Wang, J., Yin, B., Lian, J., & Wang, X. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16081029 · Cited by 33
Targeting endothelial exosomes for the prevention of cardiovascular disease
Jia, G., & Sowers, J. R. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165833 · Cited by 32
Drug delivery approaches for HuR-targeted therapy for lung cancer
Raguraman, R., Shanmugarama, S., Mehta, M., Peterson, J. E. G., Zhao, Y. D., Munshi, A., & Ramesh, R. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114068 · Cited by 35
Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles
Jurgielewicz, B. J., Stice, S. L., & Yao, Y. (2021) · Aging and Disease · doi:10.14336/ad.2021.0708 · Cited by 32
What we know on the potential use of exosomes for nanodelivery
Logozzi, M., Raimo, R. D., Mizzoni, D., & Fais, S. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.09.005 · Cited by 32
Delivering therapeutic RNA into the brain using extracellular vesicles
Shirmast, P., Shahri, M. A., Brent, A., Idris, A., & McMillan, N. A. J. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102373 · Cited by 32
Extracellular vesicle-mediated nucleic acid transfer and reprogramming in the tumor microenvironment
Parayath, N. N., Padmakumar, S., & Amiji, M. M. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.009 · Cited by 31
The potential of exosomes as a new therapeutic strategy for glioblastoma
Silva, L. C., Branco, F., Cunha, J., Vitorino, C., Gomes, C. M. F., Carrascal, M. A., Falcão, A. C., Neves, B. M., & Cruz, M. T. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114460 · Cited by 28
The novel target:exosoms derived from M2 macrophage
Hou, Y., Liu, Y., Liang, S., Ding, R., Mo, S., Yan, D., & Li, D. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1800687 · Cited by 27
Exosome as a Natural Gene Delivery Vector for Cancer Treatment
Pofali, P., Mondal, A., & Londhe, V. Y. (2020) · Current Cancer Drug Targets · doi:10.2174/1568009620666200924154149 · Cited by 28
Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer
Kugeratski, F. G., McAndrews, K. M., & Kalluri, R. (2021) · Endocrinology · doi:10.1210/endocr/bqaa250 · Cited by 27
The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer
Zhao, Z., Zhao, G., Yang, S., Zhu, S., Zhang, S., & Li, P. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02059-8 · Cited by 29
Exosomes and Brain Metastases: A Review on Their Role and Potential Applications
Oliveira, F. D., Castanho, M. A. R. B., & Neves, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910899 · Cited by 30
Nanocarriers Call the Last Shot in the Treatment of Brain Cancers
Mehrabian, A., Mashreghi, M., Dadpour, S., Badiee, A., Arabi, L., Alavizadeh, S. H., Moosavian, S. A., & Jaafari, M. R. (2022) · Technology in Cancer Research & Treatment · doi:10.1177/15330338221080974 · Cited by 32
Extracellular vesicles as central regulators of blood vessel function in cancer
Kugeratski, F. G., Santi, A., & Zanivan, S. R. (2022) · Science Signaling · doi:10.1126/scisignal.aaz4742 · Cited by 31
Therapeutic potentials of short interfering RNAs
Tam, C., Wong, J. H., Cheung, R. C. F., Zuo, T., & Ng, T. B. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8433-z · Cited by 27
Harnessing the therapeutic potential of extracellular vesicles for cancer treatment
Zhang, Y., Xiao, Y., Sun, G., Jin, X., Guo, L., Li, T., & Yin, H. H. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.001 · Cited by 27
Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases
Ji, W., Li, Y., Peng, H., Zhao, R., & Zhang, X. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114029 · Cited by 27
Yang, T., Curtis, S., Bai, A., Young, A., Derosier, D., Ripley, S., & Bai, S. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.113103 · Cited by 27
Self-citationWen, L., Wen, C., Zhang, F., Wang, K., Yuan, H., & Hu, F. (2020) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2020.102218 · Cited by 26
RNAi-Based Approaches for Pancreatic Cancer Therapy
Kim, M. J., Chang, H., Nam, G., Ko, Y., Kim, S. H., Roberts, T. M., & Ryu, J. H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101638 · Cited by 25
Saleem, S., & Kannan, R. R. (2021) · Nanoscale Research Letters · doi:10.1186/s11671-021-03592-1 · Cited by 25
Wu, X., Meng, Y., Yao, Z., Lin, X., Hu, M., Cai, S., Gao, S., & Zhang, H. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107751 · Cited by 28
Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis
Nag, S., Bhattacharya, B., Dutta, S., Mandal, D., Mukherjee, S., Anand, K., Eswaramoorthy, R., Thorat, N. D., Jha, S. K., & Gorai, S. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00212 · Cited by 24
Exosomes: Traversing the blood-brain barrier and their therapeutic potential in brain cancer
Zhang, X., Artz, N., Steindler, D. A., Hingtgen, S., & Satterlee, A. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189300 · Cited by 25
Programmable DNA Nanodevices for Applications in Neuroscience
Hivare, P., Panda, C., Gupta, S. K., & Bhatia, D. D. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00723 · Cited by 21
Exosome Mediated Cancer Therapeutic Approach:Present Status and Future Prospectives
Roy, A., Girija, A. S. S., Ganesh, P. S., Saravanan, M., & Sunny, B. C. (2023) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2023.24.2.363 · Cited by 23
An update in the applications of exosomes in cancer theranostics: from research to clinical trials
Shahraki, K., Boroumand, P. G., Lotfi, H., Radnia, F., Shahriari, H., Sargazi, S., Mortazavi, S. S., Shirvaliloo, M., Shirvalilou, S., & Sheervalilou, R. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04701-6 · Cited by 27
Cellular organelles as drug carriers for disease treatment
Hu, J., Liu, Y., Du, Y., Peng, X., & Liu, Z. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.038 · Cited by 22
Luisotti, L., Germelli, L., Piccarducci, R., Giacomelli, C., Marchetti, L., & Martini, C. (2025) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2025.33 · Cited by 23
Application of Extracellular Vesicles in Aquatic Animals: A Review of the Latest Decade
Zhao, N., Deng, Q., Zhu, C., & Zhang, B. (2021) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2021.1985429 · Cited by 23
Strategies for Engineering Exosomes and Their Applications in Drug Delivery
Zhu, M., Li, S., Li, S., Wang, H., Xu, J., Wang, Y., & Liang, G. (2021) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2021.3196 · Cited by 21
Kim, J., Hwang, Y. H., Nam, G., & Kim, I.-S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114462 · Cited by 27
Current advancements in self-assembling nanocarriers-based siRNA delivery for cancer therapy
Kandasamy, G., & Maity, D. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.113002 · Cited by 22
Ivosevic, Z., Ljujić, B., Pavlovic, D., Matovic, V., & Gazdic, M. (2023) · Cell Transplantation · doi:10.1177/09636897231207194 · Cited by 23
Jurj, A. M., Paul, D., & Călin, G. A. (2025) · BMC Cancer · doi:10.1186/s12885-025-14375-7 · Cited by 24
The Role of Extracellular Vesicles in Colorectal Cancer
Xia, Y., Yu, C., Helwig, E. J., & Li, Y. (2023) · Technology in Cancer Research & Treatment · doi:10.1177/15330338231185008 · Cited by 18
Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics
Pauwels, M. J., Xie, J., Ceroi, A., Balusu, S., Castelein, J., Wonterghem, E. V., Imschoot, G. V., Ward, A., Menheniott, T. R., Gustafsson, O., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121830 · Cited by 19
Extracellular vesicle-mediated drug delivery in breast cancer theranostics
Abdul‐Rahman, T., Roy, P., Herrera‐Calderón, R. E., Khidri, F. F., Omotesho, Q. A., Rumide, T. S., Fatima, M., Roy, S., Awuah, W. A., Atallah, O., et al. (2024) · Discover Oncology · doi:10.1007/s12672-024-01007-y · Cited by 17
Nanovesicles based drug targeting to control tumor growth and metastasis
Ansari, A., Hussain, A., Wadekar, R. R., Altamimi, M. A., Malik, A., Mujtaba, M. A., Ansari, M. Y., Siddique, M. U. M., & Goyal, S. N. (2022) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2022.100083 · Cited by 16
Progress in characterizing ABC multidrug transporters in zebrafish
Thomas, J. R., Frye, W. J. E., Robey, R. W., & Gottesman, M. M. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101035 · Cited by 15
Glioma-Derived Exosomes and Their Application as Drug Nanoparticles
Mastantuono, S., Manini, I., Loreto, C. D., Beltrami, A. P., Vindigni, M., & Cesselli, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312524 · Cited by 17
RNA Drug Delivery Using Biogenic Nanovehicles for Cancer Therapy
Li, N., Sun, Y., Fu, Y., & Sun, K. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.734443 · Cited by 15
Gonadotropin Releasing Hormone (GnRH) Triggers Neurogenesis in the Hypothalamus of Adult Zebrafish
Ceriani, R., & Whitlock, K. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115926 · Cited by 13
Nanoparticles-Based Oligonucleotides Delivery in Cancer: Role of Zebrafish as Animal Model
Bozzer, S., Bo, M. D., Toffoli, G., Macor, P., & Capolla, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081106 · Cited by 13
Efficacy of Polymer-Based Nanomedicine for the Treatment of Brain Cancer
Naki, T., & Aderibigbe, B. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051048 · Cited by 14
Exosomes: Their role in the diagnosis, progression, metastasis, and treatment of glioblastoma
Mousavikia, S. N., Darvish, L., Toossi, M. T. B., & Azimian, H. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122743 · Cited by 14
The Importance of Small Extracellular Vesicles in the Cerebral Metastatic Process
Tămaș, F., Bălașa, R., Manu, D. R., Gyorki, G., Chinezu, R., Tămaș, C., & Bălașa, A. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031449 · Cited by 12
Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors
Mehkri, Y., Woodford, S. J., Pierre, K., Dagra, A., Hernandez, J. S., Siyanaki, M. R. H., Azab, M. A., & Lucke-Wold, B. P. (2022) · Current Oncology · doi:10.3390/curroncol29110696 · Cited by 12
Advances in Intranasal Delivery of Exosomes for Central Nervous System Disorders
Arjmand, B., Mojavezi, A. R., Kamroo, A., Yazdi, R. K., Rezaei–Tavirani, M., & Vahedi, M.-S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05563-4 · Cited by 12
Construction of microfluidic blood–brain barrier model assisted by 3D coculture on cellulose fiber
Duong, D. D., Kwak, J., Song, H. S., & Lee, N. Y. (2021) · Microsystem Technologies · doi:10.1007/s00542-020-05197-7 · Cited by 10
Cui, H., Liu, Y., Yu, Y., Lv, D., Ma, S., Gao, M., Yang, Y., Yuan, C., Liu, Y., & Wang, C. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124782 · Cited by 10
Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors
Sharma, S., Rana, R., Prakash, P., & Ganguly, N. K. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04715-1 · Cited by 10
Yu, Y., Wang, L. Y., Liu, Y., Cui, H., Yuan, C., & Wang, C. X. (2024) · Pharmaceutical Research · doi:10.1007/s11095-024-03670-w · Cited by 10
Unlocking the Potential of Circulating miRNAs as Biomarkers in Glioblastoma
Suvarnapathaki, S., Serrano-Farias, A., Dudley, J. C., Bettegowda, C., & Rincón-Torroella, J. (2024) · Life · doi:10.3390/life14101312 · Cited by 10
Salim, M. W., Zhang, W., Collins‐Praino, L. E., Wang, Y., & Care, A. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202504608 · Cited by 8
Gou, Z., Yang, H., Wang, R., Wang, S., Chen, Q., Liu, Z., & Zhang, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116443 · Cited by 8
Cancer Therapy Empowered by Extracellular Vesicle-Mediated Targeted Delivery
Chen, Y., Huang, Y., Deng, Y., Liu, X., Ye, J., Li, Q., Luo, Y., Lin, Y., Liang, R., Wei, J., et al. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b23-00378 · Cited by 8
Biorobotic Drug Delivery for Biomedical Applications
Le, Q., & Shim, G. (2024) · Molecules · doi:10.3390/molecules29153663 · Cited by 7
Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation
Ramon, J., Pinheiro, C., Vandendriessche, C., Lozano−Andrés, E., Keersmaecker, H. D., Punj, D., Fraire, J. C., Geeurickx, E., Wauben, M. H. M., Vader, P., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03640-3 · Cited by 9
Atia, G. A. N., Abdeen, A., Taher, E. S., Alghonemy, W. Y., Nashar, E. M. E., Al-Zahrani, N. S., Elmorsy, E. M., Khanday, S., Alshambky, A., Taymour, N., et al. (2025) · Phytotherapy Research · doi:10.1002/ptr.70040 · Cited by 7
Khan, F. B., Shahab Uddin, M. S., Elderdery, A. Y., Goh, K. W., Ming, L. C., Ardianto, C., Palakkott, A. R., Anwar, I., Khan, M., Owais, M., et al. (2022) · Cells · doi:10.3390/cells11223664 · Cited by 6
Kögel, D., Temme, A., & Aigner, A. M. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108762 · Cited by 7
Applications of engineered exosomes in drugging noncoding RNAs for cancer therapy
Alemi, F., Sadeghsoltani, F., Fattah, K., Hassanpour, P., Malakoti, F., Kardeh, S., Izadpanah, M., Zuccari, D. A. P. D. C., Yousefi, B., & Majidinia, M. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14300 · Cited by 6
Unveiling the hidden role of extracellular vesicles in brain metastases: a comprehensive review
Li, J., Lu, S., Chen, F., & Zhu, H. Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1388574 · Cited by 7
Singh, J. P., Saini, G., Singh, B., & Tiwari, G. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/0122117385306281240427073651 · Cited by 5
Microbial Nanoparticles for Cancer Treatment
Alshehri, A. A., Almughem, F. A., Aldossary, A. M., Tawfik, E. A., Alfahad, A. J., Alyahya, S. A., & Alomary, M. N. (2021) · Springer eBooks · doi:10.1007/978-981-16-1923-6_11 · Cited by 5
Geeva, & Narayan, S. (2022) · Materials Research Innovations · doi:10.1080/14328917.2021.2023288 · Cited by 5
Tarannum, S., & Jain, K. (2023) · Springer eBooks · doi:10.1007/978-981-99-6807-7_16 · Cited by 5
Youssef, J. R., Elgammal, E. M., Mahdy, D. M., Ghazi, N., & Bebawy, G. (2026) · Pharmaceutical Research · doi:10.1007/s11095-026-04095-3 · Cited by 6
Li, W., Wang, C., & Lu, Y. (2024) · Nano Research · doi:10.1007/s12274-024-6729-8 · Cited by 5
Exploiting Exosomes for Cancer Diagnosis and Treatment
Kugeratski, F. G., & Kalluri, R. (2023) · Current cancer research · doi:10.1007/978-3-031-22903-9_3 · Cited by 4
Heendeniya, S. N., Chen, S., Bhatti, S. H., Zahra, Q. U. A., Rahimizadeh, K., Poudel, B. H., Wilton, S. D., & Veedu, R. N. (2025) · Experimental Biology and Medicine · doi:10.3389/ebm.2025.10784 · Cited by 3
Extracellular Vesicles: “Stealth Transport Aircrafts” for Drugs
Liu, C., Lin, X., & Su, C. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.94502 · Cited by 3
Delivering RNA through exosomes for cancer therapy
Zhao, T., & Wang, J. (2025) · Journal of Nanoparticle Research · doi:10.1007/s11051-025-06281-7 · Cited by 2
Kale, A., Randhave, N. V., Patil, D., Wagh, B., Setia, A., Malik, A. K., Vaishali, & Muthu, M. S. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c01185 · Cited by 2
Biological Characteristics of Exosomes and Their Applications in Aquatic Organisms
Tang, H., Zhao, X., & Gong, Y. (2026) · The FASEB Journal · doi:10.1096/fj.202504196r · Cited by 2
Zebrafish (Danio rerio) as a Viable Model to Study the Blood-Brain Barrier
Yang, T., & Bai, S. (2018) · Neuromethods · doi:10.1007/978-1-4939-8946-1_11 · Cited by 2
Self-citationZebrafish as a Versatile Model for Cancer Research
Jindal, S., Allawadhi, P., Sinha, S., Khurana, A., Bharani, K. K., & Gopinath, P. (2022) · Springer eBooks · doi:10.1007/978-981-16-5217-2_7 · Cited by 3
Extracellular Vesicles: The Challenges on the Way and Engineering Perspectives
Attia, N., Ibrahim, H. G., Abdulla, H., Mashal, M., Puras, G., & Pedraz, J. L. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_56 · Cited by 1
Colangelo, T., Saponaro, A. A., Mazzoccoli, G., Serviddio, G., & Villani, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411826 · Cited by 1
Biomedical Applications of Medicinal Plant Extracellular Vesicles: Recent Advancements and Prospects
Lin, Z., Wu, J., Xu, G., Zhu, J., Wan, H., & He, Y. T. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101616 · Cited by 2
Yang, T., Canham, S., Kaserman, E., More, M., & Bai, S. (2026) · Journal of Microencapsulation · doi:10.1080/02652048.2026.2676311 · Cited by 1
Self-citationExosomes as novel nanocarriers for cancer therapy
Li, J., Zan, J., Xu, Z., Yang, C., Han, X., Huang, S., Xu, H., & Zhen, Y. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106262 · Cited by 2
Exosomes for Drug Delivery Applications in Cancer and Cardiac Indications
Pandya, A., Pulakkat, S., & Patravale, V. B. (2022) · Methods and principles in medicinal chemistry · doi:10.1002/9783527827855.ch8 · Cited by 1
Metastatic brain tumor models and drug brain penetration analysis
Li, Y. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814704-7.00008-8
Extracellular vesicles in tumor immunotherapy
Li, J., Stephens, E. N., & Zhang, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85781-9.00009-9 · Cited by 1
The Role of Exosomes in Tumor Metastasis
Li, W., Peng, S., Aich, P., Ciou, J.-M., & Lin, Y.-K. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_69-1
Extracellular Vesicles: The Challenges on the Way and Engineering Perspectives
Attia, N., Ibrahim, H. G., Abdulla, H., Mashal, M., Puras, G., & Pedraz, J. L. (2023) · Springer eBooks · doi:10.1007/978-981-99-0846-2_56-1
Gholami, M., Morris, K., Torres, A. M., Kamal, T. T., Jahromi, B. R., Haridas, A., & Kateb, B. (2024) · Springer eBooks · doi:10.1007/978-3-030-80662-0_19
Introduction: History and development of exosomes nanovesicles
Arora, S., & Gugulothu, D. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00001-5
Exosomes in Diabetes, Cancer, and Inflammation Where Oxidative Stress Plays an Active Role
Uslu, G. A., & Uslu, H. (2025) · Physiology · doi:10.5772/intechopen.1008944
The Role of Exosomes in Tumor Metastasis
Li, W., Peng, S., Aich, P., Ciou, J.-M., & Lin, Y.-K. (2025) · Springer eBooks · doi:10.1007/978-3-032-00759-9_69
Wu, J., Li, Y.-J., Wang, J., Hu, X., Huang, S., Luo, S., & 向大雄 (2021) · Figshare · doi:10.6084/m9.figshare.17133043
Ajami, H., Soheili, M., Shirazi, A. S., Torkashvand, H., More, M., Shcherbakova, N., & Kohan, H. G. (2026) · AAPS Open · doi:10.1186/s41120-025-00142-2
Mechanisms of Extracellular Vesicle Cargo Delivery
Askarian‐Amiri, S. (2023) · theses.fr (ABES) · doi:10.70675/7fc22cfaz56eez4b3aza652z01d13ba8b908
Engineered and Targeted Exosomes for Cancer Therapy: Recent Preclinical Advances
Mussin, N. M., Zhilisbayeva, K. R., Baspakova, A. M., & Tamadon, A. (2025) · West Kazakhstan Regenerative Medicine Journal · doi:10.4103/wkrj.wkrj_6_26
Xu, B., Yang, H., Chen, K. X., Wang, L., Fan, J., 杜垬, Guo, W., Ruan, R. R., Yan, X., Yin, Y., et al. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.108979
Wang, S., Li, J., Yang, B., Li, M., Yu, M., Zhang, P., Bai, S., & Zeng, X. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1886218
Self-citation
Metadata
- Authors
- Yang, T., Fogarty, B., LaForge, B., Aziz, S., Pham, T., Lai, L., & Bai, S.
- Affiliations
- Husson University (US)
- Nova Southeastern University (US)
- Corresponding author
- Bai, Shuhua
- Venue
- The AAPS Journal
- Published
- 2016-11-23
- Volume
- 19
- Issue
- 2
- Pages
- 475-486
- ISSN
- 1550-7416 (ISSN-L)
- OpenAlex
- W2552099798
- Cited by
- 204
- References
- 52
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 24 · 2023: 27 · 2022: 29 · 2021: 40 · 2020: 22 · 2019: 16 · 2018: 11 · 2017: 5
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The AAPS Journal (publishedVersion)
- PubMed (publishedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Funders
- Husson University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, siRNA delivery, vascular endothelial growth factor, blood-brain barrier, brain endothelial cells, glioblastoma, brain cancer, CD63, bEnd.3 cells, zebrafish xenograft, U87 cells, astrocytes, tetraspanins
- MeSH terms
- Animals, Astrocytes, Blood-Brain Barrier, Brain, Brain Neoplasms, Humans, Transfection, Zebrafish, Gene Transfer Techniques, Coculture Techniques, RNA, Small Interfering, Vascular Endothelial Growth Factor A, Endothelial Cells, Cell Line, Tumor, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review