No QTc prolongation in girls and women with Turner syndrome
Open accessAbstract
CONTEXT: Turner syndrome (TS) is a genetic condition that is reported to be associated with a prolonged rate-corrected QT (QTc) interval. OBJECTIVES: To evaluate the prevalence of QTc prolongation in patients with TS, to compare their QTc intervals with healthy controls, and to investigate whether QTc prolongation is associated with a monosomy 45,X karyotype. METHOD: Girls (n = 101) and women (n = 251) with TS visiting our center from 2004-2018 were included in this cross-sectional study. QT intervals of 12-leaded electrocardiograms were measured manually, using Bazett's and Hodges formulas to correct for heart rate. A QTc interval of >450 ms for girls and >460 ms for women was considered prolonged. Corrected QT (QTc) intervals of patients with TS were compared to the QTc intervals of healthy girls and women from the same age groups derived from the literature. RESULTS: In total, 5% of the population with TS had a prolonged QTc interval using Bazett's formula and 0% using Hodges formula. Mean QTc intervals of these patients were not prolonged compared with the QTc interval of healthy individuals from the literature. Girls showed shorter mean QTc intervals compared with women. We found no association between monosomy 45,X and prolongation of the QTc interval. CONCLUSIONS: This study shows that the QTc interval in girls and women with TS is not prolonged compared with the general population derived from the literature, using both Bazett's and Hodges formulas. Furthermore, girls show shorter QTc intervals compared with women, and a monosomy 45,X karyotype is not associated with QTc prolongation.
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There is no documented association between QTc prolongation in persons with TS and sudden cardiac death.
“Importantly, there is no documented association between QTc prolongation in persons with TS and sudden cardiac death.491,493,494”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [493]
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Cites
Practical Statistics for Medical Research
Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668 · see citing works
Corrado, D., Pelliccia, A., Björnstad, H. H., Vanhees, L., Biffi, A., Börjesson, M., Panhuyzen-Goedkoop, N. M., Deligiannis, A. P., Solberg, E. E., Dugmore, D., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi108 · Cited by 1,101 · see citing works
Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., Lin, A. E., Mauras, N., Quigley, C. A., Rubin, K., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0430 · Cited by 1,101 · see citing works
Drug induced QT prolongation and torsades de pointes
Yap, Y. G., & Camm, A. J. (2003) · Heart · doi:10.1136/heart.89.11.1363 · Cited by 958 · see citing works
Prescott, E., & On behalf of the Danish task force (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl342 · Cited by 875 · see citing works
Drew, B. J., Ackerman, M. J., Funk, M., Gibler, W. B., Kligfield, P., Menon, V., Philippides, G. J., Roden, D. M., & Zareba, W. (2010) · Circulation · doi:10.1161/circulationaha.109.192704 · Cited by 821 · see citing works
Normal ECG standards for infants and children
Davignon, A., Rautaharju, P. M., Boisselle, E., Soumis, F., Mégélas, M., & Choquette, A. (1980) · Pediatric Cardiology · doi:10.1007/bf02083144 · Cited by 553 · see citing works
Luo, S., Michler, K., Johnston, P., & Macfarlane, P. W. (2004) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2004.08.030 · Cited by 454 · see citing works
AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram
Rautaharju, P. M., Surawicz, B., & Gettes, L. S. (2009) · Circulation · doi:10.1161/circulationaha.108.191096 · Cited by 412 · see citing works
New normal limits for the paediatric electrocardiogram
Rijnbeek, P. R. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2399 · Cited by 400 · see citing works
Congenital heart disease in patients with Turner’s syndrome
Mazzanti, L., & CACCIARI, E. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70119-2 · Cited by 261 · see citing works
Bazett's QT correction reviewed : Evidence that a linear QT correction for heart rate is better
Hodges, M. (1983) · Journal of the American College of Cardiology · Cited by 198 · see citing works
Normal values of the electrocardiogram for ages 16–90 years
Rijnbeek, P. R., van Herpen, G., Bots, M. L., Man, S., Verweij, N., Albert Hofman, D., Hillege, H. L., Numans, M. E., Swenne, C. A., Witteman, J. C. M., et al. (2014) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2014.07.022 · Cited by 196 · see citing works
The QT interval: too long, too short or just right.
Viskin, S. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.02.044 · Cited by 177 · see citing works
The Turner syndrome life course project: karyotype-phenotype analyses across the lifespan
Cameron‐ Pimblett, A., La Rosa, C., King, T. F. J., Davies, M. C., & Conway, G. S. (2017) · Clinical Endocrinology · doi:10.1111/cen.13394 · Cited by 161 · see citing works
Sex Hormones and the QT Interval: A Review
Sedlak, T., SHUFELT, C. L., Iribarren, C., & Merz, C. N. B. (2012) · Journal of Women s Health · doi:10.1089/jwh.2011.3444 · Cited by 148 · see citing works
Short QT Interval Prevalence and Clinical Outcomes in a Pediatric Population
Guerrier, K., Kwiatkowski, D. M., Czosek, R. J., Spar, D. S., Anderson, J. B., & Knilans, T. K. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003256 · Cited by 70 · see citing works
Recent Advances in Short QT Syndrome
Campuzano, Ó., Sarquella-Brugada, G., César, S., Arbelo, E., Brugada, J., & Brugada, R. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00149 · Cited by 69 · see citing works
Bondy, C. A., Ceniceros, I., Van, P. L., Bakalov, V. K., & Rosing, D. R. (2006) · PEDIATRICS · doi:10.1542/peds.2006-0776 · Cited by 59 · see citing works
Freriks, K., Timmers, H. J. L. M., Netea-Maier, R. T., Beerendonk, C. C. M., Otten, B. J., van der Velden, J. A. E. M., Traas, M. A. F., Mieloo, H., van de Zande, G. W. H. J. F., Hoefsloot, L. H., et al. (2013) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2013.07.008 · Cited by 59 · see citing works
Prolongation of the cardiac QTc interval in Turner syndrome
Bondy, C. A., Van, P. L., Bakalov, V. K., Sachdev, V., Malone, C. A., Ho, V. B., & Rosing, D. R. (2006) · Medicine · doi:10.1097/01.md.0000205629.16302.bc · Cited by 55 · see citing works
Moore-Palhares, D., Marcolino, M. S., Santos, T. M. M., da Silva, J. L. P., Gomes, P. R., Ribeiro, L. B., Macfarlane, P. W., & Ribeiro, A. L. P. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0572-8 · Cited by 54 · see citing works
Patel, P. J., Borovskiy, Y., Killian, A. J., Verdino, R. J., Epstein, A. E., Callans, D. J., Marchlinski, F. E., & Deo, R. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.11.008 · Cited by 49 · see citing works
The relation between QT interval and T-wave variables in hypertensive patients
Mozos, I. M., & Serban, C. (2011) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.84433 · Cited by 48 · see citing works
Long QT Interval in Turner Syndrome – A High Prevalence of LQTS Gene Mutations
Trolle, C., Mortensen, K. H., Pedersen, L. N., Berglund, A., Jensen, H. K., Andersen, N. H., & Gravholt, C. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069614 · Cited by 39 · see citing works
Noordman, I., Duijnhouwer, A., Kapusta, L., Kempers, M., Roeleveld, N., Schokking, M., Smeets, D., Freriks, K., Timmers, H., & van Alfen-van der Velden, J. (2018) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2018.01.004 · Cited by 35 · see citing works
Atrial and ventricular arryhthmogenic potential in Turner syndrome
SOZEN, A. B., CEFLE, K., KUDAT, H., OZTURK, S., OFLAZ, H., PAMUKCU, B., AKKAYA, V., ISGUVEN, P., PALANDUZ, S., OZCAN, M., et al. (2008) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2008.01154.x · Cited by 25 · see citing works
QTc interval prolongation in children with Ulrich-Turner syndrome
Pozza, R. D., Bechtold, S. M., Kääb, S., Buckl, M., Urschel, S., Netz, H., & Schwarz, H. (2006) · European Journal of Pediatrics · doi:10.1007/s00431-006-0194-0 · Cited by 20 · see citing works
Pozza, R. D., Bechtold, S. M., Urschel, S., Netz, H., & Schwarz, H. (2008) · European Journal of Pediatrics · doi:10.1007/s00431-008-0709-y · Cited by 17 · see citing works
Evaluation of QT interval correction methods in normal pediatric resting ECGs
Qiu, H., Bird, G. L., Qu, L., Vetter, V. L., & White, P. S. (2007) · Computers in cardiology · doi:10.1109/cic.2007.4745514 · Cited by 16 · see citing works
Independent Influence of Blood Pressure on QTc Interval: Results from a General Chinese Population
Sun, G., Zhou, Y., Ye, N., Wu, S., & Sun, Y.-X. (2019) · BioMed Research International · doi:10.1155/2019/1656123 · Cited by 16 · see citing works
Nielsen, D. G., Nielsen, J. C., Trolle, C., Gravholt, C. H., & Andersen, N. H. (2017) · Clinical Case Reports · doi:10.1002/ccr3.802 · Cited by 11 · see citing works
Evaluation of the Tp−Te Interval, Tp-e/QTc ratio and QT Dispersion in Patients with Turner Syndrome
Atıcı, A. (2018) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2018.98250 · Cited by 11 · see citing works
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2 of the 35 references couldn’t be matched to a known paper.
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- [13]Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 1920; 7: 353– 370.
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224 · see citing works
The changing face of Turner syndrome
Gravholt, C. H., Viuff, M., Just, J., Sandahl, K., Brun, S., van der Velden, J., Andersen, N. H., & Skakkebaek, A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac016 · Cited by 149 · see citing works
Fiot, E., Alauze, B., Donadille, B., Samara‐Boustani, D., Houang, M., FILIPPO, G. D., Bachelot, A., Delcour, C., Beyler, C., Bois, E., et al. (2022) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-022-02423-5 · Cited by 49 · see citing works
Donadille, B., & Christin‐Maître, S. (2020) · Annales d Endocrinologie · doi:10.1016/j.ando.2020.12.004 · Cited by 26 · see citing works
Sexual Dimorphisms, Anti-Hormonal Therapy and Cardiac Arrhythmias
Grouthier, V., Moey, M. Y. Y., Gandjbakhch, E., Waintraub, X., Funck-Brentano, C., Bachelot, A., & Salem, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031464 · Cited by 19 · see citing works
Noordman, I. D., Fejzic, Z., Bos, M., Duijnhouwer, A. L., Weijers, G., Kempers, M., Merkx, R., van der Velden, J. A. E. M., & Kapusta, L. (2021) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62259 · Cited by 15 · see citing works
Self-citationGroote, K. D., Patel, S. R., Mortensen, K. H., Witvrouwen, I., Duijnhouwer, A. L., Brown, N. M., Grewal, J., Chatfield, K. C., Dorfman, A. T., & Prakash, S. K. (2025) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.32139 · Cited by 6 · see citing works
Benayon, M., Latchupatula, L., Kacer, E. R., Shanjer, M., Weiss, E., Amar, S., Zweig, N., Ghadim, M. M., Portman, R., Balakrishnan, N., et al. (2023) · CJC Pediatric and Congenital Heart Disease · doi:10.1016/j.cjcpc.2023.09.010 · Cited by 5 · see citing works
Zaitoon, H., Kapusta, L., Israeli, G., Segev‐Becker, A., Beer, G., Lowenthal, A., Yaeger-Yarom, G., Oren, A., & Perl, L. (2025) · International Journal of Transgender Health · doi:10.1080/26895269.2025.2503219 · Cited by 2 · see citing works
Poudel, J., Rimal, M., Giri, A., Chikatimalla, R., Banker, H., Trivedi, Y. V., Gupta, S., & Jain, R. (2026) · Southern Medical Journal · doi:10.14423/smj.0000000000001921 · Cited by 1 · see citing works
(Arrhythmogenic potential in Turner syndrome patients)
Kaprálová, S., Pavlíček, J., Palátová, A., Vrtěl, R., Tomášková, H., Zapletalová, J., & Klásková, E. (2023) · Cor et Vasa · doi:10.33678/cor.2023.036
Prediction evaluation of the Tp-Te interval in patients with vasovagal syncope
Zhang, X., Dai, S., Wang, H., Jiang, R., Xie, Q., Wen, J., Han, M. J., Xu, Y., & Wang, G. (2025) · Clinical Autonomic Research · doi:10.1007/s10286-025-01148-2
Hu, F., Wang, Y., Chen, Y., Xu, X., Ding, Y., Ying, L., Zhang, Q., Wang, L., Zhang, Y., Chen, L., et al. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-04137-w
- Authors
- Noordman, I. D., Duijnhouwer, A. L., Coert, M., Bos, M., Kempers, M., Timmers, H. J. L. M., Fejzic, Z., van der Velden, J. A. E. M., & Kapusta, L.
- Affiliations
- Radboud University Medical Center (NL)
- Leiden University Medical Center (NL)
- Department of Pediatric Endocrinology, Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, The Netherlands
- Tel Aviv University (IL)
- Corresponding author
- Noordman, Iris D
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2020-08-24
- Volume
- 105
- Issue
- 11
- Pages
- e4148-e4156
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC7518463
- OpenAlex
- W3080704704
- Cited by
- 13
- References
- 35
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- Turner syndrome, QTc prolongation, sex differences, Bazett formula, Hodges formula, electrocardiogram, cardiac repolarization
- MeSH terms
- Adolescent, Adult, Aged, Child, Child, Preschool, Cross-Sectional Studies, Electrocardiography, Female, Heart Rate, Humans, Infant, Long QT Syndrome, Middle Aged, Turner Syndrome, Comorbidity, Prevalence, Young Adult
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