Cited by 911Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesPituitary Gland Disorders and Treatments

The DOI matches its Crossref record; 260 of the 260 references it cites were found in a registry or an index.

Human Growth Hormone and Human Aging

CORPAS, EMILIANO, HARMAN, S. MITCHELL, BLACKMAN, MARC R.·1993·Endocrine Reviews

DOI 10.1210/edrv-14-1-20

Open this paper in CoChat — free account

Abstract

UNTIL recently, there has been little scientific inquiry into the physiological significance of, and possible therapy for, GH deficiency in adulthood. This was because the lack of efficacy in humans of animal-derived (e.g.1 bovine or porcine) GH and the limited supply of human cadaveric GH restricted use of exogenous GH to treatment of GHdeficient children. The availability of recombinant human GH (rhGH) has led to a renewal of scientific and clinical interest in investigating wider indications for GH administration. It is now recognized that GH deficiency may exert adverse metabolic effects in adults with panhypopituitarism, and that these effects can be reversed or attenuated by treatment with rhGH (1, 2). Recently, it has also become apparent that, with advancing age, an increasing proportion of men and women with no clinical evidence of pituitary pathology show decreases in GH secretion and serum levels of insulin-like growth factor-I (IGF-I) (3, 4). Because GH deficiency (1, 2) and normal aging (5) are both associated with decreases in protein synthesis and percent of lean body and bone mass, and with increases in percent of body fat, it is possible that reduced GH secretion and IGF-I levels might account, at least in part, for one or more of the above effects of aging, and that some older people might benefit from treatment with rhGH. In this regard, in several recent studies, administration of rhGH for periods varying from a few weeks to 6 months has resulted in improvements in nitrogen balance, an increase in lean body mass, and a decrease in percent body fat in older persons with low IGF-I levels (3, 4, 6, 7). We review herein the published work describing the alterations in GH and IGF-I production with increasing age, and the methods, benefits, and risks of GH treatment of older persons in the light of new knowledge regarding basic physiology of GH secretion and action. We also attempt to point out areas requiring further investigations.

Integrity signals

Registry

Crossref · 10.1210/edrv-14-1-20

Cites

260 of 260 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Brazeau, P., Vale, W., Burgus, R. C., LING, N. C., Butcher, M., Rivier, J., & Guillemin, R. (1973) · Science · doi:10.1126/science.179.4068.77 · Cited by 3,536
Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
de Vos, A. M., Ultsch, M. H., & Kossiakoff, A. A. (1992) · Science · doi:10.1126/science.1549776 · Cited by 2,237
Premature mortality due to cardiovascular disease in hypopituitarism
Rosén, T., & Bengtsson, B.-Å. (1990) · The Lancet · doi:10.1016/0140-6736(90)91812-o · Cited by 1,402
The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency
Salomon, F., Cuneo, R. C., Hesp, R., & Sönksen, P. H. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912283212605 · Cited by 1,326
Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis.
Riggs, B. L., Wahner, H. W., Dunn, W. L., Mazess, R. B., Offord, K. P., & Melton, L. J. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110039 · Cited by 1,194
Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.
D’Ercole, A. J., Stiles, A. D., & Underwood, L. E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.3.935 · Cited by 1,179
BENEFICIAL EFFECTS OF GROWTH HORMONE TREATMENT IN GH-DEFICIENT ADULTS
Jørgensen, J. O. L., Thuesen, L., Ingemann-Hansen, T., Pedersen, S. A., Jørgensen, I., Skakkebæk, N. E., & Christiansen, J. S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92328-3 · Cited by 889
Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary
Berelowitz, M., Szabó, M., Frohman, L. A., Firestone, S. L., Chu, L., & Hintz, R. L. (1981) · Science · doi:10.1126/science.6262917 · Cited by 829
Inhibition of Access of Bound Somatomedin to Membrane Receptor and Immunobinding Sites: A Comparison of Radioreceptor and Radioimmunoassay of Somatomedin in Native and Acid-Ethanol-Extracted Serum*
Daughaday, W. H., MARIZ, I. K., & Blethen, S. L. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-4-781 · Cited by 733
An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.
ELGIN, R. G., Busby, W. H., & Clemmons, D. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3254 · Cited by 685

Show all 260 references

Sorted by citations

Items 101–200 of 910

Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men
Rudman, D. R., Drinka, P. J., Wilsont, C. R., Mattson, D. E., Scherman, F., Cuisinier, M. C., & Schultz, S. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb03018.x · Cited by 133
Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132
How growth hormone controls growth, obesity and sexual dimorphism
Lichanska, A. M., & Waters, M. J. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.10.006 · Cited by 128
Effects of 7 Years of Growth Hormone Replacement Therapy in Hypopituitary Adults
Chrisoulidou, A., Beshyah, S., Rutherford, O. M., Spinks, T. J., Mayet, J., Kyd, P., Anyaoku, V., Haida, A., Ariff, B., Murphy, M. C., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6910 · Cited by 127
Growth hormone signaling pathways
Carter‐Su, C., Schwartz, J., & Argetsinger, L. S. (2015) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2015.09.002 · Cited by 125
The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis
Graceli, J. B., Dettogni, R. S., Merlo, E., Niño, O. M. S., da Costa, C. S., Zanol, J. F., Rios-Morris, E., Miranda‐Alves, L., & Denicol, A. C. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110997 · Cited by 124
Life Span Extension by Reduction in Growth Hormone-Insulin-Like Growth Factor-1 Axis in a Transgenic Rat Model
Shimokawa, I., Higami, Y., Utsuyama, M., Tuchiya, T., Komatsu, T., Chiba, T., & Yamaza, H. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61173-x · Cited by 122
Does growth hormone prevent or accelerate aging?
Bartke, A., Brown‐Borg, H. M., Bode, A. M., Carlson, J. C., Hunter, W. S., & Bronson, R. T. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00032-1 · Cited by 119
Ghrelin and immunity: A young player in an old field
Dixit, V. D., & Taub, D. D. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.003 · Cited by 117
Role of Hormones in the Pathogenesis and Management of Sarcopenia
Kamel, H. K., Maas, D. L., & Duthie, E. H. (2002) · Drugs & Aging · doi:10.2165/00002512-200219110-00004 · Cited by 116
Circulating Levels of Insulin-Like Growth Factor (IGF) Binding Protein-1 and -3 in Aging Men: Relationships to Insulin, Glucose, IGF, and Dehydroepiandrosterone Sulfate Levels and Anthropometric Measures
Benbassat, C. A., Maki, K. C., & Unterman, T. G. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3930 · Cited by 116
Growth Hormone Replacement Therapy Improves Body Composition and Increases Bone Metabolism in Elderly Patients with Pituitary Disease
Fernholm, R., Bramnert, M., Hägg, E., Hilding, A., Baylink, D. J., Mohan, S., & Thorén, M. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6949 · Cited by 116
Influence of insulin-like growth factor-1 and leptin on bone mass in healthy postmenopausal women
Martini, G., Valenti, R., Giovani, S., Franci, B., Campagna, S., & Nuti, R. (2001) · Bone · doi:10.1016/s8756-3282(00)00408-7 · Cited by 114
Panorama of dissolving microneedles for transdermal drug delivery
Dalvi, M., Kharat, P., Thakor, P., Bhavana, V., Singh, S. B., & Mehra, N. K. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119877 · Cited by 113
Stimuli-sensitive hydrogels: ideal carriers for chronobiology and chronotherapy
Peppas, N. A., & Leobandung, W. (2004) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856204322793539 · Cited by 112
Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer?
Holly, J., Gunnell, D., & Smith, G. D. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620321 · Cited by 111
Delayed Aging in Ames Dwarf Mice. Relationships to Endocrine Function and Body Size
Bartke, A. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48003-7_10 · Cited by 109
Elderly Patients with Adult-Onset Growth Hormone Deficiency Are Not Osteopenic
Toogood, A. A., Adams, J. E., O'Neill, P. A., & Shalet, S. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3932 · Cited by 106
Age, Sex, and Smoking Are Predictors of Circulating Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor–Binding Protein 3
Kaklamani, V., Linos, A., Kaklamani, E., Markaki, I., & Mantzoros, C. S. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.3.813 · Cited by 106
Interactions between serum leptin, the insulin‐like growth factor‐I system, and sex, age, anthropometric and body composition variables in a healthy population randomly selected
Gómez, J. M., Maravall, F. J., Gómez, N., Navarro, M. A., Casamitjana, R., & Soler, J. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01698.x · Cited by 105
Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women
Allen, N. E., Appleby, P. N., Kaaks, R., Rinaldi, S., Davey, G. K., & Key, T. J. (2003) · Cancer Causes & Control · doi:10.1023/a:1022518321634 · Cited by 104
Comparison of GH, IGF-I, and testosterone with mRNA of receptors and myostatin in skeletal muscle in older men
MARCELL, T. J., Harman, S. M., Urban, R. J., Metz, D. D., Rodgers, B. D., & Blackman, M. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1159 · Cited by 103
Self-citation
Gene Expression Profile of the Aging Process in Rat Liver: Normalizing Effects of Growth Hormone Replacement
Tollet‐Egnell, P., Flores‐Morales, A., Ståhlberg, N., Malek, R. L., Lee, N., & Norstedt, G. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.2.0594 · Cited by 103
GH and IGF1: Roles in Energy Metabolism of Long-Living GH Mutant Mice
Brown‐Borg, H. M., & Bartke, A. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls086 · Cited by 102
Dehydroepiandrosterone sulfate and longevity: New clues for an old friend
Yen, S. S. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161278698 · Cited by 102
Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement
Maghnie, M., Aimaretti, G., Bellone, S., Bona, G., Bellone, J., Baldelli, R., de Sanctis, C., Gargantini, L., Gastaldi, R., Ghizzoni, L., et al. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01873 · Cited by 101
Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning
Ramsey, M. M., Weiner, J. L., Moore, T. P., Carter, C. S., & Sonntag, W. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.001 · Cited by 101
Periplasmic production via the pET expression system of soluble, bioactive human growth hormone
Sockolosky, J. T., & Szoka, F. C. (2012) · Protein Expression and Purification · doi:10.1016/j.pep.2012.11.002 · Cited by 101
Aging, Resistance Training, and Diabetes Prevention
Flack, K. D., Davy, K. P., Hulver, M. W., Winett, R. A., Frisard, M. I., & Davy, B. M. (2010) · Journal of Aging Research · doi:10.4061/2011/127315 · Cited by 101
Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults
Giustina, A., Barkan, A. L., Chanson, P., Grossman, A. B., Hoffman, A. R., Ghigo, E., Casanueva, F. F., Colao, A., Lamberts, S. W. J., Sheppard, M., et al. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03349263 · Cited by 98
Effect of Severe Growth Hormone (GH) Deficiency due to a Mutation in the GH-Releasing Hormone Receptor on Insulin-Like Growth Factors (IGFs), IGF-Binding Proteins, and Ternary Complex Formation Throughout Life
Aguiar-Oliveira, M. H., Gill, M. S., de, E. S., Barretto, A., Alcântara, M. R. S., Miraki‐Moud, F., Menezes, C. A., Souza, A. H. O., Martinelli, C. E., Pereira, F. A. C., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6133 · Cited by 98
Growth Hormone Administration and Exercise Effects on Muscle Fiber Type and Diameter in Moderately Frail Older People
Hennessey, J. V., Chromiak, J. A., Dellaventura, S., Reinert, S. E., Puhl, J. L., Kiel, D. P., Rosen, C. J., Vandenburgh, H. H., & MacLean, D. B. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49173.x · Cited by 98
Cholesterol and Lipoprotein Metabolism in Aging
Parini, P., Angelin, B., & Rudling, M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.832 · Cited by 97
Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles
Weilner, S., Keider, V., Winter, M., Harreither, E., Salzer, B., Weiß, F., Schraml, E., Messner, P., Pietschmann, P., Hildner, F., et al. (2016) · Aging · doi:10.18632/aging.100865 · Cited by 95
Growth Hormone-Releasing Hormone Combined with Arginine or Growth Hormone Secretagogues for the Diagnosis of Growth Hormone Deficiency in Adults
Ghigo, E., Aimaretti, G., & Arvat, E. (2001) · Endocrine · doi:10.1385/endo:15:1:029 · Cited by 94
Growth Hormone Therapy in Adults
Cummings, D. E., & Merriam, G. R. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152147 · Cited by 93
Aging and the adrenal cortex
Yen, S. S. C., & Laughlin, G. A. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00046-1 · Cited by 92
The Regulation of Growth Hormone Secretion
Ghigo, E., Arvat, E., Gianotti, L., Maccario, M., & Camanni, F. (1999) · KARGER eBooks · doi:10.1159/000061007 · Cited by 92
The GH/IGF-1 Axis and Heart Failure
Castellano, G., Affuso, F., Conza, P. D., & Fazio, S. (2009) · Current Cardiology Reviews · doi:10.2174/157340309788970306 · Cited by 91
Circulating Insulin-Like Growth Factor-1 and Its Binding Protein-3
Lam, C. S. P., Chen, M., Lacey, S. M., Yang, Q., SULLIVAN, L. M., Xanthakis, V., Safa, R., Smith, H., Peng, X., Sawyer, D. B., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.203943 · Cited by 91
Association of Insulin‐Like Growth Factor‐I with Body Composition, Weight History, and Past Health Behaviors in the Very Old: The Framingham Heart Study
Harris, T. B., Kiel, D. P., Roubenoff, R., Langlois, J. A., Hannan, M. T., Havlik, R. J., & Wilson, P. W. F. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb04497.x · Cited by 90
Growth Hormone-Releasing Peptides and Their Analogs
Camanni, F., Ghigo, E., & Arvat, E. (1998) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1997.0158 · Cited by 90
Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men
Christmas, C., O'Connor, K. G., Harman, S. M., Tobin, J. D., Münzer, T., Bellantoni, M. F., Clair, C. S., Pabst, K. M., Sorkin, J. D., & Blackman, M. R. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.1.m12 · Cited by 90
Self-citation
Decreased Estradiol Levels and Free Androgen Index and Elevated Sex Hormone-Binding Globulin Levels in Male Idiopathic Osteoporosis
Gillberg, P., Johansson, A. G., & Ljunghall, S. (1999) · Calcified Tissue International · doi:10.1007/s002239900604 · Cited by 90
Growth hormone, inflammation and aging
Masternak, M. M., & Bartke, A. (2012) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v2i0.17293 · Cited by 89
Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men
Iranmanesh, A., South, S. A., Liem, A. Y., Clemmons, D. R., Thorner, M. O., WELTMAN, A. L., & Veldhuis, J. D. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390059 · Cited by 89
Skin and brain age together: The role of hormones in the ageing process
Makrantonaki, E., Schönknecht, P., Hossini, A. M., Kaiser, E., Katsouli, M.-M., Adjaye, J., Schröder, J., & Zouboulis, C. C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.005 · Cited by 88
Relationship Between Baseline Insulin‐Like Growth Factor‐I (IGF‐I) and Femoral Bone Density in Women Aged Over 70 Years: Potential Implications for the Prevention of Age‐Related Bone Loss
Boonen, S., Lesaffre, E. M. E. H., Dequeker, J., Aerssens, J., Nijs, J., Pelemans, W., & Bouillon, R. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb01399.x · Cited by 88
Testosterone improves the regeneration of old and young mouse skeletal muscle
Serra, C., Tangherlini, F., Rudy, S., Lee, D., Toraldo, G., Sandor, N. L., Zhang, A., Jasuja, R., & Bhasin, S. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gls083 · Cited by 87
Human growth hormone and the temptations of biomedical enhancement
Conrad, P., & Potter, D. A. (2004) · Sociology of Health & Illness · doi:10.1111/j.1467-9566.2004.00386.x · Cited by 87
The skin as a mirror of the aging process in the human organism – State of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)
Makrantonaki, E., & Zouboulis, C. C. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.07.002 · Cited by 87
Effects of GHRP-2 and Hexarelin, Two Synthetic GH-Releasing Peptides, on GH, Prolactin, ACTH and Cortisol Levels in Man. Comparison with the Effects of GHRH, TRH and hCRH
Arvat, E., Vito, L. D., Maccagno, B., Broglio, F., Boghen, M. F., Deghenghi, R., Camanni, F., & Ghigo, E. (1997) · Peptides · doi:10.1016/s0196-9781(97)00016-8 · Cited by 87
Neuroendocrine Regulation of Growth Hormone Secretion in Teleost Fishes with Emphasis on the Involvement of Gonadal Sex Steroids
Holloway, A. C., & Leatherland, J. F. (1998) · Reviews in Fish Biology and Fisheries · doi:10.1023/a:1008824723747 · Cited by 87
Growth hormone and protein metabolism
Møller, N., Vendelbo, M. H., Kampmann, U., Christensen, B., Madsen, M. A., Nørrelund, H., & Jørgensen, J. O. L. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.08.015 · Cited by 86
The Association Between Sleep Duration and General and Abdominal Obesity in Koreans: Data From the Korean National Health and Nutrition Examination Survey, 2001 and 2005
Park, S. E., Kim, H. M., Kim, D. H., Kim, J., Cha, B. S., & Kim, D. J. (2009) · Obesity · doi:10.1038/oby.2008.586 · Cited by 86
Growth hormone deficiency and replacement in elderly hypopituitary adults
Monson, J. P., Abs, R., Bengtsson, B., Bennmarker, H., Feldt‐Rasmussen, U., Hernberg‐Ståhl, E., Thorén, M. C., Westberg, B., Wilton, P., & Wüster, C. C. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01104.x · Cited by 86
Effects of Hormonal Replacement Therapy on Bone Metabolism in Young Adults with Beta-thalassemia Major
Lasco, A., Morabito, N., Gaudio, A., Buemi, M., Wasniewska, M. G., & Frisina, N. (2001) · Osteoporosis International · doi:10.1007/s001980170079 · Cited by 86
Effect of training on the GH/IGF-I axis during exercise in middle-aged men: relationship to glucose homeostasis
Manetta, J., Brun, J. ‐., Maı̈moun, L., Callis, A., PREFAUT, C. G., & Mercier, J. G. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00539.2001 · Cited by 86
Effects of Exercise Training on Anabolic and Catabolic Hormones with Advanced Age: A Systematic Review
Zouhal, H., Jayavel, A., Parasuraman, K., Hayes, L. D., Tourny, C., Rhibi, F., Laher, I., Abderrahman, A. B., & Hackney, A. C. (2021) · Sports Medicine · doi:10.1007/s40279-021-01612-9 · Cited by 84
Growth hormone
Harvey, S., & Hull, K. (1997) · Endocrine · doi:10.1007/bf02801319 · Cited by 84
Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects
Arvat, E., Gianotti, L., Grottoli, S., Imbimbo, B. P., Lenaerts, V., Deghenghi, R., Camanni, F., & Ghigo, E. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962341 · Cited by 84
Short-Term Estradiol Supplementation Augments Growth Hormone (GH) Secretory Responsiveness to Dose-Varying GH-Releasing Peptide Infusions in Healthy Postmenopausal Women1
Anderson, S. M., Shah, N., Evans, W. S., Patrie, J. T., Bowers, C. Y., & Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7240 · Cited by 83
Secretion of microvesicular miRNAs in cellular and organismal aging
Weilner, S., Schraml, E., Redl, H. R., Grillari‐Voglauer, R., & Grillari, J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.017 · Cited by 82
Regulation of development and metabolism of adipose tissue by growth hormone and the insulin-like growth factor system
Louveau, I., & Gondret, F. (2004) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2004.06.004 · Cited by 82
Challenges in Detecting the Abuse of Growth Hormone in Sport
McHugh, C. M., Park, R. T., Sönksen, P. H., & Holt, R. I. G. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.047845 · Cited by 81
The influence of sleep and sleep loss upon food intake and metabolism
Crispim, C. A., Zimberg, I. Z., Dattilo, M., Padilha, H. G., Edwards, B., Waterhouse, J. M., Tufik, S., & de Mello, M. T. (2007) · Nutrition Research Reviews · doi:10.1017/s0954422407810651 · Cited by 80
Effect of Alendronate and MK-677 (a Growth Hormone Secretagogue), Individually and in Combination, on Markers of Bone Turnover and Bone Mineral Density in Postmenopausal Osteoporotic Women1
Murphy, M. G., Weiss, S., McClung, M. R., Schnitzer, T. J., Cerchio, K., Connor, J., Krupa, D. A., & Gertz, B. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7294 · Cited by 80
Chronic [D-Ala2]-growth hormone-releasing hormone administrationattenuates age-related deficits in spatial memory
Thornton, P. L., Ingram, R. L., & Sonntag, W. E. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.2.b106 · Cited by 80
Defining aging
Lemoine, M. (2020) · Biology & Philosophy · doi:10.1007/s10539-020-09765-z · Cited by 80
Immunoregulatory properties of growth hormone and prolactin
Weigent, D. A. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(96)00001-0 · Cited by 79
Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62–77 and 21–31 yr old men
Welle, S. L., Bhatt, K. S., Shah, B., & Thornton, C. A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00025-6 · Cited by 79
Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans
Perras, B., Marshall, L., Köhler, G., Jan Born, A., & Fehm, H. L. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00027-x · Cited by 78
Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats
Marzetti, E., Groban, L., Wohlgemuth, S. E., Lees, H. A., Lin, M., Jobe, H., Giovannini, S., Leeuwenburgh, C., & Carter, C. S. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00620.2007 · Cited by 77
Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies
Sonntag, W. E., Csiszár, A., de Cabo, R., Ferrucci, L., & Ungvari, Z. I. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls115 · Cited by 77
Bone Marrow Adipocytes: A Neglected Target Tissue for Growth Hormone
Gevers, E. F., Loveridge, N., & Robinson, I. C. A. F. (2002) · Endocrinology · doi:10.1210/en.2002-220428 · Cited by 77
Age-Sensitive Cognitive Function, Growth Hormone and Insulin-Like Growth Factor 1 Plasma Levels in Healthy Older Men
Aleman, A., de Vries, W. R., de Haan, E. H. F., Verhaar, H. J. J., Samson, M., & Koppeschaar, H. P. F. (2000) · Neuropsychobiology · doi:10.1159/000026636 · Cited by 76
The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat
Gómez, J. M., Maravall, F. J., Gómez, N., Navarro, M. A., Casamitjana, R., & Soler, J. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2003.11.004 · Cited by 75
Anabolic Interventions for Aging-Associated Sarcopenia
Bross, R., Javanbakht, M., & Bhasin, S. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6055 · Cited by 75
Growth Hormone Replacement Attenuates Diastolic Dysfunction and Cardiac Angiotensin II Expression in Senescent Rats
Groban, L., Pailes, N. A., Bennett, C., Carter, C. S., Chappell, M. C., Kitzman, D. W., & Sonntag, W. E. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.1.28 · Cited by 75
Skeletal muscle and aging
Navarro, A. (2001) · Frontiers in bioscience · doi:10.2741/navarro · Cited by 75
Bone metabolism and body composition in Japanese patients with active acromegaly
Kaji, H., Sugimoto, T., Nakaoka, D., Okimura, Y., Kaji, H., Abe, H., & Chihara, K. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01280.x · Cited by 74
GH and ageing: Pitfalls and new insights
Bartke, A., & Darcy, J. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.02.005 · Cited by 74
In Vivo Semiquantification of Hypothalamic Growth Hormone-Releasing Hormone (GHRH) Output in Humans: Evidence for Relative GHRH Deficiency in Aging
Russell-Aulet, M., Jaffe, C. A., DeMott-Friberg, R., & Barkan, A. L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6063 · Cited by 74
Serum Levels of Insulin-Like Growth Factor (IGF); IGF-Binding Proteins-3, -4, and -5; and Their Relationships to Bone Mineral Density and the Risk of Vertebral Fractures in Postmenopausal Women
Yamaguchi, T., Kanatani, M., Yamauchi, M., Kaji, H., Sugishita, T., Baylink, D. J., Mohan, S., Chihara, K., & Sugimoto, T. (2006) · Calcified Tissue International · doi:10.1007/s00223-005-0163-z · Cited by 74
Skeletal Involvement in Female Acromegalic Subjects: The Effects of Growth Hormone Excess in Amenorrheal and Menstruating Patients
Scillitani, A., Chiodini, I., Carnevale, V., Giannatempo, G. M., Frusciante, V., Villella, M., Pileri, M., Guglielmi, G., Giorgio, A. D., Modoni, S., et al. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.10.1729 · Cited by 74
Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat.
Rudling, M. J., Parini, P., & Angelin, B. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119398 · Cited by 74
High Diversity of the Chicken Growth Hormone Gene and Effects on Growth and Carcass Traits
Nie, Q., Sun, B., Zhang, D., Luo, C., Ishag, N. A., Lei, M., Yang, G., & Zhang, X. (2005) · Journal of Heredity · doi:10.1093/jhered/esi114 · Cited by 72
Growth hormone pulsatility profile characteristics following acute heavy resistance exercise
Nindl, B. C., Hymer, W. C., Deaver, D. R., & Kraemer, W. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.1.163 · Cited by 71
Successful 6-Month Endurance Training Does Not Alter Insulin-Like Growth Factor-I in Healthy Older Men and Women
Vitiello, M. V., Wilkinson, C. W., Merriam, G. R., Moe, K. E., Prinz, P. N., Ralph, D. D., Colasurdo, E. A., & Schwartz, R. S. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.3.m149 · Cited by 71
Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency?
den Saffele, J. K. V., Goemaere, S., Bacquer, D. D., & Kaufman, J. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00741.x · Cited by 71
Transcriptome-Wide Assessment of Human Brain and Lymphocyte Senescence
Hong, M., Myers, A., Magnusson, P. K. E., & Prince, J. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003024 · Cited by 70
The Elderly as a Sensitive Population in Environmental Exposures: Making the Case
Risher, J. F., Todd, G. D., Meyer, D., & Zunker, C. L. (2010) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4419-6406-9_2 · Cited by 70
Insulin-Like Growth Factor I
Arvat, E., Broglio, F., & Ghigo, E. (2000) · Drugs & Aging · doi:10.2165/00002512-200016010-00003 · Cited by 70
Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure
Akamizu, T., Murayama, T., Teramukai, S., Miura, K., Bando, I., Irako, T., Iwakura, H., Ariyasu, H., Hosoda, H., Tada, H., et al. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06442 · Cited by 70
Effects of single nightly injections of growth hormone—releasing hormone (GHRH 1–29) in healthy elderly men
Vittone, J. L., Blackman, M. R., Busby‐Whitehead, J., Tsiao, C., Stewart, K. J., Tobin, J., Stevens, T., Bellantoni, M. F., Rogers, M. A., Baumann, G. P., et al. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90174-8 · Cited by 70
Self-citation
Aging Thyroarytenoid and Limb Skeletal Muscle: Lessons in Contrast
Thomas, L. B., Harrison, A. L., & Stemple, J. C. (2007) · Journal of Voice · doi:10.1016/j.jvoice.2006.11.006 · Cited by 69
Growth hormone secretion in the elderly: Ageing and the somatopause
Martin, F. C., Yeo, A.-L., & Sönksen, P. H. (1997) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(97)80257-1 · Cited by 69
Blunted Growth Hormone Response to Maximal Exercise in Middle-Aged Versus Young Subjects and No Effect of Endurance Training
Zaccaria, M., Varnier, M., Piazza, P. A., Noventa, D., & Ermolao, A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.7.5853 · Cited by 68
Determinants of Serum Total and Free Testosterone Levels in Women over the Age of 65 Years
Cappola, A. R., Ratcliffe, S. J., Bhasin, S., Blackman, M. R., Cauley, J., Robbins, J., Zmuda, J. M., Harris, T., & Fried, L. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1399 · Cited by 67
Self-citation
Interaction between Aging and Syndrome X: New Insights on the Pathophysiology of Fat Distribution
Barzilai, N., & Gupta, G. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07785.x · Cited by 67

Authors: CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R.
Affiliations: National Institutes of Health (US)
Corresponding author: HARMAN, S. MITCHELL
ORCID: HARMAN, S. MITCHELL
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 1993-02
Volume: 14
Issue: 1
Pages: 20-39
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv-14-1-20
OpenAlex: W1964005327
Cited by: 911
References: 260
Citations by year: 2026: 4 · 2025: 12 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 19 · 2019: 16 · 2018: 14 · 2017: 16 · 2016: 11 · 2015: 19 · 2014: 18 · 2013: 18 · 2012: 24
FWCI: 26.77
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: human growth hormone, aging, recombinant human growth hormone, growth hormone deficiency, insulin-like growth factor I, older adults, lean body mass, fat mass, nitrogen balance, growth hormone secretion, panhypopituitarism, growth hormone therapy
MeSH terms: Adult, Aging, Animals, Humans, Immune System, Insulin-Like Growth Factor I, Receptors, Somatotropin, Risk Factors, Growth Hormone, Growth Hormone-Releasing Hormone, Receptor, IGF Type 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human Growth Hormone and Human Aging

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks