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Cited by 83Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Short-Term Estradiol Supplementation Augments Growth Hormone (GH) Secretory Responsiveness to Dose-Varying GH-Releasing Peptide Infusions in Healthy Postmenopausal Women1

Anderson, S. M., Shah, N., Evans, W. S., Patrie, J. T., Bowers, C. Y., Veldhuis, J. D.·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.2.7240
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Abstract

Estrogen is a prominent stimulus to GH secretion throughout the human life span, albeit via neuroendocrine mechanisms that are incompletely defined. Here, we test the hypothesis that estradiol replacement in postmenopausal women enhances the responsiveness of the hypothalamo-pituitary unit to the GH-releasing effect of GH-releasing peptide-2 (GHRP-2). GHRP-2 is a potent and selective synthetic hexapeptide capable of activating an endogenous GHRP receptor/effector pathway, for which a (3)Ser-octanoylated 28-amino acid ligand was cloned recently. To examine this postulate, we studied 10 healthy estrogen-withdrawn postmenopausal women, who were given oral placebo or estrogen supplementation [1 mg micronized 17 beta-estradiol (E(2)) twice daily for 7-15 days] in a patient-blinded, prospective, randomized, and within-subject cross-over design. The GH-releasing actions of five semilogarithmically increasing doses of GHRP-2 (absolute range, 0.03-3 microg/kg by bolus iv infusion) vs. saline were evaluated by frequent blood sampling on separate days in the morning while fasting. Serum GH concentrations were determined in blood sampled every 10 min using an ultrasensitive chemiluminescence assay and analyzed by multiparameter deconvolution to calculate the summed mass of GH secreted during the 2-h interval after bolus GHRP-2 infusion. Logarithmically transformed secretory responses were compared across the different dosages of infused GHRP-2 by two-way repeated measures ANOVA. Estradio…

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Crossref · 10.1210/jcem.86.2.7240

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Metadata

Authors
Anderson, S. M., Shah, N., Evans, W. S., Patrie, J. T., Bowers, C. Y., & Veldhuis, J. D.
Affiliations
  • University of Virginia Health System (US)
  • University of Virginia (US)
  • Tulane University (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-02
Volume
86
Issue
2
Pages
551-560
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.2.7240
OpenAlex
W1985867211
Cited by
83
References
7
Citations by year
2025: 1 · 2024: 3 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 1
FWCI
5.02
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Virginia
  • National Institute on Aging (R01AG014799)
  • National Center for Research Resources (M01RR000847)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
estradiol replacement, growth hormone secretion, postmenopausal women, hypothalamic-pituitary axis, estrogen withdrawal, insulin-like growth factor I, dose-response relationship, pulsatile GH secretion, deconvolution
MeSH terms
Aged, Circadian Rhythm, Dose-Response Relationship, Drug, Estradiol, Female, Hormones, Humans, Hypothalamo-Hypophyseal System, Infusions, Intravenous, Middle Aged, Oligopeptides, Reference Values, Estrogen Replacement Therapy, Postmenopause, Human Growth Hormone

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