The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Effects of Insulin-Like Growth Factor Administration and Bone Marrow Transplantation on Thymopoiesis in Aged Mice 1
Abstract
There has been considerable interest in using hormone replacement therapy to rejuvenate the involuted thymus during aging. GH and insulin-like growth factor-I (IGF-I), a mediator of GH actions, have been of particular interest because of their thymopoietic effects and the fact that their serum concentrations decline during aging. However, treatment of aging rodents with either GH or IGF-I does not restore thymus cellularity to levels present in young animals, suggesting that additional defects might limit the magnitude of their effects. In particular, deficiencies have been reported to accumulate in the bone marrow T cell precursor compartment during aging. In view of this, 18-month-old mice were administered either recombinant IGF-I, bone marrow cells from young mice, or a combination of IGF-I and young bone marrow cells. Thymus cellularity in the latter group of mice was significantly higher than in animals treated with hormone or bone marrow transplantation alone, suggesting that optimal therapies for restoring thymus cellularity must address both endocrine and hematopoietic defects that accumulate during aging. Results from in vitro studies using fetal thymic organ cultures suggest that IGF-I acts by potentiating thymic colonization by bone marrow T cell precursors and/or that the hormone affects some other event soon after thymus colonization.
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“numerous studies (42) have shown that thymus size is increased in old mice administered either hormone (101, 103).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [101]
In the citing paper
“GH and IGF-1 bind to receptors expressed on thymocytes (101) and thymic epithelial cells (102)”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [101]
Citations
Cites
The aging immune system: primer and prospectus
Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
Prolactin and Growth Hormone in the Regulation of the Immune System
Gala, R. R. (1991) · Experimental Biology and Medicine · doi:10.3181/00379727-198-43286b · Cited by 318
Clark, R. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.2.0296 · Cited by 314
Self-citationGH3 pituitary adenoma cells can reverse thymic aging in rats.
Kelley, K. W., Brief, S., Westly, H. J., Novakofski, J., Bechtel, P. J., Simon, J., & Walker, E. B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.15.5663 · Cited by 176
Insulin-like growth factor-1 stimulation of lymphopoiesis.
CLARK, R. G., Strasser, J. E., McCabe, S., Robbins, K., & Jardieu, P. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116621 · Cited by 171
Self-citationAspinall, R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3037 · Cited by 167
Donskoy, E., & Goldschneider, I. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.6.1604 · Cited by 162
Differential effects of growth hormone and prolactin on murine T cell development and function.
Murphy, W. J., Durum, S. K., & Longo, D. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.1.231 · Cited by 132
Murphy, W. J., Durum, S. K., & Longo, D. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.12.3851 · Cited by 127
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Napolitano, L. A., Schmidt, D., Gotway, M. B., Ameli, N., Filbert, E. L., Ng, M. M., Clor, J. L., Epling, L., Sinclair, E., Baum, P. D., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32830 · Cited by 21
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Pesic, V., Radojević, K., Kosec, D. J., Plecas-Solarovic, B., Perisic, M., Pilipović, I., & Leposavić, G. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2007001100009 · Cited by 11
Immunity to infections following hematopoietic cell transplantation
Brown, J. W., Weissman, I. L., & Shizuru, J. A. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00240-5 · Cited by 11
T cell function in the aged: Lessons learned from animal models
Linton, P., Lustgarten, J., & Thoman, M. L. (2006) · Clinical and Applied Immunology Reviews · doi:10.1016/j.cair.2006.06.001 · Cited by 10
Nelfinavir monotherapy increases naive T-cell numbers in HIV-negative healthy young adults
Stacey, R. V. (2007) · Frontiers in bioscience · doi:10.2741/2784 · Cited by 9
The growth hormone—Insulin-like growth factor-I axis and immunity
Naranjo, W. M., Sánchez-Gómez, M., & Roith, D. L. (2002) · Neuroimmune biology · doi:10.1016/s1567-7443(02)80005-9 · Cited by 8
Role of the Somatotropic Axis in Mammalian Aging
Brown‐Borg, H. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00002-6 · Cited by 8
Petrovic‐Djergovic, D., Rakin, A. K., Dimitrijević, L., Ristovski, J. S., Kuštrimović, N. Z., & Mićić, M. (2007) · Neuropeptides · doi:10.1016/j.npep.2007.06.003 · Cited by 6
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Metadata
- Authors
- Montecino-Rodriguez, E., Clark, R., & Dorshkind, K.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1998-10
- Volume
- 139
- Issue
- 10
- Pages
- 4120-4126
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W4251460696
- Cited by
- 36
- References
- 40
- Citations by year
- 2018: 1 · 2013: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- insulin-like growth factor I, thymopoiesis, thymus aging, bone marrow transplantation, thymus cellularity, T cell precursors, growth hormone, hormone replacement therapy, thymic organ culture, aged mice
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