The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Transcriptional Characterizations of Differences between Eutopic and Ectopic Endometrium
Abstract
Endometriosis, defined as the presence of endometrial glandular and stromal cells outside the uterine cavity, is a common gynecological disease with poorly understood pathogenesis. Using laser capture microdissection and a cDNA microarray with 9600 genes/expressed sequence tags (ESTs), we have conducted a comprehensive profiling of gene expression differences between the ectopic and eutopic endometrium taken from 12 women with endometriosis adjusted for menstrual phase and the location of the lesions. With dye-swapping and replicated arrays, we found 904 genes/ESTs that are differentially expressed. We validated the gene expression using real-time RT-PCR. We found that the expression patterns of these genes/ESTs correctly classified the 12 patients into ovarian and nonovarian endometriosis. We identified gene clusters that are location-specific. In addition, we identified several biological themes using Expression Analysis Systematic Explorer. Finally, we identified 79 pathways with over 100 genes with known functions, which include oxidative stress, focal adhesion, Wnt signaling, and MAPK signaling. The identification of these genes and their associated pathways provides new insight. Our findings will stimulate future investigations on molecular genetic mechanisms underlying the pathogenesis of endometriosis.
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“In fact, over 1000 genes are documented to be differentially expressed between adenomyotic lesions and eutopic endometrium [65] and close to 1000 genes are differentially expressed between ectopic and eutopic endometrium [66].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [66]
In the citing paper
“Yet normal endometrial stromal cells are very different in behavior from endometriotic or even adenomyotic stromal cells.”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [66]
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Cites
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232
A Gene-Expression Signature as a Predictor of Survival in Breast Cancer
van de Vijver, M. J., He, Y. D., Veer, L. V. ‘., Dai, H. A., Hart, A. A. M., Voskuil, D. W., Schreiber, G. J., Peterse, J. L., Roberts, C., Marton, M. J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021967 · Cited by 6,474
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118
Nagase, H., & Woessner, J. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21491 · Cited by 3,905
Yang, Y., Dudoit, S., Luu, P., Lin, D., Peng, V., Ngai, J., & Speed, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.e15 · Cited by 3,722
Rw, N., Hertig, A. T., & Rock, J. A. (1950) · Fertility and Sterility · doi:10.1016/s0015-0282(16)30062-0 · Cited by 2,845
Emmert‐Buck, M. R., Bonner, R. F., Smith, P. D., Chuaqui, R. F., Zhuang, Z., Goldstein, S. R., Weiss, R. A., & Liotta, L. A. (1996) · Science · doi:10.1126/science.274.5289.998 · Cited by 2,540
Exploring the new world of the genome with DNA microarrays
Brown, P. O., & Botstein, D. (1999) · Nature Genetics · doi:10.1038/4462 · Cited by 2,430
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
Flagged first, then by citations
1 of the 120 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Knapp, 1999, How old is endometriosis? Late 17th- and 18th-century European descriptions of the disease., Fertil Steril, 72, 10
- Institute, 1992, SAS technical report P-229.
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Items 201–209 of 209
The Role of Ovarian Varicose Veins and Varicocele in Cancer and Venous Thrombosis
Pacheco, K. G., de Oliveira, M. R. F., & Pacheco, M. F. (2018) · Journal of Gynecology Research · doi:10.15744/2454-3284.4.105
Burney, R. O., & Giudice, L. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00130-x
Estrogen Biosynthesis and Its Regulation in Endometriosis
Liu, X., Qi, Q.-M., & Guo, S. (2017) · Reproductive and Developmental Medicine · doi:10.4103/wkmp-0152.210698
Zanatta, A. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2013.tde-06112013-085759
Kalantaridou, S., Vrekoussis, T., Makrigiannakis, A., & Chrousos, G. P. (2007) · Elsevier eBooks · doi:10.1016/b978-012373947-6.00734-0
Petracco, R. G. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Etude phénotypique des cellules endométriosiques profondes
Leconte, M. (2012) · theses.fr (ABES) · doi:10.70675/6c60e34az6799z41eaz8bacz16682a3d37ea
Génétique et épigénétique de l'endométriose : analyse des micro-ARNs et séquençage de familles
Abo, C. (2020) · theses.fr (ABES) · doi:10.70675/1f196b86zdff4z4171zaff3zba99042c1a5d
Altered Biological Characteristics of Eutopic and Ectopic Endometrium
Silveira, C. G. T., Agic, A., Canny, G., & Hornung, D. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_17
Metadata
- Authors
- Wu, Y., Kajdacsy-Balla, A., Strawn, E., Basir, Z., Halverson, G., Jailwala, P., Wang, Y., Wang, X., Ghosh, S., & Guo, S.-W.
- Affiliations
- Medical College of Wisconsin (US)
- Department of Pathology (A.K.-B.), University of Illinois, Chicago, Illinois 60612
- University of California, Santa Barbara (US)
- Corresponding author
- Guo, Sun-Wei
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2006-01-01
- Volume
- 147
- Issue
- 1
- Pages
- 232-246
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2032547793
- Cited by
- 208
- References
- 120
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 12 · 2018: 14 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 11 · 2012: 12
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical College of Wisconsin
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, ectopic endometrium, eutopic endometrium, gene expression profiling, differentially expressed genes, endometrioma, gene clusters, oxidative stress, focal adhesions, Wnt signaling, MAPK signaling, endometriosis pathogenesis
- MeSH terms
- Base Sequence, Endometrium, Female, Humans, Menstrual Cycle, Ovarian Diseases, Pregnancy, Pregnancy, Ectopic, Reference Values, Transcription, Genetic, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Expressed Sequence Tags, Oligonucleotide Array Sequence Analysis
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