The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Transcriptional Characterizations of Differences between Eutopic and Ectopic Endometrium
Abstract
Endometriosis, defined as the presence of endometrial glandular and stromal cells outside the uterine cavity, is a common gynecological disease with poorly understood pathogenesis. Using laser capture microdissection and a cDNA microarray with 9600 genes/expressed sequence tags (ESTs), we have conducted a comprehensive profiling of gene expression differences between the ectopic and eutopic endometrium taken from 12 women with endometriosis adjusted for menstrual phase and the location of the lesions. With dye-swapping and replicated arrays, we found 904 genes/ESTs that are differentially expressed. We validated the gene expression using real-time RT-PCR. We found that the expression patterns of these genes/ESTs correctly classified the 12 patients into ovarian and nonovarian endometriosis. We identified gene clusters that are location-specific. In addition, we identified several biological themes using Expression Analysis Systematic Explorer. Finally, we identified 79 pathways with over 100 genes with known functions, which include oxidative stress, focal adhesion, Wnt signaling, and MAPK signaling. The identification of these genes and their associated pathways provides new insight. Our findings will stimulate future investigations on molecular genetic mechanisms underlying the pathogenesis of endometriosis.
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“In fact, over 1000 genes are documented to be differentially expressed between adenomyotic lesions and eutopic endometrium [65] and close to 1000 genes are differentially expressed between ectopic and eutopic endometrium [66].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [66]
In the citing paper
“Yet normal endometrial stromal cells are very different in behavior from endometriotic or even adenomyotic stromal cells.”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [66]
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Ellis, K. B., & Wood, R. (2025) · Reproductive Sciences · doi:10.1007/s43032-025-02024-0 · Cited by 3
“Wnt signalling is aberrant in EMS [154], with the downregulation of genes involved in Wnt signalling observed in endometriotic lesions [155].”
Oliveira, F. G., Silva, J. C. R. E., Gomes, A. G., Grzesiuk, J. D., Vidotto, T., Squire, J. A., Panepucci, R. A., Meola, J., & Martelli, L. R. (2024) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.61622/rbgo/2024cr12 · Cited by 2
“(16,22,23) The inconsistency of the literature findings highlights the importance of getting robust and replicable results in order to identify the genetic influences on the disease traits.”
BackgroundPacheco, K. G. (2014) · Gynecology & Obstetrics · doi:10.4172/2161-0932.1000258 · Cited by 2
“Altered molecular genetic pathways may also contribute to the effects of OS in the pathogenesis of endometriosis and endometriosis-associated infertility [32].”
BackgroundEFFECTIVENESS OF THE COMPLEX TREATMENT OF ENDOMETRIOSIS OF WOMEN’S SITUATIVE BODIES
Boychuk, A. V., КУРИЛО, О. Ю., & Khlibovska, O. I. (2018) · Scientific digest of association of obstetricians and gynecologists of Ukraine · doi:10.35278/2664-0767.1(41).2018.171500 · Cited by 2
Recent Advances in Molecular Genetics of Endometriosis
Silveira, C. G. T., Rogatto, S. R., Podgaec, S., & Abrão, M. S. (2009) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/228402650900100103 · Cited by 2
“Using microarray analysis, Wu et al (62) also evaluated microdissected epithelial cells from 25 samples of endometriosis and 12 eutopic endometrium.”
MethodRecent advances in molecular genetics of endometriosis
Silveira, C. G. T., Rogatto, S. R., Podgaec, S., & Abrão, M. S. (2009) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.2009.1980 · Cited by 1
Detection of Aristaless-related homeobox protein in ovarian sex cord-stromal tumors
Knific, T., Grazio, S. F., & Rižner, T. L. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.12.005 · Cited by 1
The nervous system and genomics in endometriosis
Zevallos, H. B. V., Markham, R., & Manconi, F. (2018) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/2284026518813487 · Cited by 1
Lee, J., Hsu, Y.-A., Huang, Y.-T., Chen, J. J.-Y., Wu, M.-Y., Tsai, F., Lin, H.-J., Huang, Y.-H., Tien, P., & Wan, L. (2025) · Maturitas · doi:10.1016/j.maturitas.2025.108211 · Cited by 1
The analysis of endometrial receptivity
Garrido‐Gómez, T., Domı́nguez, F., Ruiz, M., Vilella, F., & Simón, C. (2012) · Informa Healthcare eBooks · doi:10.3109/9781841849713.029 · Cited by 1
Endometrial Immune-Inflammatory Gene Signatures in Endometriosis
Miller, J. E., Symons, L. K., Marks, R. M., & Tayade, C. (2019) · Springer eBooks · doi:10.1007/978-3-030-28584-5_10 · Cited by 1
Guo, S. (2011) · Wiley eBooks · doi:10.1002/9781444398519.ch7 · Cited by 1
Riaz, M. A., Mecha, E. O., Omwandho, C. O. A., Zeppernick, F. A., Meinhold-Heerlein, I. M., & Konrad, L. (2023) · Preprints.org · doi:10.20944/preprints202306.0009.v1 · Cited by 1
Diagnosis of Endometriosis: Proteomics
Stephens, A. N., Rombauts, L. J. F., & Salamonsen, L. A. (2011) · doi:10.1002/9781444398519.ch31
Medical Management of Endometriosis
Rizk, B., Nawar, M. G., Rizk, C. B., & Rizk, D. B. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511547287.036
Initiation and progression of Müllerian duct derived malignancies
van der Horst, P. (2013)
Araujo, F. M. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2011.tde-11112011-220513
Hemorrhagic ascites and cachexia in 39 years old woman's
Huerta, C. M. C., Carlos, I. D. L., & Álvarez, D. (2010) · Revista Cubana de Medicina
Clinical assessment of the endometrium
Holoch, K., & Lessey, B. A. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777851.019 · Cited by 1
Endometriosis Tissues Identifies Genes Related to Organogenesis
Piccolo, M. T., Donizetti, A., Viceconte, R., Spyrou, M. A., Calogero, R., Baldi, A., & Signorile, P. G. (2013)
Precancerous Lesions of Ovarian Clear Cell and Endometrioid Carcinomas
Roma, A. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-22509-8_3
Estrogen-regulated genes in the endometrium
Hewitt, S. C., & Korach, K. S. (2008) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9780203091500.012
ЯКІСТЬ ЖИТТЯ ЖІНОК ІЗ ЕНДОМЕТРІОЗОМ ТА ПОРУШЕННЯМИ ФУНКЦІЇ ЩИТОПОДІБНОЇНОЇ ЗАЛОЗИ
Boychuk, A. V., & Kurylo, O. Y. (2017) · Здобутки клінічної і експериментальної медицини · doi:10.11603/1811-2471.2017.v1.i3.8205
Metadata
- Authors
- Wu, Y., Kajdacsy-Balla, A., Strawn, E., Basir, Z., Halverson, G., Jailwala, P., Wang, Y., Wang, X., Ghosh, S., & Guo, S.-W.
- Affiliations
- Medical College of Wisconsin (US)
- Department of Pathology (A.K.-B.), University of Illinois, Chicago, Illinois 60612
- University of California, Santa Barbara (US)
- Corresponding author
- Guo, Sun-Wei
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2006-01-01
- Volume
- 147
- Issue
- 1
- Pages
- 232-246
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2032547793
- Cited by
- 208
- References
- 120
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 12 · 2018: 14 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 11 · 2012: 12
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical College of Wisconsin
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, ectopic endometrium, eutopic endometrium, gene expression profiling, differentially expressed genes, endometrioma, gene clusters, oxidative stress, focal adhesions, Wnt signaling, MAPK signaling, endometriosis pathogenesis
- MeSH terms
- Base Sequence, Endometrium, Female, Humans, Menstrual Cycle, Ovarian Diseases, Pregnancy, Pregnancy, Ectopic, Reference Values, Transcription, Genetic, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Expressed Sequence Tags, Oligonucleotide Array Sequence Analysis
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