The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Induction of Type 3 Deiodinase Activity in Inflammatory Cells of Mice with Chronic Local Inflammation
Open accessAbstract
During illness, changes in thyroid hormone metabolism occur, so-called nonthyroidal illness (NTI). NTI has been characterized by a fall of serum T(3) due to decreased extrathyroidal conversion of T(4) into T(3) by liver type 1 deiodinase (D1), without an increase in serum TSH. Type 3 deiodinase (D3) was thought not to play an important role during NTI, but recently it has been shown that D3 activity is up-regulated in liver and skeletal muscle of critically ill patients related to hypoxia. We studied D3 gene expression and activity in liver and muscle/subcutis of mice during illness, which was induced by two different stimuli: bacterial endotoxin (lipopolysaccharide) administration, resulting in an acute systemic response, and a turpentine injection in each hindlimb, resulting in a local sc abscess. Lipopolysaccharide induced a rapid decrease in liver D1 and D3 activity but not skeletal muscle of hindlimb. In contrast, local inflammation induced by turpentine did not decrease liver D1 and D3 activity but increased markedly D3 activity in the muscle/subcutis sample containing the abscess, associated with strongly increased IL-1beta and IL-6 mRNA expression. Inflammatory cells, surrounding the abscess showed D3 and T(3)-transporter monocarboxylate transporter-8 immunoreactivity, whereas muscle cells did not show any immunoreactivity. In conclusion, local inflammation strongly induces D3 activity in inflammatory cells, especially in invading polymorphonuclear granulocytes, suggesting enhanced local degradation of T(3).
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“DIO3 protein is highly expressed in infiltrating murine neutrophils during both bacterial infection and sterile inflammation [32, 33].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [32]
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Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
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Metadata
- Authors
- Boelen, A., Kwakkel, J., Alkemade, A., Renckens, R., Kaptein, E., Kuiper, G., Wiersinga, W. M., & Visser, T. J.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Max Planck Institute for Metabolism Research (DE)
- Erasmus MC (NL)
- Corresponding author
- Boelen, A.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2005-12
- Volume
- 146
- Issue
- 12
- Pages
- 5128-5134
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2036261582
- Cited by
- 117
- References
- 34
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 3
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- type 3 deiodinase, low T3 syndrome, thyroid hormone metabolism, local inflammation, lipopolysaccharide, type I deiodinase, type 2 deiodinase, IL-1β, interleukin-6, MCT8, polymorphonuclear leukocytes, skeletal muscle, liver, hypoxia
- MeSH terms
- Abscess, Animals, Chronic Disease, Female, Hindlimb, Immunohistochemistry, Inflammation, Injections, Intraperitoneal, Injections, Subcutaneous, Interleukin-1, Iodide Peroxidase, Irritants, Lipopolysaccharides, Liver, Mice, Inbred BALB C, Mice, Inbred C57BL, Muscular Diseases, RNA, Messenger, Turpentine, Interleukin-6, Muscle, Skeletal, Membrane Transport Proteins, Monocarboxylic Acid Transporters, Symporters, Subcutaneous Tissue, Mice
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