Cited by 117Thyroid Disorders and TreatmentsAdrenal Hormones and DisordersGrowth Hormone and Insulin-like Growth Factors

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Induction of Type 3 Deiodinase Activity in Inflammatory Cells of Mice with Chronic Local Inflammation

Open access

Boelen, A., Kwakkel, J., Alkemade, A., Renckens, R., Kaptein, E., Kuiper, G., Wiersinga, W. M., Visser, T. J.·2005·Endocrinology

DOI 10.1210/en.2005-0608

Open this paper in CoChat — free account Open PDF

Abstract

During illness, changes in thyroid hormone metabolism occur, so-called nonthyroidal illness (NTI). NTI has been characterized by a fall of serum T(3) due to decreased extrathyroidal conversion of T(4) into T(3) by liver type 1 deiodinase (D1), without an increase in serum TSH. Type 3 deiodinase (D3) was thought not to play an important role during NTI, but recently it has been shown that D3 activity is up-regulated in liver and skeletal muscle of critically ill patients related to hypoxia. We studied D3 gene expression and activity in liver and muscle/subcutis of mice during illness, which was induced by two different stimuli: bacterial endotoxin (lipopolysaccharide) administration, resulting in an acute systemic response, and a turpentine injection in each hindlimb, resulting in a local sc abscess. Lipopolysaccharide induced a rapid decrease in liver D1 and D3 activity but not skeletal muscle of hindlimb. In contrast, local inflammation induced by turpentine did not decrease liver D1 and D3 activity but increased markedly D3 activity in the muscle/subcutis sample containing the abscess, associated with strongly increased IL-1beta and IL-6 mRNA expression. Inflammatory cells, surrounding the abscess showed D3 and T(3)-transporter monocarboxylate transporter-8 immunoreactivity, whereas muscle cells did not show any immunoreactivity. In conclusion, local inflammation strongly induces D3 activity in inflammatory cells, especially in invading polymorphonuclear granulocytes, suggesting enhanced local degradation of T(3).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/en.2005-0608

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 3,906
Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
Friesema, E. C. H., Ganguly, S., Abdalla, A., Fox, J. E. M., Halestrap, A. P., & Visser, T. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300909200 · Cited by 725
Self-citation
Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas
Huang, S. A., Tu, H. M., Harney, J. W., Venihaki, M., Butte, A. J., Kozakewich, H. P. W., Fishman, S. J., & Larsen, P. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007203430305 · Cited by 540
Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critically Ill Patients
Peeters, R. P., Wouters, P. J., Kaptein, E., van Toor, H., Visser, T. J., & Van den Berghe, G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-022013 · Cited by 452
Self-citation
Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor α expression by inducing Elk-1 phosphorylation and Egr-1 expression
Guha, M., O'Connell, M. A., Pawliński, R., Hollis, A., McGovern, P., Yan, S.-F., Stern, D. M., & Mackman, N. (2001) · Blood · doi:10.1182/blood.v98.5.1429 · Cited by 374
Local activation and inactivation of thyroid hormones: the deiodinase family
Köhrle, J. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00040-4 · Cited by 346
Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control.
Bouaboula, M., Legoux, P., Pessègue, B., Delpech, B., Dumont, X., Piechaczyk, M., Casellas, P., & Shire, D. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36687-6 · Cited by 324
A Novel Pathway Regulating Lipopolysaccharide-Induced Shock by ST2/T1 Via Inhibition of Toll-Like Receptor 4 Expression
Sweet, M. J., Leung, B. P. L., Kang, D., Søgaard, M., Schulz, K., Trajković, V., Campbell, C., Xu, D., & Liew, F. Y. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6633 · Cited by 248
The Nuclear Receptor CAR Is a Regulator of Thyroid Hormone Metabolism during Caloric Restriction
Maglich, J. M., Watson, J. A., McMillen, P. J., Goodwin, B. J., Willson, T. M., & Moore, J. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313601200 · Cited by 223

Show all 34 references

Research works printed but not linked: 1

Wiersinga WM 2000 Nonthyroidal illness. In: Braverman LE, Utiger RD, eds. The thyroid. Philadelphia: Lippincott; 281-295

Sorted by citations

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., Zeöld, A., & Bianco, A. C. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0019 · Cited by 891
Thyroid Hormones, Oxidative Stress, and Inflammation
Mancini, A., Segni, C. D., Raimondo, S., Olivieri, G., Silvestrini, A., Meucci, E., & Currò, D. (2016) · Mediators of Inflammation · doi:10.1155/2016/6757154 · Cited by 558
Thyroid function in critically ill patients
Fliers, E., Bianco, A. C., Langouche, L., & Boelen, A. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00225-9 · Cited by 441
Self-citation
Mechanisms behind the non-thyroidal illness syndrome: an update
Warner, M., & Beckett, G. J. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0412 · Cited by 438
Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges
Germain, D. L. S., Galton, V. A., & Hernández, A. (2009) · Endocrinology · doi:10.1210/en.2008-1588 · Cited by 303
Paradigms of dynamic control of thyroid hormone signaling
Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M. L. C. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00275 · Cited by 293
Beyond Low Plasma T3: Local Thyroid Hormone Metabolism during Inflammation and Infection
Boelen, A., Kwakkel, J., & Fliers, E. (2011) · Endocrine Reviews · doi:10.1210/er.2011-0007 · Cited by 287
Self-citation
The role of thyroid hormone in metabolism and metabolic syndrome
Teixeira, P. D. F. D. S., dos Santos, P. B., & Pazos-Moura, C. C. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820917869 · Cited by 258
Activation and inactivation of thyroid hormone by deiodinases: Local action with general consequences
Gereben, B., Zeöld, A., Dentice, M., Salvatore, D., & Bianco, A. C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7396-0 · Cited by 207
American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models: Report of the American Thyroid Association Task Force on Approaches and Strategies to Investigate Thyroid Hormone Economy and Action
Bianco, A. C., Anderson, G., Forrest, D., Galton, V. A., Gereben, B., Kim, B. W., Kopp, P. A., Liao, X. H., Obregon, M. J., Peeters, R. P., et al. (2014) · Thyroid · doi:10.1089/thy.2013.0109 · Cited by 205
An update on non-thyroidal illness syndrome
Fliers, E., & Boelen, A. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01482-4 · Cited by 218
Self-citation
The classic pathways of thyroid hormone metabolism
van der Spek, A. H., Fliers, E., & Boelen, A. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.025 · Cited by 194
The molecular basis of the non-thyroidal illness syndrome
de Vries, E. M., Fliers, E., & Boelen, A. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0133 · Cited by 192
Self-citation
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
Dentice, M., Luongo, C., Huang, S. A., Ambrosio, R., Elefante, A., Mirebeau‐Prunier, D., Zavacki, A. M., Fenzi, G., Grachtchouk, M. A., Hutchin, M. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706754104 · Cited by 176
Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells
Freitas, B. C. G., Gereben, B., Castillo, M., Kalló, I., Zeöld, A., Egri, P., Liposits, Z., Zavacki, A. M., Maciel, R. M. B., Jo, S., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41977 · Cited by 160
Local impact of thyroid hormone inactivation
Dentice, M., & Salvatore, D. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0002 · Cited by 143
Thyroid Function in Human Obesity: Underlying Mechanisms
Fontenelle, L. F., Feitosa, M. F., Severo, J. S., Freitas, T., Morais, J. B. S., Torres‐Leal, F. L., Henriques, G. S., & Marreiro, D. D. N. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-121421 · Cited by 145
MECHANISMS IN ENDOCRINOLOGY: Beyond the fixed setpoint of the hypothalamus–pituitary–thyroid axis
Fliers, E., Kalsbeek, A., & Boelen, A. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0285 · Cited by 124
Self-citation
The interplay of thyroid hormones and the immune system – where we stand and why we need to know about it
Wenzek, C., Boelen, A., Westendorf, A. M., Engel, D. R., Moeller, L. C., & Führer-Sakel, D. (2022) · European Journal of Endocrinology · doi:10.1530/eje-21-1171 · Cited by 125
Self-citation
Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock
Rodriguez‐Perez, A., Palos‐Paz, F., Kaptein, E., Visser, T. J., Dominguez‐Gerpe, L., Alvarez‐Escudero, J., & Lado‐Abeal, J. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03102.x · Cited by 110
Self-citation
Physiological role and regulation of iodothyronine deiodinases: A 2011 update
Marsili, A., Zavacki, A. M., Harney, J. W., & Larsen, P. R. (2011) · Journal of Endocrinological Investigation · doi:10.1007/bf03347465 · Cited by 103
Left-Ventricular Remodeling After Myocardial Infarction Is Associated with a Cardiomyocyte-Specific Hypothyroid Condition
Pol, C. J., Muller, A., Zuidwijk, M. J., van Deel, E. D., Kaptein, E., Saba, A., Marchini, M., Zucchi, R., Visser, T. J., Paulus, W. J., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0431 · Cited by 102
Self-citation
Thyroid hormone metabolism in innate immune cells
van der Spek, A. H., Fliers, E., & Boelen, A. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0462 · Cited by 105
Self-citation
No Effect of the Thr92Ala Polymorphism of Deiodinase-2 on Thyroid Hormone Parameters, Health-Related Quality of Life, and Cognitive Functioning in a Large Population-Based Cohort Study
Wouters, H. J. C. M., van Loon, H. C. M., van der Klauw, M. M., Elderson, M. F., Slagter, S. N., Kobold, A. M., Kema, I. P., Links, T. P., van Vliet-Ostaptchouk, J. V., & Wolffenbuttel, B. H. R. (2017) · Thyroid® · doi:10.1089/thy.2016.0199 · Cited by 97
Revisiting Thyroid Hormones in Schizophrenia
Santos, N. C., Costa, P., Ruano, D., Macedo, A., Soares, M. J., Valente, J., Pereira, A. T., Azevedo, M. H., & Palha, J. A. (2012) · Journal of Thyroid Research · doi:10.1155/2012/569147 · Cited by 97
Reawakened interest in type III iodothyronine deiodinase in critical illness and injury
Huang, S. A., & Bianco, A. C. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0727 · Cited by 95
A Novel Role for the Thyroid Hormone-Activating Enzyme Type 2 Deiodinase in the Inflammatory Response of Macrophages
Kwakkel, J., Surovtseva, O. V., de Vries, E. M., Stap, J., Fliers, E., & Boelen, A. (2014) · Endocrinology · doi:10.1210/en.2013-2066 · Cited by 88
Self-citation
The nonthyroidal illness syndrome in the non-critically ill patient
Παππά, Θ., Vagenakis, A. G., & Alevizaki, M. K. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02395.x · Cited by 83
Effect of Bariatric Surgery on Thyroid Function in Obese Patients: a Systematic Review and Meta-Analysis
Guan, B., Chen, Y., Yang, J., Yang, W., & Wang, C. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2965-2 · Cited by 79
Thyroid Hormone Supplementation Restores Spatial Memory, Hippocampal Markers of Neuroinflammation, Plasticity-Related Signaling Molecules, and β-Amyloid Peptide Load in Hypothyroid Rats
Chaalal, A., Poirier, R., Blum, D. L., Laroche, S., & Enderlin, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1111-z · Cited by 80
Thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination
Köhrle, J. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.04.001 · Cited by 75
Characterization of the Nuclear Factor-κB Responsiveness of the Human dio2 Gene
Zeöld, A., Doleschall, M., Haffner, M. C., Capelo, L. P., Menyhért, J., Liposits, Z., da Silva, W. S., Bianco, A. C., Kacskovics, I., Fekete, C., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1608 · Cited by 72
Type 3 Deiodinase Is Highly Expressed in Infiltrating Neutrophilic Granulocytes in Response to Acute Bacterial Infection
Boelen, A., Boorsma, J., Kwakkel, J., Wieland, C. W., Renckens, R., Visser, T. J., Fliers, E., & Wiersinga, W. M. (2008) · Thyroid · doi:10.1089/thy.2008.0090 · Cited by 70
Self-citation
Type 3 deiodinase and consumptive hypothyroidism: a common mechanism for a rare disease
Luongo, C., Trivisano, L., Alfano, F., & Salvatore, D. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00115 · Cited by 67
Thyroid hormone signaling and deiodinase actions in muscle stem/progenitor cells
Ambrosio, R., Stefano, M. A. D., Girolamo, D. D., & Salvatore, D. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.06.014 · Cited by 67
Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake
Boelen, A., Kwakkel, J., Wiersinga, W. M., & Fliers, E. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.07056 · Cited by 64
Self-citation
Impaired Bacterial Clearance in Type 3 Deiodinase-Deficient Mice Infected with Streptococcus pneumoniae
Boelen, A., Kwakkel, J., Wieland, C. W., St. Germain, D. L., Fliers, E., & Hernandez, A. (2009) · Endocrinology · doi:10.1210/en.2008-1133 · Cited by 63
Self-citation
Large Induction of Type III Deiodinase Expression After Partial Hepatectomy in the Regenerating Mouse and Rat Liver
Kester, M. H. A., Toussaint, M. J. M., Punt, C. A., Matondo, A. B., Aarnio, A. M., Darras, V., Everts, M. E., de Bruin, A., & Visser, T. J. (2008) · Endocrinology · doi:10.1210/en.2008-0344 · Cited by 64
Self-citation
Selenium Supplementation Alters Gene Expression Profiles Associated with Innate Immunity in Whole-Blood Neutrophils of Sheep
Hugejiletu, H., Bobe, G., Vorachek, W. R., Gorman, M. E., Mosher, W. D., Pirelli, G. J., & Hall, J. A. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9716-6 · Cited by 55
Type 3 deiodinase and solid tumors: an intriguing pair
Dentice, M., Antonini, D., & Salvatore, D. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.833189 · Cited by 53
Selenium, Selenoprotein Genes and Crohn’s Disease in a Case-Control Population from Auckland, New Zealand
Gentschew, L., Bishop, K. S., Han, D. Y., Morgan, A. R., Fraser, A. G., Lam, W. J., Karunasinghe, N., Campbell, B., & Ferguson, L. R. (2012) · Nutrients · doi:10.3390/nu4091247 · Cited by 51
Roux-en-Y gastric bypass and calorie restriction induce comparable time-dependent effects on thyroid hormone function tests in obese female subjects
Lips, M. A., Pijl, H., van Klinken, J. B., de Groot, G. H., Janssen, I. M. C., van Ramshorst, B., van Wagensveld, B. A., Swank, D. J., Dielen, F. V., & Smit, J. W. A. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0339 · Cited by 51
Skeletal muscle deiodinase type 2 regulation during illness in mice
Kwakkel, J., van Beeren, H. C., Ackermans, M. T., Platvoet-ter Schiphorst, M. C., Fliers, E., Wiersinga, W. M., & Boelen, A. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0118 · Cited by 48
Self-citation
Induction of Type 1 Iodothyronine Deiodinase to Prevent the Nonthyroidal Illness Syndrome in Mice
Yu, J., & Koenig, R. J. (2006) · Endocrinology · doi:10.1210/en.2005-1443 · Cited by 46
Cytokine-induced neutrophil chemoattractant-1 is released by the noninjured liver in a rat acute-phase model
Sheikh, N., Tron, K., Dudás, J., & Ramadori, G. P. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700435 · Cited by 45
Changes Within the Thyroid Axis During the Course of Critical Illness
Mebis, L., Debaveye, Y. A., Visser, T. J., & den Berghe, G. V. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.09.009 · Cited by 45
Self-citation
Thyroid Hormone and Deiodination in Innate Immune Cells
van der Spek, A. H., Fliers, E., & Boelen, A. (2020) · Endocrinology · doi:10.1210/endocr/bqaa200 · Cited by 41
Self-citation
Septic shock non-thyroidal illness syndrome causes hypothyroidism and conditions for reduced sensitivity to thyroid hormone
Castro‐Piedras, I., Quisenberry, L. R., Calvo, R.-M., Obregón, M.-J., & Lado‐Abeal, J. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0188 · Cited by 40
Differential effects of fasting vs food restriction on liver thyroid hormone metabolism in male rats
de Vries, E. M., van Beeren, H. C., Ackermans, M. T., Kalsbeek, A., Fliers, E., & Boelen, A. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0533 · Cited by 38
Self-citation
Integration of Computational Toxicology, Toxicogenomics Data Mining, and Omics Techniques to Unveil Toxicity Pathways
Wang, X., Li, F., Chen, J., Ji, C., & Wu, H. (2021) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.0c09196 · Cited by 37
Genomic imprinting of the type 3 thyroid hormone deiodinase gene: Regulation and developmental implications
Charalambous, M., & Hernández, A. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.015 · Cited by 34
Age-related changes in renal and hepatic cellular mechanisms associated with variations in rat serum thyroid hormone levels
Silvestri, E., Lombardi, A., de Lange, P., Schiavo, L., Lanni, A., Goglia, F., Visser, T. J., & Moreno, M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00044.2008 · Cited by 39
Self-citation
Tissue thyroid hormone metabolism is differentially regulated during illness in mice
Boelen, A., van der Spek, A. H., Bloise, F., de Vries, E. M., Surovtseva, O. V., van Beeren, M., Ackermans, M. T., Kwakkel, J., & Fliers, E. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0483 · Cited by 35
Self-citation
Leptin Administration Restores the Fasting-Induced Increase of Hepatic Type 3 Deiodinase Expression in Mice
Boelen, A., van Beeren, M., Vos, X., Surovtseva, O., Belegri, E., Saaltink, D.-J., Vreugdenhil, E., Kalsbeek, A., Kwakkel, J., & Fliers, E. (2012) · Thyroid · doi:10.1089/thy.2011.0289 · Cited by 35
Self-citation
Lower-normal TSH is associated with better metabolic risk factors: A cross-sectional study on Spanish men
Laclaustra, M., Hurtado-Roca, Y., Sendin, M., Leon, M., Ledesma, M., Andres, E. M., Fernández‐Ortíz, A., Güallar, E., Ordovás, J. M., & Casasnovas, J. A. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.09.007 · Cited by 35
Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes
Benedetti, V., Lavecchia, A. M., Locatelli, M., Brizi, V., Corna, D., Todeschini, M., Novelli, R., Benigni, A., Zoja, C., Remuzzi, G., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.130249 · Cited by 35
The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species
van der Spek, A. H., Jim, K. K., Karaczyn, A., van Beeren, H. C., Ackermans, M. T., Darras, V. M., Vandenbroucke-Grauls, C. M. J. E., Hernandez, A., Brouwer, M. C., Fliers, E., et al. (2018) · Endocrinology · doi:10.1210/en.2017-00666 · Cited by 33
Self-citation
Adult‐Onset Hypothyroidism Induces the Amyloidogenic Pathway of Amyloid Precursor Protein Processing in the Rat Hippocampus
Ghenimi, N., Alfos, S., Redonnet, A., Higueret, P., Pallet, V., & Enderlin, V. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02002.x · Cited by 31
Consumptive Hypothyroidism Resulting from Hepatic Vascular Tumors in an Athyreotic Adult
Howard, D., La Rosa, F. G., Huang, S., Salvatore, D., Mulcahey, M., Sang-Lee, J., Wachs, M., & Klopper, J. P. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2104 · Cited by 30
Modeling the nonthyroidal illness syndrome
Koenig, R. J. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32830eb838 · Cited by 29
The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils
van der Spek, A. H., Bloise, F. F., Tigchelaar, W., Dentice, M., Salvatore, D., van der Wel, N. N., Fliers, E., & Boelen, A. (2016) · Endocrinology · doi:10.1210/en.2016-1103 · Cited by 28
Self-citation
Associations between sensitivity to thyroid hormones and insulin resistance in euthyroid adults with obesity
Wei, Y., Li, X., Cui, R., Liu, J., & Wang, G. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1366830 · Cited by 26
Iodine, thymus, and immunity
Venturi, S., & Venturi, M. (2009) · Nutrition · doi:10.1016/j.nut.2009.06.002 · Cited by 26
Type 3 Deiodinase Expression in Inflammatory Spinal Cord Lesions in Rat Experimental Autoimmune Encephalomyelitis
Boelen, A., Mikita, J., Boiziau, C., Chassande, O., Fliers, E., & Petry, K. G. (2009) · Thyroid · doi:10.1089/thy.2009.0228 · Cited by 24
Self-citation
The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): An Overview
Silvestrini, A., Mordente, A., Martino, G., Bruno, C., Vergani, E., Meucci, E., & Mancini, A. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180201111159 · Cited by 25
Thyroid hormones and modulation of diastolic function: a promising target for heart failure with preserved ejection fraction
Neves, J. S., Vale, C., von Hafe, M., Borges‐Canha, M., Leite, A. R., Almeida‐Coelho, J., Lourenço, A. P., Falcão‐Pires, I., Carvalho, D. M., & Leite-Moreira, A. F. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820958331 · Cited by 26
Differential Effects of Sepsis and Chronic Inflammation on Diaphragm Muscle Fiber Type, Thyroid Hormone Metabolism, and Mitochondrial Function
Bloise, F. F., van der Spek, A. H., Surovtseva, O. V., Ortiga-Carvalho, T. M., Fliers, E., & Boelen, A. (2016) · Thyroid · doi:10.1089/thy.2015.0536 · Cited by 21
Self-citation
Acute Inflammation Increases Pituitary and Hypothalamic Glycoprotein Hormone Subunit B5 mRNA Expression in Association with Decreased Thyrotrophin Receptor mRNA Expression in Mice
van Zeijl, C. J. J., Surovtseva, O. V., Wiersinga, W. M., Fliers, E., & Boelen, A. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02116.x · Cited by 19
Self-citation
Peripheral Thyroid Hormone Conversion and Its Impact on TSH and Metabolic Activity
Holtorf, K. (2014) · Journal of Restorative Medicine · doi:10.14200/jrm.2014.3.0103 · Cited by 18
The role of thyroid hormone in the renal immune microenvironment
Han, Z., Chen, L., Zheng, H., Zheng, H., Lin, Y., Peng, F., Fan, Y., Xie, X., Wang, Z., Wang, Z., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110172 · Cited by 17
Thyroid hormone-stimulated differentiation of primary rib chondrocytes in vitro requires thyroid hormone receptor β
Rabier, B., Williams, A. J., Mallein‐Gérin, F., Williams, G. R., & Chassande, O. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06838 · Cited by 17
Increased circulating interleukin-8 in patients with resistance to thyroid hormone receptor α
van der Spek, A. H., Surovtseva, O. V., Aan, S., Tool, A. T. J., van de Geer, A., Demir, K., van Gucht, A. L. M., van Trotsenburg, A. S. P., van den Berg, T. K., Fliers, E., et al. (2017) · Endocrine Connections · doi:10.1530/ec-17-0213 · Cited by 14
Self-citation
Candidate Genes Involved in Beneficial or Adverse Responses to Commonly Eaten Brassica Vegetables in a New Zealand Crohn’s Disease Cohort
Laing, B. B., Han, D. Y., & Ferguson, L. R. (2013) · Nutrients · doi:10.3390/nu5125046 · Cited by 15
Tumor Microbial Communities and Thyroid Cancer Development—The Protective Role of Antioxidant Nutrients: Application Strategies and Future Directions
Gorini, F., & Tonacci, A. (2023) · Antioxidants · doi:10.3390/antiox12101898 · Cited by 16
Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure
Melis, M., Marino, R. B., Tian, J., Johnson, C., Sethi, R., Oertel, M., Fox, I. J., & Locker, J. D. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.11.009 · Cited by 13
Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria
Duyu, A., Çıtak, E. Ç., Ak, E., Küpeli, S., Yağcı‐Küpeli, B., Bayram, İ., Sezgin, G., Eskendari, G., & Sezer, K. (2018) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.0015 · Cited by 12
High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?
Filipchuk, M., Gassmann, J., Zamparella, T. C., Tibaldo, M. C., Carpinella, M., Tagliavini, P. S., Scarnato, P., Goicochea, M. T., Bruera, O. C., Magris, D. M. C., et al. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05424-7 · Cited by 11
Alterations of DNA methylation and expression of genes related to thyroid hormone metabolism in colon epithelium of obese patients
Shimi, G., Pourvali, K., Ghorbani, A., Nooshin, S., Karizi, S. Z., Iranirad, R., & Zand, H. (2022) · BMC Medical Genomics · doi:10.1186/s12920-022-01387-6 · Cited by 10
Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness
van Zeijl, C. J. J., Surovtseva, O. V., Kwakkel, J., van Beeren, H. C., Bassett, J. H. D., Williams, G. R., Wiersinga, W. M., Fliers, E., & Boelen, A. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00266.2014 · Cited by 10
Self-citation
The Association of Triiodothyronine-to-Thyroxine Ratio with Body Mass Index in Obese Nigerian Children and Adolescents
Emokpae, M. A., & Obazelu, P. A. (2017) · Medical Sciences · doi:10.3390/medsci5040036 · Cited by 10
Assessment of type 1 and type 3 deiodinase expression levels in depressive disorders
Gałecka, E., Kumor‐Kisielewska, A., Orzechowska, A., Maes, M. H. J., Górski, P., & Szemraj, J. (2017) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2017-056 · Cited by 9
Contributions of cytokines to nonthyroidal illness
Boelen, A., Wiersinga, W. M., & Köhrle, J. (2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000244227.21776.70 · Cited by 9
Self-citation
Deiodinase-3 is a thyrostat to regulate podocyte homeostasis
Agarwal, S., Koh, K. H., Tardi, N. J., Chen, C., Dande, R. R., Werneck‐de‐Castro, J. P., Sudhini, Y. R., Luongo, C., Salvatore, D., Samelko, B., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103617 · Cited by 8
Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice
Barnhoorn, S., Meima, M. E., Peeters, R. P., Darras, V., Leeuwenburgh, S., Hoeijmakers, J. H. J., Vermeij, W. P., & Visser, W. E. (2023) · European Thyroid Journal · doi:10.1530/etj-22-0231 · Cited by 8
Les dyshormonémies des affections non thyroïdiennes
Luca, F., Goichot, B., & Brue, T. C. (2010) · Annales d Endocrinologie · doi:10.1016/s0003-4266(10)70003-2 · Cited by 8
Deiodination and Cellular Proliferation: Parallels between Development, Differentiation, Tumorigenesis, and Now Regeneration
Huang, S. A. (2008) · Endocrinology · doi:10.1210/en.2008-1460 · Cited by 7
The role of deiodinases on metabolic alteration in cancer
Miro, C., Cicatiello, A. G., Dentice, M., & Nappi, A. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.07.003 · Cited by 7
Thyroid Hormone Metabolism
Germain, D. L. S. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00075-7 · Cited by 7
Evaluation of the Free Triiodothyronine/Free Thyroxine ratio and Euthyroid Sick Syndrome in patients with COVID-19: A cross-sectional study
Ayan, D., Balcı, T., Ünal, S., Ulucan, H., Türkyürek, C., & Bayram, E. (2021) · The Annals of Clinical and Analytical Medicine · doi:10.4328/acam.20743 · Cited by 6
Rats with altered behaviour following nerve injury show evidence of centrally altered thyroid regulation
Kilburn‐Watt, E., Banati, R. B., & Keay, K. A. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.07.004 · Cited by 6
Deiodinases’ Inhibitors: A Double-Edged Sword
Acampora, L., Miro, C., Cicatiello, A. G., Dentice, M., & Nappi, A. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl40246 · Cited by 7
Increased thyroxine levels of patients with allergic rhinitis
Lokaj‐Berisha, V., & Lumezi, B. G. (2025) · Scientific Reports · doi:10.1038/s41598-025-85762-0 · Cited by 5
Knockdown of the Type 3 Iodothyronine Deiodinase (D3) Interacting Protein Peroxiredoxin 3 Decreases D3-Mediated Deiodination in Intact Cells
Aerts, G., Drigo, R. A. E., Herck, S. L. J. V., Sammels, E., Mirebeau‐Prunier, D., Gereben, B., Zeöld, A., Harney, J. W., Huang, S. A., Mulcahey, M. A., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0702 · Cited by 6
Is there a link between polycystic ovary syndrome and non-thyroidal illness syndrome?
Karaköse, M., Çakal, E., Toplaoglu, O., Arslan, M. S., Giris, Z., Şahi̇n, M., & Delibaşı, T. (2013) · Journal of the Turkish-German Gynecological Association · doi:10.5152/jtgga.2013.47135 · Cited by 5
Maternal LiCl exposure disrupts thyroid–cerebral axis in neonatal albino rats
Mohammed, D. A. E., Ahmed, R. R., & Ahmed, R. G. (2021) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10151 · Cited by 4
Type 3 deiodinase activation mediated by the Shh/Gli1 axis promotes sepsis-induced metabolic dysregulation in skeletal muscles
Wang, G., Gao, T., Liu, Y., Duan, J., Lu, H., Jiang, A., Xu, Y., Lu, X., Li, X., Wang, Y., et al. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae066 · Cited by 5
Assessing Thyroid Function in Hospitalized Patients
LoPresti, J. S., & Patil, K. S. (2010) · Endocrine Updates · doi:10.1007/978-1-4419-1485-9_10 · Cited by 3
Relationship of thyroid parameters with chronic inflammation in patients with euthyroid type 2 diabetes
Shi, W., Chen, D., Chen, W., Chen, Y., Fu, X., Xiao, Y., Duan, W., & Zhang, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1433782 · Cited by 3
Non-thyroidal illness (NTI)
Peeters, R. P., & Boelen, A. (2022) · Oxford Textbook of Endocrinology and Diabetes 3e · doi:10.1093/med/9780198870197.003.0042 · Cited by 3
Self-citation
Deiodination and Peripheral Metabolism of Thyroid Hormone
Dentice, M., & Salvatore, D. (2019) · Springer eBooks · doi:10.1007/978-3-319-72102-6_5 · Cited by 1

Authors: Boelen, A., Kwakkel, J., Alkemade, A., Renckens, R., Kaptein, E., Kuiper, G., Wiersinga, W. M., & Visser, T. J.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Max Planck Institute for Metabolism Research (DE)
Erasmus MC (NL)
Corresponding author: Boelen, A.
ORCID: Boelen, A.
Alkemade, A.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2005-12
Volume: 146
Issue: 12
Pages: 5128-5134
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2005-0608
OpenAlex: W2036261582
Cited by: 117
References: 34
Citations by year: 2026: 2 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 3
FWCI: 4.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: type 3 deiodinase, low T3 syndrome, thyroid hormone metabolism, local inflammation, lipopolysaccharide, type I deiodinase, type 2 deiodinase, IL-1β, interleukin-6, MCT8, polymorphonuclear leukocytes, skeletal muscle, liver, hypoxia
MeSH terms: Abscess, Animals, Chronic Disease, Female, Hindlimb, Immunohistochemistry, Inflammation, Injections, Intraperitoneal, Injections, Subcutaneous, Interleukin-1, Iodide Peroxidase, Irritants, Lipopolysaccharides, Liver, Mice, Inbred BALB C, Mice, Inbred C57BL, Muscular Diseases, RNA, Messenger, Turpentine, Interleukin-6, Muscle, Skeletal, Membrane Transport Proteins, Monocarboxylic Acid Transporters, Symporters, Subcutaneous Tissue, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Induction of Type 3 Deiodinase Activity in Inflammatory Cells of Mice with Chronic Local Inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks