The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Minireview: Timely Ovulation: Circadian Regulation of the Female Hypothalamo-Pituitary-Gonadal Axis
Abstract
The preovulatory surge in the secretion of LH is timed by a neuroendocrine integrative mechanism that involves ovarian estradiol levels and the endogenous circadian system. Studies in female rats and hamsters have established that the clock in the hypothalamic suprachiasmatic nucleus has a preeminent role in setting the LH surge, and anatomical, physiological, and pharmacological data are revealing the responsible connections between suprachiasmatic nucleus neurons and GnRH and estradiol-receptive areas. Recent investigations show that GnRH and pituitary cells express circadian clock genes that might play a role in the release and reception of the GnRH signal. Analysis of the circadian regulation of the LH surge may provide a model for understanding how multiple neural oscillators function within other neuroendocrine axes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several physiological systems exhibit ultradian rhythms (URs) in the 1–3 h range, including the HPG axis60–65, the HPA axis66–72, and the suprachiasmatic nucleus73, 74 – the principal orchestrating brain area for circadian rhythms.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907
Circadian Gene Expression in Individual Fibroblasts
Nagoshi, E., Saini, C., Bauer, C. R., Laroche, T., Naef, F., & Schibler, U. (2004) · Cell · doi:10.1016/j.cell.2004.11.015 · Cited by 1,031
Silver, R., LeSauter, J., Tresco, P. A., & Lehman, M. N. (1996) · Nature · doi:10.1038/382810a0 · Cited by 792
Welsh, D. K., Yoo, S.-H., Liu, A. C., Takahashi, J. S., & Kay, S. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.057 · Cited by 726
Circadian rhythms in isolated brain regions
Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681
Multimodal Influence of Estrogen upon Gonadotropin-Releasing Hormone Neurons
Herbison, A. E. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0332 · Cited by 618
Suprachiasmatic nucleus organization
Moore, R. Y., Speh, J. C., & Leak, R. K. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0575-2 · Cited by 547
Cited by
Sorted by citations
Items 101–133 of 133
Morfologia das células intersticiais de ovários policísticos de ratas: um estudo experimental
Lombardi, L. A., Simões, R. S., Maganhin, C. C., da Silva, C. F., Maciel, G. A. R., Baracat, E. C., & Soares, J. M. (2012) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1590/s0100-72032012000700006 · Cited by 8
Mid-luteal phase progesterone effects on vigilance tasks are modulated by women’s chronotype
Palmero, L. B., Martínez‐Pérez, V., Tortajada, M., Campoy, G., & Fuentes, L. J. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105722 · Cited by 8
Biological Rhythms Workshop IB: neurophysiology of SCN pacemaker function.Preprint
Kuhlman, S. J. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.061 · Cited by 8
Gotlieb, N., Baker, C. N., Moeller, J., & Kriegsfeld, L. J. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12798 · Cited by 7
Guerrero‐Vargas, N. N., Espítia‐Bautista, E., Escalona, R., Lugo-Martínez, H., Gutiérrez‐Pérez, M., Navarro-Espíndola, R., Setién, M. F., Boy-Waxman, S., Retana-Flores, E. A., Ortega, B., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.999156 · Cited by 7
Reconfigurable, Wearable Sensors to Enable Long-Duration Circadian Biomedical Studies
Burnett, D. C., Smarr, B. L., Mesri, S., Kriegsfeld, L. J., & Pister, K. S. J. (2014) · International Conference on Body Area Networks · doi:10.4108/icst.bodynets.2014.257078 · Cited by 7
Wang, Y., & Kuehl-Kovarik, M. C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.12.013 · Cited by 6
Silva, C., Cortés, G. D., Javier, C. Y., Flores, A., & Domı́nguez, R. (2019) · Experimental Physiology · doi:10.1113/ep087942 · Cited by 6
Chen, Z., Wen, D., Cen, J., & Mu, R. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103950 · Cited by 5
Polkowska, J., Picard, S., Wańkowska, M., Cieślak, M., Caraty, A., & Tillet, Y. (2014) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/65702/2014 · Cited by 5
Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice
Lavalle, S. N., Chou, T., Hernandez, J., Naing, N. C. P., He, M. Y., Tonsfeldt, K. J., & Mellon, P. L. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111577 · Cited by 4
Frohman, L. A. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01184-0 · Cited by 5
Sandhu, K. K., & Singla, N. (2019) · Indian Journal of Animal Research · doi:10.18805/ijar.b-3822 · Cited by 3
Triggers in controlled ovarian hyperstimulation
Devi, M. G. (2023) · Fertility Science and Research · doi:10.4103/fsr.fsr_40_23 · Cited by 2
Marqués-García, F., Martinez-Bravo, C., Tejedor-Ganduxé, X., & Fossión, R. (2025) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2024-1198 · Cited by 2
KISSPEPTIN SYSTEM: A Multi-Homeostatic System
Olaniyan, O. T. (2013) · IOSR Journal of Pharmacy and Biological Sciences · doi:10.9790/3008-05487101 · Cited by 2
Lomniczi, A., Matagne, V., & Ojeda, S. R. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01187-6 · Cited by 2
Pilorz, V. (2007) · Cited by 1
Timing of puberty : Genetic regulation
Wehkalampi, K. (2008)
Role of the N-methyl-D-aspartate receptor (NMDAR)-NR2b subunit in female reproductive aging
Maffucci, J. A. (2008) · Texas ScholarWorks (Texas Digital Library)
De rol van de biologische klok en het autonome zenuwstelsel bij wakker worden
Kalsbeek, A., Yi, C., la Fleur, S. E., & Fliers, E. (2011) · Neuropraxis · doi:10.1007/s12474-011-0030-9
Neural Pathways Integrating Circadian Information into the Decision to Trigger Ovulation
Smarr, B. L. (2012) · ResearchWorks at the University of Washington (University of Washington)
El reloj circadiano ovarico: un segundero en la fisiologia de la reproduccion
Juárez-Tapia, C. R., & Miranda‐Anaya, M. (2016) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.21933/j.edsc.2016.10.183
Circadian and Metabolic Influences on the Reproductive Axis
Russo, K. A. (2016) · eScholarship (California Digital Library)
Der suprachiasmatische Nukleus und seine klinische Bedeutung
Liem, T., & Havel, M. (2018) · Osteopathische Medizin · doi:10.1016/s1615-9071(18)30114-x
Some reproductive hormones in relation to ovarian activity in rats
Aboul-Ela, A., El‐Anwar, A. H., Mabrouk, E. A., & Aboul-Khair, A. (2018) · Journal of Veterinary Medical Research · doi:10.21608/jvmr.2017.43323
The Interplay Between Female Reproductive Function and the Circadian System
Nakamura, T. J., Takasu, N. N., Cornélissen, G., Otsuka, K., & Nakamura, W. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839167553-00397
Integrating Circadian and Reproductive Rhythms in Mood Regulation
Myung, J. (2025) · Chronobiology in Medicine · doi:10.33069/cim.2025.0015
IVF Protocols and Their Rationales
Baria, N. (2026) · Springer eBooks · doi:10.1007/978-3-032-24372-0_8
Clock genes and female reproduction
Chen, C. (2009) · ERA
Metadata
- Authors
- de la Iglesia, H. O., & Schwartz, W. J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Schwartz, William J.
- ORCID
- Schwartz, William J.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2006-03-01
- Volume
- 147
- Issue
- 3
- Pages
- 1148-1153
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2136393310
- Cited by
- 134
- References
- 90
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 15 · 2014: 8 · 2013: 12 · 2012: 8
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Washington
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- ovulation timing, luteinizing hormone surge, circadian clock, suprachiasmatic nucleus, hypothalamic-pituitary-gonadal axis, gonadotropin-releasing hormone, estradiol, clock genes, neuroendocrine regulation, female reproduction
- MeSH terms
- Animals, Circadian Rhythm, Endocrine System, Estradiol, Female, Gonads, Cricetinae, Humans, Hypothalamus, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Models, Biological, Neurons, Oscillometry, Ovulation, Pituitary Gland, Suprachiasmatic Nucleus, Signal Transduction, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
