The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Functional Characterization of Genetically Labeled Gonadotropes
Abstract
Gonadotropes are crucial in the control of reproduction but difficult to isolate for functional analysis due to their scattered distribution in the anterior pituitary gland. We devised a binary genetic approach, and describe a new mouse model that allows visualization and manipulation of gonadotrope cells. Using gene targeting in embryonic stem cells, we generated mice in which Cre recombinase is coexpressed with the GnRH receptor, which is expressed in gonadotrope cells. We show that we can direct Cre-mediated recombination of a yellow fluorescent protein reporter allele specifically in gonadotropes within the anterior pituitary of these knock-in mice. More than 99% of gonadotropin-containing cells were labeled by yellow fluorescent protein fluorescence and readily identifiable in dissociated pituitary cell culture, allowing potentially unbiased sampling from the gonadotrope population. Using electrophysiology, calcium imaging, and the study of secretion on the single-cell level, the functional properties of gonadotropes isolated from male mice were analyzed. Our studies demonstrate a significant heterogeneity in the resting properties of gonadotropes and their responses to GnRH. About 50% of gonadotropes do not exhibit secretion of LH or FSH. Application of GnRH induced a broad range of both electrophysiological responses and increases in the intracellular calcium concentration. Our mouse model will also be able to direct expression of other Cre recombination-dependent reporter genes to gonadotropes and, therefore, represents a versatile new tool in the understanding of gonadotrope biology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In past studies, we reported a pituitary-specific conditional ERK double knockout (ERKdko) using the ERK1 null and ERK2 floxed alleles combined with a Cre recombinase driver regulated by the gene promoter for the α subunit to the glycoprotein hormones (αGSU)3,4 and the gonadotrope-specific Cre driver (GRIC)12,13.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [13]
In the citing paper
“this is the first report of a novel model of placental ERK gene deletion associated with expression of a GnRHR-Cre driver3,12,13”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [13]
In the citing paper
“While loss of ERK signaling within the gonadotrope has been shown to be detrimental to the function of the hypothalamic-pituitary-gonadal axis as well as the placenta”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [13]
Citations
Cites
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,562
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Visualizing an Olfactory Sensory Map
Mombaerts, P., Wang, F., Dulac, C. G., Chao, S. K., Nemes, A., Mendelsohn, M. M., Edmondson, J., & Axel, R. (1996) · Cell · doi:10.1016/s0092-8674(00)81387-2 · Cited by 1,992
Muscarinic activation of ionic currents measured by a new whole-cell recording method.
Horn, R., & Marty, A. (1988) · The Journal of general physiology · doi:10.1085/jgp.92.2.145 · Cited by 1,338
Knobil and Neill's Physiology of Reproduction
(2015) · Elsevier eBooks · doi:10.1016/c2011-1-07288-0 · Cited by 1,277
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
Rodríguez, C. I., Buchholz, F., Galloway, J. L., Sequerra, R., Kasper, J. S., Ayala, R., Stewart, A. F., & Dymecki, S. M. (2000) · Nature Genetics · doi:10.1038/75973 · Cited by 1,162
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
Buch, T., Heppner, F. L., Tertilt, C., Heinen, T. J. A. J., Kremer, M., Wunderlich, F. T., Jung, S., & Waisman, A. (2005) · Nature Methods · doi:10.1038/nmeth762 · Cited by 922
Gonadotropin-Releasing Hormone Receptors
Millar, R. P., Lu, Z.-L., Pawson, A. J., Flanagan, C. A., Morgan, K., & Maudsley, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0002 · Cited by 791
Ca2+-activated K+ channels: molecular determinants and function of the SK family
Stocker, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1516 · Cited by 534
Cited by
Sorted by citations
Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression
Stamatiades, G. A., & Kaiser, U. B. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.10.015 · Cited by 293
GnRH signaling, the gonadotrope and endocrine control of fertility
Bliss, S. P., Navratil, A. M., Xie, J., & Roberson, M. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.04.002 · Cited by 259
Ion channels and signaling in the pituitary gland
Stojilkovic, S. S., Tabak, J., & Bertram, R. (2010) · Endocrine Reviews · doi:10.1210/er.2010-0005 · Cited by 229
GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression
Thompson, I. R., & Kaiser, U. B. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.012 · Cited by 199
Hormones in synergy: Regulation of the pituitary gonadotropin genes
Thackray, V. G., Mellon, P. L., & Coss, D. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.003 · Cited by 167
Cheung, L., George, A. S., McGee, S. R., Daly, A. Z., Brinkmeier, M. L., Ellsworth, B. S., & Camper, S. A. (2018) · Endocrinology · doi:10.1210/en.2018-00750 · Cited by 156
Mechanisms of FSH synthesis: what we know, what we don't, and why you should care
Bernard, D. J., Fortin, J., Wang, Y., & Lamba, P. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.03.034 · Cited by 167
The TGF-β Family in the Reproductive TractPreprint
Monsivais, D., Matzuk, M. M., & Pangas, S. A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022251 · Cited by 148
Wen, S., Götze, I. N., Mai, O., Schauer, C., Leinders‐Zufall, T., & Boehm, U. (2011) · Endocrinology · doi:10.1210/en.2010-1208 · Cited by 117
Self-citationWen, S., Ai, W., Alim, Z., & Boehm, U. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000423107 · Cited by 112
Self-citationChu, A., Zhu, L., Blum, I. D., Mai, O., Leliavski, A., Fahrenkrug, J., Oster, H., Boehm, U., & Storch, K.-F. (2013) · Endocrinology · doi:10.1210/en.2013-1080 · Cited by 87
Self-citationWolfe, A., Divall, S., & Wu, S. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.007 · Cited by 83
The biology of gonadotroph regulation
Ciccone, N. A., & Kaiser, U. B. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832d88fb · Cited by 82
Follicle‐stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2
Fortin, J., Boehm, U., Deng, C., Treier, M., & Bernard, D. J. (2014) · The FASEB Journal · doi:10.1096/fj.14-249532 · Cited by 81
Self-citationDavis, S. W., Keisler, J. L., Millan, M. I. P., Schade, V., & Camper, S. A. (2016) · Endocrinology · doi:10.1210/en.2015-1862 · Cited by 78
Impaired Fertility and FSH Synthesis in Gonadotrope-Specific Foxl2 Knockout Mice
Tran, S., Zhou, X., Lafleur, C., Calderon, M. J., Ellsworth, B. S., Kimmins, S., Boehm, U., Treier, M., Boerboom, D., & Bernard, D. J. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1286 · Cited by 74
Self-citationLi, Y., Fortin, J., Ongaro, L., Zhou, X., Boehm, U., Schneyer, A. L., Bernard, D. J., & Lin, H. Y.-F. (2018) · Endocrinology · doi:10.1210/en.2018-00770 · Cited by 64
Self-citationSMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells in Vivo
Li, Y., Schang, G., Boehm, U., Deng, C., Graff, J. M., & Bernard, D. J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.759167 · Cited by 61
Self-citationUnravelling the role of epigenetics in reproductive adaptations to early-life environment
Bar-Sadeh, B., Rudnizky, S., Pnueli, L., Bentley, G. R., Stöger, R. J., Kaplan, A., & Melamed, P. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0370-8 · Cited by 61
Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?
Fortin, J., Ongaro, L., Li, Y., Tran, S., Lamba, P., Wang, Y., Zhou, X., & Bernard, D. J. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1004 · Cited by 57
Høivik, E. A., Bjanesoy, T. E., Mai, O., Okamoto, S., Minokoshi, Y., Shima, Y., Morohashi, K.-I., Boehm, U., & Bakke, M. (2011) · Endocrinology · doi:10.1210/en.2010-1305 · Cited by 55
Self-citationMolecular Plasticity of Male and Female Murine Gonadotropes Revealed by mRNA Sequencing
Qiao, S., Nordström, K. J. V., Muijs, L., Gasparoni, G., Tierling, S., Krause, E., Walter, J., & Boehm, U. (2015) · Endocrinology · doi:10.1210/en.2015-1836 · Cited by 49
Self-citationAn epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis
Yosefzon, Y., David, C., Tsukerman, A., Pnueli, L., Qiao, S., Boehm, U., & Melamed, P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704393114 · Cited by 51
Self-citationCoordination of calcium signals by pituitary endocrine cells in situ
Hodson, D. J., Romanò, N., Schaeffer, M., Fontanaud, P., Lafont, C., Fiordelisio, T., & Mollard, P. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.11.007 · Cited by 49
Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
Ongaro, L., Zhou, X., Wáng, Y., Schultz, H., Zhou, Z., Buddle, E. R. S., Brûlé, E., Lin, Y., Schang, G., Hagg, A., et al. (2025) · Science · doi:10.1126/science.adi4736 · Cited by 51
Self-citationSchang, A., Ngô‐Muller, V., Bleux, C., Granger, A., Chenut, M.-C., Loudes, C., Magre, S., Counis, R., Cohen-Tannoudji, J., & Laverrière, J. (2010) · Endocrinology · doi:10.1210/en.2010-0840 · Cited by 54
Molecular mechanisms of pituitary endocrine cell calcium handling
Stojilković, S. S. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.11.003 · Cited by 47
Wang, H., Graham, I. R., Hastings, R. C., Gunewardena, S., Brinkmeier, M. L., Conn, P. M., Camper, S. A., & Kumar, T. R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.621565 · Cited by 46
Ion Channels of Pituitary Gonadotrophs and Their Roles in Signaling and Secretion
Stojilković, S. S., Bjelobaba, I. M., & Zemkova, H. W. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00126 · Cited by 44
Gonadotrope Plasticity at Cellular and Population Levels
Alim, Z., Hartshorn, C., Mai, O., Stitt, I., Clay, C. M., Tobet, S. A., & Boehm, U. (2012) · Endocrinology · doi:10.1210/en.2012-1360 · Cited by 43
Self-citationFontaine, R., Ciani, E., Haug, T. M., Hodne, K., Ager-Wick, E., Baker, D. M., & Weltzien, F. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113344 · Cited by 41
Fox tales: Regulation of gonadotropin gene expression by forkhead transcription factors
Thackray, V. G. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.034 · Cited by 40
Investigating and Modelling Pituitary Endocrine Network Function
Hodson, D. J., Molino, F., Fontanaud, P., Bonnefont, X., & Mollard, P. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02052.x · Cited by 40
TGFBR3L is an inhibin B co-receptor that regulates female fertility
Brûlé, E., Wang, Y., Li, Y., Lin, Y., Zhou, X., Ongaro, L., Alonso, C. A. I., Buddle, E. R. S., Schneyer, A. L., Byeon, C., et al. (2021) · Science Advances · doi:10.1126/sciadv.abl4391 · Cited by 40
Self-citationConditional Deletion of FOXL2 and SMAD4 in Gonadotropes of Adult Mice Causes Isolated FSH Deficiency
Li, Y., Schang, G., Wang, Y., Zhou, X., Levasseur, A., Boyer, A., Deng, C., Treier, M., Boehm, U., Boerboom, D., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00100 · Cited by 39
Self-citationFunctional Pituitary Networks in Vertebrates
Santiago-Andres, Y., Golan, M., & Fiordelisio, T. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.619352 · Cited by 35
Distribution of Alarin Immunoreactivity in the Mouse Brain
Eberhard, N., Mayer, C., Santic, R., Navío, R. P., Wagner, A., Bauer, H. C., Sperk, G., Boehm, U., & Kofler, B. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9546-y · Cited by 35
Self-citationDecoster, L., Trova, S., Zucca, S., Bulk, J., Gouveia, A., Ternier, G., Lhomme, T., Legrand, A., Gallet, S., Boehm, U., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01724-1 · Cited by 38
Self-citationFortin, J., Boehm, U., Weinstein, M. B., Graff, J. M., & Bernard, D. J. (2013) · The FASEB Journal · doi:10.1096/fj.13-237818 · Cited by 30
Self-citationIntra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice
Qiao, S., Alasmi, S., Wyatt, A. K., Wartenberg, P., Wang, H., Candlish, M., Das, D., Aoki, M., Grünewald, R., Zhou, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36681-z · Cited by 28
Self-citationMurine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B
Schang, G., Ongaro, L., Schultz, H., Wang, Y., Zhou, X., Brûlé, E., Boehm, U., Lee, S., & Bernard, D. J. (2020) · Endocrinology · doi:10.1210/endocr/bqaa056 · Cited by 27
Self-citationInfluence of estrogens on GH-cell network dynamics in females: a live in situ imaging approach.
Schaeffer, M., Hodson, D., Meunier, A.-C., Lafont, C., Birkenstock, J., Carmignac, D., Murray, J., Gavois, E., Robinson, I., Tissier, P. L. L., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1430 · Cited by 23
Gonadotropin-Releasing Hormone-Regulated Prohibitin Mediates Apoptosis of the Gonadotrope Cells
Savulescu, D. M., Feng, J., Ping, Y. S., Mai, O., Boehm, U., He, B., O’Malley, B. W., & Melamed, P. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1210 · Cited by 26
Self-citationGnRH Receptor Expression and Reproductive Function Depend on JUN in GnRH Receptor‒Expressing Cells
Jonak, C. R., Lainez, N. M., Boehm, U., & Coss, D. (2018) · Endocrinology · doi:10.1210/en.2017-00844 · Cited by 25
Self-citationFunctional importance of blood flow dynamics and partial oxygen pressure in the anterior pituitary
Schaeffer, M., Hodson, D. J., Lafont, C., & Mollard, P. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07525.x · Cited by 23
Fortin, J., Kumar, V., Zhou, X., Wang, Y., Auwerx, J. H., Schoonjans, K., Boehm, U., Boerboom, D., & Bernard, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059058 · Cited by 24
Self-citationMechanisms underlying the tissue-specific and regulated activity of the Gnrhr promoter in mammals
Schang, A., Quérat, B., Simon, V., Garrel, G., Bleux, C., Counis, R., Cohen-Tannoudji, J., & Laverrière, J. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00162 · Cited by 24
Wang, Z., Feng, M., Awe, O., Ma, Y., Shen, M., Xue, P., Ahima, R. S., Wolfe, A., Segars, J. H., & Wu, S. (2019) · JCI Insight · doi:10.1172/jci.insight.127817 · Cited by 23
Tissier, P. L., Murray, J. F., & Mollard, P. (2022) · Endocrinology · doi:10.1210/endocr/bqac089 · Cited by 22
The Hippo Pathway Effectors YAP and TAZ Regulate LH Release by Pituitary Gonadotrope Cells in Mice
Lalonde-Larue, A., Boyer, A., Santos, E. C. D., Boerboom, D., Bernard, D. J., & Zamberlam, G. (2021) · Endocrinology · doi:10.1210/endocr/bqab238 · Cited by 21
Sánchez‐Cárdenas, C., & Hernández‐Cruz, A. (2010) · Neuroendocrinology · doi:10.1159/000274493 · Cited by 21
Ca2+-Activated K+ Channels in Gonadotropin-Releasing Hormone-Stimulated Mouse Gonadotrophs
Waring, D. W., & Turgeon, J. L. (2008) · Endocrinology · doi:10.1210/en.2008-1442 · Cited by 20
Fshb-iCre mice are efficient and specific Cre deleters for the gonadotrope lineage
Wang, H., Hastings, R., Miller, W. L., & Kumar, T. R. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.006 · Cited by 19
β-Catenin Stabilization in Gonadotropes Impairs FSH Synthesis in Male Mice In Vivo
Boerboom, D., Kumar, V., Boyer, A., Wang, Y., Lambrot, R., Zhou, X., Rico, C., Boehm, U., Paquet, M., Céleste, C., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1296 · Cited by 19
Self-citationVoigt, A., Hübner, S., Döring, L., Perlach, N., Hermans‐Borgmeyer, I., Boehm, U., & Meyerhof, W. (2015) · Chemical Senses · doi:10.1093/chemse/bjv049 · Cited by 19
Self-citationTran, S., Wáng, Y., Lamba, P., Zhou, X., Boehm, U., & Bernard, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076642 · Cited by 17
Self-citationAllen, S. J., García-Galiano, D., Borges, B. C., Burger, L. L., Boehm, U., & Elias, C. F. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00529.2015 · Cited by 19
Self-citationGene Targeting in Neuroendocrinology
Candlish, M., Angelis, R. D., Götz, V., & Boehm, U. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140079 · Cited by 20
Self-citationBeck, A., Götz, V., Qiao, S., Weißgerber, P., Flockerzi, V., Freichel, M., & Boehm, U. (2017) · Endocrinology · doi:10.1210/en.2016-1810 · Cited by 16
Self-citationStamatiades, G. A., Toufaily, C., Kim, H. K., Zhou, X., Thompson, I. R., Carroll, R. S., Chen, M., Weinstein, L. S., Offermanns, S., Boehm, U., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab247 · Cited by 15
Self-citation99mTc-LHRH in tumor receptor imaging
Hao, D., Sun, L., Hu, X., & Hao, X. (2017) · Oncology Letters · doi:10.3892/ol.2017.6246 · Cited by 15
Impaired LH surge amplitude in gonadotrope-specific progesterone receptor knockout mice
Toufaily, C., Schang, G., Zhou, X., Wartenberg, P., Boehm, U., Lydon, J. P., Roelfsema, F., & Bernard, D. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0013 · Cited by 15
Self-citationSex- and Age-Specific Impact of ERK Loss Within the Pituitary Gonadotrope in Mice
Brown, J. L., Xie, J., Brieño-Enriquez, M. A., Sones, J., Angulo, C. N., Boehm, U., Miller, A., Toufaily, C., Wang, Y., Bernard, D. J., et al. (2018) · Endocrinology · doi:10.1210/en.2017-00653 · Cited by 14
Self-citationDependence of the Excitability of Pituitary Cells on Cyclic Nucleotides
Stojilković, S. S., Kretschmannova, K., Tomić, M., & Stratakis, C. A. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02335.x · Cited by 13
Schang, G., Ongaro, L., Brûlé, E., Zhou, X., Wang, Y., Boehm, U., Ruf-Zamojski, F. M., Zamojski, M., Mendelev, N., Seenarine, N., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102072 · Cited by 14
Self-citationGonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells
Sheridan, D., Chakravarty, P., Golan, G., Shiakola, Y., Olsen, J., Burnett, E. C., Galichet, C., Fiordelisio, T., Mollard, P., Melamed, P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59495-7 · Cited by 13
Brown, J. L., Sones, J. L., Angulo, C. N., Abbott, K., Miller, A. D., Boehm, U., & Roberson, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45997-0 · Cited by 13
Self-citationMusashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
Moreira, A. R. S., Lim, J., Urbaniak, A. J., Banik, J., Bronson, K., Lagasse, A., Hardy, L. L., Haney, A. C., Allensworth, M. L., Miles, T. K., et al. (2023) · Endocrinology · doi:10.1210/endocr/bqad113 · Cited by 12
Self-citationGonadotropin-Releasing Hormone Inhibits Ether-a-Go-Go-Related Gene K+ Currents in Mouse Gonadotropes
Hirdes, W., Dinu, C., Bauer, C. K., Boehm, U., & Schwarz, J. R. (2010) · Endocrinology · doi:10.1210/en.2009-0718 · Cited by 12
Self-citationThe Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Banik, J., Moreira, A. R. S., Lim, J., Tomlinson, S., Hardy, L. L., Lagasse, A., Haney, A. C., Crimmins, M. R., Boehm, U., Odle, A. K., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-56002-8 · Cited by 12
Self-citationLehtonen, H., Jokela, H., Hofmann, J. I., Tola, L., Mehmood, A., Ginhoux, F., Becher, B., Greter, M., Yegutkin, G. G., Salmi, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115227 · Cited by 9
Normal gonadotropin production and fertility in gonadotrope-specific Bmpr1a knockout mice
Zhou, X., Wang, Y., Ongaro, L., Boehm, U., Kaartinen, V., Mishina, Y. M., & Bernard, D. J. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0053 · Cited by 10
Self-citationOngaro, L., Zhou, X., Cui, Y., Boehm, U., & Bernard, D. J. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz206 · Cited by 10
Self-citationMaximal Expression of Foxl2 in Pituitary Gonadotropes Requires Ovarian Hormones
Herndon, M. K., & Nilson, J. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126527 · Cited by 10
Alonso, C. A. I., David, C. D., Toufaily, C., Wang, Y., Zhou, X., Ongaro, L., Nudelman, G., Nair, V. D., Ruf-Zamojski, F. M., Boehm, U., et al. (2023) · Endocrinology · doi:10.1210/endocr/bqad050 · Cited by 8
Self-citationStruthers, R. S. (2012) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2012.02081.x · Cited by 9
Kisspeptin has an independent and direct effect on the pituitary gland in the mare
Magee, C., Bruemmer, J. E., Kirkley, K. S., Sylvester, L. A., Runyan, B., Nett, T. M., Squires, E. L., & Clay, C. M. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.07.031 · Cited by 9
Schang, A., Counis, R., Magre, S., Bleux, C., Granger, A., Ngô‐Muller, V., Chenut, M.-C., Ishaq, M., Cohen-Tannoudji, J., & Laverrière, J. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05886.x · Cited by 8
Mouse Models of Gonadotrope Development
Stallings, C. E., Kapali, J., & Ellsworth, B. S. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.08.001 · Cited by 8
Navi, L. R., Tsukerman, A., Feldman, A., Melamed, P., Tomić, M., Stojilković, S. S., Boehm, U., Seger, R., & Naor, Z. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00113 · Cited by 8
Self-citationSchultz, H., Zhou, X., Alonso, C. A. I., Ongaro, L., Lin, Y., Loka, M., Brabletz, T., Brabletz, S., Stemmler, M. P., Boehm, U., et al. (2024) · Endocrinology · doi:10.1210/endocr/bqae116 · Cited by 7
Self-citationFeldman, A., Saleh, A., Pnueli, L., Qiao, S., Shlomi, T., Boehm, U., & Melamed, P. (2018) · The FASEB Journal · doi:10.1096/fj.201800943r · Cited by 6
Self-citationSubplasmalemmal hydrogen peroxide triggers calcium influx in gonadotropes
Dang, A., Chaplin, N. L., Murtazina, D., Boehm, U., Clay, C. M., & Amberg, G. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.001830 · Cited by 7
Self-citationCell Networks in Endocrine/Neuroendocrine Gland Function
Guérineau, N. C., Campos, P., Tissier, P. L., Hodson, D. J., & Mollard, P. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210031 · Cited by 9
Schang, A. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12253 · Cited by 6
Enhancing Gonadotrope Gene Expression Through Regulatory lncRNAs
Refael, T., & Melamed, P. (2021) · Endocrinology · doi:10.1210/endocr/bqab116 · Cited by 6
Ovulation is triggered by a cyclical modulation of gonadotropes into a hyperexcitable state
Götz, V., Qiao, S., Das, D., Wartenberg, P., Wyatt, A. K., Wahl, V., Gamayun, I., Alasmi, S., Fecher‐Trost, C., Meyer, M. R., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112543 · Cited by 6
Self-citationRubinfeld, H., Cohen, Z. R., David, U. B., Fichman‐Horn, S., Levy‐Barda, A., David, C., Melamed, P., & Shimon, I. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09186-7 · Cited by 5
Lin, Y., Schang, G., Buddle, E. R. S., Schultz, H., Willis, T. L., Ruf-Zamojski, F. M., Zamojski, M., Mendelev, N., Boehm, U., Sealfon, S. C., et al. (2022) · Endocrinology · doi:10.1210/endocr/bqac131 · Cited by 5
Self-citationImaging Calcium Responses in GFP-tagged Neurons of Hypothalamic Mouse Brain Slices
Schauer, C., & Leinders‐Zufall, T. (2012) · Journal of Visualized Experiments · doi:10.3791/4213 · Cited by 5
Cellular distribution of Egr1 transcription in the male rat pituitary gland
Man, P.-S., Wells, T., & Carter, D. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0158 · Cited by 5
Myostatin is a major endocrine driver of follicle-stimulating hormone synthesisPreprint
Ongaro, L., Zhou, X., Wang, Y., Zhou, Z., Schultz, H., Buddle, E. R. S., Brûlé, E., Lin, Y., Schang, G., Castonguay, R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.30.555595 · Cited by 5
Self-citationConstantin, S., Sokanovic, S. J., Mochimaru, Y., Smiljanić, K., Sivcev, S., Prévide, R. M., Wray, S., Balla, T., & Stojilković, S. S. (2023) · Endocrinology · doi:10.1210/endocr/bqad168 · Cited by 4
Smiljanić, K., Constantin, S., Nessa, N., & Stojilković, S. S. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112638 · Cited by 3
Murtazina, D. A., Arreguin-Arevalo, J. A., Cantlon, J. D., Ebrahimpour-Boroojeny, A., Shrestha, A., Hicks, J. A., Magee, C., Kirkley, K. S., Jones, K., Nett, T. M., et al. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz166 · Cited by 3
TRP Channels in Reproductive (Neuro)Endocrinology
Leinders‐Zufall, T., & Boehm, U. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-05161-1_16 · Cited by 3
Self-citationPnueli, L., Shalev, D., Refael, T., David, C., Boehm, U., & Melamed, P. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111349 · Cited by 3
Self-citationDecoster, L., Trova, S., Zucca, S., Gouveia, A., Bulk, J., Ternier, G., Lhomme, T., Legrand, A., Boehm, U., Hrabovszky, E., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3115610/v1 · Cited by 3
Self-citationGonadotrophs have a dual origin, with most derived from pituitary stem cells during minipubertyPreprint
Sheridan, D., Chakravarty, P., Golan, G., Shiakola, Y., Olsen, J., Burnett, E. C., Galichet, C., Mollard, P., Melamed, P., Lovell-Badge, R. H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.09.610834 · Cited by 3
Mouse Cre drivers: tools for studying disorders of the human female neuroendocrine-reproductive axis
Chemerinski, A., Liu, C., Morelli, S. S., Babwah, A. V., & Douglas, N. C. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac012 · Cited by 2
Metadata
- Authors
- Wen, S., Schwarz, J. R., Niculescu, D., Dinu, C., Bauer, C. K., Hirdes, W., & Boehm, U.
- Affiliations
- Universität Hamburg (DE)
- Institute for Neural Signal Transduction (S.W., J.R.S., D.N., C.D., W.H., U.B.), Center for Molecular Neurobiology, D-20253 Hamburg, Germany
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2008-03-06
- Volume
- 149
- Issue
- 6
- Pages
- 2701-2711
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2070693587
- Cited by
- 112
- References
- 38
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 8 · 2012: 5
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- gonadotrophs, GnRH receptor, Cre recombinase, anterior pituitary, GnRH response, luteinizing hormone secretion, follicle-stimulating hormone secretion, intracellular calcium, single-cell secretion
- MeSH terms
- Animals, Calcium, Electrophysiology, Exons, Gonadotropins, Humans, Mice, Transgenic, Pituitary Gland, Anterior, Potassium, Receptors, LHRH, Patch-Clamp Techniques, Mice, Gonadotrophs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
