Cited by 300Regulation of Appetite and ObesityDiabetes Treatment and ManagementNeuropeptides and Animal Physiology

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Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

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Williams, Diana L., Baskin, Denis G., Schwartz, Michael W.·2009·Endocrinology

DOI 10.1210/en.2008-1045PMC PMC2659282

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Abstract

A physiological role in satiety is proposed for glucagon-like peptide-1 (GLP-1), secreted by the distal intestine in response to ingested nutrients. Here we report that in rats, ip injection of the GLP-1 receptor (GLP-1-R) antagonist exendin 9-39 (Ex9) elicited hyperphagia, but only at times of day when intake is otherwise low. Furthermore, ip administration of Ex9 attenuated satiety induced by either a voluntarily consumed sucrose meal (by 100%) or an intragastric glucose load (by 40%). To determine whether these effects involve blockade of GLP-1-R in brain or at a peripheral site, we injected Ex9 either centrally (into the third ventricle) or peripherally (ip) prior to GLP-1 injected either centrally or peripherally. Anorexia induced by peripheral GLP-1 was fully blocked by peripheral, but not central, pretreatment with Ex9, whereas the opposite was true for anorexic effect of central GLP-1. Thus, ip Ex9 appears to attenuate satiety via peripheral GLP-1-R blockade. Finally, anorexia induced by ip injection of exendin-4 (a GLP-1-R agonist) was due to both reduced meal size and increased duration between meals. We conclude that GLP-1 released from the intestine in response to ingested nutrients is a physiologically active satiety signal.

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Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
A role for glucagon-like peptide-1 in the central regulation of feeding
Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950
Cholecystokinin decreases food intake in rats.
Gibbs, J., Young, R. C., & Smith, G. P. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0034870 · Cited by 1,502
Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
Larsen, P. J., Tang-Christensen, M., Holst, J. J., & Ørskov, C. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00434-4 · Cited by 663
The inhibitory effects of peripheral administration of peptide YY3–36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathway
Abbott, C. R., Monteiro, M. P., Small, C. J., Sajedi, A., Smith, K. L., Parkinson, J. R. C., Ghatei, M. A., & Bloom, S. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.011 · Cited by 617
A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis
Baggio, L. L., Huang, Q., Brown, T. J., & Drucker, D. J. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2492 · Cited by 389
Gastrointestinal satiety signals II. Cholecystokinin
Moran, T. H., & Kinzig, K. P. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00434.2003 · Cited by 346
Peripheral Oxyntomodulin Reduces Food Intake and Body Weight Gain in Rats
Dakin, C. L., Small, C. J., Batterham, R. L., Neary, N. M., Cohen, M. A., Patterson, M., Ghatei, M. A., & Bloom, S. R. (2004) · Endocrinology · doi:10.1210/en.2003-1338 · Cited by 345
Gastrointestinal Satiety Signals
Chaudhri, O. B., Salem, V., Murphy, K. G., & Bloom, S. R. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100506 · Cited by 344
Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
Vahl, T. P., Tauchi, M., Durler, T. S., Elfers, E. E., Fernandes, T. M., Bitner, R. D., Ellis, K. S., Woods, S. C., Seeley, R. J., Herman, J. P., et al. (2007) · Endocrinology · doi:10.1210/en.2006-0153 · Cited by 318 · cited 2×
“GLP-1’s incretin effects have been hypothesized to occur via a local action on afferent autonomic fibers in the gut and/or hepatic portal vein, as opposed to a direct action on -cells (33).”
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Show all 31 references

Research works printed but not linked: 2

Barrera, 2007, Keystone Symposia (J2), Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis, 144
Hayes, 2007, Caudal brainstem integration is sufficient for anorectic responses to central and to peripheral GLP-1R agonist treatment with endogenous hindbrain GLP-1R activity contributing to satiation control, Obesity, 15, A15

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Authors: Williams, D. L., Baskin, D. G., & Schwartz, M. W.
Affiliations: Florida State University (US)
University of Washington (US)
VA Puget Sound Health Care System (US)
Corresponding author: Williams, Diana L.
ORCID: Williams, Diana L.
Baskin, Denis G.
Schwartz, Michael W.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2008-12-12
Volume: 150
Issue: 4
Pages: 1680-1687
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2008-1045
PMC: PMC2659282
OpenAlex: W2082052031
Cited by: 300
References: 31
Citations by year: 2026: 7 · 2025: 10 · 2024: 15 · 2023: 7 · 2022: 8 · 2021: 21 · 2020: 11 · 2019: 9 · 2018: 17 · 2017: 16 · 2016: 27 · 2015: 22 · 2014: 27 · 2013: 28 · 2012: 22
FWCI: 7.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Endocrinology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-083042, P30-DK 17047, R01DK052989, DK-52989, K99DK078779, P01DK068384, DK-68384, P30DK035816, P30DK017047, R01DK083042)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: glucagon-like peptide-1, satiety, GLP-1 receptor, exendin-9-39, exendin-4, hyperphagia, anorexia, intestinal hormone secretion, meal size
MeSH terms: Glucagon-Like Peptide-1 Receptor, Exenatide, Animals, Anorexia, Eating, Injections, Male, Peptides, Satiety Response, Venoms, Receptors, Glucagon, Rats

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Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

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