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Cited by 49Adipose Tissue and MetabolismRegulation of Appetite and ObesityDiabetes Treatment and Management

Glucagon, GLP-1 and Thermogenesis

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González-García, Ismael, Milbank, Edward, Diéguez, Carlos, López, Miguel, Contreras, Cristina·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20143445PMC PMC6678955
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Abstract

Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, many studies have focused on the nervous system and endocrine factors that control the activity of this tissue. There is long-established evidence that the counter-regulatory hormone glucagon negatively influences energy balance, enhances satiety, and increases energy expenditure. Despite compelling evidence showing that glucagon has direct action on BAT thermogenesis, recent findings are questioning this conventional attribute of glucagon action. Glucagon like peptide-1 (GLP-1) is an incretin secreted by the intestinal tract which strongly decreases feeding, and, furthermore, improves metabolic parameters associated with obesity and diabetes. Therefore, GLP-1 receptors (GLP-1-R) have emerged as a promising target in the treatment of metabolic disorders. In this short review, we will summarize the latest evidence in this regard, as well as the current therapeutic glucagon- and GLP-1-based approaches to treating obesity.

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  • Unimolecular co-agonists of GLP-1R and GcgR were the first to emerge, seeking to leverage the anorectic and anti-diabetic effects of GLP-1 with the ability of Gcg to increase energy expenditure.

    “Unimolecular co-agonists of GLP-1R and the glucagon receptor (GcgR) were the first to emerge, seeking to leverage the anorectic and anti-diabetic effects of GLP-1 with the ability of Gcg to increase energy expenditure [[17], [18], [19]]”

    From Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice (2022) · cites this paper as [17]

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Cited by

Sorted by citations

Authors
González-García, I., Milbank, E., Diéguez, C., López, M., & Contreras, C.
Affiliations
  • Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany
  • Universidade de Santiago de Compostela (ES)
  • Universidad Complutense de Madrid (ES)
Corresponding author
Contreras, Cristina
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-07-13
Volume
20
Issue
14
Pages
3445
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms20143445
PMC
PMC6678955
OpenAlex
W2960344041
Cited by
49
References
25
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 1
FWCI
0.65
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Hispana (submittedVersion, cc-by)
  • Library Open Repository (Universidad Complutense Madrid) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Repositorio institucional da Universidade de Santiago de Compostela (University of Santiago de Compostela) (submittedVersion, other-oa)
  • Site cant be reached (submittedVersion, cc-by)
  • PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by)
Funders
  • Ministerio de Economía, Industria y Competitividad, Gobierno de España (SAF2015-71026-R)
  • Xunta de Galicia (2015-CP079)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
glucagon, glucagon-like peptide-1, brown adipose tissue, thermogenesis, energy expenditure, energy balance, GLP-1 receptor, obesity treatment, incretins, satiety, metabolic homeostasis
MeSH terms
Animals, Adipose Tissue, Brown, Energy Metabolism, Glucagon, Humans, Obesity, Thermogenesis, Glucagon-Like Peptide 1, Molecular Targeted Therapy

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