The Type II Iodothyronine Deiodinase Is Up-Regulated in Skeletal Muscle during Prolonged Critical Illness
Abstract
Context: Critical illness is associated with the low T3 syndrome. It remains unclear whether altered type II deiodinase activity (D2) in skeletal muscle contributes to this syndrome. Objective: Our objective was to study D2 expression and activity in skeletal muscle of acute and prolonged critically ill patients. Design and Setting: We conducted a clinical observational study in acute and prolonged critical illness with comparison with healthy controls at a university hospital surgical intensive care unit. Patients: Subjects included 63 prolonged critically ill patients who died in the intensive care unit, 21 acutely ill patients, and 38 controls matched for age, gender, and body mass index. Results: Elevated expression of the D2 gene and D2 activity in skeletal muscle of prolonged, but not acute, critically ill patients were observed in the face of low circulating thyroid hormone levels. Conclusions: Reduced D2 activity does not appear to play a role in the pathogenesis of the low T3 syndrome of critical illness.
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DIO2 mRNA expression and activity remain unchanged in skeletal muscle tissue of patients with acute surgical stress compared to healthy controls.
“By contrast, DIO2 mRNA expression and activity remain unchanged in skeletal muscle tissue of patients with acute surgical stress compared to healthy controls [30].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [30]
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- Authors
- Mebis, L., Langouche, L., Visser, T. J., & Van den Berghe, G.
- Affiliations
- KU Leuven (BE)
- Erasmus MC (NL)
- Department of Intensive Care Medicine (L.M., L.L., G.V.d.B.), Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2007-08-01
- Volume
- 92
- Issue
- 8
- Pages
- 3330-3333
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2130754426
- Cited by
- 101
- References
- 13
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- type 2 deiodinase, skeletal muscle, low T3 syndrome, critical illness, prolonged critical illness, thyroid hormone metabolism, gene expression, enzyme activity, thyroid hormone levels, intensive care unit patients
- MeSH terms
- Iodothyronine Deiodinase Type II, Aged, Female, Humans, Hydrocortisone, Iodide Peroxidase, Male, Radioimmunoassay, RNA, Thyroid Hormones, Up-Regulation, Body Mass Index, Critical Illness, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction
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