The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Molecular, Immunohistochemical, and Pharmacological Evidence of Oxytocin’s Role as Inhibitor of Carbohydrate But Not Fat Intake
Open accessAbstract
Oxytocin (OT) facilitates feeding termination stemming from high osmolality, stomach distention, and malaise. Recent knockout (KO) studies suggested a crucial function for OT in carbohydrate intake: OT-/- mice had increased preference for carbohydrates, including sucrose, but not fat (Intralipid). In striking contrast, sugar appetite was unaffected in the OT receptor KO mouse; data from wild-type animals have been insufficient. Therefore, we examined the involvement of OT in the regulation of sucrose vs. fat intake in C57BL/6 mice that served as a background KO strain. We exposed mice to a meal of sucrose or Intralipid and determined that the percentage of c-Fos-immunoreactive paraventricular hypothalamic OT neurons was elevated at termination of intake of either of the tastants, but this increase was 2-fold higher in sucrose-fed mice. A 48-h exposure to sucrose compared with Intralipid caused up-regulation of OT mRNA, whereas inherent individual preferences for sucrose vs. fat were not associated with differences in baseline OT expression as established with quantitative PCR. We found that L-368,899, an OT receptor antagonist, increased sugar intake when sucrose was presented alone or concurrently with Intralipid; it had no effect on Intralipid or total calorie consumption. L-368,899 affected Fos immunoreactivity in the paraventricular hypothalamus, arcuate nucleus, amygdala, and nucleus of the solitary tract, areas involved in aversion, satiety, and reward. This pattern ser…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The intake of sugar compared with an equicaloric fat solution induces a selective, twofold increase in hypothalamic oxytocinergic neuronal activity, whereas central nervous oxytocin receptor antagonism triggers the intake of sucrose but not fat (47).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [47]
In the citing paper
“The intake of sugar compared with an equicaloric fat solution induces a selective, twofold increase in hypothalamic oxytocinergic neuronal activity, whereas central nervous oxytocin receptor antagonism triggers the intake of sucrose but not fat (47).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [47]
Citations
Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data
Ramakers, C. R. B., Ruijter, J. M., Deprez, R. H. L., & Moorman, A. F. M. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01423-4 · Cited by 3,740
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283
A conditional knockout mouse line of the oxytocin receptor
Lee, H.-J., Caldwell, H. K., Macbeth, A. H., Tolu, S. G., & Young, W. S. (2008) · Endocrinology · doi:10.1210/en.2007-1710 · Cited by 269
Sweetener Preference of C57BL/6ByJ and 129P3/J Mice
Bachmanov, A. A. (2001) · Chemical Senses · doi:10.1093/chemse/26.7.905 · Cited by 265
Oxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 254
Verbalis, J. G., Stricker, E. M., ROBINSON, A. G., & Hoffman, G. E. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00264.x · Cited by 184
Cited by
Sorted by citations
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423
The determinants of food choice
Leng, G., Adan, R. A. H., Belot, M., Brunstrom, J. M., de Graaf, K., Dickson, S. L., Hare, T. A., Maier, S. U., Menzies, J., Preissl, H., et al. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s002966511600286x · Cited by 465
The determinants of food choice
Leng, G., Adan, R. A. H., Belot, M. V. K., Brunstrom, J. M., de Graaf, K. C., Dickson, S. L., Hare, T. A., Maier, S. U., Menzies, J. R. W., Preissl, H. T., et al. (2017) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-146390 · Cited by 255
Hypothalamic neuropeptides and the regulation of appetite
Parker, J., & Bloom, S. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.004 · Cited by 242
Oxytocin Reduces Reward-Driven Food Intake in Humans
Ott, V., Finlayson, G., Lehnert, H., Heitmann, B., Heinrichs, M., Born, J., & Hallschmid, M. (2013) · Diabetes · doi:10.2337/db13-0663 · Cited by 226
Metadata
- Authors
- Olszewski, P. K., Klockars, A., Olszewska, A. M., Fredriksson, R., Schiöth, H. B., & Levine, A. S.
- Affiliations
- University of Minnesota (US)
- Uppsala University (SE)
- Department of Neuroscience (P.K.O., A.K., A.M.O., R.F., H.B.S.), Functional Pharmacology, Uppsala University, Uppsala Biomedical Center, Uppsala SE 75124, Sweden
- Corresponding author
- Levine, Allen S.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-08-04
- Volume
- 151
- Issue
- 10
- Pages
- 4736-4744
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC2946140
- OpenAlex
- W2021699660
- Cited by
- 104
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 13 · 2020: 3 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 9
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Systembolaget
- National Institutes of Health
- National Institute on Drug Abuse (R01DA021280)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK 50456, P30DK050456)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, sucrose intake, dietary fat intake, carbohydrate preference, paraventricular hypothalamus, Fos-like immunoreactivity, L-368,899, oxytocin receptor antagonist, satiety, food reward, arcuate nucleus, amygdala, nucleus tractus solitarius, osmolality
- MeSH terms
- Animals, Appetite Regulation, Camphanes, Dietary Carbohydrates, Dietary Fats, Eating, Feeding Behavior, Hormone Antagonists, Immunohistochemistry, Male, Mice, Inbred C57BL, Oxytocin, Piperazines, Down-Regulation, Receptors, Oxytocin, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
