Cited by 104Regulation of Appetite and ObesityNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

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Molecular, Immunohistochemical, and Pharmacological Evidence of Oxytocin’s Role as Inhibitor of Carbohydrate But Not Fat Intake

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Olszewski, Pawel K., Klockars, Anica, Olszewska, Agnieszka M., Fredriksson, Robert, Schiöth, Helgi B., Levine, Allen S.·2010·Endocrinology

DOI 10.1210/en.2010-0151PMC PMC2946140

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Abstract

Oxytocin (OT) facilitates feeding termination stemming from high osmolality, stomach distention, and malaise. Recent knockout (KO) studies suggested a crucial function for OT in carbohydrate intake: OT-/- mice had increased preference for carbohydrates, including sucrose, but not fat (Intralipid). In striking contrast, sugar appetite was unaffected in the OT receptor KO mouse; data from wild-type animals have been insufficient. Therefore, we examined the involvement of OT in the regulation of sucrose vs. fat intake in C57BL/6 mice that served as a background KO strain. We exposed mice to a meal of sucrose or Intralipid and determined that the percentage of c-Fos-immunoreactive paraventricular hypothalamic OT neurons was elevated at termination of intake of either of the tastants, but this increase was 2-fold higher in sucrose-fed mice. A 48-h exposure to sucrose compared with Intralipid caused up-regulation of OT mRNA, whereas inherent individual preferences for sucrose vs. fat were not associated with differences in baseline OT expression as established with quantitative PCR. We found that L-368,899, an OT receptor antagonist, increased sugar intake when sucrose was presented alone or concurrently with Intralipid; it had no effect on Intralipid or total calorie consumption. L-368,899 affected Fos immunoreactivity in the paraventricular hypothalamus, arcuate nucleus, amygdala, and nucleus of the solitary tract, areas involved in aversion, satiety, and reward. This pattern ser…

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Authors: Olszewski, P. K., Klockars, A., Olszewska, A. M., Fredriksson, R., Schiöth, H. B., & Levine, A. S.
Affiliations: University of Minnesota (US)
Uppsala University (SE)
Department of Neuroscience (P.K.O., A.K., A.M.O., R.F., H.B.S.), Functional Pharmacology, Uppsala University, Uppsala Biomedical Center, Uppsala SE 75124, Sweden
Corresponding author: Levine, Allen S.
ORCID: Olszewski, Pawel K.
Klockars, Anica
Fredriksson, Robert
Levine, Allen S.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2010-08-04
Volume: 151
Issue: 10
Pages: 4736-4744
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2010-0151
PMC: PMC2946140
OpenAlex: W2021699660
Cited by: 104
References: 45
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 13 · 2020: 3 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 9
FWCI: 2.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Endocrinology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Vetenskapsrådet
Systembolaget
National Institutes of Health
National Institute on Drug Abuse (R01DA021280)
National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK 50456, P30DK050456)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, sucrose intake, dietary fat intake, carbohydrate preference, paraventricular hypothalamus, Fos-like immunoreactivity, L-368,899, oxytocin receptor antagonist, satiety, food reward, arcuate nucleus, amygdala, nucleus tractus solitarius, osmolality
MeSH terms: Animals, Appetite Regulation, Camphanes, Dietary Carbohydrates, Dietary Fats, Eating, Feeding Behavior, Hormone Antagonists, Immunohistochemistry, Male, Mice, Inbred C57BL, Oxytocin, Piperazines, Down-Regulation, Receptors, Oxytocin, Mice, Knockout, Mice

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Molecular, Immunohistochemical, and Pharmacological Evidence of Oxytocin’s Role as Inhibitor of Carbohydrate But Not Fat Intake

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