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Molecular, Immunohistochemical, and Pharmacological Evidence of Oxytocin’s Role as Inhibitor of Carbohydrate But Not Fat Intake
Open accessAbstract
Oxytocin (OT) facilitates feeding termination stemming from high osmolality, stomach distention, and malaise. Recent knockout (KO) studies suggested a crucial function for OT in carbohydrate intake: OT-/- mice had increased preference for carbohydrates, including sucrose, but not fat (Intralipid). In striking contrast, sugar appetite was unaffected in the OT receptor KO mouse; data from wild-type animals have been insufficient. Therefore, we examined the involvement of OT in the regulation of sucrose vs. fat intake in C57BL/6 mice that served as a background KO strain. We exposed mice to a meal of sucrose or Intralipid and determined that the percentage of c-Fos-immunoreactive paraventricular hypothalamic OT neurons was elevated at termination of intake of either of the tastants, but this increase was 2-fold higher in sucrose-fed mice. A 48-h exposure to sucrose compared with Intralipid caused up-regulation of OT mRNA, whereas inherent individual preferences for sucrose vs. fat were not associated with differences in baseline OT expression as established with quantitative PCR. We found that L-368,899, an OT receptor antagonist, increased sugar intake when sucrose was presented alone or concurrently with Intralipid; it had no effect on Intralipid or total calorie consumption. L-368,899 affected Fos immunoreactivity in the paraventricular hypothalamus, arcuate nucleus, amygdala, and nucleus of the solitary tract, areas involved in aversion, satiety, and reward. This pattern ser…
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“The intake of sugar compared with an equicaloric fat solution induces a selective, twofold increase in hypothalamic oxytocinergic neuronal activity, whereas central nervous oxytocin receptor antagonism triggers the intake of sucrose but not fat (47).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [47]
In the citing paper
“The intake of sugar compared with an equicaloric fat solution induces a selective, twofold increase in hypothalamic oxytocinergic neuronal activity, whereas central nervous oxytocin receptor antagonism triggers the intake of sucrose but not fat (47).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [47]
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Metadata
- Authors
- Olszewski, P. K., Klockars, A., Olszewska, A. M., Fredriksson, R., Schiöth, H. B., & Levine, A. S.
- Affiliations
- University of Minnesota (US)
- Uppsala University (SE)
- Department of Neuroscience (P.K.O., A.K., A.M.O., R.F., H.B.S.), Functional Pharmacology, Uppsala University, Uppsala Biomedical Center, Uppsala SE 75124, Sweden
- Corresponding author
- Levine, Allen S.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-08-04
- Volume
- 151
- Issue
- 10
- Pages
- 4736-4744
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC2946140
- OpenAlex
- W2021699660
- Cited by
- 104
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 13 · 2020: 3 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 9
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Systembolaget
- National Institutes of Health
- National Institute on Drug Abuse (R01DA021280)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK 50456, P30DK050456)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, sucrose intake, dietary fat intake, carbohydrate preference, paraventricular hypothalamus, Fos-like immunoreactivity, L-368,899, oxytocin receptor antagonist, satiety, food reward, arcuate nucleus, amygdala, nucleus tractus solitarius, osmolality
- MeSH terms
- Animals, Appetite Regulation, Camphanes, Dietary Carbohydrates, Dietary Fats, Eating, Feeding Behavior, Hormone Antagonists, Immunohistochemistry, Male, Mice, Inbred C57BL, Oxytocin, Piperazines, Down-Regulation, Receptors, Oxytocin, Mice, Knockout, Mice
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