Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

Shared Principles in NF-κB Signaling

Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,814 · see citing works

Mammalian neural stem cells.

Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 3,949 · see citing works

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works

NF-κB at the crossroads of life and death

Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709 · see citing works

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works

Alzheimer's disease

Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61349-9 · Cited by 2,336 · see citing works

Inflammatory links between obesity and metabolic disease

Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works

Inflammasomes in health and disease

Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works

Parkinson's disease

Lees, A. J., Hardy, J., & Revesz, T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60492-x · Cited by 1,956 · see citing works

Oxidative stress in neurodegeneration: Cause or consequence?

Andersen, J. K. (2004) · Nature Medicine · doi:10.1038/nrn1434 · Cited by 1,869 · see citing works

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works

Anatomy and regulation of the central melanocortin system

Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583 · see citing works

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350 · see citing works

Insulin sensitivity: Modulation by nutrients and inflammation

Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191 · see citing works

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D. E., Tsukumo, D. M. L., Anhe, G., Amaral, M. E., Takahashi, H. K., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2760-08.2009 · Cited by 1,125 · see citing works

Anti-inflammatory Agents: Present and Future

Dinarello, C. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.043 · Cited by 1,095 · see citing works

Mechanisms of leptin action and leptin resistance.

Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074 · see citing works

Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence

Hamer, M., & Chida, Y. (2009) · Psychological Medicine · doi:10.1017/s0033291708003681 · Cited by 988 · see citing works

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works

Circuitry of nuclear factor κB signaling

Hoffmann, A., & Baltimore, D. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00375.x · Cited by 907 · see citing works

Obesity and leptin resistance: distinguishing cause from effect

Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.002 · Cited by 906 · see citing works

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

Ozcan, L., Ergin, A. S., Lu, A., Chung, J., Sarkar, S., Nie, D., Myers, M. G., & Ozcan, U. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.004 · Cited by 875 · see citing works

Obesity-Associated Hypertension

Rahmouni, K., Correia, M., Haynes, W. G., & Mark, A. L. (2004) · Hypertension · doi:10.1161/01.hyp.0000151325.83008.b4 · Cited by 780 · see citing works

Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance

Kokoeva, M. V., Yin, H., & Flier, J. S. (2005) · Science · doi:10.1126/science.1115360 · Cited by 704 · see citing works

How widespread is adult neurogenesis in mammals?

Gould, E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2147 · Cited by 658 · see citing works

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651 · see citing works

Neuronal PTP1B regulates body weight, adiposity and leptin action

Bence, K. K., Delibegovic, M., Xue, B., Gorgun, C. Z., Hotamisligil, G. S., Neel, B. G., & Kahn, B. B. (2006) · Nature Medicine · doi:10.1038/nm1435 · Cited by 633 · see citing works

Toll-like receptors modulate adult hippocampal neurogenesis

Rolls, A., Shechter, R., London, A., Ziv, Y., Ronen, A., Levy, R., & Schwartz, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1629 · Cited by 620 · see citing works

Obesity‐induced inflammation: a metabolic dialogue in the language of inflammation

Ferrante, A. W. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01852.x · Cited by 613 · see citing works

Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior

Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607 · see citing works

The Hormonal Control of Food Intake

Coll, A. P., Farooqi, I. S., & O’Rahilly, S. (2007) · Cell · doi:10.1016/j.cell.2007.04.001 · Cited by 605 · see citing works

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

Posey, K. A., Clegg, D. J., Printz, R. L., Byun, J., Morton, G. J., Vivekanandan-Giri, A., Pennathur, S., Baskin, D. G., Heinecke, J. W., Woods, S. C., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90377.2008 · Cited by 586 · see citing works

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta‐analysis

Beydoun, M. A., Beydoun, H. A., & Wang, Y. (2008) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00473.x · Cited by 563 · see citing works

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3079 · Cited by 502 · see citing works

Mitochondrial diseases

Schapira, A. H. V. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61305-6 · Cited by 499 · see citing works

The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight

King, B. M. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.10.007 · Cited by 490 · see citing works

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

Kleinridders, A., Schenten, D., Könner, A. C., Belgardt, B. F., Mauer, J., Okamura, T., Wunderlich, F. T., Medzhitov, R., & Brüning, J. C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.013 · Cited by 483 · see citing works

Hypothalamic sensing of fatty acids

Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478 · see citing works

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

Moraes, J. C., Coope, A., Morari, J., Cintra, D. E., Roman, E. A., Pauli, J. R., Romanatto, T., Carvalheira, J. B. C., de Oliveira, A. L. R., Saad, M. J. A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005045 · Cited by 427 · see citing works

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

Sorrells, S. F., Caso, J. R., Munhoz, C. D., & Sapolsky, R. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.032 · Cited by 425 · see citing works

From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

Williams, K. W., & Elmquist, J. K. (2012) · Nature Neuroscience · doi:10.1038/nn.3217 · Cited by 421 · see citing works

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.

Zabolotny, J. M., Kim, Y.-B., Welsh, L. A., Kershaw, E. E., Neel, B. G., & Kahn, B. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800061200 · Cited by 404 · see citing works

Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells

Emsley, J. G., Mitchell, B. D., Kempermann, G., & Macklis, J. D. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.04.002 · Cited by 398 · see citing works

Diabetes and the Risk of Multi-System Aging Phenotypes: A Systematic Review and Meta-Analysis

Lu, F.-P., Lin, K.-P., & Kuo, H.-K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004144 · Cited by 398 · see citing works

Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis

Elmquist, J. K., Coppari, R., Balthasar, N., Ichinose, M., & Lowell, B. B. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20786 · Cited by 388 · see citing works

Attenuation of leptin and insulin signaling by SOCS proteins

Howard, J. K., & Flier, J. S. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.09.007 · Cited by 371 · see citing works

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

Li, J., Tang, Y., & Cai, D. (2012) · Nature Cell Biology · doi:10.1038/ncb2562 · Cited by 344 · see citing works

Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations

Petit-Paitel, A., Kawarai, T., Paitel, E., Sanjo, N., Maj, M. C., Scheid, M. P., Chen, F., Gu, Y., Hasegawa, H., Salehi‐Rad, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505143200 · Cited by 329 · see citing works

Toll-like receptors: linking inflammation to metabolism

Könner, A. C., & Brüning, J. C. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.007 · Cited by 327 · see citing works

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

Salminen, A., Kauppinen, A., Suuronen, T., Kaarniranta, K., & Ojala, J. O. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-41 · Cited by 327 · see citing works

Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis

Meissner, F., Molawi, K., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002396107 · Cited by 319 · see citing works

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

Thaler, J. P., & Schwartz, M. W. (2010) · Endocrinology · doi:10.1210/en.2010-0336 · Cited by 313 · see citing works

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice

McNay, D. E. G., Briançon, N., Kokoeva, M. V., Maratos–Flier, E., & Flier, J. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43134 · Cited by 312 · see citing works

High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

Morrison, C. D., Pistell, P. J., Ingram, D. K., Johnson, W. D., Liu, Y., Fernandez‐Kim, S. O., White, C. L., Purpera, M. N., Uranga, R. M., Bruce‐Keller, A. J., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06865.x · Cited by 291 · see citing works

CNS leptin and insulin action in the control of energy homeostasis

Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 275 · see citing works

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

Meng, Q., & Cai, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254417 · Cited by 259 · see citing works

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

Ramesh Babu, J., Lamar Seibenhener, M., Peng, J., Strom, A., Kemppainen, R., Cox, N., Zhu, H., Wooten, M. C., Diaz‐Meco, M. T., Moscat, J., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05340.x · Cited by 258 · see citing works

Evidence for constitutive neural cell proliferation in the adult murine hypothalamus

Kokoeva, M. V., Yin, H., & Flier, J. S. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21492 · Cited by 246 · see citing works

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

White, C. L., Pistell, P. J., Purpera, M. N., Gupta, S., Fernandez-Kim, S.-O., Hise, T. L., Keller, J. N., Ingram, D. K., Morrison, C. D., & Bruce-Keller, A. J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.04.002 · Cited by 245 · see citing works

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells

Kievit, P., Howard, J. K., Badman, M. K., Balthasar, N., Coppari, R., Mori, H., Lee, C. E., Elmquist, J. K., Yoshimura, A., & Flier, J. S. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.010 · Cited by 242 · see citing works

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

Milanski, M., Arruda, A. P., Coope, A., Ignácio-Souza, L. M., Nuñez, C. E. C., Roman, E. A., Romanatto, T., Pascoal, L. B., Caricilli, A. M., Torsoni, M. A., et al. (2012) · Diabetes · doi:10.2337/db11-0390 · Cited by 228 · see citing works

De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance

Pierce, A. A., & Xu, A. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2479-09.2010 · Cited by 224 · see citing works

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB

Purkayastha, S., Zhang, G., & Cai, D. (2011) · Nature Medicine · doi:10.1038/nm.2372 · Cited by 220 · see citing works

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39620 · Cited by 214 · see citing works

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

Arruda, A. P., Milanski, M., Coope, A., Torsoni, A. S., Ropelle, E. R., de Carvalho, D. P., Carvalheira, J. B. C., & Velloso, L. A. (2011) · Endocrinology · doi:10.1210/en.2010-0659 · Cited by 203 · see citing works

Obesity and vulnerability of the CNS

Bruce-Keller, A. J., Keller, J. N., & Morrison, C. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.004 · Cited by 200 · see citing works

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

Cai, D., & Liu, T. (2012) · Aging · doi:10.18632/aging.100431 · Cited by 189 · see citing works

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Loh, K., Fukushima, A., Zhang, X., Galić, S., Briggs, D. I., Enriori, P. J., Simonds, S. E., Wiede, F., Reichenbach, A., Hauser, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.011 · Cited by 180 · see citing works

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

Purkayastha, S., Zhang, H., Zhang, G., Ahmed, Z., Wang, Y., & Cai, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006875108 · Cited by 179 · see citing works

The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation

Sandoval, D., Cota, D., & Seeley, R. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.120806.095256 · Cited by 178 · see citing works

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

Reed, A. S., Unger, E. K., Olofsson, L. E., Piper, M. L., Myers, M. G., & Xu, A. W. (2010) · Diabetes · doi:10.2337/db09-1024 · Cited by 176 · see citing works

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

Belgardt, B., Mauer, J., Wunderlich, F. T., Ernst, M. B., Pál, M., Spohn, G., Brönneke, H. S., Brodesser, S., Hampel, B., Schauss, A. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001796107 · Cited by 168 · see citing works

Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.

de la Monte, S. M., Longato, L., Tong, M., & Wands, J. R. (2009) · PubMed · Cited by 167 · see citing works

IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase

Dugan, L. L., Ali, S. S., Shekhtman, G., Roberts, A. J., Lucero, J., Quick, K. L., & Behrens, M. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005518 · Cited by 165 · see citing works

Hypothalamic inflammation: a double‐edged sword to nutritional diseases

Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 159 · see citing works

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

Won, J. C., Jang, P., Namkoong, C., Koh, E. H., Kim, S. K., Park, J., Lee, K., & Kim, M. (2009) · Obesity · doi:10.1038/oby.2009.194 · Cited by 153 · see citing works

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration

Alirezaei, M., Kiosses, W. B., Flynn, C. T., Brady, N. R., & Fox, H. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002906 · Cited by 147 · see citing works

Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

Nerurkar, P. V., Johns, L. M., Buesa, L. M., Kipyakwai, G. K., Volper, E. M., Sato, R., Shah, P. A., Fehér, D., Williams, P. G., & Nerurkar, V. R. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-64 · Cited by 145 · see citing works

Hypothalamic inflammation and energy homeostasis: Resolving the paradox

Thaler, J. P., Choi, S. J., Schwartz, M. W., & Wisse, B. E. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.002 · Cited by 144 · see citing works

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

Hetz, C., Valenzuela, V., Collyer, E., Armentano, D., Parsons, G., & Court, F. A. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.8 · Cited by 141 · see citing works

Discussion point stem cells and neurogenesis in the adult brain

Cameron, H. A., & McKay, R. D. G. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80099-8 · Cited by 140 · see citing works

Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

Picardi, P. K., Calegari, V. C., Prada, P. O., Moraes, J. C., ARAUJO, E. P. D., Gomes‐Marcondes, M. C. C., Ueno, M., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2008) · Endocrinology · doi:10.1210/en.2007-1506 · Cited by 127 · see citing works

Feeding signals and brain circuitry

Dietrich, M. O., & Horváth, T. L. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06963.x · Cited by 123 · see citing works

Central insulin and leptin-mediated autonomic control of glucose homeostasis

Marino, J. S., Xu, Y., & Hill, J. W. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.03.001 · Cited by 123 · see citing works

Role of the hypothalamic–pituitary–thyroid axis in metabolic regulation by JNK1Preprint

Sabio, G., Cavanagh, J., Barrett, T., Jung, D. Y., Ko, H. J., Ong, H., Morel, C., Mora, A., Reilly, J., Kim, J. K., et al. (2010) · Genes & Development · doi:10.1101/gad.1878510 · Cited by 117 · see citing works

The Fat-Brain Axis Enters a New Dimension

Elmquist, J. K., & Flier, J. S. (2004) · Science · doi:10.1126/science.1096746 · Cited by 111 · see citing works

Modeling mitochondrial function in aging neurons

Melov, S. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.004 · Cited by 111 · see citing works

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

Scheele, C., Nielsen, A. R., Walden, T. B., Sewell, D. A., Fischer, C. P., Brogan, R. J., Petrovic, N., Larsson, O., Tesch, P. A., Wennmalm, K., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8520com · Cited by 110 · see citing works

High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice

Bousquet, M., St‐Amour, I., Vandal, M., Julien, P., Cicchetti, F., & Calon, F. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.09.009 · Cited by 110 · see citing works

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

Sadagurski, M., Cheng, Z., Rozzo, A., Palazzolo, I., Kelley, G. R., Dong, X., Krainc, D., & White, M. F. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46305 · Cited by 107 · see citing works

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

Son, S. M., Song, H., Byun, J., Park, K. S., Jang, H. C., Park, Y. J., & Mook‐Jung, I. (2012) · Autophagy · doi:10.4161/auto.21861 · Cited by 98 · see citing works

Getting away from glucose: fanning the flames of obesity-induced inflammation

Shoelson, S. E., & Goldfine, A. B. (2009) · Nature Medicine · doi:10.1038/nm0409-373 · Cited by 98 · see citing works

Autophagy, inflammation and neurodegenerative disease

Alirezaei, M., Kemball, C. C., & Whitton, J. L. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07500.x · Cited by 92 · see citing works

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene

Ryu, K., Garza, J. C., Lu, X., Barsh, G. S., & Kopito, R. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800096105 · Cited by 91 · see citing works

NFκB-mediated metabolic inflammation in peripheral tissues versus central nervous system

Cai, D. (2009) · Cell Cycle · doi:10.4161/cc.8.16.9386 · Cited by 79 · see citing works

Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1−/− mouse brain

Liao, G., Cheung, S., Galeano, J., Ji, A. X., Qin, Q., & Bi, X. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.027 · Cited by 77 · see citing works

Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding

Oh‐I, S., Thaler, J. P., Ogimoto, K., Wisse, B. E., Morton, G. J., & Schwartz, M. W. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00026.2010 · Cited by 62 · see citing works

A Role for Astrocytes in the Central Control of Metabolism

Yi, C., Habegger, K. M., Chowen, J. A., Stern, J. E., & Tschöp, M. H. (2011) · Neuroendocrinology · doi:10.1159/000324888 · Cited by 60 · see citing works

Grape Seed and Skin Extract Prevents High-Fat Diet-Induced Brain Lipotoxicity in Rat

Charradi, K., Elkahoui, S., Karkouch, I., Limam, F., Hassine, F. B., & Aouani, E. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0821-2 · Cited by 51 · see citing works

Metabolic syndrome: a brain disease

Singh, R. B., Gupta, S. S., Dherange, P., Meester, F. D., Wilczyńska, A., Alam, S. E., Pella, D., & Wilson, D. W. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-122 · Cited by 47 · see citing works

One Step from Prediabetes to Diabetes: Hypothalamic Inflammation?

Cai, D. (2012) · Endocrinology · doi:10.1210/en.2011-2183 · Cited by 31 · see citing works

Different early ER-stress responses in the CLN8mnd mouse model of neuronal ceroid lipofuscinosis

Galizzi, G., Russo, D., Deidda, I., Cascio, C., Passantino, R., Guarneri, R., Bigini, P., Mennini, T., Drago, G., & Guarneri, P. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.11.041 · Cited by 30 · see citing works

Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response

Camacho‐Morales, A., Rodriguez-Cuenca, S., Blount, M., Prieur, X., Barbarroja, N., Fuller, M., Hardingham, G. E., & Vidal‐Puig, A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.06.031 · Cited by 24 · see citing works

Increased E4 Activity in Mice Leads to Ubiquitin-containing Aggregates and Degeneration of Hypothalamic Neurons Resulting in Obesity

Susaki, E. A., Kaneko-Oshikawa, C., Miyata, K., Tabata, M., Yamada, T., Oike, Y., Katagiri, H., & Nakayama, K. I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105841 · Cited by 17 · see citing works

Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377 · see citing works

Mechanisms Linking Inflammation to Insulin Resistance

Chen, L., Chen, R., Wang, H., & Liang, F. (2015) · International Journal of Endocrinology · doi:10.1155/2015/508409 · Cited by 644 · see citing works

Inflammatory Response in the CNS: Friend or Foe?

Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573 · see citing works

Mitochondrial dysfunction in obesity

de Mello, A. H., Costa, A. B., Engel, J. D. G., & Rezin, G. T. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.11.019 · Cited by 508 · see citing works

Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress

Yan, L. (2014) · Journal of Diabetes Research · doi:10.1155/2014/137919 · Cited by 403 · see citing works

Chronic peripheral inflammation, hippocampal neurogenesis, and behavior

Chesnokova, V., Pechnick, R. N., & Wawrowsky, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.01.017 · Cited by 299 · see citing works

Zebrafish as a Model for Obesity and Diabetes

Zang, L., Maddison, L. A., & Chen, W. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00091 · Cited by 302 · see citing works

Neuroinflammation and brain atrophy in former NFL players: An in vivo multimodal imaging pilot study

Coughlin, J. M., Wang, Y., Munro, C. A., Ma, S., Chen, Y., Chen, S., Airan, R. D., Kim, P. K., Adams, A. V., Garcia, C., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.019 · Cited by 236 · see citing works

Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care

Pillon, N. J., Loos, R. J. F., Marshall, S. M., & Zierath, J. R. (2021) · Cell · doi:10.1016/j.cell.2021.02.012 · Cited by 238 · see citing works

Targeting Neuroinflammation to Treat Alzheimer’s Disease

Ardura-Fabregat, A., Boddeke, E., Boza‐Serrano, A., Brioschi, S., Castro‐Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., Heneka, M. T., et al. (2017) · CNS Drugs · doi:10.1007/s40263-017-0483-3 · Cited by 236 · see citing works

Obesity associated with increased brain age from midlife

Ronan, L., Alexander‐Bloch, A. F., Wagstyl, K., Farooqi, I. S., Brayne, C., TYLER, L. K., & Fletcher, P. C. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.010 · Cited by 228 · see citing works

Leptin treatment: Facts and expectations

Paz-Filho, G., Mastronardi, C. A., & Licinio, J. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.014 · Cited by 220 · see citing works

Structural Brain Changes Associated with Overweight and Obesity

Apo, E. G., Mondragón‐Maya, A., Ferrari-Díaz, M., & Silva‐Pereyra, J. (2021) · Journal of Obesity · doi:10.1155/2021/6613385 · Cited by 203 · see citing works

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

Spielman, L. J., Little, J. P., & Klegeris, A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.06.004 · Cited by 182 · see citing works

FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

Wang, Q., Yuan, J., Yu, Z., Lin, L., Jiang, Y., Cao, Z., Zhuang, P., Whalen, M. J., Song, B., Wang, X., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0663-7 · Cited by 157 · see citing works

A four-day Western-style dietary intervention causes reductions in hippocampal-dependent learning and memory and interoceptive sensitivity

Attuquayefio, T., Stevenson, R. J., Oaten, M., & Francis, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172645 · Cited by 147 · see citing works

Neuroinflammatory basis of metabolic syndrome

Purkayastha, S., & Cai, D. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.005 · Cited by 145 · see citing works

Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response

Yan, J., Zhang, H., Yin, Y. I., Li, J., Tang, Y., Purkayastha, S., Li, L., & Cai, D. (2014) · Nature Medicine · doi:10.1038/nm.3616 · Cited by 142 · see citing works

“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

Cai, D., & Khor, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.021 · Cited by 134 · see citing works

Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease

Lutz, M. I., Milenković, I., Regelsberger, G., & Kovács, G. G. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8288-8 · Cited by 131 · see citing works

Leptin regulation of hippocampal synaptic function in health and disease

Irving, A. J., & Harvey, J. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0155 · Cited by 123 · see citing works

Contribution of specific ceramides to obesity-associated metabolic diseases

Hammerschmidt, P., & Brüning, J. C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04401-3 · Cited by 127 · see citing works

Disease-Induced Neuroinflammation and Depression

Benatti, C., Blom, J. M. C., Rigillo, G., Alboni, S., Zizzi, F., Torta, R., Brunello, N., & Tascedda, F. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160321104749 · Cited by 121 · see citing works

Liver Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet

da Silva-Santi, L. G., Antunes, M. M., Caparroz‐Assef, S. M., Carbonera, F., Masi, L. N., Curi, R., Visentainer, J. V., & Bazotte, R. B. (2016) · Nutrients · doi:10.3390/nu8110682 · Cited by 121 · see citing works

The Role of Immune Cells in Oxi-Inflamm-Aging

de Toda, I. M., Ceprián, N., Cerro, E. D., & la Fuente, M. D. (2021) · Cells · doi:10.3390/cells10112974 · Cited by 121 · see citing works

Being overweight is associated with hippocampal atrophy: the PATH Through Life Study

Cherbuin, N., Sargent‐Cox, K. A., Fraser, M. A., Sachdev, P. S., & Anstey, K. J. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.106 · Cited by 119 · see citing works

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle

Varela-Rodríguez, B. M., Pena-Bello, L., Juiz-Valiña, P., Bretal, B. V., Cordido, F., & Sangiao‐Alvarellos, S. (2016) · Scientific Reports · doi:10.1038/srep29898 · Cited by 111 · see citing works

Role of hypothalamic neurogenesis in feeding regulation

Sousa-Ferreira, L., de Almeida, L. P., & Cavadas, C. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.10.005 · Cited by 110 · see citing works

Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

Tang, Y., Purkayastha, S., & Cai, D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.10.002 · Cited by 109 · see citing works

N-3 polyunsaturated fatty acids in animal models with neuroinflammation: An update

Trépanier, M., Hopperton, K. E., Orr, S. K., & Bazinet, R. P. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.045 · Cited by 109 · see citing works

Metabolic syndrome induces inflammation and impairs gonadotropin-releasing hormone neurons in the preoptic area of the hypothalamus in rabbits

Morelli, A., Sarchielli, E., Comeglio, P., Filippi, S., Vignozzi, L., Marini, M., Rastrelli, G., Maneschi, E., Cellai, I., Persani, L., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.017 · Cited by 107 · see citing works

FGF1 — a new weapon to control type 2 diabetes mellitus

Gasser, E., Moutos, C. P., Downes, M., & Evans, R. M. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.78 · Cited by 106 · see citing works

High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss

Duffy, C. M., Hofmeister, J. J., Nixon, J. P., & Butterick, T. A. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.008 · Cited by 107 · see citing works

Polyphenol Microbial Metabolites Exhibit Gut and Blood–Brain Barrier Permeability and Protect Murine Microglia against LPS-Induced Inflammation

Johnson, S. L., Kirk, R. D., DaSilva, N. A., Ma, H., Seeram, N. P., & Bertin, M. J. (2019) · Metabolites · doi:10.3390/metabo9040078 · Cited by 100 · see citing works

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

Orellana, A. M., Vasconcelos, A. R., Leite, J. A., Lima, L. D. S., Andreotti, D. Z., Munhoz, C. D., Kawamoto, E. M., & Scavone, C. (2015) · Aging · doi:10.18632/aging.100853 · Cited by 96 · see citing works

Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose‐fed rats

Li, J., Ge, C., Xu, M., Wang, W., Yu, R., Fan, C., & Kong, L. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400307 · Cited by 91 · see citing works

Targeting SREBPs for treatment of the metabolic syndrome

Soyal, S. M., Nofziger, C., Dossena, S., Paulmichl, M., & Patsch, W. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.010 · Cited by 91 · see citing works

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

Lee, D. A., Yoo, S., Pak, T. K., Salvatierra, J., Velarde, E., Aja, S. M., & Blackshaw, S. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00157 · Cited by 86 · see citing works

Hypothalamic Obesity in Craniopharyngioma Patients: Disturbed Energy Homeostasis Related to Extent of Hypothalamic Damage and Its Implication for Obesity Intervention

Roth, C. L. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4091774 · Cited by 90 · see citing works

Microglia activation due to obesity programs metabolic failure leading to type two diabetes

Maldonado‐Ruiz, R., Montalvo-Martínez, L., Fuentes‐Mera, L., & Camacho‐Morales, A. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.10 · Cited by 85 · see citing works

Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans

Shao, X., Lu, W., Gao, F., Li, D., Hu, J., Li, Y., Zuo, Z., Jie, H., Zhao, Y., & Cen, X. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1480-16.2016 · Cited by 83 · see citing works

Perturbation of Hypothalamic MicroRNA Expression Patterns in Male Rats After Metabolic Distress: Impact of Obesity and Conditions of Negative Energy Balance

Sangiao‐Alvarellos, S., Pena-Bello, L., Manfredi-Lozano, M., Tena‐Sempere, M., & Cordido, F. (2014) · Endocrinology · doi:10.1210/en.2013-1770 · Cited by 78 · see citing works

Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function

Jayaraman, A., Lent-Schochet, D., & Pike, C. J. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0162-y · Cited by 78 · see citing works

Identification of diagnostic genes for both Alzheimer’s disease and Metabolic syndrome by the machine learning algorithm

Li, J., Zhang, Y., Lu, T., Liang, R., Wu, Z., Liu, M., Qin, L., Chen, H., Yan, X., Deng, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1037318 · Cited by 80 · see citing works

Obesity and stroke: Can we translate from rodents to patients?

Haley, M. J., & Lawrence, C. (2016) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x16670411 · Cited by 73 · see citing works

Systemic metabolic derangement, pulmonary effects, and insulin insufficiency following subchronic ozone exposure in rats

Miller, D. B., Snow, S. J., Henriquez, A. R., Schladweiler, M. C. J., Ledbetter, A. D., Richards, J. H., Andrews, D. L., & Kodavanti, U. P. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.06.027 · Cited by 75 · see citing works

Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury

Fleiss, B., Wong, F. Y., Brownfoot, F., Shearer, I. K., Baud, O., Walker, D. W., Gressèns, P., & Tolcos, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00188 · Cited by 73 · see citing works

Role of orexin A signaling in dietary palmitic acid-activated microglial cells

Duffy, C. M., Yuan, C., Wisdorf, L. E., Billington, C. J., Kotz, C. M., Nixon, J. P., & Butterick, T. A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.08.033 · Cited by 74 · see citing works

Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion

Cavallucci, V., Fidaleo, M., & Pani, G. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.007 · Cited by 72 · see citing works

Fasting: From Physiology to Pathology

Tang, D., Tang, Q., Huang, W., Zhang, Y., Tian, Y., & Fu, X. (2023) · Advanced Science · doi:10.1002/advs.202204487 · Cited by 71 · see citing works

Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis

Bóbbo, V. C. D., Engel, D. F., Jara, C. P., Mendes, N. F., Haddad-Tóvolli, R., do Prado, T. P., Sidarta-Oliveira, D., Morari, J., Velloso, L. A., & ARAUJO, E. P. D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02242-8 · Cited by 69 · see citing works

Aging of the Retina: Molecular and Metabolic Turbulences and Potential Interventions

Campello, L., Singh, N., Advani, J., Mondal, A. K., Corso‐Díaz, X., & Swaroop, A. (2021) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100419-114940 · Cited by 67 · see citing works

Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins

McCormick, S. M., & Heller, N. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00549 · Cited by 67 · see citing works

The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia

Folch, J., Olloquequi, J., Ettcheto, M., Busquets, O., Sánchez‐López, E., Cano, A. C., Espinosa-Jiménez, T., García, M. L., Beas‐Zárate, C., Casadesús, G., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00236 · Cited by 68 · see citing works

Metformin Restores Hippocampal Neurogenesis and Learning and Memory via Regulating Gut Microbiota in the Obese Mouse Model

Ma, X., Xiao, W., Li, H., Pang, P., Xue, F., Wan, L., Pei, L., & Yan, H. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.011 · Cited by 67 · see citing works

Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

Rahman, M. H., Bhusal, A., Kim, J., Jha, M. K., Song, G. J., Go, Y., Jang, I., Lee, I., & Suk, K. (2020) · Nature Communications · doi:10.1038/s41467-020-19576-1 · Cited by 66 · see citing works

HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis

Peng, X., Sun, B., Tang, C., Shi, C., Xie, X., Wang, X., Jiang, D., Li, S., Jia, Y., Tang, H., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.12.011 · Cited by 66 · see citing works

Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice

Mao, J., Langley, S. A., Huang, Y., Hang, M., Bouchard, K. E., Celniker, S., Brown, J., Jansson, J. K., Karpen, G. H., & Snijders, A. M. (2015) · Scientific Reports · doi:10.1038/srep16247 · Cited by 66 · see citing works

Microbiota impacts on chronic inflammation and metabolic syndrome - related cognitive dysfunction

Arnoriaga‐Rodríguez, M., & Fernández‐Real, J. M. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09537-5 · Cited by 67 · see citing works

The role of astrocytes in the hypothalamic response and adaptation to metabolic signals

Chowen, J. A., Argente-Arizón, P., Freire‐Regatillo, A., Frago, L. M., Horváth, T. L., & Argente, J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.001 · Cited by 63 · see citing works

Neuroinflammatory and autonomic mechanisms in diabetes and hypertension

Han, C., Rice, M. W., & Cai, D. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00012.2016 · Cited by 63 · see citing works

Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation

Duffy, C. M., Xu, H., Nixon, J. P., Bernlohr, D., & Butterick, T. A. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.02.004 · Cited by 63 · see citing works

Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response

Tracy, L. M., Bergqvist, F., Ivanova, E. V., Jacobsen, K. T., & Iverfeldt, K. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0068-7 · Cited by 63 · see citing works

Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation.

Wanrooy, B. J., Kumar, K. P., Wen, S. W., Qin, C. X., Ritchie, R. H., & Wong, C. H. Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1329-8 · Cited by 63 · see citing works

Leptin in Health and Disease: Facts and Expectations at its Twentieth Anniversary

Pοlyzos, S. A., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.017 · Cited by 63 · see citing works

Short-term high-fat diet induces cognitive decline, aggression, and anxiety-like behavior in adult zebrafish

Picolo, V. L., de Quadros, V. A., Canzian, J., Grisólia, C. K., Goulart, J. T., Pantoja, C., Bem, A. F. D., & Rosemberg, D. B. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110288 · Cited by 61 · see citing works

Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation

Zhang, Q., Jin, K., Chen, B., Liu, R., Cheng, S., Zhang, Y., & Lü, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.884579 · Cited by 60 · see citing works

Hypothalamic mitochondrial abnormalities occur downstream of inflammation in diet-induced obesity

Carraro, R. S., de Souza, G. F. P., Solon, C., Razolli, D. S., Chausse, B., Barbizan, R., Victorio, S. C. D. S., & Velloso, L. A. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.07.029 · Cited by 61 · see citing works

Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder

McElroy, S. L., Kemp, D. E., Friedman, E. S., Reilly-Harrington, N. A., Sylvia, L. G., Calabrese, J. R., Rabideau, D. J., Ketter, T. A., Thase, M. E., Singh, V. K., et al. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12460 · Cited by 60 · see citing works

High-refined carbohydrate diet consumption induces neuroinflammation and anxiety-like behavior in mice

Gomes, J. A. S., da Silva, J. F., Marçal, A. P., da Silva, G. C., Gomes, G. F., de Oliveira, A. C. P., Soares, V. L., Oliveira, M. C., Ferreira, A. V. M., & de Aguiar, D. C. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108317 · Cited by 59 · see citing works

Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity and diabetes: Translational significance

Rahman, M. H., Bhusal, A., Lee, W., Lee, I., & Suk, K. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.024 · Cited by 57 · see citing works

Neurodevelopmental origin and adult neurogenesis of the neuroendocrine hypothalamus

Maggi, R., Zasso, J., & Conti, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00440 · Cited by 55 · see citing works

Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging

Yin, Z., Raj, D. D. A., Schaafsma, W., van der Heijden, R. A., Kooistra, S. M., Reijne, A. C., Zhang, X., Moser, J., Brouwer, N., Heeringa, P., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00065 · Cited by 56 · see citing works

Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation

Ribeiro, M. F., Santos, A. A., Afonso, M. B., Rodrigues, P., Santos, S. S., Castro, R., Rodrigues, C., & Solá, S. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa165 · Cited by 53 · see citing works

Hypothalamic Apelin/Reactive Oxygen Species Signaling Controls Hepatic Glucose Metabolism in the Onset of Diabetes

Drougard, A., Duparc, T., Brénachot, X., Carneiro, L., Gouazé, A., Fournel, A., Geurts, L., Cadoudal, T., Prats, A., Pénicaud, L., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5182 · Cited by 54 · see citing works

Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia

Tran, D. Q., Tse, E. K., Kim, M. H., & Belsham, D. D. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.05.015 · Cited by 54 · see citing works

Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases

Martín-Jiménez, C., García-Vega, Á. S., Cabezas, R., Aliev, G., Echeverrı́a, V., González, J., & Barreto, G. E. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.001 · Cited by 55 · see citing works

High-fat diet and neuroinflammation: The role of mitochondria

Song, M., Bai, Y., & Song, F. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107615 · Cited by 54 · see citing works

SARM1 deletion restrains NAFLD induced by high fat diet (HFD) through reducing inflammation, oxidative stress and lipid accumulation

Pan, Z.-G., & An, X.-S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.115 · Cited by 50 · see citing works

Carbohydrate-enriched diet predispose to anxiety and depression-like behavior after stress in mice

Santos, C. J., Ferreira, A. V. M., de Oliveira, A. L. F., Oliveira, M. C., Gomes, J. S., & de Aguiar, D. C. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1213529 · Cited by 52 · see citing works

Implications of resistin in type 2 diabetes mellitus and coronary artery disease: Impairing insulin function and inducing pro‐inflammatory cytokines

Emamalipour, M., Seidi, K., Jahanban‐Esfahlan, A., & Jahanban‐Esfahlan, R. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28913 · Cited by 54 · see citing works

A systematic review of the biological mediators of fat taste and smell

Jaime-Lara, R. B., Brooks, B. E., Vizioli, C., Chiles, M., Nawal, N., Figueroa, R. S. E. O., Livinski, A. A., Agarwal, K., Colina, C., Iannarino, N., et al. (2022) · Physiological Reviews · doi:10.1152/physrev.00061.2021 · Cited by 53 · see citing works

Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity

Rachid, B., van de Sande‐Lee, S., Rodovalho, S., Folli, F. B., Beltramini, G. C., Morari, J., Amorim, B. J., Pedro, T., Ramalho, A. F. S., Bombassaro, B., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.94 · Cited by 51 · see citing works

Redox status, inflammation, necroptosis and inflammasome as indispensable contributors to high fat diet (HFD)-induced neurodegeneration; Effect of N-acetylcysteine (NAC)

Keshk, W. A., Ibrahim, M. A., Shalaby, S. M., Zalat, Z., & Elseady, W. S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108227 · Cited by 49 · see citing works

CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells

Burke, S. J., Karlstad, M. D., Regal, K. M., Sparer, T. E., Lu, D., Elks, C. M., Grant, R. W., Stephens, J. M., Burk, D. H., & Collier, J. J. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.03.007 · Cited by 48 · see citing works

Metabolic syndrome: a brain disease

Singh, R. B., Gupta, S. S., Dherange, P., Meester, F. D., Wilczyńska, A., Alam, S. E., Pella, D., & Wilson, D. W. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-122 · Cited by 47 · see citing works

Association Between Central and Peripheral Age-Related Hearing Loss and Different Frailty Phenotypes in an Older Population in Southern Italy

Sardone, R., Castellana, F., Bortone, I., Lampignano, L., Zupo, R., Lozupone, M., Griseta, C., Dibello, V., Seripa, D., Guerra, V., et al. (2021) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2020.5334 · Cited by 47 · see citing works

Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals

Freire‐Regatillo, A., Argente-Arizón, P., Argente, J., García‐Segura, L. M., & Chowen, J. A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00051 · Cited by 45 · see citing works

Brain Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet

da Silva-Santi, L. G., Antunes, M. M., Mori, M., de Almeida-Souza, C. B., Visentainer, J. V., Carbonera, F., Crisma, A. R., Masi, L. N., Hirabara, S. M., Curi, R., et al. (2018) · Nutrients · doi:10.3390/nu10091277 · Cited by 45 · see citing works

Long-Lasting Metabolic Imbalance Related to Obesity Alters Olfactory Tissue Homeostasis and Impairs Olfactory-Driven Behaviors

Lacroix, M.-C., Caillol, M., Durieux, D., Monnerie, R., Grébert, D., Pellerin, L., Repond, C., Tolle, V., Zizzari, P., & Baly, C. (2015) · Chemical Senses · doi:10.1093/chemse/bjv039 · Cited by 44 · see citing works

In renovascular hypertension, TNF-α type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure

Korim, W. S., Elsaafien, K., Basser, J. R., Setiadi, A., May, C. N., & Yao, S. T. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy268 · Cited by 44 · see citing works

The impact of chronic blackberry intake on the neuroinflammatory status of rats fed a standard or high-fat diet

Meireles, M., Marques, C., Norberto, S., Fernandes, I., Mateus, N. F. D. C. B., Rendeiro, C., Spencer, J. P. E., Faria, A., & Calhau, C. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.05.008 · Cited by 45 · see citing works

The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4

Lin, M.-H., Cheng, P.-C., Hsiao, P.-J., Chen, S.-C., Hung, C.-H., Kuo, C.-H., Huang, S.-K., & Clair Chiou, H.-Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109653 · Cited by 42 · see citing works

Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty

Ullah, R., Su, Y. R., Shen, Y., Li, C., Xu, X., Zhang, J., Huang, K., Rauf, N., He, Y., Cheng, J., et al. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0530-y · Cited by 44 · see citing works

The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent

Argente-Arizón, P., Díaz, F., Ros, P., Barrios, V., Tena‐Sempere, M., García‐Segura, L. M., Argente, J., & Chowen, J. A. (2017) · Endocrinology · doi:10.1210/en.2017-00539 · Cited by 44 · see citing works

Assessing the fetal effects of maternal obesity via transcriptomic analysis of cord blood: a prospective case–control study

Edlow, A. G., Hui, L., Wick, H., Fried, I., & Bianchi, D. W. (2015) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13795 · Cited by 41 · see citing works

Altered Circadian Rhythm and Metabolic Gene Profile in Rats Subjected to Advanced Light Phase Shifts

Herrero, L., Valcárcel-Jiménez, L., da Silva, C. A., Albert, N., Dı́ez-Noguera, A., Cambras, T., & Serra, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122570 · Cited by 41 · see citing works

Aging, the Metabolic Syndrome, and Ischemic Stroke

Lucke-Wold, B. P., Logsdon, A. F., Turner, R. C., Rosen, C. L., & Huber, J. D. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.07.001 · Cited by 41 · see citing works

Population-based body–brain mapping links brain morphology with anthropometrics and body composition

Gurholt, T. P., Kaufmann, T., Frei, O., Alnæs, D., Haukvik, U. K., van der Meer, D., Moberget, T., O’Connell, K. S., Leinhard, O. D., Linge, J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01414-7 · Cited by 38 · see citing works

Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus

Li, J., Tang, Y., Purkayastha, S., Yan, J., & Cai, D. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.012 · Cited by 39 · see citing works

Neuroinflammation in Overnutrition-Induced Diseases

Cai, D. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-407766-9.00008-0 · Cited by 19 · see citing works

OBESITY AND TYPE 3 DIABETES: NUTRITIONAL APPROACHES AND THERAPEUTIC IMPLICATION

Sakr, A. (2019) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2019.10144.1023 · Cited by 1 · see citing works

Neuroinflamação hipotalâmica na obesidade como gatilho para doença de Parkinson

Pereira, K. (2020)

Structural Brain Changes Associated with Overweight and Obesity

Apo, E. G., Mondragón‐Maya, A., Ferrari-Díaz, M., & Silva‐Pereyra, J. (2021) · Journal of Obesity · doi:10.1155/2021/6613385 · Cited by 203 · see citing works

Neuroinflammatory basis of metabolic syndrome

Purkayastha, S., & Cai, D. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.005 · Cited by 145 · see citing works