Cited by 128Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Sexual Dimorphism in the Posterior Pituitary Response to Stress in the Rat*

WILLIAMS, T. D. M., CARTER, D. A., LIGHTMAN, S. L.·1985·Endocrinology

Abstract

The posterior pituitary response to immobilization was studied in male and female rats. Plasma levels of arginine vasopressin (AVP) and oxytocin (OT) were measured both in control rats and in rats immobilized in an acrylic restrainer for 1 min. In male rats immobilization did not result in any change in AVP (control: 1.3 +/- 0.2 pmol/liter, mean +/- SEM; immobilized: 2.3 +/- 0.6 pmol/liter), although there was a small but significant increase in OT (control; 4.1 +/- 0.5 pmol/liter; immobilized: 10.2 +/- 2.2 pmol/liter; P less than 0.005). In female rats a marked rise was observed in AVP (control: 1.4 +/- 0.3 pmol/liter; immobilized: 5.5 +/- 1.3 pmol/liter; P less than 0.005), and the rise in OT was considerably greater (P less than 0.01) than that found in males (control: 4.7 +/- 0.8 pmol/liter; immobilized: 26.0 +/- 5.6 pmol/liter; P less than 0.001). Further groups of male and female rats were gonadectomized 2 weeks before immobilization. Basal levels of AVP and OT were unchanged. Orchidectomized males had an increased OT response to immobilization compared with sham-operated males (P less than 0.05) whereas the AVP response was not significantly changed. Ovariectomy did not significantly affect either the AVP or OT responses. Although the neural pathways responsible for the neurohypophyseal response to immobilization are not known, this data demonstrate that the response is dependent on the sex of the rat.

Integrity signals

Registry

Crossref · 10.1210/endo-116-2-738

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
WILLIAMS, T. D. M., CARTER, D. A., & LIGHTMAN, S. L.
Venue
Endocrinology
Published
1985-02
Volume
116
Issue
2
Pages
738-740
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W2037355675
Cited by
128
References
8
Citations by year
2022: 2 · 2021: 6 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2012: 2
FWCI
24.38
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
sexual dimorphism, neurohypophysis, restraint stress, vasopressin, oxytocin, gonadectomy, orchiectomy, ovariectomy, stress hormones, rats
MeSH terms
Animals, Arginine Vasopressin, Castration, Female, Male, Oxytocin, Pituitary Gland, Posterior, Rats, Inbred Strains, Sex Characteristics, Stress, Physiological, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review