Beyond acne: Current aspects of sebaceous gland biology and function
Open accessAbstract
The sebaceous gland is most commonly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland's central role in acne pathogenesis, early research had focused on its lipogenic activity. Less studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin, and skin aging have only recently attracted the attention of researchers from different disciplines. Here, we summarize recent multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.
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Sebaceous lipids make an important contribution in maintaining the integrity of the skin barrier along with lipids of epidermal origin, thus contributing to the body's first line of defence.
“Moreover, sebaceous lipids make an important contribution in maintaining the integrity of the skin barrier along with lipids of epidermal origin2,52 thus contributing to the body's first line of defence.53”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [53]
Cites
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Skin changes in the obese patient
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“Moreover, sebaceous lipids make an important contribution in maintaining the integrity of the skin barrier along with lipids of epidermal origin(2,52) thus contributing to the body’s first line of defence.(53)”
BackgroundSelf-citationSebum lipids influence macrophage polarization and activation
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Self-citation
- Authors
- Zouboulis, C. C., Picardo, M., Ju, Q., Kurokawa, I., Törőcsik, D., Bíró, T., & Schneider, M. R.
- Affiliations
- Städtisches Klinikum Dessau (DE)
- San Gallicano Hospital (IT)
- Shanghai Jiao Tong University (CN)
- Meiwa Hospital (JP)
- University of Debrecen (HU)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Zouboulis, Christos C.
- ORCID
- Venue
- Reviews in Endocrine and Metabolic Disorders
- Published
- 2016-09
- Volume
- 17
- Issue
- 3
- Pages
- 319-334
- ISSN
- 1389-9155 (ISSN-L)
- 1573-2606
- OpenAlex
- W2531587677
- Cited by
- 174
- References
- 12
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 20 · 2023: 18 · 2022: 17 · 2021: 15 · 2020: 21 · 2019: 20 · 2018: 12 · 2017: 9 · 2016: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- green
- link.springer.com
- Licence
- Locations
- Reviews in Endocrine and Metabolic Disorders (publishedVersion)
- PubMed (publishedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- sebaceous glands, sebum, acne, transcription factors, neuroendocrine regulation, innate immunity, skin aging, skin diseases, therapeutic target
- MeSH terms
- Animals, Humans, Sebaceous Glands
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