Cited by 3,209Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsToxic Organic Pollutants Impact

The DOI matches its Crossref record; 854 of the 858 references it cites were found in a registry or an index.

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

Open access

Vandenberg, Laura N., Colborn, Theo, Hayes, Tyrone B., Heindel, Jerrold J., Jacobs, David R., Lee, Duk-Hee, Shioda, Toshi, Soto, Ana M., vom Saal, Frederick S., Welshons, Wade V., Zoeller, R. Thomas, Myers, John Peterson·2012·Endocrine Reviews

DOI 10.1210/er.2011-1050PMC PMC3365860

Open this paper in CoChat — free account

Abstract

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of "the dose makes the poison," because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five examples from the EDC literature. Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined. We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from the cell culture, animal, and epidemiology literature. We illustrate that nonmonotonic responses and low-dose effects are remarkably common in studies of natural hormones and EDCs. Whether low doses of EDCs influence certain human disorders is no longer conjecture, because epidemiological studies show that environmental exposures to EDCs are associated with human diseases and disabilities. We conclude that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses. Thus, fundamental changes in chemical testing and safety determination are needed to protect human health.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/er.2011-1050

Cites

854 of 854 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Self-citation
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for Humans and Wildlife
van den Berg, M., Birnbaum, L. S., Bosveld, A. T. C., Brunström, B., Cook, P. M., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., et al. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106775 · Cited by 3,301
Human exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
Self-citation
The origins of the developmental origins theory
Barker, D. J. P. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01809.x · Cited by 2,955
National Health and Nutrition Examination Survey
Rothwell, C. J. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_6177 · Cited by 2,093
ORGANIZING ACTION OF PRENATALLY ADMINISTERED TESTOSTERONE PROPIONATE ON THE TISSUES MEDIATING MATING BEHAVIOR IN THE FEMALE GUINEA PIG 1
PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934
Estrogen receptors: how do they signal and what are their targets
Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews · doi:10.1152/physrev.00026.2006 · Cited by 1,857
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854
Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
Sharpe, R. M., & Skakkebæk, N. E. (1993) · The Lancet · doi:10.1016/0140-6736(93)90953-e · Cited by 1,849

Flagged first, then by citations

Show all 858 references

4 of the 858 references couldn’t be matched to a known paper.

Research works printed but not linked: 13

Centers for Disease Control, 2008, National Biomonitoring Program
U.S. Food and Drug Administration, 2009, Information for consumers (drugs)
Jones, 1996, Summation of basic endocrine data, 1
Hayes, 2011, Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes, J Steroid Biochem Mol Biol, 127, 64, 10.1016/j.jsbmb.2011.03.015 · DOI
Carrasco, 2000, Thyroid iodide transport: the Na+/I− symporter (NIS), 52
Ghassabian, 2011, Maternal thyroid function during pregnancy and parent-report problem behavior of the offspring up to age three years. The Generation R Study, Pediatr Res, 69, 454, 10.1203/PDR.0b013e3182125b0c · DOI
Sheehan, 1997, Low dose effects of hormones: a challenge for risk assessment, Risk Policy Report, 4, 31
vom Saal, 1998, Challenging risk assessment, Forum Appl Res Public Policy, 13, 11
Center for the Evaluation of Risks to Human Reproduction, 2008, Bisphenol A: public comments
Taylor, 2011, Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposure, Environ Health Perspect, 119, 422, 10.1289/ehp.1002514 · DOI
Carson, 1962, Silent spring
Hayes, 1998, Endocrine disruptors in amphibians: potential impacts and the usefulness of amphibian screens for detecting endocrine disrupting compounds, Sci J (Kagaku), 68, 557
Lee, 2010, Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study, Environ Health Perspect, 118, 1235, 10.1289/ehp.0901480 · DOI

Sorted by citations

Items 801–900 of 1,004

Multilevel ecotoxicity assessment of environmentally relevant bisphenol A concentrations using the soil invertebrate Eisenia fetida
Babić, S., Barišić, J., Bielen, A., Bošnjak, I., Klobučar, R. S., Ujević, I., Strunjak‐Perović, I., Popović, N. T., & Čož‐Rakovac, R. (2016) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2016.07.017 · Cited by 45
Comparison of sub-lethal metabolic perturbations of select legacy and novel perfluorinated alkyl substances (PFAS) in Daphnia magna
Labine, L. M., Pereira, E. A. O., Kleywegt, S. M., Jobst, K. J., Simpson, A. J., & Simpson, M. J. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113582 · Cited by 47
Co-Exposure to Bisphenols, Parabens, and Antimicrobials and Association with Coronary Heart Disease: Oxidative Stress as a Potential Mediating Factor?
Zhang, D., Liu, X., Xiao, Q., Han, L., Yang, J., Li, X., Xu, J., Zheng, Q., Ma, J., Chen, J., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c06488 · Cited by 47
A targeted review on occurrence, remediation, and risk assessments of bisphenol A in Africa
Ucheana, I. A., Omeka, M. E., Ezugwu, A. L., Agbasi, J. C., Egbueri, J. C., Abugu, H. O., & Aralu, C. C. (2024) · Environmental Monitoring and Assessment · doi:10.1007/s10661-024-13337-z · Cited by 45
Health impacts of exposure to synthetic chemicals in food
Muncke, J., Touvier, M., Trasande, L., & Scheringer, M. (2025) · Nature Medicine · doi:10.1038/s41591-025-03697-5 · Cited by 50
Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A
Kendziorski, J. A., & Belcher, S. M. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.08.001 · Cited by 45
Modulation of Metabolizing Enzymes by Bisphenol A in Human and Animal Models
Quesnot, N., Bucher, S., Fromenty, B., & Robin, M. (2014) · Chemical Research in Toxicology · doi:10.1021/tx500087p · Cited by 45
Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice
Kassotis, C. D., Bromfield, J. J., Klemp, K. C., Meng, C.-X., Wolfe, A., Zoeller, R. T., Balise, V. D., Isiguzo, C. J., Tillitt, D. E., & Nagel, S. C. (2016) · Endocrinology · doi:10.1210/en.2016-1242 · Cited by 45
Self-citation
Non-target effects of a glyphosate-based herbicide on Common toad larvae ( Bufo bufo , Amphibia) and associated algae are altered by temperature
Baier, F., Gruber, E., Hein, T. I. A., Bondar‐Kunze, E., Ivanković, M., Mentler, A., Brühl, C. A., Spangl, B., & Zaller, J. G. (2016) · PeerJ · doi:10.7717/peerj.2641 · Cited by 45
Endocrine disruptors: Revisiting concepts and dogma in toxicology
Barouki, R. (2017) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2017.07.005 · Cited by 45
Bisphenol A release from an orthodontic resin composite: A GC/MS and LC/MS study
Deviot, M., Lachaise, I., Högg, C., Durner, J., Reichl, F., Attal, J., & Dursun, E. (2017) · Dental Materials · doi:10.1016/j.dental.2017.11.018 · Cited by 44
Estrogenic and anti‐estrogenic activity of butylparaben, butylated hydroxyanisole, butylated hydroxytoluene and propyl gallate and their binary mixtures on two estrogen responsive cell lines (T47D‐Kbluc, MCF‐7)
Pop, A., Drugan, T., Gutleb, A., Lupu, D., Cherfan, J., Loghin, F., & Kiss, B. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3601 · Cited by 41
Estrogenic Compounds: Chemical Characteristics, Detection Methods, Biological and Environmental Effects
Pamplona-Silva, M. T., Mazzeo, D. E. C., Bianchi, J., & Marin‐Morales, M. A. (2018) · Water Air & Soil Pollution · doi:10.1007/s11270-018-3796-z · Cited by 46
Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort
Mustieles, V., Casas, M., Ferrando-Marco, P., Hernández, O. O., Reina-Pérez, I., Rodríguez‐Carrillo, A., Vela-Soria, F., Pérez‐Lobato, R., Navarrete‐Muñoz, E. M., Freire, C., et al. (2019) · Environmental Research · doi:10.1016/j.envres.2019.03.045 · Cited by 45
Transcriptional Profiling of the Murine Airway Response to Acute Ozone Exposure
Tovar, A., Smith, G. J., Thomas, J. M., Crouse, W. L., Harkema, J. R., & Kelada, S. N. P. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz219 · Cited by 41
Low-dose Bisphenol-A Promotes Epigenetic Changes at Pparγ Promoter in Adipose Precursor Cells
Longo, M., Zatterale, F., Naderi, J., Nigro, C., Oriente, F., Formisano, P., Miele, C., & Bèguinot, F. (2020) · Nutrients · doi:10.3390/nu12113498 · Cited by 47
Ozone Pollution Alters Olfaction and Behavior of Pollinators
Vanderplanck, M., Lapeyre, B., Brondani, M., Opsommer, M., Dufaÿ, M., Hossaert‐McKey, M., & Proffit, M. (2021) · Antioxidants · doi:10.3390/antiox10050636 · Cited by 45
To Cull or Not To Cull? Considerations for Studies of Endocrine-Disrupting Chemicals
Suvorov, A., & Vandenberg, L. N. (2016) · Endocrinology · doi:10.1210/en.2016-1145 · Cited by 45
Self-citation
Interventions to Reduce Exposure to Synthetic Phenols and Phthalates from Dietary Intake and Personal Care Products: a Scoping Review
Yang, T., Jovanovic, N., Chong, F., Worcester, M., Sakhi, A. K., Thomsen, C., Garlantézec, R., Chevrier, C., Jensen, G. K., Cingotti, N., et al. (2023) · Current Environmental Health Reports · doi:10.1007/s40572-023-00394-8 · Cited by 46
Reproductive toxicity and thyroid effects in Sprague Dawley rats exposed to low doses of ethylenethiourea
Maranghi, F., Angelis, S. D., Tassinari, R., Chiarotti, F., Lorenzetti, S., Moracci, G., Marcoccia, D., Gilardi, E., Virgilio, A. D., Eusepi, A., et al. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.05.048 · Cited by 44
Perinatal exposure to genistein affects the normal development of anxiety and aggressive behaviors and nitric oxide system in CD1 male mice
Gomez, A. R., Filice, F., Gotti, S., & Panzica, G. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.020 · Cited by 45
Low-dose and combined effects of oral exposure to bisphenol A and diethylstilbestrol on the male reproductive system in adult Sprague-Dawley rats
JIANG, X. H., Chen, H., Cui, Z.-H., Yin, L., Zhang, W., Liu, W., Han, F., Ao, L., Cao, J., & Liu, J.-Y. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.02.014 · Cited by 44
Tributyltin disrupts feeding and energy metabolism in the goldfish (Carassius auratus)
Zhang, J., Sun, P., Yang, F., Kong, T., & Zhang, R. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.02.127 · Cited by 44
Estrogenic Activity Measurements in Water Using Diffusive Gradients in Thin-Film Coupled with an Estrogen Bioassay
Guo, W., Langenhove, K. V., Denison, M. S., Baeyens, W., Elskens, M. T., & Gao, Y. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03537 · Cited by 44
Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis
Eladak, S., Moison, D., Guerquin, M.-J., Matilionyte, G., Kilcoyne, K. R., N’Tumba-Byn, T., Messiaen, S., Deceuninck, Y., Pozzi-Gaudin, S., Benachi, A., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191934 · Cited by 44
Mechanisms of action, chemical characteristics, and model systems of obesogens
Griffin, M. D., Pereira, S. R., DeBari, M. K., & Abbott, R. D. (2020) · BMC Biomedical Engineering · doi:10.1186/s42490-020-00040-6 · Cited by 48
Associations among urinary triclosan and bisphenol A concentrations and serum sex steroid hormone measures in the Canadian and U.S. Populations
Pollock, T., Arbuckle, T. E., Guth, M., Bouchard, M. F., & St-Amand, A. (2020) · Environment International · doi:10.1016/j.envint.2020.106229 · Cited by 44
Impact of endocrine-disrupting chemicals on steroidogenesis and consequences on testicular function
Walker, C., Garza, S., Papadopoulos, V., & Culty, M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111215 · Cited by 44
Chronic low-level perfluorooctane sulfonate (PFOS) exposure promotes testicular steroidogenesis through enhanced histone acetylation
Alam, N., Han, X., Nan, B., Liu, L., Tian, M., Shen, H., & Huang, Q. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117518 · Cited by 44
Characterization of retinoic acid–induced neurobehavioral effects in developing zebrafish
Wang, Y., Chen, J., Du, C., Li, C., Huang, C., & Dong, Q. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2453 · Cited by 44
Assessing human health risk to endocrine disrupting chemicals: a focus on prenatal exposures and oxidative stress
Neier, K. E., Marchlewicz, E. H., Dolinoy, D. C., & Padmanabhan, V. (2015) · Endocrine Disruptors · doi:10.1080/23273747.2015.1069916 · Cited by 44
Prenatal exposure to bisphenols and risk of preterm birth: Findings from Guangxi Zhuang birth cohort in China
Liang, J. L., Yang, C., Liu, T., Tan, H. J. J., Sheng, Y., Wei, L., Tang, P., Huang, H., Zeng, X., Liu, S., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112960 · Cited by 41
BPS and BPF are as Carcinogenic as BPA and are Not Viable Alternatives for its Replacement
Edaes, F. S., & de Souza, C. B. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220316141032 · Cited by 44
Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling
Kimura, E., Kubo, K., Matsuyoshi, C., Benner, S., Hosokawa, M., Endo, T., Ling, W., Kohda, M., Yokoyama, K., Nakajima, K., et al. (2015) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2015.10.005 · Cited by 43
Endocrine disruptive compounds and cardio-metabolic risk factors in children
Khalil, N., Chen, A., & Lee, M. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.09.015 · Cited by 44
The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic–pituitary–gonadal and hypothalamic–pituitary–adrenal axes during the early development of zebrafish (Danio rerio)
Liang, Y., Huang, G., Ying, G., Liu, S., Jiang, Y., Liu, S., & Peng, F. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.01.062 · Cited by 43
Pubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell Function Leading to Early Neoplasia in Regenerated Glands
Wang, D., Gao, H., Bandyopadhyay, A. M., Wu, A., Yeh, I., Chen, Y., Zou, Y., Huang, C., Walter, C. A., Dong, Q., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0260 · Cited by 45
Estrogen-Like Disruptive Effects of Dietary Exposure to Bisphenol A or 17α-Ethinyl Estradiol in CD1 Mice
Kendig, E. L., Buesing, D. R., Christie, S. M., Cookman, C. J., Gear, R. B., Hugo, E. R., Kasper, S. N., Kendziorski, J. A., Ungi, K. R., Williams, K., et al. (2012) · International Journal of Toxicology · doi:10.1177/1091581812463254 · Cited by 43
Low-dose developmental exposure to bisphenol A alters the femoral bone geometry in wistar rats
Lejonklou, M. H., Christiansen, S., Örberg, J., Shen, L., Larsson, S., Boberg, J., Hass, U., & Lind, P. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.08.114 · Cited by 42
Endocrine disruptors and the tumor microenvironment: A new paradigm in breast cancer biology
Burks, H. E., Pashos, N. C., Martin, E. C., McLachlan, J. A., Bunnell, B. A., & Burow, M. E. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.010 · Cited by 43
Food components and contaminants as (anti)androgenic molecules
Marcoccia, D., Pellegrini, M., Fiocchetti, M., Lorenzetti, S., & Marino, M. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0555-5 · Cited by 43
Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet
Labaronne, E., Pinteur, C., Véga, N., Pesenti, S., Julien, B., Meugnier, E., Vidal, H., Naville, D., & Magueresse‐Battistoni, B. L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.04.001 · Cited by 43
Male rat exposure to low dose of di(2-ethylhexyl) phthalate during pre-pubertal, pubertal and post-pubertal periods: Impact on sperm count, gonad histology and testosterone secretion
Oudir, M., Chader, H., Bouzid, B., Bendisari, K., Latreche, B., Boudalia, S., & Iguer‐Ouada, M. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.11.004 · Cited by 43
Response of phase I and II detoxification enzymes, glutathione, metallothionein and acetylcholine esterase to mercury and dimethoate in signal crayfish (Pacifastacus leniusculus)
Gunderson, M. P., Nguyen, B. T., Reyes, J. C. C., Holden, L. L., French, J. M. T., Smith, B. D., & Lineberger, C. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.05.183 · Cited by 43
Effects of low, subchronic exposure of 2,4-Dichlorophenoxyacetic acid (2,4-D) and commercial 2,4-D formulations on early life stages of fathead minnows (Pimephales promelas)
Dehnert, G. K., Freitas, M. B., DeQuattro, Z. A., Barry, T. P., & Karasov, W. H. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4209 · Cited by 42
Qualitative analysis of dental material ingredients, composite resins and sealants using liquid chromatography coupled to quadrupole time of flight mass spectrometry
Vervliet, P., Nys, S. D., Boonen, I., Duca, R. C., Elskens, M. T., LANDUYT, K. L. V., & Covaci, A. (2018) · Journal of Chromatography A · doi:10.1016/j.chroma.2018.09.039 · Cited by 43
Species-specific accumulation and temporal trends of bisphenols and benzophenones in mollusks from the Chinese Bohai Sea during 2006–2015
Liao, C., & Kannan, K. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.10.271 · Cited by 44
Molecular Imprinted Poly-Cyclodextrin for Selective Removal of Dibutyl Phthalate
Dolai, J., Ali, H., & Jana, N. R. (2019) · ACS Applied Polymer Materials · doi:10.1021/acsapm.9b01024 · Cited by 43
Immune Cells in the Uterine Remodeling: Are They the Target of Endocrine Disrupting Chemicals?
Meyer, N., & Zenclussen, A. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00246 · Cited by 43
A Sensitive Impedimetric Aptasensor Based on Carbon Nanodots Modified Electrode for Detection of 17ß-Estradiol
Zaid, M. H. M., Abdullah, J., Rozi, N., Rozlan, A. A. M., & Hanifah, S. A. (2020) · Nanomaterials · doi:10.3390/nano10071346 · Cited by 43
The neonicotinoid thiamethoxam impairs male fertility in solitary bees, Osmia cornuta
Strobl, V., Albrecht, M., Villamar‐Bouza, L., Tosi, S., Neumann, P., & Straub, L. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117106 · Cited by 44
Perinatal exposure to endocrine disrupting chemicals and neurodevelopment: How articles of daily use influence the development of our children
O’Shaughnessy, K. L., Fischer, F., & Zenclussen, A. C. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101568 · Cited by 48
Dose-response metabolomics and pathway sensitivity to map molecular cartography of bisphenol A exposure
Zhao, H., Liu, M., Lv, Y., & Fang, M. (2021) · Environment International · doi:10.1016/j.envint.2021.106893 · Cited by 43
Prenatal Exposure to Nonpersistent Chemical Mixtures and Offspring IQ and Emotional and Behavioral Problems
van den Dries, M. A., Ferguson, K. K., Keil, A. P., Pronk, A., Spaan, S., Ghassabian, A., Santos, S., Jaddoe, V. W. V., Trasande, L., Tiemeier, H. W., et al. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c04455 · Cited by 46
Estrogen Impact on Autoimmunity Onset and Progression: the Paradigm of Systemic Lupus Erythematosus
Pierdominici, M., & Ortona, E. (2013) · Cited by 42
Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review)
Margina, D. M., Nițulescu, G. M., Ungurianu, A., Mesnage, R., Γούμενου, Μ., Sarigiannis, D. A., Aschner, M., Spandidos, D. A., Renieri, E. A., Hernández, A. F., et al. (2019) · World Academy of Sciences Journal · doi:10.3892/wasj.2019.17 · Cited by 42
In-situ treatment of herbicide-contaminated groundwater–Feasibility study for the cases atrazine and bromacil using two novel nanoremediation-type materials
Gawel, A., Seiwert, B., Sühnholz, S., Schmitt‐Jansen, M., & Mackenzie, K. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122470 · Cited by 42
Iodine as a potential endocrine disruptor—a role of oxidative stress
Karbownik‐Lewińska, M., Stępniak, J., Iwan, P., & Lewiñski, A. (2022) · Endocrine · doi:10.1007/s12020-022-03107-7 · Cited by 42
Microplastic exposure is associated with epigenomic effects in the model organism Pimephales promelas (fathead minnow)
Wade, M. J., Bucci, K., Rochman, C. M., & Meek, M. H. (2024) · Journal of Heredity · doi:10.1093/jhered/esae027 · Cited by 45
Prenatal exposure to persistent organochlorine pollutants is associated with high insulin levels in 5-year-old girls
Tang-Péronard, J. L., Heitmann, B., Jensen, T. K., Vinggaard, A., Madsbad, S., Steuerwald, U., Grandjean, P., Weihe, P., Nielsen, F., & Andersen, H. (2015) · Environmental Research · doi:10.1016/j.envres.2015.07.009 · Cited by 41
Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus)
Gabrielsen, K. M., Krokstad, J. S., Villanger, G. D., Blair, D. A. D., Obregón, M.-J., Sonne, C., Dietz, R., Letcher, R. J., & Jenssen, B. M. (2014) · Environmental Research · doi:10.1016/j.envres.2014.09.019 · Cited by 43
Disruption of paired-associate learning in rat offspring perinatally exposed to dioxins
Kakeyama, M., Endo, T., Zhang, Y., Miyazaki, W., & Tohyama, C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1161-y · Cited by 41
Clarity in the face of confusion: new studies tip the scales on bisphenol A ( BPA )
Vandenberg, L. N., & Prins, G. S. (2016) · Andrology · doi:10.1111/andr.12219 · Cited by 42
Self-citation
Antibody production and application for immunoassay development of environmental hormones: a review
Tian, W., Wang, L., Lei, H., Sun, Y., & Xiao, Z. (2018) · Chemical and Biological Technologies in Agriculture · doi:10.1186/s40538-018-0117-0 · Cited by 42
Multiple sub-lethal thresholds for cellular responses to thermal stressors in an estuarine fish
Jeffries, K. M., Fangue, N. A., & Connon, R. E. (2018) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2018.06.020 · Cited by 43
Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures
Horzmann, K. A., Reidenbach, L. S., Thanki, D. H., Winchester, A. E., Qualizza, B. A., Ryan, G. A., Egan, K. E., Hedrick, V., Sobreira, T. J. P., Peterson, S. M., et al. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.07.006 · Cited by 44
Effects of folic acid on testicular toxicity induced by bisphenol-A in male Wistar rats
Gules, O., Yıldız, M., Naseer, Z., & Tatar, M. (2018) · Biotechnic & Histochemistry · doi:10.1080/10520295.2018.1493222 · Cited by 42
Dose-dependent transcriptomic responses of zebrafish eleutheroembryos to Bisphenol A
Martínez, R., Esteve‐Codina, A., Nogareda, L. H., Ortiz‐Villanueva, E., Barata, C., Tauler, R., Raldúa, D., Piña, B., & Navarro‐Martín, L. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.09.043 · Cited by 42
Could the endocrine disruptor bisphenol-A be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions
Emfietzoglou, R., Spyrou, N., Mantzoros, C. S., & Dalamaga, Μ. (2018) · Metabolism · doi:10.1016/j.metabol.2018.11.007 · Cited by 42
Mini-review: Epigenetic mechanisms that promote transgenerational actions of endocrine disrupting chemicals: Applications to behavioral neuroendocrinology
Martini, M., Corces, V. G., & Rissman, E. F. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104677 · Cited by 42
Stress, Sex, and Sugar: Glucocorticoids and Sex-Steroid Crosstalk in the Sex-Specific Misprogramming of Metabolism
Ruíz, D., Padmanabhan, V., & Sargis, R. M. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa087 · Cited by 46
The Association of Ovarian Reserve with Exposure to Bisphenol A and Phthalate in Reproductive-aged Women
Park, S. Y., Jeon, J. H., Jeong, K., Chung, H. W., Lee, H., Sung, Y., Ye, S., & Ha, E. (2020) · Journal of Korean Medical Science · doi:10.3346/jkms.2021.36.e1 · Cited by 46
The phenotypic and transcriptomic effects of developmental exposure to nanomolar levels of estrone and bisphenol A in zebrafish
Wu, C., Shields, J. N., Akemann, C., Meyer, D. N., Connell, M. L., Baker, B. B., Pitts, D. K., & Baker, T. R. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143736 · Cited by 42
Assessing the Public Health Implications of the Food Preservative Propylparaben: Has This Chemical Been Safely Used for Decades
Vandenberg, L. N., & Bugos, J. (2021) · Current Environmental Health Reports · doi:10.1007/s40572-020-00300-6 · Cited by 42
Self-citation
Factors Associated with Exposure to Dietary Bisphenols in Adolescents
Robles-Aguilera, V., Gálvez-Ontiveros, Y., Rodrigo, L. S., Salcedo‐Bellido, I., Aguilera, J., Zafra‐Gómez, A., Monteagudo, C., & Rivas, A. (2021) · Nutrients · doi:10.3390/nu13051553 · Cited by 44
Effects of air pollution exposure on social behavior: a synthesis and call for research
Weitekamp, C. A., & Hofmann, H. A. (2021) · Environmental Health · doi:10.1186/s12940-021-00761-8 · Cited by 47
Policy Decisions on Endocrine Disruptors Should Be Based on Science Across Disciplines: A Response to Dietrich et al.
Gore, A. C., Balthazart, J., Bikle, D. D., Carpenter, D. O., Crews, D. P., Czernichow, P., Diamanti‐Kandarakis, E., Dores, R. M., Grattan, D. R., Hof, P. R., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1854 · Cited by 42
Risk Evaluation of Endocrine-Disrupting Chemicals: Effects of Developmental Exposure to Low Doses of Bisphenol A on Behavior and Physiology in Mice ( Mus musculus )
Gioiosa, L., Palanza, P., Parmigiani, S., & vom Saal, F. S. (2015) · Dose-Response · doi:10.1177/1559325815610760 · Cited by 41
Technofossils of the Anthropocene
Taffel, S. (2016) · Cultural Politics an International Journal · doi:10.1215/17432197-3648906 · Cited by 45
Association between early-childhood exposure to perfluoroalkyl substances and ADHD symptoms: A prospective cohort study
Kim, J. I., Kim, B.-N., Lee, Y. A., Shin, C. H., Hong, Y.-C., Døssing, L. D., Hildebrandt, G., & Lim, Y. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163081 · Cited by 42
Self assembled DC sputtered nanostructured rutile TiO2 platform for bisphenol A detection
Singh, N., Khondakar, K. R., Ali, M. A., Agrawal, V. V., & Biradar, A. M. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.01.041 · Cited by 41
Evidence of reproductive disruption associated with neuroendocrine changes induced by UV–B filters, phtalates and nonylphenol during sexual maturation in rats of both gender
Ponzo, O., & Carbone, S. (2013) · Toxicology · doi:10.1016/j.tox.2013.05.014 · Cited by 41
Principles of Adaptive Sorting Revealed byIn SilicoEvolution
Lalanne, J., & François, P. (2013) · Physical Review Letters · doi:10.1103/physrevlett.110.218102 · Cited by 41
The role of P450 metabolism in the estrogenic activity of bifenthrin in fish
DeGroot, B. C., & Brander, S. M. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2014.07.007 · Cited by 41
Hormesis and public health: can glutathione depletion and mitochondrial dysfunction due to very low-dose chronic exposure to persistent organic pollutants be mitigated?
Lee, D., & Jacobs, D. R. (2014) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2014-203861 · Cited by 44
Self-citation
Effects of Bisphenol A on ion channels: Experimental evidence and molecular mechanisms
Soriano, S., Ripoll, C., Alonso‐Magdalena, P., Fuentes, E., Quesada, I., Nadal, Á., & Martínez‐Pinna, J. (2016) · Steroids · doi:10.1016/j.steroids.2016.02.020 · Cited by 41
Magnetic mesoporous polymelamine-formaldehyde resin as an adsorbent for endocrine disrupting chemicals
Song, Y., Ma, R., Jiao, C., Hao, L., Wang, C., Wu, Q., & Wang, Z. (2017) · Microchimica Acta · doi:10.1007/s00604-017-2593-5 · Cited by 41
Bisphenol A (BPA) modulates the expression of endocrine and stress response genes in the freshwater snail Physa acuta
Morales, M., Martínez-Paz, P., Sánchez‐Argüello, P., Morcillo, G., & Martínez‐Guitarte, J. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.01.034 · Cited by 44
Cytotoxicity measurement of Bisphenol A (BPA) and its substitutes using human keratinocytes
Son, S., Nam, K., Kim, H., Gye, M. C., & Shin, I. (2018) · Environmental Research · doi:10.1016/j.envres.2018.03.043 · Cited by 41
The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures
Santamaría, C. G., Abud, J. E., Porporato, M., Meyer, N., Zenclussen, A. C., Kass, L., & Rodriguez, H. A. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.12.016 · Cited by 41
Transgenerational effects of obesogens
Lee, M. K., & Blumberg, B. (2019) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13214 · Cited by 41
Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system
Liu, S., Yu, M., Xie, X., Ru, Y., & Ru, S. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126635 · Cited by 41
Density and proximity to hydraulic fracturing wells and birth outcomes in Northeastern British Columbia, Canada
Caron-Beaudoin, É., Whitworth, K. W., Bosson-Rieutort, D., Wendling, G., Liu, S., & Verner, M.-A. (2020) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-020-0245-z · Cited by 41
The nexus between alternatives assessment and green chemistry: supporting the development and adoption of safer chemicals
Tickner, J. A., Simon, R., Jacobs, M., Pollard, L. D., & van Bergen, S. K. (2020) · Green Chemistry Letters and Reviews · doi:10.1080/17518253.2020.1856427 · Cited by 43
Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels
Mohan, H., Lenis, M. G., Laurette, E. Y., Tejada, O., Sanghvi, T., Leung, K., Cahill, L. S., Sled, J. G., Delgado-Olguı́n, P., Greene, N. D. E., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103167 · Cited by 41
Reducing overall herbicide use may reduce risks to humans but increase toxic loads to honeybees, earthworms and birds
Cech, R., Jovanovic, S., Kegley, S. E., Hertoge, K., Leisch, F., & Zaller, J. G. (2022) · Environmental Sciences Europe · doi:10.1186/s12302-022-00622-2 · Cited by 41
Chemistry Education For Sustainability
Sjöström, J., Rauch, F., & Eilks, I. (2015) · SensePublishers eBooks · doi:10.1007/978-94-6300-175-5_9 · Cited by 41
Salivary bisphenol A levels and their association with composite resin restoration
Lee, J., Yi, S.-K., Kim, S.-Y., Kim, J.-S., Son, S., Jeong, S.-H., & Kim, J. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.12.123 · Cited by 41
Impact of endocrine disrupting chemicals and pharmaceuticals on Sertoli cell development and functions
Corpuz-Hilsabeck, M., & Culty, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1095894 · Cited by 40
Exposure to phenols, chlorophenol pesticides, phthalate and PAHs and mortality risk: A prospective study based on 6 rounds of NHANES
Di, D., Zhang, R., Zhou, H., Wei, M., Cui, Y., Zhang, J., Yuan, T., Liu, Q., Zhou, T., Liu, J., et al. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138650 · Cited by 40

Authors: Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., Zoeller, R. T., & Myers, J. P.
Affiliations: Tufts University (US)
The Endocrine Disruption Exchange (T.C.), Paonia, Colorado 81428;
Museum of Vertebrate Zoology (US)
National Institutes of Health (US)
University of Minnesota (US)
Kyungpook National University (KR)
Massachusetts General Hospital (US)
Division of Biological Sciences (F.S.v.S.) University of Missouri-Columbia, Columbia, Missouri 65211;
University of Missouri (US)
University of Massachusetts Amherst (US)
Environmental Health Sciences (J.P.M.), Charlottesville, Virginia 22902
Corresponding author: Vandenberg, Laura N.
ORCID: Vandenberg, Laura N.
Heindel, Jerrold J.
Jacobs, David R.
Lee, Duk-Hee
Shioda, Toshi
Soto, Ana M.
Zoeller, R. Thomas
Myers, John Peterson
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2012-03-14
Volume: 33
Issue: 3
Pages: 378-455
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2011-1050
PMC: PMC3365860
OpenAlex: W2097327668
Cited by: 3,209
References: 858
Citations by year: 2026: 237 · 2025: 196 · 2024: 203 · 2023: 193 · 2022: 225 · 2021: 263 · 2020: 233 · 2019: 209 · 2018: 253 · 2017: 235 · 2016: 224 · 2015: 215 · 2014: 254 · 2013: 195 · 2012: 69
FWCI: 27.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Endocrine Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R56HL053560, HL 53560, R01HL053560)
National Institute of General Medical Sciences (F32GM087107, GM 087107)
National Institute of Environmental Health Sciences (ES08314, R01ES008314, ES010026, ES 018764, R56ES010026, R01ES010026, RC2ES018764)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: endocrine disruptors, low-dose effects, non-monotonic dose-response, dose-response relationship, hormesis, chemical safety assessment, chemical testing
MeSH terms: Bisphenol A Compounds, Amphibians, Animals, Animals, Wild, Atrazine, Benzhydryl Compounds, Breast, Dioxins, Dose-Response Relationship, Drug, Environmental Exposure, Female, Herbicides, Humans, Male, Perchlorates, Phenols, Prostate, Spermatogenesis, Thyroid Gland, Twins, Sexual Development, Endocrine Disruptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks