Cited by 3,209Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsToxic Organic Pollutants Impact

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Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

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Vandenberg, Laura N., Colborn, Theo, Hayes, Tyrone B., Heindel, Jerrold J., Jacobs, David R., Lee, Duk-Hee, Shioda, Toshi, Soto, Ana M., vom Saal, Frederick S., Welshons, Wade V., Zoeller, R. Thomas, Myers, John Peterson·2012·Endocrine Reviews

DOI 10.1210/er.2011-1050PMC PMC3365860

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Abstract

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of "the dose makes the poison," because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five examples from the EDC literature. Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined. We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from the cell culture, animal, and epidemiology literature. We illustrate that nonmonotonic responses and low-dose effects are remarkably common in studies of natural hormones and EDCs. Whether low doses of EDCs influence certain human disorders is no longer conjecture, because epidemiological studies show that environmental exposures to EDCs are associated with human diseases and disabilities. We conclude that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses. Thus, fundamental changes in chemical testing and safety determination are needed to protect human health.

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Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Self-citation
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for Humans and Wildlife
van den Berg, M., Birnbaum, L. S., Bosveld, A. T. C., Brunström, B., Cook, P. M., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., et al. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106775 · Cited by 3,301
Human exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
Self-citation
The origins of the developmental origins theory
Barker, D. J. P. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01809.x · Cited by 2,955
National Health and Nutrition Examination Survey
Rothwell, C. J. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_6177 · Cited by 2,093
ORGANIZING ACTION OF PRENATALLY ADMINISTERED TESTOSTERONE PROPIONATE ON THE TISSUES MEDIATING MATING BEHAVIOR IN THE FEMALE GUINEA PIG 1
PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934
Estrogen receptors: how do they signal and what are their targets
Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews · doi:10.1152/physrev.00026.2006 · Cited by 1,857
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854
Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
Sharpe, R. M., & Skakkebæk, N. E. (1993) · The Lancet · doi:10.1016/0140-6736(93)90953-e · Cited by 1,849

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Centers for Disease Control, 2008, National Biomonitoring Program
U.S. Food and Drug Administration, 2009, Information for consumers (drugs)
Jones, 1996, Summation of basic endocrine data, 1
Hayes, 2011, Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes, J Steroid Biochem Mol Biol, 127, 64, 10.1016/j.jsbmb.2011.03.015 · DOI
Carrasco, 2000, Thyroid iodide transport: the Na+/I− symporter (NIS), 52
Ghassabian, 2011, Maternal thyroid function during pregnancy and parent-report problem behavior of the offspring up to age three years. The Generation R Study, Pediatr Res, 69, 454, 10.1203/PDR.0b013e3182125b0c · DOI
Sheehan, 1997, Low dose effects of hormones: a challenge for risk assessment, Risk Policy Report, 4, 31
vom Saal, 1998, Challenging risk assessment, Forum Appl Res Public Policy, 13, 11
Center for the Evaluation of Risks to Human Reproduction, 2008, Bisphenol A: public comments
Taylor, 2011, Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposure, Environ Health Perspect, 119, 422, 10.1289/ehp.1002514 · DOI
Carson, 1962, Silent spring
Hayes, 1998, Endocrine disruptors in amphibians: potential impacts and the usefulness of amphibian screens for detecting endocrine disrupting compounds, Sci J (Kagaku), 68, 557
Lee, 2010, Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study, Environ Health Perspect, 118, 1235, 10.1289/ehp.0901480 · DOI

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Herrero, Ó., Aquilino, M., Sánchez‐Argüello, P., & Planelló, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193387 · Cited by 75
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de Cock, M., de Boer, M. R., Lamoree, M. H., Legler, J., & van de Bor, M. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110707001 · Cited by 76
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Oppeneer, S. J., & Robien, K. (2014) · Public Health Nutrition · doi:10.1017/s1368980014002213 · Cited by 77
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Mansur, A., Adir, M., Yerushalmi, G., Hourvitz, A., Gitman, H., Yung, Y., Orvieto, R., & Machtinger, R. (2016) · Human Reproduction · doi:10.1093/humrep/dew088 · Cited by 77
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Liao, C., Shi, J., Wang, X., Zhu, Q., & Kannan, K. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.07.076 · Cited by 74

Authors: Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., Zoeller, R. T., & Myers, J. P.
Affiliations: Tufts University (US)
The Endocrine Disruption Exchange (T.C.), Paonia, Colorado 81428;
Museum of Vertebrate Zoology (US)
National Institutes of Health (US)
University of Minnesota (US)
Kyungpook National University (KR)
Massachusetts General Hospital (US)
Division of Biological Sciences (F.S.v.S.) University of Missouri-Columbia, Columbia, Missouri 65211;
University of Missouri (US)
University of Massachusetts Amherst (US)
Environmental Health Sciences (J.P.M.), Charlottesville, Virginia 22902
Corresponding author: Vandenberg, Laura N.
ORCID: Vandenberg, Laura N.
Heindel, Jerrold J.
Jacobs, David R.
Lee, Duk-Hee
Shioda, Toshi
Soto, Ana M.
Zoeller, R. Thomas
Myers, John Peterson
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2012-03-14
Volume: 33
Issue: 3
Pages: 378-455
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2011-1050
PMC: PMC3365860
OpenAlex: W2097327668
Cited by: 3,209
References: 858
Citations by year: 2026: 237 · 2025: 196 · 2024: 203 · 2023: 193 · 2022: 225 · 2021: 263 · 2020: 233 · 2019: 209 · 2018: 253 · 2017: 235 · 2016: 224 · 2015: 215 · 2014: 254 · 2013: 195 · 2012: 69
FWCI: 27.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Endocrine Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R56HL053560, HL 53560, R01HL053560)
National Institute of General Medical Sciences (F32GM087107, GM 087107)
National Institute of Environmental Health Sciences (ES08314, R01ES008314, ES010026, ES 018764, R56ES010026, R01ES010026, RC2ES018764)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: endocrine disruptors, low-dose effects, non-monotonic dose-response, dose-response relationship, hormesis, chemical safety assessment, chemical testing
MeSH terms: Bisphenol A Compounds, Amphibians, Animals, Animals, Wild, Atrazine, Benzhydryl Compounds, Breast, Dioxins, Dose-Response Relationship, Drug, Environmental Exposure, Female, Herbicides, Humans, Male, Perchlorates, Phenols, Prostate, Spermatogenesis, Thyroid Gland, Twins, Sexual Development, Endocrine Disruptors

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Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

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