Cited by 3,209Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsToxic Organic Pollutants Impact

The DOI matches its Crossref record; 854 of the 858 references it cites were found in a registry or an index.

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

Open access

Vandenberg, Laura N., Colborn, Theo, Hayes, Tyrone B., Heindel, Jerrold J., Jacobs, David R., Lee, Duk-Hee, Shioda, Toshi, Soto, Ana M., vom Saal, Frederick S., Welshons, Wade V., Zoeller, R. Thomas, Myers, John Peterson·2012·Endocrine Reviews

DOI 10.1210/er.2011-1050PMC PMC3365860

Open this paper in CoChat — free account

Abstract

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of "the dose makes the poison," because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five examples from the EDC literature. Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined. We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from the cell culture, animal, and epidemiology literature. We illustrate that nonmonotonic responses and low-dose effects are remarkably common in studies of natural hormones and EDCs. Whether low doses of EDCs influence certain human disorders is no longer conjecture, because epidemiological studies show that environmental exposures to EDCs are associated with human diseases and disabilities. We conclude that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses. Thus, fundamental changes in chemical testing and safety determination are needed to protect human health.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/er.2011-1050

Cites

854 of 854 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Self-citation
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for Humans and Wildlife
van den Berg, M., Birnbaum, L. S., Bosveld, A. T. C., Brunström, B., Cook, P. M., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., et al. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106775 · Cited by 3,301
Human exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
Self-citation
The origins of the developmental origins theory
Barker, D. J. P. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01809.x · Cited by 2,955
National Health and Nutrition Examination Survey
Rothwell, C. J. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_6177 · Cited by 2,093
ORGANIZING ACTION OF PRENATALLY ADMINISTERED TESTOSTERONE PROPIONATE ON THE TISSUES MEDIATING MATING BEHAVIOR IN THE FEMALE GUINEA PIG 1
PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934
Estrogen receptors: how do they signal and what are their targets
Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews · doi:10.1152/physrev.00026.2006 · Cited by 1,857
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854
Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
Sharpe, R. M., & Skakkebæk, N. E. (1993) · The Lancet · doi:10.1016/0140-6736(93)90953-e · Cited by 1,849

Flagged first, then by citations

Show all 858 references

4 of the 858 references couldn’t be matched to a known paper.

Research works printed but not linked: 13

Centers for Disease Control, 2008, National Biomonitoring Program
U.S. Food and Drug Administration, 2009, Information for consumers (drugs)
Jones, 1996, Summation of basic endocrine data, 1
Hayes, 2011, Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes, J Steroid Biochem Mol Biol, 127, 64, 10.1016/j.jsbmb.2011.03.015 · DOI
Carrasco, 2000, Thyroid iodide transport: the Na+/I− symporter (NIS), 52
Ghassabian, 2011, Maternal thyroid function during pregnancy and parent-report problem behavior of the offspring up to age three years. The Generation R Study, Pediatr Res, 69, 454, 10.1203/PDR.0b013e3182125b0c · DOI
Sheehan, 1997, Low dose effects of hormones: a challenge for risk assessment, Risk Policy Report, 4, 31
vom Saal, 1998, Challenging risk assessment, Forum Appl Res Public Policy, 13, 11
Center for the Evaluation of Risks to Human Reproduction, 2008, Bisphenol A: public comments
Taylor, 2011, Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposure, Environ Health Perspect, 119, 422, 10.1289/ehp.1002514 · DOI
Carson, 1962, Silent spring
Hayes, 1998, Endocrine disruptors in amphibians: potential impacts and the usefulness of amphibian screens for detecting endocrine disrupting compounds, Sci J (Kagaku), 68, 557
Lee, 2010, Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study, Environ Health Perspect, 118, 1235, 10.1289/ehp.0901480 · DOI

Sorted by citations

Items 701–800 of 1,004

Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle
Wei, J., Hao, Q., Chen, C., Li, J., Han, X., Lei, Z., Wang, T., Wang, Y., You, X., Chen, X., et al. (2020) · Theranostics · doi:10.7150/thno.45253 · Cited by 53
Perinatal Exposure to Low-Dose Bisphenol A Impairs Spatial Learning and Memory in Male Rats
Kuwahara, R., Kawaguchi, S., Kohara, Y., Cui, H., & Yamashita, K. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13093fp · Cited by 52
Exposure to low doses of oxybenzone during perinatal development alters mammary gland morphology in male and female mice
Matouskova, K., Jerry, D. J., & Vandenberg, L. N. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.08.002 · Cited by 52
Self-citation
Sunscreen pollution and tourism governance: Science and innovation are necessary for biodiversity conservation and sustainable tourism
Downs, C. A., Cruz, O. T., & Remengesau, T. E. (2022) · Aquatic Conservation Marine and Freshwater Ecosystems · doi:10.1002/aqc.3791 · Cited by 52
A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots
Jacobson, T., Kler, J. S., Bae, Y., Chen, J., Ladror, D. T., Iyer, R., Nunes, D., Montgomery, N. D., Pleil, J. D., & Funk, W. E. (2022) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-022-00460-7 · Cited by 56
Bisphenol A exposure disturbs the bone metabolism: An evolving interest towards an old culprit
Thent, Z. C., Froemming, G. R. A., & Muid, S. A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.02.013 · Cited by 53
Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina)
Frank, D. F., Brander, S. M., Hasenbein, S., Harvey, D. J., Lein, P. J., Geist, J. P., & Connon, R. E. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.10.014 · Cited by 52
Assessing the interactions between micropollutants and nanoparticles in engineered and natural aquatic environments
Besha, A. T., Liu, Y., Fang, C., Bekele, D. N., & Naidu, R. (2019) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2019.1629799 · Cited by 52
Mass Spectrometry Imaging Combined with Metabolomics Revealing the Proliferative Effect of Environmental Pollutants on Multicellular Tumor Spheroids
Xie, P., Liang, X., Song, Y., & Cai, Z. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02025 · Cited by 52
A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement
Woodruff, T. J., Rayasam, S. D. G., Axelrad, D. A., Koman, P. D., Chartres, N., Bennett, D. H., Birnbaum, L. S., Brown, P., Carignan, C. C., Cooper, C., et al. (2023) · Environmental Health · doi:10.1186/s12940-022-00930-3 · Cited by 59
Self-citation
Fluoride in drinking water: An in-depth analysis of its prevalence, health effects, advances in detection and treatment
Dar, F. A., & Kurella, S. (2023) · Materials Today Proceedings · doi:10.1016/j.matpr.2023.05.645 · Cited by 51
Exposure to bisphenol A associated with multiple health-related outcomes in humans: An umbrella review of systematic reviews with meta-analyses
Lin, M.-H., Lee, C., Chuang, Y., & Shih, C. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116900 · Cited by 52
Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys
Elsworth, J. D., Jentsch, J. D., Groman, S. M., Roth, R. H., Redmond, E. D., & Leranth, C. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23735 · Cited by 51
Further Limiting Bisphenol A In Food Uses Could Provide Health And Economic Benefits
Trasande, L. (2014) · Health Affairs · doi:10.1377/hlthaff.2013.0686 · Cited by 51
Plastic bodies in a plastic world: multi-disciplinary approaches to study endocrine disrupting chemicals
Vandenberg, L. N., Luthi, D., & Quinerly, D. '. (2015) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2015.01.071 · Cited by 53
Self-citation
Contaminant Effects on California Bay–Delta Species and Human Health
State and Federal Contractors Water Agency, Fong, S., Louie, S., Werner, I., Davis, J., & Connon, R. E. (2016) · San Francisco Estuary and Watershed Science · doi:10.15447/sfews.2016v14iss4/art5 · Cited by 51
Disruption of the hypothalamic-pituitary-thyroid axis on co-exposures to dithiocarbamate and neonicotinoid pesticides: Study in a wildlife bird, Amandava amandava
Pandey, S. P., & Mohanty, B. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.02.010 · Cited by 51
Review of non‐monotonic dose‐responses of substances for human risk assessment
Beausoleil, C., Beronius, A., Bodin, L., Bokkers, B. G. H., Boon, P., Burger, M., Cao, Y., Wit, L. D., Fischer, A., Hanberg, A., et al. (2016) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2016.en-1027 · Cited by 51
Acute exposure to tris (2-butoxyethyl) phosphate (TBOEP) affects growth and development of embryo-larval zebrafish
Liu, Y., Wu, D., Xu, Q., Yu, L., Liu, C., & Wang, J. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.07.015 · Cited by 52
Sub-lethal effects of herbicides penoxsulam, imazamox, fluridone and glyphosate on Delta Smelt (Hypomesus transpacificus)
Jin, J., Kurobe, T., Ramírez-Duarte, W. F., Bolotaolo, M. B., Lam, C. H., Pandey, P. K., Hung, T., Stillway, M. E., Zweig, L., Caudill, J., et al. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.01.019 · Cited by 51
Obesogenic Effect of Sulfamethoxazole on Drosophila melanogaster with Simultaneous Disturbances on Eclosion Rhythm, Glucolipid Metabolism, and Microbiota
Yu, Z., Shen, J., Li, Z., Yao, J., Li, W., Xue, L., Vandenberg, L. N., & Yin, D. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b07889 · Cited by 50
Self-citation
Associations of environmental phthalate exposure with male steroid hormone synthesis and metabolism: An integrated epidemiology and toxicology study
Tian, M., Wu, S., Wang, Y., Liu, L., Zhang, J., Shen, H., Lu, Y.-Y., Bao, H., & Huang, Q. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129213 · Cited by 49
Low Dose of BPA Induces Liver Injury through Oxidative Stress, Inflammation and Apoptosis in Long–Evans Lactating Rats and Its Perinatal Effect on Female PND6 Offspring
Linillos-Pradillo, B., Rancán, L., Paredes, S. D., Schlumpf, M., LICHTENSTEIGER, W., Vara, E., & Tresguerres, J. A. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054585 · Cited by 50
Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations
Chen, Q., Jia, A., Snyder, S. A., Gong, Z., & Lam, S. H. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.09.089 · Cited by 52
Bisphenol A accumulation in eggs disrupts the endocrine regulation of growth in rainbow trout larvae
Birceanu, O., Servos, M. R., & Vijayan, M. M. (2015) · Aquatic Toxicology · doi:10.1016/j.aquatox.2015.01.028 · Cited by 50
Endocrine actions of pesticides measured in the Flemish environment and health studies (FLEHS I and II)
Croes, K., Hond, E. D., Bruckers, L. M., Govarts, E., Schoeters, G. E. R., Covaci, A., Loots, I., Morrens, B., Nelen, V., Sioen, I., et al. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3437-z · Cited by 50
Emerging Issues in Public Health Genomics
Roberts, J. S., Dolinoy, D. C., & Tarini, B. A. (2014) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090413-025514 · Cited by 53
Morphologic and molecular changes in the placenta: what we can learn from environmental exposures
Vrooman, L. A., Xin, F., & Bartolomei, M. S. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.08.016 · Cited by 49
Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases: The Hokkaido Study on Environment and Children's Health
Bamai, Y. A., Miyashita, C., Araki, A., Nakajima, T., Sasaki, S., & Kishi, R. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.09.270 · Cited by 48
Bisphenol A alters oocyte maturation by prematurely closing gap junctions in the cumulus cell-oocyte complex
Acuña-Hernández, D. G., Mendoza, L. A., Santacruz-Márquez, R., García‐Zepeda, S. P., Parra-Forero, L. Y., Olivares-Reyes, J. A., & Hernández‐Ochoa, I. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.02.011 · Cited by 50
Chronic exposure to a pervasive pharmaceutical pollutant erodes among-individual phenotypic variation in a fish
Tan, H., Polverino, G., Martin, J. M., Bertram, M. G., Wiles, S. C., Palacios, M. M., Bywater, C. L., White, C. R., & Wong, B. B. M. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114450 · Cited by 51
The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review
Jummaat, F. B., Yahya, E. B., Khalil, H. P. S. A., Adnan, A. S., Alqadhi, A. M., Abdullah, C. K., Atty Sofea, A. K., Olaiya, N. G., & Abdat, M. (2021) · Polymers · doi:10.3390/polym13040633 · Cited by 53
Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption
Lorigo, M., & Cairrão, E. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101054 · Cited by 50
Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women
Björvang, R. D., & Damdimopoulou, P. (2020) · Upsala Journal of Medical Sciences · doi:10.1080/03009734.2020.1727073 · Cited by 50
A comprehensive aquatic risk assessment of the beta-blocker propranolol, based on the results of over 600 research papers
Sumpter, J. P., Runnalls, T. J., Donnachie, R. L., & Owen, S. F. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148617 · Cited by 49
The environmental pollution caused by cemeteries and cremations: A review
Franco, D. S. P., Georgin, J., Campo, L. A. V., Mayoral, M. A., Goenaga, J. O., Fruto, C. M., Neckel, A., Oliveira, M. L., & Ramos, C. G. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.136025 · Cited by 65
Application of microwave-assisted micro-solid-phase extraction for determination of parabens in human ovarian cancer tissues
Sajid, M., Basheer, C., Narasimhan, K., Choolani, M. A., & Lee, H. K. (2015) · Journal of Chromatography B · doi:10.1016/j.jchromb.2015.07.020 · Cited by 49
The environmental roots of non-communicable diseases (NCDs) and the epigenetic impacts of globalization
Vineis, P., Stringhini, S., & Porta, M. S. (2014) · Environmental Research · doi:10.1016/j.envres.2014.02.002 · Cited by 50
Associations between cadmium exposure and circulating levels of sex hormones in postmenopausal women
Ali, I., Engström, A., Vahter, M., Skerfving, S., Lundh, T., Lidfeldt, J., Samsioe, G., Halldin, K., & Åkesson, A. (2014) · Environmental Research · doi:10.1016/j.envres.2014.08.009 · Cited by 52
Prospective associations between persistent organic pollutants and metabolic syndrome: A nested case–control study
Lee, Y., Kim, K.-S., Kim, S.-A., Hong, N.-S., Lee, S., & Lee, D. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.07.039 · Cited by 49
Self-citation
Effects of Endocrine-Disrupting Chemicals and Epigenetic Modifications in Ovarian Cancer: A Review
Samtani, R., Sharma, N., & Garg, D. (2017) · Reproductive Sciences · doi:10.1177/1933719117711261 · Cited by 52
Interference of dibutylphthalate on human prostate cell viability
Lorenzo, M. D., Forte, M., Valiante, S., Laforgia, V., & Falco, M. D. (2017) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2017.09.030 · Cited by 49
Psycho-Neuro-Endocrine-Immunology: A Psychobiological Concept
França, K., & Lotti, T. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-56017-5_11 · Cited by 49
Understanding Society and Natural Resources
Manfredo, M. J., Duke, E., Rechkemmer, A., & Vaske, J. J. (2014) · Springer eBooks · doi:10.1007/978-94-017-8959-2 · Cited by 57
Environmental ototoxicants, a potential new class of chemical stressors
Fábelová, L., Loffredo, C. A., Klánová, J., Hilscherová, K., Horvat, M., Tihányi, J., Richterová, D., Palkovičová, Ľ., Wimmerová, S., Sisto, R., et al. (2019) · Environmental Research · doi:10.1016/j.envres.2019.01.042 · Cited by 49
Ecotoxicological Analysis of Emerging Contaminants from Wastewater Discharges in the Coastal Zone of Cihuatlán (Jalisco, Mexico)
Arguello-Pérez, M. Á., Mendoza-Pérez, J. A., Gomez, A. T., Ramírez-Ayala, E., Godínez-Domínguez, E., & Silva-Bátiz, F. D. A. (2019) · Water · doi:10.3390/w11071386 · Cited by 49
Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials
Berge, T. L. L., Lygre, G. B., Lie, S. A., Lindh, C. H., & Bjorkman, L. L. (2019) · European Journal Of Oral Sciences · doi:10.1111/eos.12647 · Cited by 50
Cigarette Waste in Popular Beaches in Thailand: High Densities that Demand Environmental Action
Kungskulniti, N., Charoenca, N., Hamann, S. L., Pitayarangsarit, S., & Mock, J. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15040630 · Cited by 48
Bisphenol S increases the obesogenic effects of a high-glucose diet through regulating lipid metabolism in Caenorhabditis elegans
Xiao, X., Zhang, X., Bai, J., Li, J., Zhang, C., Zhao, Y., Zhu, Y. G., Zhang, J., & Zhou, X. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127813 · Cited by 48
Bisphenols impact hormone levels in animals: A meta-analysis
Rubin, A. M., & Seebacher, F. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154533 · Cited by 48
EDC-Predictor: A Novel Strategy for Prediction of Endocrine-Disrupting Chemicals by Integrating Pharmacological and Toxicological Profiles
Yu, Z., Wu, Z., Zhou, M., Cao, K., Li, W., Liu, G., & Tang, Y. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c08558 · Cited by 48
Contaminants and their ecological risk assessment in beach sediments and water along the Maharashtra coast of India: A comprehensive approach using microplastics, heavy metal(loid)s, pharmaceuticals, personal care products and plasticisers
Kumkar, P., Verma, C. R., Hýsek, Š., Pise, M., Żółtowska‐Aksamitowska, S., Gosavi, S. M., Mercl, F., Božík, M., Praus, L., Hanková, K., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164712 · Cited by 48
The time for ambitious action is now: Science-based recommendations for plastic chemicals to inform an effective global plastic treaty
Brander, S. M., Senathirajah, K., Fernandez, M. O., Weis, J. S., Kumar, E., Jahnke, A., Hartmann, N. B., Alava, J. J., Farrelly, T. A., Almroth, B. C., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174881 · Cited by 56
Bisphenol diglycidyl ethers and bisphenol A and their hydrolysis in drinking water
Lane, R. F., Adams, C. D., Randtke, S. J., & Carter, R. E. (2014) · Water Research · doi:10.1016/j.watres.2014.09.043 · Cited by 48
Evaluating chemical effects on mammary gland development: A critical need in disease prevention
Osborne, G., Rudel, R. A., & Schwarzman, M. R. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.07.077 · Cited by 51
Exogenous Hormonal Regulation in Breast Cancer Cells by Phytoestrogens and Endocrine Disruptors
Albini, A., Rosano, C., Angelini, G., Amaro, A. A., Esposito, A. I., Maramotti, S., Noonan, D. M., & Pfeffer, U. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131129124640 · Cited by 49
Xenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels
Rosa, P. L., Pellegrini, M., Totta, P., Acconcia, F., & Marino, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088961 · Cited by 48
Changes in urinary bisphenol A concentrations associated with placement of dental composite restorations in children and adolescents
Maserejian, N. N., Trachtenberg, F. L., Wheaton, O. B., Calafat, A. M., Ranganathan, G., Kim, H., & Hauser, R. B. (2016) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2016.02.020 · Cited by 52
Occurrence of Legacy and New Persistent Organic Pollutants in Avian Tissues from King George Island, Antarctica
Kim, J.-T., Son, M.-H., Kang, J., Kim, J., Jung, J.-W., & Chang, Y. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03181 · Cited by 48
Potential Health Risk of Endocrine Disruptors in Construction Sector and Plastics Industry: A New Paradigm in Occupational Health
Fučić, A., Galea, K. S., Duca, R. C., Yamani, M. E., Fréry, N., Godderis, L., Halldorsson, T. I., Iavicoli, I., Ndaw, S., Ribeiro, E., et al. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15061229 · Cited by 48
The impact of propranolol, 17α-ethinylestradiol, and gemfibrozil on early life stages of marine organisms: effects and risk assessment
Capolupo, M., Díaz-Garduño, B., & Martín-Díaz, M. L. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3185-6 · Cited by 48
Persistent Organic Pollutants in Human Breast Milk and Associations with Maternal Thyroid Hormone Homeostasis
Li, Z., Albrecht, M. C., Fromme, H., Schramm, K., & Angelis, M. D. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b06054 · Cited by 48
Late-life consequences of short-term exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood in female mice
Chiang, C., Lewis, L. R., Borkowski, G., & Flaws, J. A. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.12.006 · Cited by 48
The imbalance of Treg/Th17 cells induced by perinatal bisphenol A exposure is associated with activation of the PI3K/Akt/mTOR signaling pathway in male offspring mice
Gao, L., Dong, Y., Lin, R., Meng, Y., Wu, F., & Jia, L. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111177 · Cited by 53
Environmentally relevant mixture of S-metolachlor and its two metabolites affects thyroid metabolism in zebrafish embryos
Kuchovská, E., Pípal, M., Bláhová, L., Chandran, N. N., Morin, B., Gonzalez, P., & Bláha, L. (2020) · Aquatic Toxicology · doi:10.1016/j.aquatox.2020.105444 · Cited by 48
Glyphosate, pathways to modern diseases IV: cancer and related pathologies
Samsel, A., & Seneff, S. (2015) · Journal of Biological Physics and Chemistry · doi:10.4024/11sa15r.jbpc.15.03 · Cited by 54
Reliable quantification of bisphenol A and its chlorinated derivatives in human urine using UPLC–MS/MS method
Venisse, N., Grignon, C., Brunet, B., Ayraud-Thévenot, S., Bacle, A., Migeot, V., & Dupuis, A. (2014) · Talanta · doi:10.1016/j.talanta.2014.02.064 · Cited by 47
Autopsy, thanatopraxy, cemeteries and crematoria as hotspots of toxic organic contaminants in the funeral industry continuum
Gwenzi, W. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141819 · Cited by 47
REPRODUCTIVE TOXICOLOGY: Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways
Patisaul, H. B. (2021) · Reproduction · doi:10.1530/rep-20-0596 · Cited by 53
Dynamic Metabolic Disruption in Rats Perinatally Exposed to Low Doses of Bisphenol-A
Tremblay‐Franco, M., Cabaton, N. J., Canlet, C., Gautier, R., Schaeberle, C. M., Jourdan, F., Sonnenschein, C., Vinson, F., Soto, A. M., & Zalko, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141698 · Cited by 47
Self-citation
Use of Bisphenol A-containing baby bottles in Cameroon and Nigeria and possible risk management and mitigation measures: community as milestone for prevention
Pouokam, G. B., Ajaezi, G. C., Mantovani, A., Orisakwe, O. E., & Frazzoli, C. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.02.026 · Cited by 47
Blood Lead Levels and Serum Insulin-Like Growth Factor 1 Concentrations in Peripubertal Boys
Fleisch, A. F., Burns, J. S., Williams, P. L., Lee, M., Sergeyev, O., Korrick, S., & Hauser, R. B. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1206105 · Cited by 47
Exposure of Female Rats to an Environmentally Relevant Mixture of Brominated Flame Retardants Targets the Ovary, Affecting Folliculogenesis and Steroidogenesis
Lefèvre, P. L. C., Berger, R. G., Ernest, S. R., Gaertner, D. W., Rawn, D. F., Wade, M., Robaire, B., & Hales, B. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.134452 · Cited by 42
Low-Dose Effects: Nonmonotonic Responses for the Toxicity of a Bacillus thuringiensis Biocide to Daphnia magna
Machado, A. A. D. S., Zarfl, C., Rehse, S., & Kloas, W. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b03056 · Cited by 47
Determination of selected steroid hormones in some surface water around animal farms in Cape Town using HPLC-DAD
Olatunji, O. S., Fatoki, O. S., Opeolu, B. O., Ximba, B. J., & Chitongo, R. (2017) · Environmental Monitoring and Assessment · doi:10.1007/s10661-017-6070-8 · Cited by 47
Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis
Zhu, M. P., Chen, X., Li, Y., Yin, N., Faiola, F., Qin, Z., & Wei, W. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.7b06270 · Cited by 46
Perinatal exposures to phthalates and phthalate mixtures result in sex-specific effects on body weight, organ weights and intracisternal A-particle (IAP) DNA methylation in weanling mice
Neier, K. E., Cheatham, D., Bedrosian, L. D., & Dolinoy, D. C. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000430 · Cited by 48
Epigenetic modifications associated with in utero exposure to endocrine disrupting chemicals BPA, DDT and Pb
Onuzulu, C. D., Rotimi, O. A., & Rotimi, S. O. (2019) · Reviews on Environmental Health · doi:10.1515/reveh-2018-0059 · Cited by 50
Prenatal exposure to a phthalate mixture leads to multigenerational and transgenerational effects on uterine morphology and function in mice
Li, K., Liszka, M., Zhou, C., Brehm, E., Flaws, J. A., & Nowak, R. A. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.02.012 · Cited by 46
Calcium signaling as a possible mechanism behind increased locomotor response in zebrafish larvae exposed to a human relevant persistent organic pollutant mixture or PFOS
Christou, M., Fraser, T. W. K., Berg, V., Ropstad, E., & Kamstra, J. H. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109702 · Cited by 48
Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment
Rodrigues, P., Cunha, V. F. P. M., Oliva-Teles, L., Ferreira, M., & Guimarães, L. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.123171 · Cited by 56
Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats
Shih, M., Tain, Y., Chen, Y.-W., Hsu, W.-H., Yeh, Y., Chang, S. K. C., Liao, J.-X., & Hou, C. (2021) · Molecules · doi:10.3390/molecules26134010 · Cited by 47
(Anti)Fragility and Convex Responses in Medicine
Taleb, N. N. (2018) · Springer proceedings in complexity · doi:10.1007/978-3-319-96661-8_32 · Cited by 46
Bisphenol A: A Model Endocrine Disrupting Chemical With a New Potential Mechanism of Action
Nagel, S. C., & Bromfield, J. J. (2013) · Endocrinology · doi:10.1210/en.2013-1370 · Cited by 52
Insulin Resistance and Environmental Pollutants: Experimental Evidence and Future Perspectives
Hectors, T. L. M., Vanparys, C., Gaal, L. F. V., Jorens, P. G., Covaci, A., & Blust, R. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1307082 · Cited by 48
Bisphenol A in edible part of seafood
Repossi, A., Farabegoli, F., Gazzotti, T., Zironi, E., & Pagliuca, G. (2016) · Italian Journal of Food Safety · doi:10.4081/ijfs.2016.5666 · Cited by 46
Effects of a glyphosate‐based herbicide on the uterus of adult ovariectomized rats
Varayoud, J., Durando, M., Ramos, J. G., Milesi, M. M., Ingaramo, P. I., Muñoz‐de‐Toro, M., & Luque, E. H. (2016) · Environmental Toxicology · doi:10.1002/tox.22316 · Cited by 46
Temperature-Dependence of Glyphosate-Based Herbicide's Effects on Egg and Tadpole Growth of Common Toads
Baier, F., Jedinger, M., Gruber, E., & Zaller, J. G. (2016) · Frontiers in Environmental Science · doi:10.3389/fenvs.2016.00051 · Cited by 46
Combinatory effects of low concentrations of 17α-etinylestradiol and citalopram on non-reproductive behavior in adult zebrafish (Danio rerio)
Porseryd, T., Kellner, M., Caspillo, N. R., Volkova, K., Elabbas, L. E., Ullah, S., Olsén, H., Dinnétz, P., & Hällström, I. P. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.10.001 · Cited by 46
Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity
van Vugt‐Lussenburg, B. M. A., van der Lee, R. B., Man, H.-Y., Middelhof, I., Brouwer, A., Besselink, H. T., & van der Burg, B. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.11.005 · Cited by 46
hCG and Its Disruption by Environmental Contaminants during Human Pregnancy
Paulesu, L. R., Rao, C. V., Ietta, F., Pietropolli, A., & Ticconi, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030914 · Cited by 46
Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo
Leverrier, S., Mitchell, R. T., Becker, E., Lecante, L. L., Maamar, M. B., Homer, N. Z. M., Lavoué, V., Kristensen, D. M., Dejucq‐Rainsford, N., Jégou, B., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dex383 · Cited by 46
Chronic environmentally relevant levels of simvastatin disrupt embryonic development, biochemical and molecular responses in zebrafish (Danio rerio)
Barros, S., Montes, R., Quintana, J. B., Rodil, R., André, A., Capitão, A., Soares, J., Santos, M. M., & Neuparth, T. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.05.014 · Cited by 46
Timing of Exposure and Bisphenol-A: Implications for Diabetes Development
Tudurí, E., Marroquí, L., dos Santos, R. S., Quesada, I., Fuentes, E., & Alonso‐Magdalena, P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00648 · Cited by 47
Pharmaceuticals and pesticides in rural community drinking waters of Quebec, Canada – a regional study on the susceptibility to source contamination
Husk, B. R., Sanchez, J. S., Leduc, R., Takser, L., Savary, O., & Cabana, H. (2019) · Water Quality Research Journal · doi:10.2166/wqrj.2019.038 · Cited by 46
Maternal exposure to bisphenol A during pregnancy interferes ovaries development of F1 female mice
Wei, Y., Han, C., Li, S., Cui, Y., Bao, Y., & Shi, W. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.09.045 · Cited by 46
Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models
Couderq, S., Leemans, M., & Fini, J. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110779 · Cited by 47
In utero exposure to low doses of genistein and di‐(2‐ethylhexyl) phthalate (DEHP) alters innate immune cells in neonatal and adult rat testes
Walker, C., Ghazisaeidi, S., Collet, B., Boisvert, A., & Culty, M. (2020) · Andrology · doi:10.1111/andr.12840 · Cited by 46
Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective
DEMENEIX, B. A., Vandenberg, L. N., Ivell, R., & Zoeller, R. T. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa085 · Cited by 47
Self-citation
Sex-specific oxidative damage effects induced by BPA and its analogs on primary hippocampal neurons attenuated by EGCG
Meng, L., Liu, J., Wang, C., Ouyang, Z., Kuang, J., Pang, Q., & Fan, R. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128450 · Cited by 45

Authors: Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., Zoeller, R. T., & Myers, J. P.
Affiliations: Tufts University (US)
The Endocrine Disruption Exchange (T.C.), Paonia, Colorado 81428;
Museum of Vertebrate Zoology (US)
National Institutes of Health (US)
University of Minnesota (US)
Kyungpook National University (KR)
Massachusetts General Hospital (US)
Division of Biological Sciences (F.S.v.S.) University of Missouri-Columbia, Columbia, Missouri 65211;
University of Missouri (US)
University of Massachusetts Amherst (US)
Environmental Health Sciences (J.P.M.), Charlottesville, Virginia 22902
Corresponding author: Vandenberg, Laura N.
ORCID: Vandenberg, Laura N.
Heindel, Jerrold J.
Jacobs, David R.
Lee, Duk-Hee
Shioda, Toshi
Soto, Ana M.
Zoeller, R. Thomas
Myers, John Peterson
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2012-03-14
Volume: 33
Issue: 3
Pages: 378-455
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2011-1050
PMC: PMC3365860
OpenAlex: W2097327668
Cited by: 3,209
References: 858
Citations by year: 2026: 237 · 2025: 196 · 2024: 203 · 2023: 193 · 2022: 225 · 2021: 263 · 2020: 233 · 2019: 209 · 2018: 253 · 2017: 235 · 2016: 224 · 2015: 215 · 2014: 254 · 2013: 195 · 2012: 69
FWCI: 27.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Endocrine Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R56HL053560, HL 53560, R01HL053560)
National Institute of General Medical Sciences (F32GM087107, GM 087107)
National Institute of Environmental Health Sciences (ES08314, R01ES008314, ES010026, ES 018764, R56ES010026, R01ES010026, RC2ES018764)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: endocrine disruptors, low-dose effects, non-monotonic dose-response, dose-response relationship, hormesis, chemical safety assessment, chemical testing
MeSH terms: Bisphenol A Compounds, Amphibians, Animals, Animals, Wild, Atrazine, Benzhydryl Compounds, Breast, Dioxins, Dose-Response Relationship, Drug, Environmental Exposure, Female, Herbicides, Humans, Male, Perchlorates, Phenols, Prostate, Spermatogenesis, Thyroid Gland, Twins, Sexual Development, Endocrine Disruptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks