Plasma adiponectin concentrations in early pregnancy and subsequent risk of gestational diabetes mellitus
Abstract
Low plasma adiponectin has been identified as a risk factor for type 2 diabetes. Our objective was to determine the extent to which low maternal plasma adiponectin is predictive of gestational diabetes mellitus (GDM), a condition that is biochemically and epidemiologically similar to type 2 diabetes. We used a prospective, nested case-control study design to compare maternal plasma adiponectin concentrations in 41 cases with 70 controls. Subjects were selected from a population of 968 women who provided blood samples in early pregnancy. Plasma adiponectin was determined using an ELISA. Adiponectin concentrations were statistically significantly lower in women with GDM than controls (4.4 vs. 8.1 micro g/ml, P < 0.001). Approximately 73% of women with GDM, compared with 33% of controls, had adiponectin concentrations less than 6.4 micro g/ml. After adjusting for confounding, women with adiponectin concentrations less than 6.4 micro g/ml experienced a 4.6-fold increased risk of GDM, as compared with those with higher concentrations (95% confidence interval, 1.8-11.6). Our findings are consistent with other reports suggesting an association between hypoadiponectemia and risk of type 2 diabetes. Our findings extend the literature to include GDM. Studies designed to examine the effect of dietary and pharmacological mediators of adiponectin concentrations in pregnant and nonpregnant subjects are warranted.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GDM is associated with decreased adiponectin.
“GDM is similarly associated with decreased adiponectin [102].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [102]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,324 · see citing works
Brown, R. A., Hastie, T. J., & Tibshirani, R. J. (1991) · Biometrics · doi:10.2307/2532174 · Cited by 8,263 · see citing works
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133 · see citing works
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,659 · see citing works
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511 · see citing works
Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D., & Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-003-1074-z · Cited by 1,483 · see citing works
Association of Hypoadiponectinemia With Coronary Artery Disease in Men
Kumada, M., Kihara, S., Sumitsuji, S., Kawamoto, T., Matsumoto, S., Ouchi, N., Arita, Y., Okamoto, Y., Shimomura, I., Hiraoka, H., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000048856.22331.50 · Cited by 1,419 · see citing works
Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.8.3815 · Cited by 1,181 · see citing works
Adiponectin and protection against type 2 diabetes mellitus
Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120 · see citing works
Adiponectin and development of type 2 diabetes in the Pima Indian population
Lindsay, R. S., Funahashi, T., Hanson, R. L., Matsuzawa, Y., Tanaka, S., Tataranni, P. A., Knowler, W. C., & Krakoff, J. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09335-2 · Cited by 1,094 · see citing works
Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C., & Matsuzawa, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1126 · Cited by 1,072 · see citing works
Adiponectin: More Than Just Another Fat Cell Hormone?
Chandran, M., Phillips, S. A., Ciaraldi, T. P., & Henry, R. R. (2003) · Diabetes Care · doi:10.2337/diacare.26.8.2442 · Cited by 1,007 · see citing works
Vionnet, N., Hani, E. H., Dupont, S., Gallina, S., Francke, S., Dotte, S., de Matos, F., Durand, E., Leprêtre, F., Lecœur, C., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/316887 · Cited by 679 · see citing works
(1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-3-461 · Cited by 663 · see citing works
Combs, T. P., Berg, A. H., Rajala, M. W., Klebanov, S., Iyengar, P., Jimenez-Chillaron, J. C., Patti, M. E., Klein, S. L., Weinstein, R. S., & Scherer, P. E. (2003) · Diabetes · doi:10.2337/diabetes.52.2.268 · Cited by 544 · see citing works
Adiponectin and resistin--new hormones of white adipose tissue.
Bełtowski, J. (2003) · PubMed · Cited by 267 · see citing works
Plasma Adiponectin Levels in Overweight and Obese Asians
Yang, W., Lee, W., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C., Chen, C., Tai, T., & Chuang, L. (2002) · Obesity Research · doi:10.1038/oby.2002.150 · Cited by 221 · see citing works
Adiponectin Levels in Women with Polycystic Ovary Syndrome
Orio, F., Palomba, S., Cascella, T., Milan, G., Mioni, R., Pagano, C., Zullo, F., Colao, A., Lombardi, G., & Vettor, R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-022033 · Cited by 173 · see citing works
Miyazaki, T., Shimada, K., Mokuno, H., & Daida, H. (2003) · Heart · doi:10.1136/heart.89.6.663 · Cited by 78 · see citing works
Pendergrass, M. L., Fazioni, E., & DeFronzo, R. A. (1995) · Diabetes reviews · Cited by 52 · see citing works
Kazuo, K. A. R. A., Boutin, P., Mori, Y., Tobe, K., Christian Dina, C., Yasuda, K., Yamauchi, T., Otabe, S., Okada, T., 江藤一弘, et al. (2002) · Institutional Repositories DataBase (IRDB) · doi:10.2337/diabetes.51.2.536
Flagged first, then by citations
Research works printed but not linked: 2
- [19]19. Williams MA,MittendorfR 2000 Maternal morbidity. In: Goldman MB, Hatch M, eds. Women and health. London: Academic Press Inc.; 172-181
- [21]21. Rothman KJ, Greenland S 1998 Modern epidemiology. 2nd ed. Philadelphia: Lippincott-Raven Publishers; 359-432
Cited by
Sorted by citations
Buchanan, T. A., & Xiang, A. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524531 · Cited by 2,123 · see citing works
The Pathophysiology of Gestational Diabetes Mellitus
Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113342 · Cited by 1,874 · see citing works
Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes
Barbour, L. A., McCurdy, C. E., Hernandez, T. L., Kirwan, J. P., Catalano, P. M., & Friedman, J. E. (2007) · Diabetes Care · doi:10.2337/dc07-s202 · Cited by 811 · see citing works
Rich-Edwards, J. W., Fraser, A., Lawlor, D. A., & Catov, J. M. (2014) · Epidemiologic Reviews · doi:10.1093/epirev/mxt006 · Cited by 417 · see citing works
Buchanan, T. A., Xiang, A., Kjos, S. L., & Watanabe, R. (2007) · Diabetes Care · doi:10.2337/dc07-s201 · Cited by 417 · see citing works
Adipokines in gestational diabetes
Fasshauer, M., Blüher, M., & Stumvoll, M. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70176-1 · Cited by 230 · see citing works
Lorenzo-Almorós, A., Hang, T., Peiró, C., Soriano-Guillén, L., Egido, J., Tuñón, J., & Lorenzo, Ó. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0935-9 · Cited by 202 · see citing works
Screening for biomarkers predictive of gestational diabetes mellitus
Georgiou, H. M., Lappas, M., Georgiou, G. M., Marita, A., Bryant, V. J., Hiscock, R., Permezel, M., Khalil, Z., & Rice, G. E. (2008) · Acta Diabetologica · doi:10.1007/s00592-008-0037-8 · Cited by 151 · see citing works
Gunderson, E. P., Quesenberry, C. P., Jacobs, D. R., Feng, J., Lewis, C. E., & Sidney, S. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq267 · Cited by 96 · see citing works
Non-pharmacological management of gestational diabetes: The role of myo-inositol
Guardo, F. D., Currò, J. M., Valenti, G., Rossetti, P., Di Gregorio, L. M., Conway, F., Chiofalo, B., Garzon, S., Bruni, S., & Rizzo, G. (2020) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2019-0111 · Cited by 14 · see citing works
- Authors
- Williams, M. A., Qiu, C., Muy-Rivera, M., Vadachkoria, S., Song, T., & Luthy, D. A.
- Affiliations
- University of Washington (US)
- Swedish Medical Center (US)
- Corresponding author
- Williams, Michelle A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-05
- Volume
- 89
- Issue
- 5
- Pages
- 2306-2311
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1971950604
- Cited by
- 220
- References
- 25
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 15 · 2021: 11 · 2020: 10 · 2019: 11 · 2018: 10 · 2017: 16 · 2016: 7 · 2015: 14 · 2014: 8 · 2013: 14 · 2012: 9
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD032562, HD R01 32562)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- adiponectin, gestational diabetes mellitus, early pregnancy, type 2 diabetes risk, biomarkers of diabetes risk
- MeSH terms
- Adult, Enzyme-Linked Immunosorbent Assay, Female, Humans, Osmolar Concentration, Pregnancy, Pregnancy Trimester, First, Prospective Studies, Proteins, Risk Factors, Case-Control Studies, Diabetes, Gestational, Intercellular Signaling Peptides and Proteins, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
