Overexpression of 11β-Hydroxysteroid Dehydrogenase-1 in Adipose Tissue Is Associated with Acquired Obesity and Features of Insulin Resistance: Studies in Young Adult Monozygotic Twins
Abstract
11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyzes the interconversion of inactive cortisone to active cortisol. Overexpression of 11beta-HSD-1 in murine adipose tissue results in glucocorticoid receptor (GR)alpha overexpression, central obesity, and insulin resistance. It is controversial whether 11beta-HSD-1 or GRalpha expression are increased in human adipose tissue in obesity. We studied effects of acquired obesity on 11beta-HSD-1 gene (real-time PCR) and protein (Western blotting) expression in sc adipose tissue in 17 monozygotic twin pairs aged 24-27 yr with a mean intrapair difference in body mass index (BMI) of 3.8 kg/m(2) (range 0.4-10.1 kg/m(2)). Intrapair correlations were calculated to study effects of acquired obesity on 11beta-HSD-1 expression. Western blot analysis of adipose tissue homogenates identified approximately 50- and approximately 68-kDa proteins specific for 11beta-HSD-1. Both structural forms correlated positively with 11beta-HSD-1 mRNA concentrations. Intrapair differences in 11beta-HSD-1 mRNA, and the 50- and 68-kDa proteins in sc adipose tissue correlated positively with those in BMI (kilograms per square meter) (r = 0.78 for 11beta-HSD-1 mRNA, P = 0.0002; r = 0.87 for the 11beta-HSD-1 50-kDa protein, P = 0.0003; and r = 0.62 for the 11beta-HSD-1 68-kDa protein, P = 0.033), total body fat (percent) (r = 0.65, P = 0.005; r = 0.83, P = 0.001; and r = 0.69, P = 0.013, respectively) and sc fat (cubed centimeters) (r = 0.66, P = 0.004; r = 0.94, P = 0.0001; and r = 0.71, P = 0.009, respectively). Furthermore, 11beta-HSD-1 mRNA and 50-kDa protein expression, but not 68-kDa protein expression, correlated positively with intrapair differences in intraabdominal fat mass (cubed centimeters) (r = 0.62, P = 0.008; r = 0.69, P = 0.013; r = 0.48, P = 0.112) and serum fasting insulin concentration (milliunits per liter) (r = 0.76, P = 0.0004; r = 0.60, P = 0.037; and r = 0.43, P = 0.160, respectively). Intrapair differences in GRalpha expression were significantly inversely correlated with those in BMI and total and sc fat mass. In conclusion, expression of 11beta-HSD-1 in sc adipose tissue is increased in human acquired obesity and is closely related to accumulation of sc and intraabdominal fat and features of insulin resistance.
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These adipokine changes include increased production of inflammatory cytokines, plasminogen activator inhibitor-1, and other bioactive products, while the protective adipokine adiponectin is reduced.
“These include increased production of inflammatory cytokines, 35,36 plasminogen activator inhibitor-1, 37 and other bioactive products 38 -40 ; at the same time the potentially protective adipokine, adiponectin, is reduced.41,42”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [39]
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.76.9.4350 · Cited by 51,421 · see citing works
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works
A transgenic model of visceral obesity and the metabolic syndrome
Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766 · see citing works
Mazess, R., Barden, H. S., Bisek, J., & Hanson, J. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.6.1106 · Cited by 1,465 · see citing works
Desbuquois, B., & Aurbach, G. D. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-5-732 · Cited by 1,301 · see citing works
Classical twin studies and beyond
Boomsma, D., Busjahn, A., & Peltonen, L. (2002) · Nature Reviews Genetics · doi:10.1038/nrg932 · Cited by 1,105 · see citing works
Kotelevtsev, Y. V., Holmes, M. C., Burchell, A. N., Houston, P., Schmoll, D., Jamieson, P. M., Best, R., Brown, R., Edwards, C. R. W., Seckl, J. R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14924 · Cited by 858 · see citing works
Vidal‐Puig, A., Considine, R. V., Jimenez‐Liñan, M., Werman, A., Pories, W. J., Caro, J. F., & Flier, J. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119424 · Cited by 785 · see citing works
Does central obesity reflect “Cushing's disease of the omentum”?
Bujalska, I. J., Kumar, S., & Stewart, P. M. (1997) · The Lancet · doi:10.1016/s0140-6736(96)11222-8 · Cited by 753 · see citing works
11β-Hydroxysteroid Dehydrogenase
Stewart, P. M., & Krozowski, Z. S. (1997) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60646-9 · Cited by 716 · see citing works
Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity
Rask, E., Olsson, T., Söderberg, S., Andrew, R., Livingstone, D. E. W., Johnson, O., & Walker, B. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7453 · Cited by 657 · see citing works
Regulation of Expression of ob mRNA and Protein by Glucocorticoids and cAMP
Slieker, L. J., Sloop, K. W., Surface, P. L., Kriauciunas, A., LaQuier, F., Manetta, J. V., Bue-Valleskey, J. M., & Stephens, T. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5301 · Cited by 476 · see citing works
Rask, E., Walker, B., Söderberg, S., Livingstone, D., Eliasson, M., Johnson, O., Andrew, R., & Olsson, T. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.7.8661 · Cited by 467 · see citing works
Stewart, P. M., Boulton, A., Kumar, S., Clark, P. M. S., & Shackleton, C. H. L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5538 · Cited by 398 · see citing works
Livingstone, D. E. W., Jones, G. C., Smith, K., Jamieson, P. M., Andrew, R., Kenyon, C. J., & Walker, B. R. (2000) · Endocrinology · doi:10.1210/endo.141.2.7297 · Cited by 348 · see citing works
A microfluorometric method for the determination of free fatty acids in plasma
Miles, J., Glasscock, R., Aikens, J., Gerich, J. E., & Haymond, M. W. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38029-9 · Cited by 329 · see citing works
Schousboe, K., Willemsen, G. A. H. M., Kyvik, K. O., Mortensen, J., Boomsma, D. I., Cornes, B. K., Davis, C. J., Fagnani, C., Hjelmborg, J., Kaprio, J. A., et al. (2003) · Twin Research · doi:10.1375/136905203770326411 · Cited by 326 · see citing works
Self-citationGlucocorticoids and muscle catabolism
Hasselgren, P.-O. (1999) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-199905000-00002 · Cited by 297 · see citing works
Kaprio, J. A., Pulkkinen, L., & Rose, R. J. (2002) · Twin Research · doi:10.1375/136905202320906101 · Cited by 293 · see citing works
Self-citationDraper, N., Walker, E. A., Bujalska, I. J., Tomlinson, J. W., Chalder, S. M., Arlt, W., Lavery, G. G., Bedendo, O., Ray, D. W., Laing, I., et al. (2003) · Nature Genetics · doi:10.1038/ng1214 · Cited by 285 · see citing works
Alberts, P., Nilsson, C., Selén, G., Engblom, L. O. M., Edling, N. H. M., Norling, S., Klingström, G., Larsson, C., Forsgren, M., Ashkzari, M., et al. (2003) · Endocrinology · doi:10.1210/en.2003-0344 · Cited by 263 · see citing works
Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome
KHANI, S., & TAYEK, J. A. (2001) · Clinical Science · doi:10.1042/cs1010739 · Cited by 259 · see citing works
Paulmyer‐Lacroix, O., Boullu, S., Oliver, C., Alessi, M., & Grino, M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8614 · Cited by 241 · see citing works
Wake, D. J., Rask, E., Livingstone, D. E. W., Söderberg, S., Olsson, T., & Walker, B. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030286 · Cited by 231 · see citing works
Lindsay, R. S., Wake, D. J., Nair, S., Bunt, J., Livingstone, D. E. W., Permana, P. A., Tataranni, P. A., & Walker, B. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-030017 · Cited by 225 · see citing works
Barf, T. A., Vallgårda, J., Emond, R., Häggström, C., Kurz, G., Nygren, A. S., Larwood, V., Mosialou, E., Axelsson, K., Olsson, R., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025530f · Cited by 211 · see citing works
Immunohistochemical Localization of Type 1 11β-Hydroxysteroid Dehydrogenase in Human Tissues1
Ricketts, M., Verhaeg, J. M., Bujalska, I. J., Howie, A. J., Rainey, W. E., & Stewart, P. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.4.4706 · Cited by 197 · see citing works
Odermatt, A., Arnold, P., Stauffer, A., Frey, B. M., & Frey, F. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28762 · Cited by 190 · see citing works
Tomlinson, J., Sinha, B., Bujalska, I. J., Hewison, M., & Stewart, P. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020687 · Cited by 187 · see citing works
Sutinen, J., Häkkinen, A.-M., Westerbacka, J., Seppälä-Lindroos, A., Vehkavaara, S., Halavaara, J., Järvinen, A., Ristola, M., & Yki-Järvinen, H. (2002) · AIDS · doi:10.1097/00002030-200211080-00011 · Cited by 184 · see citing works
Self-citationWesterbacka, J., Yki‐Järvinen, H., Vehkavaara, S., Häkkinen, A., Andrew, R., Wake, D. J., Seckl, J. R., & Walker, B. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030596 · Cited by 176 · see citing works
Self-citationLiver‐Fat Accumulation and Insulin Resistance in Obese Women with Previous Gestational Diabetes
Tiikkainen, M., Tamminen, M., Häkkinen, A., Bergholm, R., Vehkavaara, S., Halavaara, J. T., Teramo, K., Rissanen, A., & Yki‐Järvinen, H. (2002) · Obesity Research · doi:10.1038/oby.2002.118 · Cited by 161 · see citing works
Self-citationRask, E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.7.3330 · Cited by 127 · see citing works
A New Method for the Continuous Monitoring of Blood Glucose by Measurement of Dissolved Oxygen
Kadish, A. H., & Hall, D. A. (1965) · Clinical Chemistry · doi:10.1093/clinchem/11.9.869 · Cited by 123 · see citing works
Livingstone, D. E. W. (2000) · Endocrinology · doi:10.1210/en.141.2.560 · Cited by 121 · see citing works
Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome
KHANI, S., & Tayek, J. A. (2001) · Clinical Science · doi:10.1042/cs20010180 · Cited by 91 · see citing works
Paulmyer-Lacroix, O. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.6.2701 · Cited by 72 · see citing works
Immunohistochemical Localization of Type 1 11 -Hydroxysteroid Dehydrogenase in Human Tissues
Ricketts, M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.4.1325 · Cited by 71 · see citing works
A transgenic model of visceral obesity and the metabolic syndrome
Szidonya, L. K., & Hunyady, L. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00581-7 · Cited by 63 · see citing works
Wong, C. ‐. (2020) · Catalysis from A to Z · doi:10.1002/9783527809080.cataz08679 · Cited by 55 · see citing works
TASKINEN, M.-R., KUUSI, T., YKI-JÄARVINEN, & NIKKILÄ, E. A. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-291 · Cited by 47 · see citing works
Kaprio, J. A., Pulkkinen, L., & Rose, R. J. (2002) · Twin Research · doi:10.1375/twin.5.5.366 · Cited by 40 · see citing works
Self-citationSchousboe, K., Willemsen, G. A. H. M., Kyvik, K. O., et al. (2003) · Twin Research · doi:10.1375/twin.6.5.409 · Cited by 39 · see citing works
Assay of glucose transport in human fat cells obtained by needle biopsy
Yki-J�rvinen, H., Nikkil�, E. A., Kubo, K., & Foley, J. E. (1986) · Diabetologia · doi:10.1007/bf00452064 · Cited by 20 · see citing works
Self-citationThurston, L. M., Chin-Smith, E. C., Jonas, K., Bujalska, I., Stewart, P., Abayasekara, D. R. E., & Michael, A. E. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780127 · Cited by 20 · see citing works
Expression of 11β-hydroxysteroid dehydrogenase type 2 in an ACTH-producing small cell lung cancer
Parks, L. L., Turney, M. K., Gaitan, D., & Kovacs, W. J. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00125-3 · Cited by 11 · see citing works
Determination of Lumenal Orientation of Microsomal 50-kDa Esterase/N-Deacetylase
Ozols, J. (1998) · Biochemistry · doi:10.1021/bi9807916 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583 · see citing works
Bays, H. E., González-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W., & Henry, R. R. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.343 · Cited by 531 · see citing works
Glucocorticoids and cardiovascular disease
Walker, B. R. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0455 · Cited by 529 · see citing works
Correlation of Obesity and Osteoporosis: Effect of Fat Mass on the Determination of Osteoporosis
Zhao, L., Jiang, H., Papasian, C. J., Maulik, D., Drees, B. M., Hamilton, J., & Deng, H. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070813 · Cited by 529 · see citing works
Free fatty acids and insulin resistance
Delarue, J., & Magnan, C. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328042ba90 · Cited by 463 · see citing works
Diagnosis and management of the metabolic syndrome
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000200416.65370.a0 · Cited by 434 · see citing works
Rodriguez, A. C. I., Epel, E. S., White, M. L., Standen, E. C., Seckl, J. R., & Tomiyama, A. J. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.014 · Cited by 422 · see citing works
Pietiläinen, K. H., Sysi‐Aho, M., Rissanen, A., Seppänen‐Laakso, T., Yki‐Järvinen, H., Kaprio, J. A., & Orešič, M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000218 · Cited by 415 · see citing works
Self-citationMacfarlane, D. P., Forbes, S., & Walker, B. R. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0054 · Cited by 385 · see citing works
Lee, M., Pramyothin, P., Karastergiou, K., & Fried, S. K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.029 · Cited by 380 · see citing works
Rosenstock, J., Banarer, S., Fonseca, V. A., Inzucchi, S. E., Sun, W. Y., Yao, W., Hollis, G. F., Flores, R., Levy, R., Williams, W. V., et al. (2010) · Diabetes Care · doi:10.2337/dc09-2315 · Cited by 315 · see citing works
Pietiläinen, K. H., Naukkarinen, J., Rissanen, A., Saharinen, J., Ellonen, P., Keränen, H., Suomalainen, A., Götz, A., Suortti, T., Yki‐Järvinen, H., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050051 · Cited by 299 · see citing works
Self-citationTreatment of type 2 diabetes: challenges, hopes, and anticipated successes
Nauck, M. A., Wefers, J., & Meier, J. J. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00113-3 · Cited by 300 · see citing works
The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome
Wang, M. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-3 · Cited by 276 · see citing works
The adipocyte as an active participant in energy balance and metabolism
Badman, M. K., & Flier, J. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.058 · Cited by 256 · see citing works
Adipocyte-Specific Glucocorticoid Inactivation Protects Against Diet-Induced Obesity
Kershaw, E. E., Morton, N. M., Dhillon, H., Ramage, L. E., Seckl, J. R., & Flier, J. S. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1023 · Cited by 253 · see citing works
Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans
Pietiläinen, K. H., Róg, T., Seppänen‐Laakso, T., Virtue, S., Gopalacharyulu, P. V., Tang, J. P., Rodríguez‐Cuenca, S., Maciejewski, A., Naukkarinen, J., Ruskeepää, A., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000623 · Cited by 238 · see citing works
Self-citationKaserer, T., Beck, K. R., Akram, M., Odermatt, A., & Schuster, D. (2015) · Molecules · doi:10.3390/molecules201219880 · Cited by 208 · see citing works
Sandeep, T. C., Andrew, R., Homer, N. Z. M., Andrews, R. C., Smith, K., & Walker, B. R. (2005) · Diabetes · doi:10.2337/diabetes.54.3.872 · Cited by 205 · see citing works
11β-hydroxysteroid dehydrogenase 1: translational and therapeutic aspects
Gathercole, L. L., Lavery, G. G., Morgan, S. A., Cooper, M. S., Sinclair, A. J., Tomlinson, J. W., & Stewart, P. M. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1050 · Cited by 196 · see citing works
Cooper, M. S., & Stewart, P. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1412 · Cited by 183 · see citing works
Cortisol—cause and cure for metabolic syndrome?
Walker, B. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01998.x · Cited by 179 · see citing works
Morton, N. M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.024 · Cited by 163 · see citing works
Inhibition of 11ß-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target
Wamil, M., & Seckl, J. R. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.06.001 · Cited by 162 · see citing works
Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism
Qi, D., & Rodrigues, B. B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00453.2006 · Cited by 162 · see citing works
Early life programming of obesity and metabolic disease
Cottrell, E. C., & Ozanne, S. E. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.017 · Cited by 156 · see citing works
Tissue Production of Cortisol by 11β‐Hydroxysteroid Dehydrogenase Type 1 and Metabolic Disease
Walker, B. R., & Andrew, R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.012 · Cited by 148 · see citing works
Androgen metabolism in adipose tissue: Recent advances
Blouin, K., Veilleux, A., Luu-The, V., & Tchernof, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.035 · Cited by 149 · see citing works
Makkonen, J., Pietiläinen, K. H., Rissanen, A., Kaprio, J. A., & Yki‐Järvinen, H. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.025 · Cited by 145 · see citing works
Self-citation11&Bgr;-Hydroxysteroid Dehydrogenase Type 1 and Obesity
Morton, N. M., & Seckl, J. R. (2008) · KARGER eBooks · doi:10.1159/000115363 · Cited by 134 · see citing works
Deep Subcutaneous Adipose Tissue: A Distinct Abdominal Adipose Depot
Walker, G. E., Verti, B., Marzullo, P., Savia, G., Mencarelli, M., Zurleni, F., Liuzzi, A., & Blasio, A. M. D. (2007) · Obesity · doi:10.1038/oby.2007.231 · Cited by 129 · see citing works
Kaprio, J. A. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706779462778 · Cited by 123 · see citing works
Self-citationThe role of sex steroids in white adipose tissue adipocyte function
Newell‐Fugate, A. E. (2017) · Reproduction · doi:10.1530/rep-16-0417 · Cited by 114 · see citing works
Schuster, D., Maurer, E. M., Laggner, C., Nashev, L. G., Wilckens, T., Langer, T., & Odermatt, A. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0600794 · Cited by 110 · see citing works
Modulation of glucocorticoid metabolism by the growth hormone – IGF‐1 axis
Agha, A., & Monson, J. P. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02763.x · Cited by 108 · see citing works
Anagnostis, P. G., Katsiki, N., Adamidou, F., Athyros, V. G., Karagiannis, A. I., Kita, M. D., & Mikhailidis, D. P. (2012) · Metabolism · doi:10.1016/j.metabol.2012.05.002 · Cited by 107 · see citing works
Bays, H. E., Blonde, L., & Rosenson, R. S. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.6.871 · Cited by 102 · see citing works
Omental 11β‐hydroxysteroid Dehydrogenase 1 Correlates with Fat Cell Size Independently of Obesity
Michailidou, Z., Jensen, M. D., Dumesic, D. A., Chapman, K. E., Seckl, J. R., Walker, B. R., & Morton, N. M. (2007) · Obesity · doi:10.1038/oby.2007.618 · Cited by 102 · see citing works
Hughes, K. A., Webster, S., & Walker, B. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.4.481 · Cited by 77 · see citing works
The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes
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The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans
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Self-citationCauses and consequences of obesity: the contribution of recent twin studies
Naukkarinen, J., Rissanen, A., Kaprio, J. A., & Pietiläinen, K. H. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.192 · Cited by 97 · see citing works
Self-citationThe Pharmacophore Concept and Its Applications in Computer-Aided Drug Design
Seidel, T., Schuetz, D. A., Garon, A., & Langer, T. (2019) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-030-14632-0_4 · Cited by 90 · see citing works
Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue
Apostolova, G., Schweizer, R. A. S., Balázs, Z., Kostadinova, R. M., & Odermatt, A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00442.2004 · Cited by 87 · see citing works
Pietiläinen, K. H., Korkeila, M., Bogl, L. H., Westerterp, K. R., Yki‐Järvinen, H., Kaprio, J. A., & Rissanen, A. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.251 · Cited by 86 · see citing works
Self-citationMustelin, L., Pietiläinen, K. H., Rissanen, A., Sovijärvi, A. R., Piirilä, P., Naukkarinen, J., Peltonen, L., Kaprio, J., & Yki-Järvinen, H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00580.2007 · Cited by 85 · see citing works
Self-citationBoullu‐Ciocca, S., Achard, V., Tassistro, V., Dutour, A., & Grino, M. (2007) · Diabetes · doi:10.2337/db07-1316 · Cited by 84 · see citing works
Véniant, M. M., Hale, C., Hungate, R. W., Gahm, K. H., Emery, M. G., Jona, J. A., Joseph, S., Adams, J., Hague, A. B., Moniz, G. A., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100242d · Cited by 82 · see citing works
Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
Gathercole, L., & Stewart, P. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.060 · Cited by 82 · see citing works
Sai, S., Esteves, C. L., Kelly, V., Michailidou, Z., Anderson, K., Coll, A. P., Nakagawa, Y., Ohzeki, T., Seckl, J. R., & Chapman, K. E. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0489 · Cited by 81 · see citing works
Rohde, J. J., Pliushchev, M. A., Sorensen, B. K., Wódka, D., Shuai, Q., Wang, J., Fung, S., Monzon, K., Chiou, W. J. H., Pan, L., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0609364 · Cited by 78 · see citing works
Veilleux, A., Rhéaume, C., Daris, M., Luu-The, V., & Tchernof, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2011 · Cited by 77 · see citing works
Comparative enzymology of 11β-hydroxysteroid dehydrogenase type 1 from six species
Arampatzis, S., Kadereit, B., Schuster, D., Balázs, Z., Schweizer, R. A. S., Frey, F. J., Langer, T., & Odermatt, A. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01736 · Cited by 76 · see citing works
Adipose tissue 11β-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing’s syndrome
Mariniello, B., Ronconi, V., Rilli, S., Bernante, P., Boscaro, M., Mantero, F., & Giacchetti, G. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02228 · Cited by 75 · see citing works
Adiposopathy: why do adiposity and obesity cause metabolic disease?
Bays, H. E., & Ballantyne, C. M. (2006) · Future Lipidology · doi:10.2217/17460875.1.4.389 · Cited by 73 · see citing works
Disruption of glucocorticoid action by environmental chemicals: Potential mechanisms and relevance
Odermatt, A., Gumy, C., Atanasov, A. G., & Dzyakanchuk, A. A. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.010 · Cited by 75 · see citing works
Satish, L., LaFramboise, W. A., O’Gorman, D. B., Johnson, S. L., Janto, B., Gan, B. S., Baratz, M. E., Hu, F. Z., Post, J. C., Ehrlich, G. D., et al. (2008) · BMC Medical Genomics · doi:10.1186/1755-8794-1-10 · Cited by 73 · see citing works
Nuotio-Antar, A. M., Hachey, D. L., & Hasty, A. H. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00522.2007 · Cited by 73 · see citing works
Tomlinson, J., & Stewart, P. M. (2005) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0023 · Cited by 72 · see citing works
11 β ‐Hydroxysteroid dehydrogenase type 1 inhibition in type 2 diabetes mellitus
Hollis, G. F., & Huber, R. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01305.x · Cited by 72 · see citing works
Pietiläinen, K. H., Kannisto, K., Korsheninnikova, E., Rissanen, A., Kaprio, J. A., Ehrenborg, E., Hamsten, A., & Yki‐Järvinen, H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2848 · Cited by 71 · see citing works
Self-citationNyirenda, M., Carter, R., Tang, J. I.-S., de Vries, A., Schlumbohm, C., Hillier, S. G., Streit, F., Oellerich, M., Armstrong, V. W., Fuchs, E., et al. (2009) · Diabetes · doi:10.2337/db09-0873 · Cited by 70 · see citing works
Fetal origins of insulin resistance and the metabolic syndrome: A key role for adipose tissue?
Meas, T. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.09.001 · Cited by 69 · see citing works
Alberti, L., Girola, A., Gilardini, L., Conti, A., Cattaldo, S., Micheletto, G., & Invitti, C. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803677 · Cited by 69 · see citing works
Baudrand, R. F., Carvajal, C. A., Riquelme, A. J., Morales, M., Solı́s, N., Pizarro, M., Escalona, A., Boza, C., Pérez, G., Domínguez, A., et al. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9937-0 · Cited by 68 · see citing works
Perrone, C. E., Mattocks, D. A. L., Hristopoulos, G., Plummer, J. D., Krajcik, R. A., & Orentreich∥, N. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700194-jlr200 · Cited by 69 · see citing works
Goedecke, J. H., Wake, D. J., Levitt, N. S., Lambert, E. V., Collins, M. R., Morton, N. M., Andrew, R., Seckl, J. R., & Walker, B. R. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02552.x · Cited by 67 · see citing works
Veilleux, A., Laberge, P. Y., Morency, J., Noël, S., Luu-The, V., & Tchernof, A. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.024 · Cited by 64 · see citing works
Novel therapeutics for type 2 diabetes: insulin resistance
Altaf, Q. A., Barnett, A. H., & Tahrani, A. A. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12400 · Cited by 64 · see citing works
Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity
Padmavathi, I. J. N., Rao, K. R., Lagishetty, V., Ganeshan, M., Kumar, K. A., Rao, C. N., Nemani, H., Ismail, A., & Raghunath, M. (2009) · Diabetes · doi:10.2337/db09-0779 · Cited by 63 · see citing works
Insulin resistance induced by hydrocortisone is increased in patients with abdominal obesity
Darmon, P., Dadoun, F., Boullu-Ciocca, S., Grino, M., Alessi, M.-C., & Dutour, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00654.2005 · Cited by 59 · see citing works
Witchel, S. F., & DeFranco, D. B. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0323 · Cited by 58 · see citing works
Obesity and Type 2 Diabetes Do Not Alter Splanchnic Cortisol Production in Humans
Basu, R., Singh, R., Basu, A., Chittilapilly, E. G., Johnson, M. C., TOFFOLO, G. M., Cobelli, C., & Rizza, R. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2390 · Cited by 58 · see citing works
Insulin and Dexamethasone Dynamically Regulate Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1
Balachandran, A., Guan, H., Sellan, M. E., Uum, S. H. M. V., & Yang, K. (2008) · Endocrinology · doi:10.1210/en.2008-0088 · Cited by 57 · see citing works
Wake, D. J., Homer, N. Z. M., Andrew, R., & Walker, B. R. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0819 · Cited by 57 · see citing works
Subcutaneous Abdominal Adipose Tissue Subcompartments: Potential Role in Rosiglitazone Effects
Walker, G. E., Marzullo, P., Verti, B., Guzzaloni, G., Maestrini, S., Zurleni, F., Liuzzi, A., & Blasio, A. M. D. (2008) · Obesity · doi:10.1038/oby.2008.326 · Cited by 56 · see citing works
Modulation of glucocorticoid action and the treatment of type-2 diabetes
Tomlinson, J., & Stewart, P. M. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.07.003 · Cited by 56 · see citing works
Westerbacka, J., Cornér, A., Kannisto, K., Kolak, M., Makkonen, J., Korsheninnikova, E., Nyman, T., Hamsten, A., Fisher, R. M., & Yki‐Järvinen, H. (2005) · Diabetologia · doi:10.1007/s00125-005-0075-5 · Cited by 55 · see citing works
Self-citationFotsch, C. H., & Wang, M. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800369f · Cited by 55 · see citing works
Laryea, G. N., Muglia, L. M., Arnett, M. G., & Muglia, L. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.09.002 · Cited by 53 · see citing works
Walker, B. R. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s002966510700523x · Cited by 54 · see citing works
11β-HSD1 in Human Fetal Membranes as a Potential Therapeutic Target for Preterm Birth
Wang, W., Chen, Z., Myatt, L., & Sun, K. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00188 · Cited by 50 · see citing works
Jean, D. J. S., Yuan, C., Bercot, E. A., Cupples, R. L., Chen, M., Fretland, J., Hale, C., Hungate, R. W., Komorowski, R., Véniant, M. M., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm061214f · Cited by 50 · see citing works
Woods, C. P., Corrigan, M., Gathercole, L., TAYLOR, A. E. R., Hughes, B. A., Gaoatswe, G., Manolopoulos, K. N., Hogan, A. E., O’Connell, J., Stewart, P. M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4120 · Cited by 47 · see citing works
11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes
Morgan, S., & Tomlinson, J. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.504713 · Cited by 47 · see citing works
Densmore, V. S., Morton, N. M., Mullins, J. J., & Seckl, J. R. (2006) · Endocrinology · doi:10.1210/en.2006-0106 · Cited by 47 · see citing works
Makkonen, J., Westerbacka, J., Kolak, M., Sutinen, J., Cornér, A., Hamsten, A., Fisher, R. M., & Yki‐Järvinen, H. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803635 · Cited by 45 · see citing works
Self-citationPeixoto, R. D. S., Turban, S., Battle, J. H., Chapman, K. E., Seckl, J. R., & Morton, N. M. (2008) · Endocrinology · doi:10.1210/en.2007-1028 · Cited by 45 · see citing works
Obesity, sleep apnea, aldosterone, and hypertension
Goodfriend, T. L. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0042-x · Cited by 44 · see citing works
Thieringer, R., & Hermanowski‐Vosatka, A. (2005) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.3.5.911 · Cited by 43 · see citing works
Blackett, P. R., & Sanghera, D. K. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2012.04.079 · Cited by 44 · see citing works
The discovery of 2-anilinothiazolones as 11β-HSD1 inhibitors
Yuan, C., Jean, D. J. S., Liu, Q., Cai, L., Li, A., Han, N., Moniz, G. A., Askew, B. C., Hungate, R. W., Johansson, L., et al. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.09.070 · Cited by 41 · see citing works
Essential roles of 11β-HSD1 in regulating brown adipocyte function
Liu, J., Kong, X., Wang, L., Qi, H., Di, W., Zhang, X., Wu, L., Chen, X., Yu, J., Zha, J., et al. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0099 · Cited by 41 · see citing works
Genetic manipulation of 11β-hydroxysteroid dehydrogenases in mice
Paterson, J. M., Seckl, J. R., & Mullins, J. J. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00017.2005 · Cited by 41 · see citing works
Dube, S., Norby, B., Pattan, V., Carter, R. E., Basu, A., & Basu, R. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3017 · Cited by 39 · see citing works
11β-HSD1, Inflammation, Metabolic Disease and Age-related Cognitive (dys)Function
Chapman, K. E., & Seckl, J. R. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9504-9 · Cited by 38 · see citing works
Virtual screening applications in short-chain dehydrogenase/reductase research
Beck, K. R., Kaserer, T., Schuster, D., & Odermatt, A. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.03.008 · Cited by 38 · see citing works
Adipose tissue in cortisol excess: What Cushing’s syndrome can teach us?
Bavaresco, A., Mazzeo, P., Lazzara, M., & Barbot, M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116137 · Cited by 40 · see citing works
Constantinopoulos, P., Michalaki, M. A., Kottorou, A. E., Habeos, I. G., Psyrogiannis, A. I., Kalfarentzos, F., & Kyriazopoulou, V. E. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0626 · Cited by 35 · see citing works
- Authors
- Kannisto, K., Pietiläinen, K. H., Ehrenborg, E., Rissanen, A., Kaprio, J., Hamsten, A., & Yki-Järvinen, H.
- Affiliations
- Karolinska Institutet (SE)
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Corresponding author
- Kannisto, Katja
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-09
- Volume
- 89
- Issue
- 9
- Pages
- 4414-4421
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2102335700
- Cited by
- 205
- References
- 45
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 10
- FWCI
- 17.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- European Commission (QLG2-CT-2002-01254, 01254)
- Hjärt-Lungfonden
- Karolinska Institutet
- Stockholms Läns Landsting
- Svenska Läkaresällskapet
- Medical Research Council
- Socialstyrelsen
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- 11β-hydroxysteroid dehydrogenase type 1, insulin resistance, subcutaneous adipose tissue, monozygotic twins, glucocorticoid receptor alpha, cortisol, body mass index, adipose tissue gene expression, young adults, adipocyte hypertrophy
- MeSH terms
- Adipose Tissue, Fatty Acids, Nonesterified, Humans, Insulin Resistance, Obesity, Receptors, Glucocorticoid, RNA, Messenger, Twins, Monozygotic, Up-Regulation, Gene Expression Regulation, Enzymologic, 11-beta-Hydroxysteroid Dehydrogenase Type 1
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