Metabolic and Behavioral Characteristics of Metabolically Obese but Normal-Weight Women
Abstract
A unique subset of individuals termed metabolically obese but normal weight (MONW) has been identified. These young women are potentially at increased risk for development of the metabolic syndrome despite their young age and normal body mass index. We seek to determine metabolic and behavioral factors that could potentially distinguish MONW women from young women with a normal metabolic profile.Ninety-six women were classified as MONW (n = 12) or non-MONW (n = 84) based on a cut point of insulin sensitivity (as estimated by the homeostasis model assessment). Potentially distinguishing phenotypes between groups measured included serum lipids, ghrelin, leptin, adiponectin, body composition and body fat distribution, resting and physical activity energy expenditure, peak oxygen uptake, dietary intake, dietary behavior, and family history and lifestyle variables. Despite a similar body mass index between groups, MONW women showed higher percent body fat, lower fat-free mass, lower physical activity energy expenditure, and lower peak oxygen uptake than non-MONW women. Plasma cholesterol level was higher in MONW women, whereas no differences were noted for other blood lipids, ghrelin, leptin, adiponectin, and resting energy expenditure. MONW women had lower dietary restraint scores than non-MONW women, but no differences were noted in disinhibition, hunger, and dietary intake. Stepwise regression analysis performed on all subjects showed that 33.5% of the unique variance of the homeostasis model assessment was explained with the variables of percentage of body fat (17.1%), level of dietary restraint (10.4%), and age (6%). Both metabolic and dietary behavioral variables contribute to the deleterious metabolic profile of MONW women. They display lower insulin sensitivity due potentially to a cluster of sedentary behavior patterns that contribute to their higher adiposity. Furthermore, cognitive attitudes toward food (i.e. dietary restraint) and concomitant lifestyle behaviors may play a role in regulating insulin sensitivity in MONW women.
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Environmental factors proposed to influence the development of insulin resistance include dietary composition, sedentary behavioral patterns, and cognitive attitudes toward food (dietary restraints).
“Environmental factors that have been proposed to influence the development of insulin resistance are dietary composition, sedentary behavioral patterns, and also cognitive attitudes toward food (i.e., dietary restraints) (2).”
From Eating Meals Irregularly: A Novel Environmental Risk Factor for the Metabolic Syndrome (2008) · cites this paper as [2]
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- Authors
- Conus, F., Allison, D. B., Rabasa-Lhoret, R., St-Onge, M., St-Pierre, D. H., Tremblay-Lebeau, A., & Poehlman, E. T.
- Affiliations
- Université de Montréal (CA)
- University of Alabama at Birmingham (US)
- Unité Metabolique (F.C., R.R.-L., M.S.-O., D.H.S.-P., A.T.-L.), Département de Nutrition, Faculté de Médecine, Université de Montréal, Montréal, Québec H3T 1A8, Canada
- Scriptus Medicus (E.T.P.), Montréal, Québec H2L 3R8, Canada
- Corresponding author
- Conus, Florence
- ORCID
- Allison, David B.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-10-01
- Volume
- 89
- Issue
- 10
- Pages
- 5013-5020
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2164648624
- Cited by
- 215
- References
- 57
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 14 · 2015: 18 · 2014: 18 · 2013: 11 · 2012: 19
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- insulin sensitivity, metabolic syndrome, young women, body fat percentage, fat-free mass, physical activity energy expenditure, peak oxygen uptake, dietary restraint, ghrelin, leptin, adiponectin, serum cholesterol, sedentary behavior, dietary behavior, HOMA
- MeSH terms
- Adolescent, Adult, Body Weight, Energy Intake, Cholesterol, Energy Metabolism, Female, Humans, Obesity, Risk Factors, Cohort Studies, Health Behavior, Body Mass Index, Multivariate Analysis, Leptin, Intercellular Signaling Peptides and Proteins, Peptide Hormones, Risk Reduction Behavior, Adiponectin, Ghrelin
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