Nonobese fatty liver disease
Abstract
Nonalcoholic fatty liver disease (NAFLD) refers to a group of conditions characterized by hepatic steatosis in the absence of significant alcohol consumption. NAFLD is seen commonly in patients with metabolic abnormalities associated with obesity, such as type II diabetes, dyslipidemia, and metabolic syndrome. Evidently, however, not all obese subjects develop NAFLD and, more importantly, NAFLD can be found in nonobese individuals. Although NAFLD occurring in nonobese subjects has been reported in children and adults of all ethnicities, it appears to be recognized more frequently in Asians, even when strict ethnicity-specific body mass index criteria are used to define obesity. Studies based on liver biopsies suggest that the prevalence of nonalcoholic steatohepatitis and fibrosis does not differ significantly between nonobese NAFLD and NAFLD in obese patients. Visceral obesity as opposed to general obesity, high fructose and cholesterol intake, and genetic risk factors (eg, palatin-like phospholipase domain-containing 3) may be associated with nonobese NAFLD. In general, nonalcoholic steatohepatitis is associated with increased mortality, primarily from cardiovascular causes, independent of other metabolic factors. Although data regarding the mortality impact of nonobese NAFLD are not as mature, it may be important to identify high-risk nonobese NAFLD patients and manage their metabolic profile. Currently, lifestyle modification to reduce visceral adiposity, including dietary changes and physical activity, remains the standard of care in patients with nonobese NAFLD.
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MASLD also occurs in individuals with normal weight with a prevalence of ~10%.
“MASLD also occurs in individuals with normal weight with a prevalence of ~10 % [35].”
From Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease? (2024) · cites this paper as [35]
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- Authors
- Kim, D., & Kim, W. R.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Kim, W. Ray
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 15
- Issue
- 4
- Pages
- 474-485
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2521475965
- Cited by
- 341
- References
- 132
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 28 · 2023: 33 · 2022: 43 · 2021: 54 · 2020: 50 · 2019: 47 · 2018: 23 · 2017: 21 · 2016: 3 · 2014: 1
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- non-alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, liver fibrosis, visceral obesity, metabolic syndrome, type 2 diabetes, dyslipidemia, fructose consumption, cholesterol intake, cardiovascular mortality, lifestyle modification, dietary intervention, physical activity
- MeSH terms
- Ethnicity, Feeding Behavior, Humans, Life Style, Exercise, Prevalence, Survival Analysis, Genetic Predisposition to Disease, Non-alcoholic Fatty Liver Disease
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