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Cited by 101Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Vascular Dysfunction and Metabolic Parameters in Polycystic Ovary Syndrome

Meyer, C., McGrath, B. P., Cameron, J., Kotsopoulos, D., Teede, H. J.·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2004-1487
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Abstract

CONTEXT: Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and the metabolic syndrome; however, the cardiovascular (CV) manifestations of PCOS remain unclear. OBJECTIVE: The objective of this study was to examine the relationships between IR, metabolic parameters, androgens, and markers of early CV disease in PCOS. DESIGN: We conducted an observational study examining noninvasive markers of early CV disease in women with PCOS including structural [carotid intimal media thickness (IMT)] and functional measures (arterial function with pulse wave velocity and endothelial function with brachial arterial flow-mediated vasodilation). Metabolic parameters included insulin and glucose during an oral glucose tolerance test and lipid and androgen levels. SETTING: Participants were recruited from the general community. PATIENTS: Eighty overweight women with PCOS who were nonsmokers and not on oral contraceptives or other medications known to affect IR participated in the study. RESULTS: Stepwise regression analysis showed that after adjustment for age and body mass index, IMT was significantly correlated with blood pressure (BP) load (P = 0.03) and inversely with dehydroepiandrosterone sulfate (DHEAS) (P = 0.01). After correction for androgen status, IMT was correlated with fasting glucose and area under curve (AUC) insulin. Flow-mediated vasodilation was inversely related to lipids (P = 0.02), whereas pulse wave velocity was related to BP (P < 0.001), AUC insulin (P = 0.04), and AUC glucose (P = 0.035). CONCLUSION: In overweight women with PCOS, insulin resistance and BP interacted negatively with arterial structural and functional measures. DHEAS correlated inversely with arterial structure, suggesting possible cardioprotective effects of endogenous DHEAS in women with PCOS. Additional research is needed to clarify these findings.

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Crossref · 10.1210/jc.2004-1487

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Metadata

Authors
Meyer, C., McGrath, B. P., Cameron, J., Kotsopoulos, D., & Teede, H. J.
Affiliations
Dandenong Hospital (AU)
Corresponding author
Teede, H. J.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-08-01
Volume
90
Issue
8
Pages
4630-4635
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2004-1487
OpenAlex
W1992054212
Cited by
101
References
38
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 5
FWCI
9.81
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
polycystic ovary syndrome, insulin resistance, cardiovascular risk, carotid intima-media thickness, flow-mediated dilation, pulse wave velocity, endothelial function, arterial stiffness, dehydroepiandrosterone sulfate, blood pressure, fasting blood glucose, serum lipids, metabolic syndrome, overweight women
MeSH terms
Adolescent, Adult, Androgens, Carotid Artery Diseases, Endothelium, Vascular, Female, Humans, Insulin Resistance, Middle Aged, Obesity, Polycystic Ovary Syndrome, Pulsatile Flow, Regression Analysis, Ultrasonography, Vasodilation, Blood Pressure Monitoring, Ambulatory

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