Evidence for Association Between Polycystic Ovary Syndrome and Premature Carotid Atherosclerosis in Middle-Aged Women
Abstract
Abstract —Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder characterized by obesity, hyperandrogenism, and insulin resistance. An adverse lipid profile has also been observed in PCOS-affected women, suggesting that these individuals may be at increased risk for coronary heart disease at a young age. The objective of the present study was to evaluate subclinical atherosclerosis among women with PCOS and age-matched control subjects. A total of 125 white PCOS cases and 142 controls, aged ≥30 years were recruited. Collection of baseline sociodemographic data, reproductive hormone levels, and cardiovascular risk factors was conducted from 1992 to 1994. During follow-up (1996 to 1999), these women underwent B-mode ultrasonography of the carotid arteries for the evaluation of carotid intima-media wall thickness (IMT) and the prevalence of plaque. A significant difference was observed in the distribution of carotid plaque among PCOS cases compared with controls: 7.2% (9 of 125) of PCOS cases had a plaque index of ≥3 compared with 0.7% (1 of 142) of similarly aged controls ( P =0.05). Overall and in the group aged 30 to 44 years, no difference was noted in mean carotid IMT between PCOS cases and controls. Among women aged ≥45 years, PCOS cases had significantly greater mean IMT than did control women (0.78±0.03 versus 0.70±0.01 mm, P =0.005). This difference remained significant after adjustment for age and BMI ( P <0.05). These results suggest that (1) lifelong exposure to an adverse cardiovascular risk profile in women with PCOS may lead to premature atherosclerosis, and (2) the PCOS-IMT association is explained in part by weight and fat distribution and associated risk factors. There may be an independent effect of PCOS unexplained by the above variables that is related to the hormonal dysregulation of this condition.
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In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD have been noted and are related to IR and obesity.
“In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD 29,30,83 have been noted and are related to IR and obesity. 84-89”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [88]
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- Authors
- Talbott, E. O., Guzick, D. S., Sutton-Tyrrell, K., McHugh-Pemu, K. P., Zborowski, J. V., Remsberg, K. E., & Kuller, L. H.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2000-11
- Volume
- 20
- Issue
- 11
- Pages
- 2414-2421
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2172146521
- Cited by
- 511
- References
- 40
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 10 · 2018: 13 · 2017: 7 · 2016: 7 · 2015: 26 · 2014: 29 · 2013: 15 · 2012: 28
- FWCI
- 19.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL44664, R01HL044664)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, premature atherosclerosis, carotid intima-media thickness, carotid plaque, subclinical atherosclerosis, middle-aged women, cardiovascular risk factors, hyperandrogenism, insulin resistance, obesity, body mass index, lipid profile, coronary heart disease risk
- MeSH terms
- Age Factors, Arteriosclerosis, Carotid Artery Diseases, Female, Humans, Middle Aged, Polycystic Ovary Syndrome, Risk Factors, Case-Control Studies, Carotid Artery, Common, Tunica Intima, Endosonography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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