Cited by 711Posttraumatic Stress Disorder ResearchStress Responses and CortisolMaternal Mental Health During Pregnancy and Postpartum

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Transgenerational Effects of Posttraumatic Stress Disorder in Babies of Mothers Exposed to the World Trade Center Attacks during Pregnancy

Abstract

CONTEXT: Reduced cortisol levels have been linked with vulnerability to posttraumatic stress disorder (PTSD) and the risk factor of parental PTSD in adult offspring of Holocaust survivors. OBJECTIVE: The purpose of this study was to report on the relationship between maternal PTSD symptoms and salivary cortisol levels in infants of mothers directly exposed to the World Trade Center collapse on September 11, 2001 during pregnancy. DESIGN: Mothers (n = 38) collected salivary cortisol samples from themselves and their 1-yr-old babies at awakening and at bedtime. RESULTS: Lower cortisol levels were observed in both mothers (F = 5.15, df = 1, 34; P = 0.030) and babies of mothers (F = 8.0, df = 1, 29; P = 0.008) who developed PTSD in response to September 11 compared with mothers who did not develop PTSD and their babies. Lower cortisol levels were most apparent in babies born to mothers with PTSD exposed in their third trimesters. CONCLUSIONS: The data suggest that effects of maternal PTSD related to cortisol can be observed very early in the life of the offspring and underscore the relevance of in utero contributors to putative biological risk for PTSD.

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Crossref · 10.1210/jc.2005-0550

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Metadata

Authors
Yehuda, R., Engel, S. M., Brand, S. R., Seckl, J., Marcus, S. M., & Berkowitz, G. S.
Affiliations
  • James J. Peters VA Medical Center (US)
  • Western General Hospital (GB)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Yehuda, Rachel
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2005-07
Volume
90
Issue
7
Pages
4115-4118
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2124699909
Cited by
711
References
24
Citations by year
2026: 5 · 2025: 26 · 2024: 20 · 2023: 25 · 2022: 32 · 2021: 38 · 2020: 83 · 2019: 41 · 2018: 36 · 2017: 38 · 2016: 32 · 2015: 37 · 2014: 36 · 2013: 42 · 2012: 26
FWCI
37.79
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • New York Community Trust
  • National Institute of Mental Health (5 R01 MH64675-03, R01MH064675)
  • National Institute of Environmental Health Sciences (P42 ES07384, P42ES007384)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
post-traumatic stress disorder, maternal PTSD, transgenerational effects, salivary cortisol, infants, World Trade Center attacks, September 11 attacks, prenatal exposure, third trimester, biological risk
MeSH terms
Adult, Female, Humans, Hydrocortisone, Pregnancy, Pregnancy Complications, Stress Disorders, Post-Traumatic, Terrorism

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