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Cited by 210Pituitary Gland Disorders and TreatmentsAdrenal and Paraganglionic TumorsNeuroendocrine Tumor Research Advances

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Long-term impaired quality of life in Cushing's syndrome despite initial improvement after surgical remission

Lindsay, John R., Nansel, Tonya, Baid, Smita, Gumowski, Julie, Nieman, Lynnette K.·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-1058
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Abstract

CONTEXT: Cushing's syndrome (CS) is associated with symptoms that may impair health-related quality of life (HRQL). METHODS: We used the short-form 36 survey to evaluate HRQL in 23 patients with Cushing's disease before and after transsphenoidal surgery (age, 42.7 +/- 12.0 yr; 19 women and four men) and in a cross-section of 343 CS patients (age, 48.2 +/- 14.1 yr; 265 women and 78 men) in remission for up to 25.8 yr after surgery (adrenal, 5%; ectopic, 6%). The z-scores were calculated for short-form 36 domains, and physical (PCS) and mental (MCS) summary scores were compared with those of age- and sex-matched controls (n = 6742). RESULTS: Active Cushing's disease was associated with low PCS and MCS scores (P < 0.05). Despite residual postoperative impairment, primarily of physical domains, all HRQL parameters improved after treatment with transsphenoidal surgery (3.2 +/- 1.5 yr; P < 0.05). In the cross-section in remission at follow-up, there was a small, but significant (P < 0.05), impairment of both PCS and MCS. A longitudinal postoperative analysis confirmed stable, but impaired, HRQL over time. Logistic regression demonstrated that previous pituitary radiation and current glucocorticoid use had little effect on HRQL outcomes. CONCLUSION: CS is associated with impaired HRQL, which partially resolves after treatment. At longer-term follow-up, however, there is residual impairment of HRQL. Determination of modifiable factors that contribute to impaired HRQL may help reduce the physical and psychosocial burden of this disease.

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Metadata

Authors
Lindsay, J. R., Nansel, T., Baid, S., Gumowski, J., & Nieman, L. K.
Affiliations
National Institutes of Health (US)
Corresponding author
Nieman, Lynnette K.
ORCID
Nieman, Lynnette K.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-02
Volume
91
Issue
2
Pages
447-453
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-1058
OpenAlex
W2149619533
Cited by
210
References
24
Citations by year
2026: 5 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 14 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 12 · 2017: 9 · 2016: 13 · 2015: 22 · 2014: 14 · 2013: 16 · 2012: 20
FWCI
6.82
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (Queen's University Belfast) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
Keywords
Cushing's syndrome, Cushing's disease, health-related quality of life, transsphenoidal surgery, surgical remission, long-term outcomes, physical function, mental health, glucocorticoid use, residual impairment
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Cushing Syndrome, Female, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Surveys and Questionnaires, Remission Induction, Cohort Studies

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